GREMLIN Database
LUXS - S-ribosylhomocysteine lyase
UniProt: P45578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12712
Length: 171 (146)
Sequences: 991 (401)
Seq/√Len: 33.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_R133_M3.6921.00
38_L146_I3.2801.00
50_E133_M3.2531.00
67_H106_A3.1981.00
42_V45_K3.0711.00
21_V34_T2.7711.00
10_D13_R2.7171.00
19_V104_W2.4721.00
51_R133_M2.2390.99
41_C142_I2.1870.99
48_M142_I2.1080.99
56_L143_A2.0920.98
124_N127_Q2.0850.98
50_E84_R2.0360.98
96_D99_R2.0320.98
55_T134_H1.8880.97
109_E113_K1.8770.97
12_T125_V1.8660.97
56_L111_V1.8330.96
49_P52_G1.8210.96
75_I91_L1.7790.96
33_I90_S1.7720.96
144_R148_E1.7370.95
15_E42_V1.7290.95
105_K109_E1.6630.94
60_F107_A1.6300.93
120_I134_H1.6240.93
10_D126_Y1.6080.93
52_G138_E1.6040.92
53_I87_F1.5580.91
81_M88_Y1.5290.91
48_M53_I1.5200.90
60_F64_M1.5050.90
145_S149_R1.4910.89
117_Q140_Q1.4530.88
3_L127_Q1.4210.87
4_L122_E1.4070.86
109_E152_R1.4040.86
75_I89_M1.3770.85
27_T30_G1.3680.85
17_P42_V1.3320.83
28_P76_I1.3220.83
32_A94_T1.3220.83
36_F93_G1.3110.82
28_P31_D1.3020.82
24_T32_A1.2720.80
52_G135_S1.2430.79
105_K147_L1.2380.78
64_M75_I1.2250.78
89_M100_V1.2140.77
55_T120_I1.1850.75
22_A35_V1.1640.74
52_G142_I1.1610.74
78_I146_I1.1190.71
68_L103_A1.1190.71
101_A105_K1.1100.70
64_M89_M1.0970.69
60_F104_W1.0970.69
141_D145_S1.0920.69
148_E152_R1.0880.69
141_D144_R1.0780.68
106_A109_E1.0780.68
138_E141_D1.0730.68
97_E101_A1.0590.67
111_V143_A1.0580.66
109_E144_R1.0370.65
67_H110_D1.0240.64
14_M20_R1.0200.64
63_F67_H1.0150.63
5_D9_V1.0120.63
96_D102_D1.0070.63
17_P41_C1.0050.62
76_I90_S1.0000.62
112_L140_Q0.9860.61
19_V142_I0.9760.60
46_E145_S0.9750.60
21_V97_E0.9750.60
60_F78_I0.9620.59
47_V135_S0.9600.59
41_C145_S0.9580.59
118_N140_Q0.9500.58
112_L144_R0.9450.58
25_M94_T0.9440.58
135_S138_E0.9400.57
3_L8_T0.9300.56
78_I87_F0.9300.56
137_Q144_R0.9260.56
2_P5_D0.9190.55
64_M103_A0.9150.55
27_T33_I0.9120.55
95_P99_R0.9120.55
15_E150_D0.9090.55
114_V118_N0.9080.55
22_A79_S0.8990.54
17_P142_I0.8950.54
22_A81_M0.8810.52
14_M42_V0.8800.52
36_F97_E0.8750.52
19_V100_V0.8720.52
40_F120_I0.8640.51
14_M18_A0.8540.50
56_L108_M0.8520.50
107_A111_V0.8410.49
35_V81_M0.8380.49
56_L78_I0.8310.48
49_P138_E0.8270.48
55_T132_Q0.8230.48
68_L100_V0.8220.47
22_A88_Y0.8150.47
12_T126_Y0.8080.46
130_T133_M0.8000.46
19_V146_I0.7960.45
98_Q102_D0.7900.45
91_L103_A0.7830.44
9_V18_A0.7810.44
27_T31_D0.7790.44
35_V88_Y0.7760.44
102_D106_A0.7710.43
100_V104_W0.7690.43
9_V14_M0.7550.42
32_A96_D0.7540.42
33_I76_I0.7530.42
19_V101_A0.7490.41
14_M35_V0.7470.41
20_R79_S0.7460.41
105_K152_R0.7350.40
13_R126_Y0.7330.40
41_C53_I0.7250.39
119_Q127_Q0.7210.39
109_E112_L0.7170.39
100_V148_E0.7120.38
35_V122_E0.7110.38
139_A143_A0.7070.38
68_L96_D0.7070.38
32_A153_I0.7040.38
78_I84_R0.6990.37
59_L63_F0.6940.37
63_F106_A0.6920.37
24_T94_T0.6860.36
61_A65_R0.6800.36
45_K125_V0.6800.36
35_V77_D0.6760.36
1_M66_N0.6750.36
36_F95_P0.6680.35
9_V104_W0.6640.35
47_V130_T0.6620.35
100_V103_A0.6610.34
84_R131_Y0.6600.34
20_R77_D0.6560.34
40_F45_K0.6560.34
18_A22_A0.6530.34
10_D125_V0.6500.34
40_F108_M0.6460.33
4_L18_A0.6450.33
18_A42_V0.6440.33
26_N29_H0.6340.32
76_I117_Q0.6320.32
23_K103_A0.6300.32
38_L103_A0.6270.32
87_F120_I0.6260.32
147_L152_R0.6260.32
40_F53_I0.6240.32
4_L90_S0.6190.31
34_T93_G0.6180.31
7_F61_A0.6140.31
18_A53_I0.6140.31
108_M143_A0.6120.31
4_L35_V0.6100.31
40_F48_M0.6080.31
64_M104_W0.6030.30
109_E148_E0.6010.30
17_P149_R0.6010.30
100_V137_Q0.5990.30
3_L9_V0.5980.30
41_C46_E0.5960.30
55_T133_M0.5960.30
62_G66_N0.5950.30
60_F111_V0.5930.30
9_V42_V0.5930.30
64_M78_I0.5920.29
34_T91_L0.5920.29
101_A151_V0.5910.29
8_T62_G0.5900.29
31_D76_I0.5880.29
36_F100_V0.5870.29
75_I107_A0.5850.29
108_M112_L0.5770.28
61_A122_E0.5740.28
123_L134_H0.5720.28
12_T134_H0.5650.28
144_R152_R0.5630.28
21_V24_T0.5610.27
114_V140_Q0.5610.27
66_N103_A0.5600.27
70_G141_D0.5580.27
112_L152_R0.5570.27
59_L108_M0.5540.27
18_A35_V0.5460.26
47_V133_M0.5420.26
34_T94_T0.5380.26
135_S141_D0.5370.26
22_A77_D0.5370.26
21_V36_F0.5330.26
59_L121_P0.5310.25
98_Q101_A0.5270.25
114_V119_Q0.5230.25
46_E149_R0.5230.25
91_L100_V0.5170.25
84_R130_T0.5160.24
23_K62_G0.5150.24
36_F134_H0.5140.24
14_M79_S0.5140.24
27_T92_I0.5120.24
49_P107_A0.5100.24
69_N106_A0.5090.24
24_T93_G0.5070.24
104_W152_R0.5020.24
59_L114_V0.5010.24
61_A77_D0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j6wA 2 0.9415 100 0.068 Contact Map
4xchA 4 0.8713 100 0.133 Contact Map
1vjeA 2 0.8713 100 0.136 Contact Map
1j98A 2 0.883 100 0.14 Contact Map
1j6xA 2 0.8772 100 0.157 Contact Map
2q7aA 2 0.4327 21.1 0.96 Contact Map
3iixA 1 0.6842 18.6 0.96 Contact Map
3s4eA 1 0.7076 13.4 0.963 Contact Map
4jmkA 1 0.7485 11.7 0.964 Contact Map
1eexG 1 0.2456 11.2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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