XAPA - ECOLI - GREMLIN Contacts

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XAPA - Purine nucleoside phosphorylase 2

UniProt:	P45563	Sequences: MSQVQFSHNPLFCIDIIKTYKPDFTPRVAFILGSGLGALADQIENAVAISYEKLPGFPVSTVHGHAGELVLGHLQGVPVVCMKGRGHFYEGRGMTIMTDAIRTFKLLGCELLFCTNAAGSLRPEVGAGSLVALKDHINTMPGTPMVGLNDDRFGERFFSLANAYDAEYRALLQKVAKEEGFPLTEGVFVSYPGPNFETAAEIRMMQIIGGDVVGMSVVPEVISARHCDLKVVAVSAITNMAEGLSDVKLSHAQTLAAAELSKQNFINLICGFLRKIA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG20250
Length:	277 (241)
Sequences:	3875 (2318)
Seq/√Len:	149.3

ECOLI - XAPA
BACSU - PUNA
SULSO - MTAP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
165_D	230_K	4.334	1.00
173_Q	185_E	3.515	1.00
189_V	205_M	3.175	1.00
204_M	208_I	3.115	1.00
131_V	212_V	3.021	1.00
189_V	210_G	3.004	1.00
172_L	232_V	2.842	1.00
122_R	211_D	2.686	1.00
191_Y	205_M	2.633	1.00
71_L	80_V	2.618	1.00
48_A	68_E	2.589	1.00
167_E	230_K	2.557	1.00
27_R	110_E	2.537	1.00
45_N	73_H	2.458	1.00
271_G	274_R	2.353	1.00
143_T	195_N	2.328	1.00
163_A	221_V	2.303	1.00
172_L	272_F	2.288	1.00
178_E	275_K	2.222	1.00
27_R	78_P	2.170	1.00
126_G	129_S	2.124	1.00
98_T	223_S	2.087	1.00
140_M	190_S	2.062	1.00
174_K	275_K	1.971	1.00
73_H	78_P	1.960	1.00
50_S	68_E	1.923	1.00
27_R	77_V	1.920	1.00
137_I	210_G	1.905	1.00
68_E	83_K	1.896	1.00
123_P	206_Q	1.855	1.00
43_I	81_C	1.828	1.00
129_S	184_T	1.821	1.00
256_A	260_L	1.803	1.00
212_V	237_I	1.780	1.00
111_L	230_K	1.771	1.00
29_A	104_F	1.760	1.00
178_E	271_G	1.757	1.00
188_F	214_G	1.713	1.00
170_A	174_K	1.700	1.00
175_V	271_G	1.687	1.00
44_E	73_H	1.674	1.00
132_A	173_Q	1.662	1.00
75_Q	274_R	1.662	1.00
175_V	179_E	1.660	1.00
31_I	101_I	1.642	1.00
120_S	237_I	1.598	1.00
134_K	185_E	1.582	1.00
132_A	169_R	1.562	1.00
105_K	227_C	1.555	1.00
179_E	271_G	1.523	1.00
112_L	229_L	1.516	1.00
69_L	80_V	1.501	1.00
179_E	267_N	1.487	1.00
42_Q	270_C	1.484	1.00
252_A	256_A	1.474	1.00
197_E	239_N	1.466	1.00
31_I	114_C	1.441	1.00
132_A	183_L	1.433	1.00
75_Q	270_C	1.428	1.00
73_H	76_G	1.422	1.00
138_N	141_P	1.404	1.00
202_I	239_N	1.404	1.00
93_G	96_I	1.401	1.00
162_N	199_A	1.399	1.00
122_R	125_V	1.398	1.00
116_N	235_S	1.392	1.00
162_N	166_A	1.375	1.00
114_C	221_V	1.374	1.00
257_A	260_L	1.358	1.00
128_G	257_A	1.346	1.00
176_A	183_L	1.345	1.00
164_Y	217_V	1.338	1.00
146_V	192_P	1.315	1.00
69_L	103_T	1.315	1.00
202_I	241_A	1.314	1.00
203_R	207_I	1.307	1.00
169_R	173_Q	1.304	1.00
121_L	202_I	1.294	1.00
175_V	275_K	1.284	1.00
133_L	233_A	1.270	1.00
102_R	106_L	1.253	1.00
54_L	102_R	1.251	1.00
181_F	264_N	1.248	1.00
131_V	237_I	1.241	1.00
196_F	254_T	1.238	1.00
52_E	57_F	1.229	1.00
259_E	262_K	1.226	1.00
105_K	110_E	1.224	1.00
38_A	266_I	1.220	1.00
205_M	210_G	1.214	1.00
137_I	189_V	1.200	1.00
88_F	94_M	1.198	1.00
67_G	85_R	1.180	1.00
105_K	229_L	1.178	1.00
136_H	164_Y	1.175	1.00
111_L	168_Y	1.170	1.00
66_A	83_K	1.170	1.00
101_I	227_C	1.162	1.00
257_A	261_S	1.161	1.00
141_P	192_P	1.142	1.00
127_A	240_M	1.131	0.99
106_L	153_F	1.120	0.99
125_V	237_I	1.114	0.99
247_V	253_Q	1.111	0.99
171_L	275_K	1.102	0.99
39_L	74_L	1.098	0.99
126_G	240_M	1.094	0.99
195_N	222_I	1.086	0.99
236_A	261_S	1.081	0.99
250_S	253_Q	1.074	0.99
260_L	264_N	1.074	0.99
114_C	233_A	1.068	0.99
101_I	112_L	1.059	0.99
271_G	275_K	1.053	0.99
202_I	243_G	1.050	0.99
50_S	57_F	1.048	0.99
251_H	255_L	1.042	0.99
232_V	272_F	1.034	0.99
125_V	184_T	1.034	0.99
175_V	272_F	1.018	0.99
120_S	125_V	1.006	0.99
171_L	174_K	0.998	0.99
28_V	273_L	0.973	0.98
80_V	104_F	0.973	0.98
130_L	236_A	0.972	0.98
109_C	229_L	0.970	0.98
139_T	189_V	0.969	0.98
190_S	218_V	0.966	0.98
196_F	251_H	0.965	0.98
130_L	234_V	0.955	0.98
48_A	85_R	0.937	0.98
181_F	268_L	0.936	0.98
134_K	169_R	0.935	0.98
142_G	146_V	0.930	0.98
202_I	244_L	0.922	0.98
203_R	206_Q	0.913	0.98
90_E	93_G	0.913	0.98
29_A	109_C	0.911	0.98
255_L	259_E	0.908	0.98
102_R	226_H	0.907	0.98
190_S	219_P	0.896	0.97
162_N	165_D	0.894	0.97
24_F	78_P	0.893	0.97
238_T	258_A	0.892	0.97
169_R	185_E	0.889	0.97
217_V	233_A	0.876	0.97
206_Q	244_L	0.873	0.97
236_A	265_F	0.871	0.97
160_L	222_I	0.866	0.97
113_F	269_I	0.864	0.97
80_V	109_C	0.864	0.97
245_S	248_K	0.862	0.97
205_M	213_V	0.858	0.97
129_S	182_P	0.857	0.97
92_R	96_I	0.857	0.97
124_E	184_T	0.856	0.97
263_Q	267_N	0.855	0.97
203_R	211_D	0.854	0.97
118_A	212_V	0.852	0.96
82_M	104_F	0.846	0.96
176_A	268_L	0.840	0.96
49_I	71_L	0.839	0.96
202_I	242_E	0.837	0.96
197_E	202_I	0.836	0.96
48_A	70_V	0.833	0.96
88_F	192_P	0.832	0.96
261_S	264_N	0.823	0.96
54_L	69_L	0.821	0.96
171_L	272_F	0.819	0.96
168_Y	232_V	0.819	0.96
126_G	182_P	0.813	0.95
120_S	240_M	0.808	0.95
69_L	107_L	0.808	0.95
159_S	249_L	0.807	0.95
244_L	249_L	0.806	0.95
191_Y	239_N	0.803	0.95
142_G	192_P	0.803	0.95
173_Q	177_K	0.798	0.95
121_L	205_M	0.794	0.95
116_N	217_V	0.793	0.95
137_I	204_M	0.789	0.95
132_A	172_L	0.787	0.95
183_L	268_L	0.784	0.94
165_D	225_R	0.778	0.94
175_V	178_E	0.778	0.94
118_A	237_I	0.777	0.94
162_N	225_R	0.776	0.94
42_Q	266_I	0.775	0.94
143_T	146_V	0.773	0.94
171_L	175_V	0.768	0.94
239_N	244_L	0.765	0.94
251_H	254_T	0.765	0.94
94_M	219_P	0.761	0.94
133_L	212_V	0.756	0.93
26_P	71_L	0.755	0.93
48_A	83_K	0.753	0.93
174_K	177_K	0.747	0.93
221_V	231_V	0.746	0.93
50_S	53_K	0.744	0.93
90_E	151_D	0.744	0.93
111_L	165_D	0.741	0.93
264_N	267_N	0.741	0.93
145_M	222_I	0.740	0.93
113_F	272_F	0.737	0.92
163_A	198_T	0.734	0.92
125_V	131_V	0.731	0.92
43_I	72_G	0.727	0.92
113_F	232_V	0.720	0.92
145_M	218_V	0.718	0.91
234_V	268_L	0.715	0.91
136_H	160_L	0.715	0.91
166_A	170_A	0.713	0.91
191_Y	197_E	0.713	0.91
191_Y	202_I	0.712	0.91
134_K	186_G	0.712	0.91
242_E	249_L	0.711	0.91
136_H	198_T	0.711	0.91
202_I	249_L	0.710	0.91
132_A	234_V	0.706	0.91
218_V	221_V	0.705	0.91
135_D	163_A	0.704	0.91
135_D	187_V	0.702	0.90
105_K	228_D	0.702	0.90
239_N	243_G	0.697	0.90
28_V	77_V	0.694	0.90
138_N	143_T	0.693	0.90
140_M	192_P	0.691	0.90
203_R	244_L	0.690	0.90
199_A	239_N	0.690	0.90
28_V	111_L	0.686	0.89
143_T	192_P	0.686	0.89
139_T	205_M	0.683	0.89
53_K	103_T	0.681	0.89
243_G	249_L	0.681	0.89
136_H	218_V	0.680	0.89
199_A	242_E	0.678	0.89
160_L	163_A	0.677	0.89
204_M	207_I	0.677	0.89
88_F	142_G	0.676	0.89
94_M	98_T	0.675	0.89
49_I	107_L	0.675	0.89
80_V	107_L	0.672	0.88
258_A	262_K	0.671	0.88
267_N	270_C	0.670	0.88
137_I	208_I	0.660	0.88
253_Q	256_A	0.659	0.87
57_F	103_T	0.657	0.87
27_R	111_L	0.657	0.87
172_L	268_L	0.657	0.87
138_N	142_G	0.651	0.87
139_T	191_Y	0.647	0.87
74_L	273_L	0.647	0.87
129_S	264_N	0.646	0.86
140_M	191_Y	0.643	0.86
31_I	112_L	0.643	0.86
177_K	182_P	0.642	0.86
263_Q	266_I	0.641	0.86
55_P	102_R	0.640	0.86
225_R	228_D	0.639	0.86
30_F	273_L	0.639	0.86
189_V	208_I	0.638	0.86
134_K	187_V	0.637	0.86
267_N	271_G	0.635	0.86
125_V	129_S	0.631	0.85
161_A	242_E	0.630	0.85
111_L	167_E	0.630	0.85
24_F	71_L	0.630	0.85
121_L	206_Q	0.629	0.85
70_V	85_R	0.628	0.85
126_G	184_T	0.623	0.84
37_G	83_K	0.619	0.84
199_A	249_L	0.617	0.84
179_E	268_L	0.617	0.84
116_N	214_G	0.616	0.84
122_R	240_M	0.616	0.84
34_S	196_F	0.616	0.84
94_M	140_M	0.615	0.84
38_A	262_K	0.613	0.83
218_V	222_I	0.612	0.83
164_Y	233_A	0.610	0.83
37_G	81_C	0.610	0.83
234_V	269_I	0.607	0.83
69_L	104_F	0.605	0.83
94_M	97_M	0.604	0.83
154_G	226_H	0.604	0.83
242_E	245_S	0.602	0.82
141_P	145_M	0.598	0.82
94_M	142_G	0.595	0.82
224_A	231_V	0.594	0.82
134_K	199_A	0.594	0.82
34_S	251_H	0.594	0.82
135_D	161_A	0.592	0.81
240_M	244_L	0.587	0.81
114_C	231_V	0.586	0.81
102_R	223_S	0.585	0.81
125_V	212_V	0.583	0.80
262_K	266_I	0.582	0.80
188_F	217_V	0.582	0.80
239_N	246_D	0.582	0.80
163_A	199_A	0.580	0.80
162_N	169_R	0.578	0.80
179_E	182_P	0.573	0.79
172_L	234_V	0.572	0.79
140_M	219_P	0.570	0.79
89_Y	95_T	0.570	0.79
130_L	265_F	0.567	0.78
118_A	238_T	0.567	0.78
204_M	210_G	0.566	0.78
24_F	73_H	0.565	0.78
244_L	248_K	0.565	0.78
112_L	224_A	0.565	0.78
38_A	41_D	0.564	0.78
74_L	77_V	0.564	0.78
175_V	232_V	0.564	0.78
219_P	223_S	0.560	0.78
224_A	229_L	0.559	0.77
139_T	208_I	0.559	0.77
55_P	90_E	0.554	0.77
260_L	263_Q	0.554	0.77
31_I	104_F	0.551	0.76
102_R	227_C	0.549	0.76
43_I	46_A	0.545	0.76
138_N	190_S	0.543	0.75
87_H	117_A	0.536	0.75
125_V	211_D	0.535	0.74
143_T	147_G	0.533	0.74
166_A	169_R	0.532	0.74
123_P	240_M	0.532	0.74
134_K	203_R	0.532	0.74
88_F	146_V	0.531	0.74
136_H	217_V	0.529	0.74
164_Y	169_R	0.528	0.73
116_N	233_A	0.528	0.73
133_L	217_V	0.527	0.73
162_N	248_K	0.527	0.73
121_L	191_Y	0.527	0.73
113_F	234_V	0.526	0.73
163_A	225_R	0.525	0.73
114_C	217_V	0.525	0.73
25_T	78_P	0.519	0.72
256_A	259_E	0.518	0.72
170_A	173_Q	0.517	0.72
262_K	265_F	0.517	0.72
35_G	87_H	0.517	0.72
39_L	42_Q	0.516	0.72
121_L	189_V	0.516	0.72
255_L	258_A	0.516	0.72
240_M	245_S	0.515	0.72
151_D	155_E	0.514	0.71
41_D	266_I	0.512	0.71
58_P	92_R	0.508	0.71
101_I	104_F	0.507	0.70
25_T	109_C	0.507	0.70
145_M	158_F	0.507	0.70
30_F	79_V	0.506	0.70
25_T	110_E	0.506	0.70
110_E	230_K	0.506	0.70
94_M	192_P	0.504	0.70
133_L	235_S	0.503	0.70
174_K	178_E	0.503	0.70
45_N	72_G	0.502	0.70
121_L	239_N	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p4sA	3	0.9819	100	0.256	Contact Map
3la8A	1	0.8917	100	0.264	Contact Map
4earA	3	0.9892	100	0.275	Contact Map
1g2oA	3	0.9422	100	0.279	Contact Map
4m1eA	5	0.9856	100	0.282	Contact Map
1vmkA	3	0.9097	100	0.283	Contact Map
1tcvA	3	0.9856	100	0.285	Contact Map
3odgA	3	0.9819	100	0.289	Contact Map
3khsA	3	0.9458	100	0.289	Contact Map
3fucA	3	0.9603	100	0.293	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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