GREMLIN Database
DXR - 1-deoxy-D-xylulose 5-phosphate reductoisomerase
UniProt: P45568 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12715
Length: 398 (380)
Sequences: 3318 (2126)
Seq/√Len: 109.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R48_E5.5681.00
9_S45_Q3.6951.00
3_Q29_R3.1641.00
17_T98_M3.1131.00
193_T197_D3.0811.00
204_D349_Q3.0591.00
355_D358_A2.9911.00
179_V261_R2.9711.00
298_D301_K2.9321.00
198_L201_M2.7981.00
139_V146_L2.7721.00
18_L49_F2.7581.00
115_R138_A2.7071.00
19_D277_R2.7051.00
223_A353_F2.6571.00
180_S247_E2.6241.00
192_E314_R2.5731.00
352_R355_D2.4741.00
4_L21_V2.4651.00
253_Q306_T2.4141.00
119_T145_Q2.3321.00
243_A325_F2.2871.00
194_P197_D2.2781.00
226_M335_L2.2201.00
42_M56_M2.2191.00
43_V68_M2.2181.00
22_R49_F2.2091.00
180_S261_R2.2031.00
344_A348_A2.2011.00
112_A115_R2.1971.00
111_L138_A2.1641.00
244_S326_E2.1131.00
242_S245_Q2.1001.00
374_C377_D2.1001.00
38_N41_R2.0771.00
361_L365_E2.0411.00
21_V30_V1.9761.00
331_A364_L1.9741.00
137_D141_Q1.9731.00
179_V296_P1.9431.00
319_K323_E1.9301.00
343_V347_L1.9231.00
53_Y79_L1.9211.00
363_V389_A1.9201.00
232_Y322_M1.8881.00
295_K301_K1.8691.00
192_E308_A1.8611.00
363_V385_A1.8201.00
330_A367_M1.7931.00
193_T205_Q1.7351.00
191_R308_A1.7281.00
46_C54_A1.7061.00
33_L45_Q1.7031.00
41_R44_E1.6991.00
312_Y319_K1.6721.00
156_I181_I1.6661.00
330_A381_V1.6481.00
341_I390_R1.6431.00
203_P349_Q1.6401.00
53_Y88_M1.6181.00
19_D23_H1.6121.00
382_D386_R1.6011.00
5_T32_A1.6011.00
83_Q87_D1.5671.00
193_T201_M1.5571.00
27_H288_N1.5491.00
226_M360_N1.5381.00
138_A141_Q1.5091.00
159_S268_L1.4931.00
312_Y322_M1.4931.00
30_V33_L1.4861.00
10_T35_A1.4851.00
236_R246_M1.4831.00
133_R137_D1.4831.00
29_R52_R1.4821.00
196_R199_A1.4781.00
324_A364_L1.4721.00
32_A88_M1.4701.00
345_A393_V1.4641.00
380_S383_A1.4581.00
259_M299_F1.4521.00
41_R45_Q1.4401.00
39_V56_M1.4401.00
115_R142_S1.4381.00
207_C219_S1.4371.00
207_C220_V1.4301.00
31_V91_L1.4301.00
82_Q108_L1.4251.00
2_K119_T1.4241.00
232_Y248_V1.4221.00
363_V388_V1.4211.00
236_R325_F1.4191.00
55_V88_M1.4111.00
226_M317_C1.4081.00
114_I144_A1.4071.00
345_A350_Q1.3991.00
54_A76_T1.3981.00
34_V85_A1.3931.00
36_G57_D1.3861.00
316_P361_L1.3811.00
359_L389_A1.3811.00
229_G321_A1.3691.00
351_I355_D1.3631.00
110_T120_I1.3621.00
15_C45_Q1.3601.00
34_V88_M1.3561.00
317_C360_N1.3501.00
387_E391_K1.3421.00
225_M312_Y1.3331.00
247_E309_A1.3301.00
62_A66_K1.3260.99
37_K58_D1.3220.99
114_I120_I1.3170.99
317_C357_A1.3110.99
366_K388_V1.2910.99
310_P318_L1.2870.99
98_M149_V1.2840.99
163_P262_Y1.2790.99
43_V65_L1.2740.99
189_P315_Y1.2690.99
52_R93_D1.2660.99
383_A387_E1.2650.99
202_T205_Q1.2640.99
15_C41_R1.2610.99
127_S135_F1.2590.99
61_S64_L1.2590.99
212_W254_S1.2550.99
130_T378_V1.2470.99
133_R237_W1.2390.99
198_L354_T1.2370.99
362_S365_E1.2360.99
181_I241_A1.2350.99
55_V79_L1.2330.99
191_R252_P1.2250.99
31_V52_R1.2110.99
98_M121_L1.2080.99
58_D61_S1.2000.99
236_R242_S1.1980.99
236_R243_A1.1900.99
44_E48_E1.1880.99
301_K309_A1.1870.99
174_E177_G1.1840.99
380_S384_N1.1840.99
203_P347_L1.1690.99
388_V391_K1.1680.99
96_Q284_M1.1670.99
334_A367_M1.1610.99
46_C69_L1.1600.99
86_C108_L1.1370.98
35_A56_M1.1360.98
33_L42_M1.1270.98
35_A42_M1.1260.98
56_M61_S1.1230.98
40_T64_L1.1170.98
373_Q377_D1.1160.98
258_S270_Q1.1120.98
385_A389_A1.1070.98
77_E87_D1.1030.98
40_T44_E1.1010.98
40_T68_M1.1000.98
220_V347_L1.0950.98
39_V65_L1.0940.98
182_L247_E1.0920.98
327_Q331_A1.0910.98
108_L379_L1.0910.98
216_R348_A1.0900.98
259_M267_V1.0890.98
341_I389_A1.0890.98
46_C51_P1.0860.98
195_L354_T1.0750.98
370_R373_Q1.0740.98
300_C309_A1.0740.98
154_N282_H1.0740.98
4_L96_Q1.0730.98
359_L392_E1.0710.98
342_T360_N1.0680.98
236_R240_N1.0660.98
53_Y91_L1.0640.98
285_A290_V1.0610.98
319_K361_L1.0610.98
115_R141_Q1.0600.98
52_R77_E1.0480.97
163_P268_L1.0460.97
3_Q95_D1.0400.97
23_H293_G1.0390.97
3_Q31_V1.0380.97
177_G263_Q1.0270.97
117_G142_S1.0260.97
224_T356_I1.0240.97
190_F206_A1.0240.97
381_V385_A1.0160.97
311_D314_R1.0150.97
217_K339_N1.0140.97
96_Q121_L1.0140.97
323_E327_Q1.0060.97
367_M384_N1.0010.96
138_A142_S0.9990.96
194_P314_R0.9990.96
17_T284_M0.9970.96
9_S41_R0.9940.96
55_V84_A0.9860.96
232_Y246_M0.9860.96
104_A130_T0.9820.96
9_S33_L0.9770.96
299_F302_L0.9740.96
63_K67_T0.9730.96
323_E365_E0.9680.96
149_V283_T0.9650.96
199_A358_A0.9600.96
37_K61_S0.9520.95
56_M62_A0.9480.95
362_S392_E0.9450.95
28_F285_A0.9420.95
63_K66_K0.9390.95
94_V97_V0.9380.95
112_A116_A0.9350.95
154_N283_T0.9290.95
43_V47_L0.9280.95
194_P198_L0.9280.95
28_F290_V0.9270.95
64_L68_M0.9220.94
121_L149_V0.9210.94
225_M314_R0.9200.94
341_I382_D0.9180.94
5_T88_M0.9160.94
30_V45_Q0.9160.94
47_L74_S0.9160.94
111_L135_F0.9130.94
157_F286_W0.9120.94
114_I138_A0.9120.94
31_V94_V0.9100.94
189_P192_E0.9070.94
96_Q119_T0.9060.94
207_C216_R0.9040.94
21_V28_F0.9040.94
59_E63_K0.9020.94
241_A245_Q0.9020.94
47_L73_G0.9010.94
97_V118_K0.9000.94
323_E326_E0.9000.94
384_N388_V0.8980.94
362_S366_K0.8920.93
211_N272_G0.8910.93
230_L339_N0.8890.93
189_P250_I0.8890.93
193_T314_R0.8880.93
200_T352_R0.8850.93
342_T359_L0.8830.93
24_N285_A0.8740.93
203_P219_S0.8730.93
195_L199_A0.8700.93
262_Y268_L0.8690.93
208_R219_S0.8680.92
18_L22_R0.8630.92
192_E252_P0.8590.92
176_N263_Q0.8580.92
104_A382_D0.8560.92
157_F287_P0.8560.92
99_A120_I0.8540.92
197_D205_Q0.8540.92
206_A220_V0.8540.92
316_P358_A0.8530.92
182_L261_R0.8520.92
357_A360_N0.8520.92
299_F303_S0.8510.92
19_D22_R0.8500.92
248_V318_L0.8490.92
320_L361_L0.8490.92
194_P199_A0.8470.92
376_D380_S0.8470.92
114_I135_F0.8460.91
136_M237_W0.8420.91
256_I259_M0.8420.91
113_A120_I0.8410.91
350_Q390_R0.8410.91
32_A53_Y0.8380.91
90_A112_A0.8370.91
101_I105_A0.8360.91
272_G278_T0.8360.91
99_A127_S0.8310.91
334_A363_V0.8290.91
79_L88_M0.8260.90
177_G288_N0.8250.90
351_I359_L0.8250.90
59_E80_S0.8250.90
99_A110_T0.8240.90
248_V310_P0.8230.90
66_K70_Q0.8210.90
341_I344_A0.8200.90
263_Q291_N0.8190.90
6_I30_V0.8190.90
281_A285_A0.8160.90
46_C76_T0.8150.90
92_E118_K0.8140.90
16_S19_D0.8140.90
93_D118_K0.8130.90
185_G225_M0.8130.90
359_L363_V0.8110.90
130_T333_T0.8110.90
156_I258_S0.8100.90
384_N387_E0.8070.89
330_A369_M0.8060.89
62_A78_V0.8060.89
195_L314_R0.8030.89
251_H305_L0.8020.89
24_N290_V0.8010.89
64_L67_T0.8000.89
198_L314_R0.7920.89
119_T144_A0.7920.89
256_I269_A0.7910.88
114_I139_V0.7880.88
86_C90_A0.7840.88
232_Y243_A0.7830.88
5_T94_V0.7820.88
195_L357_A0.7820.88
195_L313_D0.7800.88
31_V53_Y0.7770.88
367_M388_V0.7770.88
217_K221_D0.7760.88
341_I345_A0.7740.87
162_Q268_L0.7680.87
66_K77_E0.7670.87
5_T89_A0.7650.87
62_A80_S0.7650.87
136_M139_V0.7640.87
372_P377_D0.7620.87
39_V61_S0.7600.86
324_A332_T0.7600.86
85_A101_I0.7570.86
182_L300_C0.7530.86
300_C303_S0.7510.86
341_I386_R0.7490.86
388_V392_E0.7450.85
316_P319_K0.7440.85
327_Q369_M0.7440.85
55_V85_A0.7430.85
59_E83_Q0.7430.85
320_L335_L0.7430.85
250_I315_Y0.7410.85
232_Y325_F0.7390.85
333_T381_V0.7390.85
237_W240_N0.7370.85
336_N339_N0.7350.85
375_V379_L0.7320.84
334_A381_V0.7310.84
178_V260_V0.7280.84
335_L364_L0.7260.84
322_M325_F0.7220.84
195_L225_M0.7210.83
128_L136_M0.7200.83
82_Q86_C0.7180.83
69_L74_S0.7180.83
387_E390_R0.7180.83
159_S262_Y0.7170.83
6_I17_T0.7160.83
16_S99_A0.7150.83
98_M284_M0.7150.83
322_M326_E0.7140.83
114_I142_S0.7140.83
256_I305_L0.7130.83
86_C112_A0.7090.82
111_L375_V0.7090.82
224_T353_F0.7090.82
308_A315_Y0.7070.82
278_T294_V0.7060.82
229_G332_T0.7050.82
250_I308_A0.7050.82
155_A258_S0.7040.82
23_H291_N0.7030.82
313_D319_K0.7030.82
189_P308_A0.7010.82
39_V43_V0.7000.82
247_E300_C0.7000.82
16_S277_R0.7000.82
255_V271_L0.7000.82
330_A372_P0.6920.81
211_N254_S0.6910.81
250_I314_R0.6860.80
53_Y77_E0.6850.80
24_N27_H0.6840.80
161_P282_H0.6840.80
70_Q73_G0.6840.80
179_V263_Q0.6840.80
179_V265_G0.6830.80
273_E294_V0.6830.80
9_S15_C0.6820.80
158_Q289_R0.6810.80
163_P177_G0.6800.80
178_V241_A0.6780.80
345_A389_A0.6770.79
3_Q93_D0.6760.79
42_M45_Q0.6750.79
193_T198_L0.6750.79
161_P268_L0.6730.79
203_P207_C0.6720.79
124_N127_S0.6680.78
27_H285_A0.6660.78
250_I310_P0.6650.78
20_V281_A0.6640.78
247_E261_R0.6630.78
81_G84_A0.6620.78
42_M61_S0.6610.78
271_L305_L0.6590.78
83_Q86_C0.6590.78
325_F332_T0.6580.77
5_T31_V0.6550.77
199_A352_R0.6540.77
204_D216_R0.6530.77
372_P378_V0.6520.77
333_T378_V0.6500.77
199_A354_T0.6490.76
136_M240_N0.6440.76
255_V302_L0.6430.76
256_I307_F0.6430.76
44_E47_L0.6390.75
79_L87_D0.6390.75
359_L393_V0.6340.75
104_A379_L0.6330.75
23_H277_R0.6310.74
39_V42_M0.6310.74
259_M269_A0.6290.74
243_A322_M0.6290.74
229_G317_C0.6260.74
36_G85_A0.6240.74
108_L112_A0.6230.74
205_Q208_R0.6230.74
216_R347_L0.6220.73
105_A382_D0.6220.73
220_V343_V0.6210.73
82_Q105_A0.6190.73
127_S131_C0.6170.73
249_L300_C0.6160.73
358_A362_S0.6160.73
2_K96_Q0.6150.73
91_L94_V0.6130.72
84_A87_D0.6100.72
267_V297_L0.6100.72
60_A64_L0.6100.72
345_A390_R0.6070.72
200_T203_P0.6070.72
97_V113_A0.6070.72
299_F305_L0.6060.71
46_C78_V0.6050.71
25_P28_F0.6040.71
256_I302_L0.6010.71
331_A369_M0.6000.71
147_L154_N0.5990.71
195_L358_A0.5990.71
111_L115_R0.5970.70
5_T53_Y0.5950.70
97_V116_A0.5930.70
330_A377_D0.5910.70
324_A331_A0.5890.69
121_L154_N0.5890.69
182_L267_V0.5880.69
232_Y236_R0.5880.69
252_P308_A0.5860.69
12_S213_S0.5860.69
207_C347_L0.5850.69
65_L78_V0.5850.69
381_V384_N0.5840.69
12_S16_S0.5830.69
323_E361_L0.5820.68
34_V57_D0.5820.68
225_M315_Y0.5810.68
65_L69_L0.5810.68
261_R296_P0.5790.68
194_P201_M0.5790.68
106_G110_T0.5790.68
46_C65_L0.5780.68
216_R220_V0.5770.68
130_T133_R0.5760.68
182_L259_M0.5750.68
50_S75_R0.5750.68
233_I243_A0.5730.67
120_I135_F0.5720.67
345_A359_L0.5710.67
195_L250_I0.5700.67
329_Q333_T0.5700.67
262_Y265_G0.5690.67
252_P265_G0.5670.66
59_E82_Q0.5660.66
259_M300_C0.5660.66
329_Q332_T0.5660.66
373_Q378_V0.5650.66
40_T43_V0.5650.66
203_P208_R0.5650.66
139_V142_S0.5650.66
111_L134_L0.5640.66
378_V381_V0.5620.66
79_L84_A0.5620.66
189_P219_S0.5620.66
39_V68_M0.5610.66
189_P201_M0.5600.65
329_Q381_V0.5590.65
207_C343_V0.5580.65
360_N364_L0.5550.65
281_A290_V0.5550.65
157_F161_P0.5540.65
87_D90_A0.5530.65
324_A335_L0.5530.65
325_F329_Q0.5520.64
192_E225_M0.5510.64
156_I239_F0.5510.64
290_V293_G0.5470.64
50_S74_S0.5470.64
243_A326_E0.5470.64
39_V64_L0.5460.64
53_Y94_V0.5440.63
74_S78_V0.5440.63
57_D84_A0.5440.63
32_A55_V0.5440.63
160_L262_Y0.5420.63
15_C19_D0.5420.63
265_G296_P0.5420.63
54_A78_V0.5400.63
32_A94_V0.5400.63
120_I144_A0.5370.62
197_D200_T0.5360.62
77_E92_E0.5360.62
34_V55_V0.5350.62
9_S34_V0.5350.62
69_L73_G0.5350.62
306_T309_A0.5350.62
161_P262_Y0.5350.62
69_L78_V0.5340.62
120_I127_S0.5330.62
359_L362_S0.5310.61
159_S289_R0.5310.61
330_A333_T0.5300.61
89_A94_V0.5300.61
266_S270_Q0.5300.61
297_L303_S0.5300.61
201_M223_A0.5290.61
135_F138_A0.5280.61
203_P216_R0.5280.61
160_L178_V0.5280.61
31_V93_D0.5250.61
19_D275_D0.5240.60
161_P177_G0.5240.60
99_A146_L0.5230.60
69_L76_T0.5220.60
334_A384_N0.5220.60
330_A373_Q0.5220.60
55_V94_V0.5210.60
355_D359_L0.5210.60
114_I127_S0.5180.60
90_A115_R0.5170.59
312_Y318_L0.5150.59
32_A91_L0.5150.59
45_Q51_P0.5140.59
147_L157_F0.5130.59
107_L135_F0.5120.59
192_E250_I0.5120.59
267_V271_L0.5120.59
122_L146_L0.5120.59
337_A382_D0.5110.59
58_D80_S0.5110.59
110_T135_F0.5110.59
43_V64_L0.5100.58
191_R314_R0.5100.58
330_A370_R0.5050.58
87_D91_L0.5050.58
57_D85_A0.5030.57
229_G318_L0.5030.57
175_Q240_N0.5020.57
204_D207_C0.5010.57
43_V74_S0.5000.57
299_F304_A0.5000.57
319_K326_E0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q0qA 2 1 100 0.008 Contact Map
3au8A 2 0.9874 100 0.014 Contact Map
4zn6A 2 0.9824 100 0.02 Contact Map
4y67A 2 0.9975 100 0.021 Contact Map
3a06A 2 0.9246 100 0.039 Contact Map
2y1eA 2 0.9422 100 0.095 Contact Map
1r0kA 2 0.9623 100 0.13 Contact Map
3uplA 2 0.8467 99.9 0.84 Contact Map
3ingA 2 0.696 99.9 0.852 Contact Map
3do5A 2 0.706 99.9 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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