GREMLIN Database
AIS - Lipopolysaccharide core heptose(II)-phosphate phosphatase
UniProt: P45565 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13155
Length: 200 (175)
Sequences: 149 (104)
Seq/√Len: 7.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_T109_V4.9130.99
134_G164_Y3.6120.95
56_V141_I3.3210.92
58_L157_T3.3180.92
94_F105_S3.3160.92
41_I47_A2.7840.82
159_N166_A2.6840.80
19_L28_G2.6580.79
70_N82_K2.4920.74
56_V142_K2.4720.74
29_T36_N2.4130.72
112_I173_T2.1480.62
102_D151_K2.1250.62
57_V181_G2.1190.61
50_A53_H2.1110.61
29_T33_W2.0910.60
105_S130_L2.0650.59
59_F101_F2.0400.58
112_I137_I2.0280.58
166_A183_V2.0090.57
149_P190_K1.9670.55
75_D109_V1.9160.53
73_L84_T1.8650.51
23_A41_I1.8620.51
58_L182_L1.8580.51
122_K132_Q1.7910.48
34_S37_G1.7870.48
29_T34_S1.6910.44
50_A147_K1.6760.44
50_A98_I1.6710.43
67_R74_S1.6470.42
122_K189_G1.6380.42
81_V85_Q1.6300.42
90_L145_Q1.6260.42
106_S147_K1.6180.41
27_L38_L1.6030.41
74_S109_V1.5450.38
68_S91_G1.5290.38
163_T173_T1.5280.38
70_N83_G1.5270.38
107_N152_N1.5260.38
81_V115_A1.5210.38
53_H98_I1.5160.37
57_V94_F1.5130.37
119_S151_K1.5040.37
27_L71_Q1.4650.35
104_Y176_P1.4070.33
62_A179_L1.3900.33
163_T172_A1.3870.33
136_E140_A1.3780.32
28_G154_V1.3550.31
33_W37_G1.3460.31
98_I153_I1.3380.31
53_H147_K1.2660.28
160_H165_I1.2580.28
129_R155_I1.2580.28
50_A153_I1.2540.28
44_K167_K1.2350.27
162_L166_A1.2280.27
18_L24_I1.2260.27
160_H176_P1.2180.27
145_Q168_D1.1910.26
87_A91_G1.1880.26
86_D184_M1.1880.26
41_I150_D1.1870.26
109_V177_D1.1850.26
29_T37_G1.1770.26
15_I154_V1.1750.26
20_A149_P1.1700.25
119_S182_L1.1590.25
62_A83_G1.1510.25
163_T167_K1.1500.25
127_D141_I1.1490.25
153_I183_V1.1310.24
66_D91_G1.1170.24
124_L132_Q1.1150.24
70_N170_R1.1130.24
115_A192_Y1.0910.23
151_K182_L1.0860.23
162_L176_P1.0800.23
25_A69_T1.0520.22
162_L170_R1.0280.21
98_I156_F1.0180.21
28_G116_T1.0100.21
115_A177_D1.0090.21
111_T139_S0.9990.20
44_K124_L0.9950.20
67_R121_G0.9920.20
35_S38_L0.9800.20
146_S159_N0.9780.20
147_K153_I0.9740.20
119_S159_N0.9700.20
85_Q187_E0.9640.20
21_L24_I0.9620.20
58_L119_S0.9600.19
98_I159_N0.9560.19
98_I155_I0.9520.19
67_R83_G0.9440.19
134_G191_V0.9430.19
106_S159_N0.9420.19
79_I129_R0.9390.19
28_G31_A0.9370.19
44_K55_V0.9260.19
129_R146_S0.9170.18
18_L109_V0.9150.18
41_I46_L0.9050.18
19_L27_L0.8970.18
103_L156_F0.8930.18
89_E132_Q0.8820.18
24_I89_E0.8820.18
76_K109_V0.8800.18
19_L24_I0.8730.17
84_T107_N0.8720.17
38_L164_Y0.8720.17
50_A155_I0.8660.17
59_F103_L0.8640.17
31_A34_S0.8530.17
90_L176_P0.8500.17
57_V169_K0.8470.17
32_A49_L0.8390.17
77_T190_K0.8350.16
96_A116_T0.8310.16
109_V132_Q0.8300.16
21_L28_G0.8270.16
132_Q187_E0.8270.16
155_I159_N0.8260.16
90_L160_H0.8260.16
54_P101_F0.8260.16
115_A164_Y0.8190.16
59_F102_D0.8120.16
130_L136_E0.8090.16
58_L165_I0.8080.16
137_I168_D0.8020.16
53_H153_I0.7960.16
53_H107_N0.7930.16
35_S94_F0.7910.16
107_N147_K0.7850.15
134_G138_Y0.7810.15
51_Q92_N0.7750.15
54_P151_K0.7720.15
102_D156_F0.7610.15
147_K152_N0.7550.15
118_F173_T0.7510.15
167_K174_F0.7460.15
56_V181_G0.7400.14
16_I22_A0.7340.14
51_Q79_I0.7320.14
22_A89_E0.7310.14
150_D177_D0.7310.14
25_A30_H0.7300.14
102_D153_I0.7290.14
126_V160_H0.7280.14
84_T92_N0.7280.14
97_D130_L0.7260.14
59_F159_N0.7260.14
27_L101_F0.7180.14
123_K126_V0.7030.14
21_L177_D0.7000.14
154_V181_G0.6980.14
141_I187_E0.6940.14
54_P126_V0.6920.14
134_G189_G0.6920.14
47_A169_K0.6860.13
55_V81_V0.6850.13
19_L35_S0.6840.13
115_A179_L0.6790.13
46_L57_V0.6780.13
54_P59_F0.6650.13
104_Y180_D0.6630.13
31_A37_G0.6620.13
97_D183_V0.6610.13
53_H152_N0.6580.13
59_F74_S0.6500.13
49_L62_A0.6400.13
25_A105_S0.6370.13
16_I111_T0.6300.12
27_L36_N0.6240.12
19_L43_N0.6170.12
28_G33_W0.6170.12
70_N162_L0.6160.12
62_A86_D0.6140.12
50_A152_N0.6120.12
44_K95_S0.6120.12
137_I140_A0.6090.12
173_T176_P0.6070.12
48_R181_G0.6060.12
98_I147_K0.6060.12
119_S165_I0.6030.12
105_S126_V0.5970.12
50_A107_N0.5940.12
89_E92_N0.5930.12
31_A94_F0.5880.12
83_G105_S0.5820.12
45_T83_G0.5820.12
104_Y162_L0.5800.12
94_F124_L0.5780.12
101_F146_S0.5760.11
69_T92_N0.5720.11
20_A128_K0.5720.11
127_D142_K0.5630.11
95_S105_S0.5630.11
59_F180_D0.5630.11
146_S166_A0.5620.11
112_I179_L0.5610.11
126_V184_M0.5600.11
92_N145_Q0.5570.11
44_K59_F0.5550.11
24_I167_K0.5520.11
157_T184_M0.5520.11
38_L108_T0.5480.11
87_A157_T0.5420.11
55_V121_G0.5420.11
53_H156_F0.5400.11
59_F184_M0.5350.11
50_A114_S0.5290.11
96_A154_V0.5280.11
50_A156_F0.5270.11
23_A26_G0.5240.11
150_D179_L0.5100.10
16_I20_A0.5060.10
138_Y169_K0.5040.10
61_H158_H0.5000.10
65_C158_H0.5000.10
61_H161_C0.5000.10
65_C110_R0.5000.10
65_C80_T0.5000.10
61_H113_Q0.5000.10
61_H110_R0.5000.10
72_C78_G0.5000.10
61_H64_R0.5000.10
65_C113_Q0.5000.10
61_H65_C0.5000.10
61_H72_C0.5000.10
61_H78_G0.5000.10
61_H80_T0.5000.10
72_C110_R0.5000.10
72_C80_T0.5000.10
65_C161_C0.5000.10
65_C78_G0.5000.10
63_E78_G0.5000.10
63_E80_T0.5000.10
63_E110_R0.5000.10
63_E113_Q0.5000.10
63_E158_H0.5000.10
63_E161_C0.5000.10
64_R72_C0.5000.10
64_R78_G0.5000.10
158_H161_C0.5000.10
64_R80_T0.5000.10
64_R110_R0.5000.10
64_R113_Q0.5000.10
64_R158_H0.5000.10
64_R161_C0.5000.10
65_C72_C0.5000.10
63_E72_C0.5000.10
72_C113_Q0.5000.10
72_C158_H0.5000.10
60_R80_T0.5000.10
80_T110_R0.5000.10
60_R78_G0.5000.10
78_G110_R0.5000.10
60_R72_C0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a6pA 2 0.71 99.5 0.812 Contact Map
1e58A 2 0.735 99.5 0.817 Contact Map
3d8hA 2 0.745 99.5 0.818 Contact Map
4gpzA 2 0.745 99.4 0.82 Contact Map
1fztA 1 0.76 99.4 0.822 Contact Map
1ujcA 1 0.695 99.4 0.822 Contact Map
1qhfA 3 0.735 99.4 0.823 Contact Map
3d4iA 2 0.775 99.4 0.823 Contact Map
1h2eA 1 0.73 99.4 0.824 Contact Map
3mbkA 2 0.73 99.4 0.825 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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