GREMLIN Database
YBDH - Uncharacterized oxidoreductase YbdH
UniProt: P45579 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12692
Length: 362 (320)
Sequences: 14096 (9602)
Seq/√Len: 536.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_A347_P3.5381.00
325_D351_R3.4971.00
214_E304_R3.1791.00
287_A299_T3.1321.00
81_A85_D2.7741.00
79_L105_L2.7631.00
19_P157_E2.6001.00
90_V102_A2.5511.00
219_D222_N2.5221.00
51_T55_P2.5051.00
346_T349_T2.4541.00
37_A89_V2.4271.00
74_S135_D2.4001.00
24_H27_D2.3171.00
165_Q276_T2.2961.00
164_Q168_L2.2721.00
212_S236_I2.2501.00
112_P150_F2.2401.00
20_G157_E2.2111.00
34_L89_V2.2071.00
324_I351_R2.1341.00
259_V354_F2.0981.00
36_R63_K2.0971.00
215_Q222_N2.0511.00
317_D323_E1.9861.00
347_P351_R1.9851.00
317_D322_A1.9791.00
92_G102_A1.9661.00
300_G304_R1.9571.00
66_L78_Q1.9461.00
44_R48_A1.9361.00
21_S24_H1.9361.00
23_N52_K1.9151.00
204_A207_D1.9111.00
160_L223_Q1.9091.00
154_V238_A1.8961.00
54_P58_G1.8741.00
99_L115_A1.8681.00
178_W205_I1.8651.00
214_E218_S1.8451.00
169_A276_T1.8271.00
75_D78_Q1.8061.00
328_I351_R1.8001.00
260_H277_K1.7931.00
51_T54_P1.7891.00
215_Q219_D1.7291.00
83_S111_L1.7211.00
58_G64_H1.7101.00
82_E85_D1.7051.00
286_S298_L1.7021.00
35_S88_S1.6971.00
289_L341_L1.6701.00
28_F31_D1.6661.00
174_T209_L1.6541.00
68_R75_D1.6351.00
266_L326_K1.6341.00
26_H56_A1.6261.00
325_D347_P1.6161.00
303_Q309_T1.5791.00
310_T313_E1.5721.00
42_G45_A1.5641.00
327_V354_F1.5631.00
323_E326_K1.5571.00
38_V83_S1.5501.00
326_K330_H1.5431.00
40_I102_A1.5401.00
328_I347_P1.5351.00
38_V82_E1.5301.00
175_L206_R1.5111.00
167_L234_D1.5071.00
73_E77_Q1.5041.00
249_R252_R1.4611.00
76_V101_T1.4591.00
78_Q81_A1.4491.00
74_S77_Q1.4481.00
37_A91_I1.4191.00
46_I50_Q1.4041.00
52_K157_E1.3791.00
207_D211_N1.3711.00
157_E160_L1.3691.00
204_A208_V1.3691.00
114_V151_M1.3671.00
218_S304_R1.3531.00
219_D249_R1.3521.00
28_F151_M1.3421.00
159_I234_D1.3411.00
76_V132_W1.3341.00
55_P59_L1.3291.00
272_F277_K1.3271.00
292_D296_A1.3131.00
99_L124_A1.3061.00
280_Y314_L1.3061.00
19_P160_L1.3061.00
171_I213_S1.2851.00
14_N28_F1.2831.00
297_Q300_G1.2831.00
326_K329_A1.2831.00
172_G302_Y1.2771.00
299_T303_Q1.2761.00
19_P235_A1.2731.00
30_T60_P1.2721.00
90_V106_A1.2711.00
65_I82_E1.2661.00
212_S215_Q1.2661.00
92_G113_F1.2611.00
55_P58_G1.2521.00
25_L53_L1.2491.00
163_P166_Y1.2481.00
53_L93_V1.2441.00
76_V105_L1.2401.00
36_R65_I1.2401.00
203_Q207_D1.2391.00
169_A273_L1.2361.00
22_F52_K1.2341.00
15_Y242_M1.2321.00
54_P64_H1.2311.00
211_N236_I1.2301.00
18_H24_H1.2301.00
89_V114_V1.2291.00
83_S87_R1.2241.00
349_T352_A1.2171.00
159_I238_A1.2151.00
77_Q81_A1.1981.00
38_V87_R1.1941.00
76_V80_A1.1911.00
177_K209_L1.1871.00
266_L330_H1.1801.00
20_G23_N1.1721.00
40_I105_L1.1701.00
43_K66_L1.1651.00
36_R88_S1.1641.00
200_N204_A1.1581.00
45_A48_A1.1581.00
348_D351_R1.1571.00
44_R47_A1.1561.00
171_I237_I1.1541.00
348_D352_A1.1511.00
18_H21_S1.1441.00
259_V281_G1.1441.00
172_G307_L1.1431.00
255_A282_I1.1391.00
329_A333_R1.1321.00
19_P223_Q1.1321.00
16_F28_F1.1301.00
255_A345_L1.1171.00
222_N247_G1.1151.00
134_N137_G1.1041.00
29_F89_V1.1031.00
283_L299_T1.1011.00
22_F116_V1.0851.00
162_A166_Y1.0851.00
287_A290_G1.0791.00
83_S90_V1.0751.00
78_Q82_E1.0681.00
272_F280_Y1.0651.00
43_K47_A1.0611.00
21_S153_L1.0611.00
288_L349_T1.0521.00
22_F158_I1.0501.00
68_R72_S1.0491.00
267_P323_E1.0471.00
164_Q217_L1.0441.00
52_K55_P1.0441.00
129_L143_E1.0401.00
50_Q54_P1.0381.00
40_I67_F1.0361.00
211_N215_Q1.0291.00
20_G155_E1.0231.00
39_W54_P1.0191.00
92_G115_A1.0181.00
222_N233_V1.0071.00
120_A167_L1.0031.00
24_H28_F0.9991.00
73_E132_W0.9991.00
16_F151_M0.9911.00
209_L237_I0.9881.00
61_G64_H0.9841.00
167_L216_A0.9811.00
332_L347_P0.9801.00
52_K56_A0.9711.00
321_Q324_I0.9711.00
167_L220_Q0.9661.00
80_A84_G0.9651.00
58_G61_G0.9611.00
16_F24_H0.9601.00
39_W50_Q0.9501.00
157_E223_Q0.9491.00
126_W152_V0.9461.00
300_G303_Q0.9421.00
126_W242_M0.9411.00
27_D60_P0.9401.00
290_G295_L0.9401.00
330_H333_R0.9371.00
259_V350_L0.9371.00
172_G279_A0.9351.00
102_A113_F0.9341.00
107_R147_D0.9311.00
256_A282_I0.9291.00
107_R145_F0.9271.00
23_N56_A0.9261.00
74_S78_Q0.9241.00
81_A84_G0.9161.00
325_D329_A0.9161.00
34_L112_P0.9141.00
178_W244_G0.9121.00
199_I294_V0.9101.00
83_S109_L0.9061.00
58_G63_K0.9061.00
292_D295_L0.9051.00
164_Q306_H0.9021.00
72_S75_D0.8991.00
41_Y46_I0.8961.00
29_F114_V0.8891.00
26_H60_P0.8861.00
260_H264_T0.8821.00
181_A212_S0.8781.00
257_H274_H0.8781.00
215_Q218_S0.8781.00
328_I332_L0.8751.00
283_L302_Y0.8731.00
92_G99_L0.8731.00
89_V112_P0.8701.00
36_R86_D0.8671.00
291_Q343_V0.8651.00
106_A111_L0.8651.00
14_N31_D0.8621.00
101_T105_L0.8621.00
216_A220_Q0.8591.00
181_A247_G0.8591.00
83_S105_L0.8571.00
99_L117_P0.8571.00
199_I202_A0.8571.00
256_A278_V0.8571.00
239_G243_V0.8551.00
22_F157_E0.8551.00
258_A338_I0.8461.00
182_V208_V0.8451.00
262_G330_H0.8441.00
288_L343_V0.8391.00
208_V211_N0.8381.00
115_A149_N0.8321.00
28_F153_L0.8271.00
42_G48_A0.8261.00
41_Y98_L0.8241.00
183_V187_Q0.8191.00
23_N157_E0.8181.00
26_H30_T0.8141.00
273_L276_T0.8121.00
156_P235_A0.8121.00
208_V236_I0.8091.00
210_L297_Q0.8091.00
22_F155_E0.8061.00
46_I51_T0.8061.00
74_S136_A0.8041.00
106_A113_F0.8041.00
262_G354_F0.8021.00
184_L187_Q0.8011.00
72_S135_D0.7991.00
309_T313_E0.7971.00
40_I79_L0.7971.00
168_L217_L0.7951.00
73_E135_D0.7931.00
27_D31_D0.7921.00
176_A282_I0.7921.00
171_I174_T0.7911.00
77_Q80_A0.7851.00
293_D296_A0.7851.00
164_Q197_L0.7791.00
39_W64_H0.7781.00
165_Q169_A0.7761.00
220_Q223_Q0.7731.00
56_A59_L0.7711.00
162_A170_G0.7701.00
26_H59_L0.7661.00
261_N334_P0.7661.00
255_A285_Q0.7661.00
79_L101_T0.7651.00
70_H97_A0.7631.00
67_F101_T0.7621.00
201_N243_V0.7591.00
76_V104_A0.7541.00
19_P156_P0.7471.00
284_V287_A0.7461.00
260_H278_V0.7451.00
201_N204_A0.7421.00
37_A88_S0.7401.00
42_G66_L0.7361.00
160_L221_Q0.7351.00
113_F150_F0.7311.00
65_I87_R0.7291.00
215_Q233_V0.7291.00
280_Y283_L0.7271.00
259_V284_V0.7251.00
90_V111_L0.7221.00
164_Q218_S0.7201.00
49_A93_V0.7191.00
44_R66_L0.7171.00
27_D30_T0.7171.00
327_V331_T0.7171.00
25_L116_V0.7161.00
325_D328_I0.7151.00
179_Y206_R0.7151.00
195_V198_G0.7141.00
29_F34_L0.7141.00
281_G353_A0.7121.00
211_N214_E0.7111.00
288_L345_L0.7111.00
299_T309_T0.7101.00
212_S233_V0.7101.00
25_L153_L0.7091.00
147_D150_F0.7081.00
128_P145_F0.7061.00
179_Y298_L0.7061.00
263_L277_K0.7051.00
181_A215_Q0.7051.00
217_L305_F0.7051.00
72_S268_Q0.7021.00
217_L306_H0.7001.00
175_L209_L0.6991.00
214_E217_L0.6981.00
334_P337_S0.6971.00
209_L240_G0.6971.00
324_I328_I0.6941.00
70_H268_Q0.6931.00
308_P313_E0.6911.00
332_L350_L0.6861.00
122_T174_T0.6831.00
76_V131_V0.6821.00
279_A302_Y0.6801.00
46_I54_P0.6791.00
321_Q325_D0.6791.00
115_A152_V0.6751.00
15_Y210_L0.6731.00
168_L307_L0.6711.00
22_F53_L0.6681.00
80_A105_L0.6661.00
171_I305_F0.6651.00
216_A233_V0.6641.00
92_G98_L0.6641.00
40_I98_L0.6601.00
343_V349_T0.6591.00
16_F153_L0.6571.00
61_G65_I0.6571.00
37_A62_A0.6571.00
45_A49_A0.6571.00
255_A350_L0.6551.00
175_L179_Y0.6511.00
81_A136_A0.6491.00
298_L302_Y0.6491.00
16_F21_S0.6481.00
276_T308_P0.6461.00
200_N207_D0.6451.00
70_H75_D0.6441.00
176_A256_A0.6411.00
216_A252_R0.6401.00
165_Q273_L0.6391.00
287_A291_Q0.6391.00
185_A344_T0.6381.00
14_N151_M0.6371.00
120_A238_A0.6311.00
52_K158_I0.6301.00
104_A132_W0.6301.00
166_Y169_A0.6271.00
223_Q235_A0.6231.00
205_I244_G0.6221.00
51_T58_G0.6211.00
80_A108_R0.6181.00
168_L306_H0.6181.00
206_R210_L0.6171.00
28_F32_E0.6161.00
23_N55_P0.6151.00
285_Q289_L0.6121.00
220_Q234_D0.6111.00
30_T35_S0.6081.00
324_I354_F0.6081.00
345_L350_L0.6061.00
79_L82_E0.6031.00
178_W202_A0.6031.00
23_N59_L0.6021.00
53_L56_A0.6011.00
75_D101_T0.6011.00
164_Q220_Q0.6001.00
278_V281_G0.6001.00
116_V153_L0.5991.00
181_A202_A0.5981.00
331_T354_F0.5981.00
322_A325_D0.5981.00
183_V286_S0.5971.00
22_F56_A0.5971.00
134_N143_E0.5971.00
49_A158_I0.5971.00
26_H29_F0.5951.00
39_W93_V0.5951.00
303_Q313_E0.5941.00
175_L305_F0.5941.00
279_A307_L0.5911.00
29_F91_I0.5911.00
177_K212_S0.5911.00
47_A51_T0.5911.00
212_S237_I0.5901.00
179_Y186_P0.5890.99
180_E255_A0.5880.99
17_S235_A0.5840.99
173_D274_H0.5840.99
126_W246_L0.5820.99
212_S216_A0.5760.99
210_L214_E0.5760.99
208_V240_G0.5750.99
159_I167_L0.5740.99
35_S63_K0.5740.99
288_L353_A0.5730.99
181_A199_I0.5720.99
282_I302_Y0.5720.99
345_L353_A0.5700.99
345_L349_T0.5700.99
44_R70_H0.5680.99
248_D253_V0.5670.99
29_F62_A0.5670.99
263_L354_F0.5660.99
176_A278_V0.5640.99
266_L327_V0.5640.99
68_R78_Q0.5620.99
311_L316_V0.5620.99
123_C241_G0.5600.99
34_L88_S0.5600.99
263_L272_F0.5570.99
104_A130_S0.5570.99
266_L323_E0.5550.99
36_R87_R0.5540.99
70_H98_L0.5500.99
175_L301_A0.5490.99
41_Y45_A0.5470.99
255_A298_L0.5460.99
127_T245_G0.5460.99
166_Y273_L0.5450.99
301_A305_F0.5440.99
18_H156_P0.5440.99
173_D257_H0.5430.99
258_A337_S0.5430.99
276_T307_L0.5420.99
140_L274_H0.5420.99
129_L141_H0.5370.99
330_H334_P0.5360.99
68_R268_Q0.5350.99
335_V339_H0.5350.99
272_F276_T0.5340.99
40_I101_T0.5340.99
91_I114_V0.5330.99
164_Q167_L0.5320.99
49_A52_K0.5320.99
220_Q233_V0.5310.99
144_I147_D0.5310.99
120_A159_I0.5310.99
264_T277_K0.5300.99
182_V203_Q0.5290.99
208_V212_S0.5290.99
186_P252_R0.5280.99
288_L346_T0.5280.99
208_V243_V0.5250.99
299_T310_T0.5190.99
283_L287_A0.5180.99
77_Q135_D0.5120.99
130_S142_Y0.5120.99
204_A243_V0.5100.99
15_Y152_V0.5090.99
213_S217_L0.5080.99
267_P272_F0.5080.99
308_P314_L0.5070.99
82_E87_R0.5070.99
235_A239_G0.5060.98
179_Y286_S0.5050.98
185_A340_Y0.5040.98
303_Q306_H0.5020.98
41_Y93_V0.5020.98
40_I90_V0.5010.98
168_L171_I0.5010.98
259_V285_Q0.5010.98
93_V116_V0.5010.98
215_Q220_Q0.5000.98
179_Y282_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9171 100 0.155 Contact Map
3bfjA 5 0.9144 100 0.155 Contact Map
4fr2A 2 0.9144 100 0.165 Contact Map
1rrmA 2 0.9199 100 0.168 Contact Map
1vljA 2 0.9337 100 0.172 Contact Map
3zdrA 2 0.9171 100 0.182 Contact Map
1ta9A 5 0.9779 100 0.192 Contact Map
1o2dA 1 0.9033 100 0.193 Contact Map
3uhjA 5 0.9448 100 0.194 Contact Map
3iv7A 2 0.9199 100 0.196 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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