GREMLIN Database
XAPA - Purine nucleoside phosphorylase 2
UniProt: P45563 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20250
Length: 277 (241)
Sequences: 3875 (2318)
Seq/√Len: 149.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_D230_K4.3341.00
173_Q185_E3.5151.00
189_V205_M3.1751.00
204_M208_I3.1151.00
131_V212_V3.0211.00
189_V210_G3.0041.00
172_L232_V2.8421.00
122_R211_D2.6861.00
191_Y205_M2.6331.00
71_L80_V2.6181.00
48_A68_E2.5891.00
167_E230_K2.5571.00
27_R110_E2.5371.00
45_N73_H2.4581.00
271_G274_R2.3531.00
143_T195_N2.3281.00
163_A221_V2.3031.00
172_L272_F2.2881.00
178_E275_K2.2221.00
27_R78_P2.1701.00
126_G129_S2.1241.00
98_T223_S2.0871.00
140_M190_S2.0621.00
174_K275_K1.9711.00
73_H78_P1.9601.00
50_S68_E1.9231.00
27_R77_V1.9201.00
137_I210_G1.9051.00
68_E83_K1.8961.00
123_P206_Q1.8551.00
43_I81_C1.8281.00
129_S184_T1.8211.00
256_A260_L1.8031.00
212_V237_I1.7801.00
111_L230_K1.7711.00
29_A104_F1.7601.00
178_E271_G1.7571.00
188_F214_G1.7131.00
170_A174_K1.7001.00
175_V271_G1.6871.00
44_E73_H1.6741.00
132_A173_Q1.6621.00
75_Q274_R1.6621.00
175_V179_E1.6601.00
31_I101_I1.6421.00
120_S237_I1.5981.00
134_K185_E1.5821.00
132_A169_R1.5621.00
105_K227_C1.5551.00
179_E271_G1.5231.00
112_L229_L1.5161.00
69_L80_V1.5011.00
179_E267_N1.4871.00
42_Q270_C1.4841.00
252_A256_A1.4741.00
197_E239_N1.4661.00
31_I114_C1.4411.00
132_A183_L1.4331.00
75_Q270_C1.4281.00
73_H76_G1.4221.00
138_N141_P1.4041.00
202_I239_N1.4041.00
93_G96_I1.4011.00
162_N199_A1.3991.00
122_R125_V1.3981.00
116_N235_S1.3921.00
162_N166_A1.3751.00
114_C221_V1.3741.00
257_A260_L1.3581.00
128_G257_A1.3461.00
176_A183_L1.3451.00
164_Y217_V1.3381.00
146_V192_P1.3151.00
69_L103_T1.3151.00
202_I241_A1.3141.00
203_R207_I1.3071.00
169_R173_Q1.3041.00
121_L202_I1.2941.00
175_V275_K1.2841.00
133_L233_A1.2701.00
102_R106_L1.2531.00
54_L102_R1.2511.00
181_F264_N1.2481.00
131_V237_I1.2411.00
196_F254_T1.2381.00
52_E57_F1.2291.00
259_E262_K1.2261.00
105_K110_E1.2241.00
38_A266_I1.2201.00
205_M210_G1.2141.00
137_I189_V1.2001.00
88_F94_M1.1981.00
67_G85_R1.1801.00
105_K229_L1.1781.00
136_H164_Y1.1751.00
111_L168_Y1.1701.00
66_A83_K1.1701.00
101_I227_C1.1621.00
257_A261_S1.1611.00
141_P192_P1.1421.00
127_A240_M1.1310.99
106_L153_F1.1200.99
125_V237_I1.1140.99
247_V253_Q1.1110.99
171_L275_K1.1020.99
39_L74_L1.0980.99
126_G240_M1.0940.99
195_N222_I1.0860.99
236_A261_S1.0810.99
250_S253_Q1.0740.99
260_L264_N1.0740.99
114_C233_A1.0680.99
101_I112_L1.0590.99
271_G275_K1.0530.99
202_I243_G1.0500.99
50_S57_F1.0480.99
251_H255_L1.0420.99
232_V272_F1.0340.99
125_V184_T1.0340.99
175_V272_F1.0180.99
120_S125_V1.0060.99
171_L174_K0.9980.99
28_V273_L0.9730.98
80_V104_F0.9730.98
130_L236_A0.9720.98
109_C229_L0.9700.98
139_T189_V0.9690.98
190_S218_V0.9660.98
196_F251_H0.9650.98
130_L234_V0.9550.98
48_A85_R0.9370.98
181_F268_L0.9360.98
134_K169_R0.9350.98
142_G146_V0.9300.98
202_I244_L0.9220.98
203_R206_Q0.9130.98
90_E93_G0.9130.98
29_A109_C0.9110.98
255_L259_E0.9080.98
102_R226_H0.9070.98
190_S219_P0.8960.97
162_N165_D0.8940.97
24_F78_P0.8930.97
238_T258_A0.8920.97
169_R185_E0.8890.97
217_V233_A0.8760.97
206_Q244_L0.8730.97
236_A265_F0.8710.97
160_L222_I0.8660.97
113_F269_I0.8640.97
80_V109_C0.8640.97
245_S248_K0.8620.97
205_M213_V0.8580.97
129_S182_P0.8570.97
92_R96_I0.8570.97
124_E184_T0.8560.97
263_Q267_N0.8550.97
203_R211_D0.8540.97
118_A212_V0.8520.96
82_M104_F0.8460.96
176_A268_L0.8400.96
49_I71_L0.8390.96
202_I242_E0.8370.96
197_E202_I0.8360.96
48_A70_V0.8330.96
88_F192_P0.8320.96
261_S264_N0.8230.96
54_L69_L0.8210.96
171_L272_F0.8190.96
168_Y232_V0.8190.96
126_G182_P0.8130.95
120_S240_M0.8080.95
69_L107_L0.8080.95
159_S249_L0.8070.95
244_L249_L0.8060.95
191_Y239_N0.8030.95
142_G192_P0.8030.95
173_Q177_K0.7980.95
121_L205_M0.7940.95
116_N217_V0.7930.95
137_I204_M0.7890.95
132_A172_L0.7870.95
183_L268_L0.7840.94
165_D225_R0.7780.94
175_V178_E0.7780.94
118_A237_I0.7770.94
162_N225_R0.7760.94
42_Q266_I0.7750.94
143_T146_V0.7730.94
171_L175_V0.7680.94
239_N244_L0.7650.94
251_H254_T0.7650.94
94_M219_P0.7610.94
133_L212_V0.7560.93
26_P71_L0.7550.93
48_A83_K0.7530.93
174_K177_K0.7470.93
221_V231_V0.7460.93
50_S53_K0.7440.93
90_E151_D0.7440.93
111_L165_D0.7410.93
264_N267_N0.7410.93
145_M222_I0.7400.93
113_F272_F0.7370.92
163_A198_T0.7340.92
125_V131_V0.7310.92
43_I72_G0.7270.92
113_F232_V0.7200.92
145_M218_V0.7180.91
234_V268_L0.7150.91
136_H160_L0.7150.91
166_A170_A0.7130.91
191_Y197_E0.7130.91
191_Y202_I0.7120.91
134_K186_G0.7120.91
242_E249_L0.7110.91
136_H198_T0.7110.91
202_I249_L0.7100.91
132_A234_V0.7060.91
218_V221_V0.7050.91
135_D163_A0.7040.91
135_D187_V0.7020.90
105_K228_D0.7020.90
239_N243_G0.6970.90
28_V77_V0.6940.90
138_N143_T0.6930.90
140_M192_P0.6910.90
203_R244_L0.6900.90
199_A239_N0.6900.90
28_V111_L0.6860.89
143_T192_P0.6860.89
139_T205_M0.6830.89
53_K103_T0.6810.89
243_G249_L0.6810.89
136_H218_V0.6800.89
199_A242_E0.6780.89
160_L163_A0.6770.89
204_M207_I0.6770.89
88_F142_G0.6760.89
94_M98_T0.6750.89
49_I107_L0.6750.89
80_V107_L0.6720.88
258_A262_K0.6710.88
267_N270_C0.6700.88
137_I208_I0.6600.88
253_Q256_A0.6590.87
57_F103_T0.6570.87
27_R111_L0.6570.87
172_L268_L0.6570.87
138_N142_G0.6510.87
139_T191_Y0.6470.87
74_L273_L0.6470.87
129_S264_N0.6460.86
140_M191_Y0.6430.86
31_I112_L0.6430.86
177_K182_P0.6420.86
263_Q266_I0.6410.86
55_P102_R0.6400.86
225_R228_D0.6390.86
30_F273_L0.6390.86
189_V208_I0.6380.86
134_K187_V0.6370.86
267_N271_G0.6350.86
125_V129_S0.6310.85
161_A242_E0.6300.85
111_L167_E0.6300.85
24_F71_L0.6300.85
121_L206_Q0.6290.85
70_V85_R0.6280.85
126_G184_T0.6230.84
37_G83_K0.6190.84
199_A249_L0.6170.84
179_E268_L0.6170.84
116_N214_G0.6160.84
122_R240_M0.6160.84
34_S196_F0.6160.84
94_M140_M0.6150.84
38_A262_K0.6130.83
218_V222_I0.6120.83
164_Y233_A0.6100.83
37_G81_C0.6100.83
234_V269_I0.6070.83
69_L104_F0.6050.83
94_M97_M0.6040.83
154_G226_H0.6040.83
242_E245_S0.6020.82
141_P145_M0.5980.82
94_M142_G0.5950.82
224_A231_V0.5940.82
134_K199_A0.5940.82
34_S251_H0.5940.82
135_D161_A0.5920.81
240_M244_L0.5870.81
114_C231_V0.5860.81
102_R223_S0.5850.81
125_V212_V0.5830.80
262_K266_I0.5820.80
188_F217_V0.5820.80
239_N246_D0.5820.80
163_A199_A0.5800.80
162_N169_R0.5780.80
179_E182_P0.5730.79
172_L234_V0.5720.79
140_M219_P0.5700.79
89_Y95_T0.5700.79
130_L265_F0.5670.78
118_A238_T0.5670.78
204_M210_G0.5660.78
24_F73_H0.5650.78
244_L248_K0.5650.78
112_L224_A0.5650.78
38_A41_D0.5640.78
74_L77_V0.5640.78
175_V232_V0.5640.78
219_P223_S0.5600.78
224_A229_L0.5590.77
139_T208_I0.5590.77
55_P90_E0.5540.77
260_L263_Q0.5540.77
31_I104_F0.5510.76
102_R227_C0.5490.76
43_I46_A0.5450.76
138_N190_S0.5430.75
87_H117_A0.5360.75
125_V211_D0.5350.74
143_T147_G0.5330.74
166_A169_R0.5320.74
123_P240_M0.5320.74
134_K203_R0.5320.74
88_F146_V0.5310.74
136_H217_V0.5290.74
164_Y169_R0.5280.73
116_N233_A0.5280.73
133_L217_V0.5270.73
162_N248_K0.5270.73
121_L191_Y0.5270.73
113_F234_V0.5260.73
163_A225_R0.5250.73
114_C217_V0.5250.73
25_T78_P0.5190.72
256_A259_E0.5180.72
170_A173_Q0.5170.72
262_K265_F0.5170.72
35_G87_H0.5170.72
39_L42_Q0.5160.72
121_L189_V0.5160.72
255_L258_A0.5160.72
240_M245_S0.5150.72
151_D155_E0.5140.71
41_D266_I0.5120.71
58_P92_R0.5080.71
101_I104_F0.5070.70
25_T109_C0.5070.70
145_M158_F0.5070.70
30_F79_V0.5060.70
25_T110_E0.5060.70
110_E230_K0.5060.70
94_M192_P0.5040.70
133_L235_S0.5030.70
174_K178_E0.5030.70
45_N72_G0.5020.70
121_L239_N0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p4sA 3 0.9819 100 0.256 Contact Map
3la8A 1 0.8917 100 0.264 Contact Map
4earA 3 0.9892 100 0.275 Contact Map
1g2oA 3 0.9422 100 0.279 Contact Map
4m1eA 5 0.9856 100 0.282 Contact Map
1vmkA 3 0.9097 100 0.283 Contact Map
1tcvA 3 0.9856 100 0.285 Contact Map
3odgA 3 0.9819 100 0.289 Contact Map
3khsA 3 0.9458 100 0.289 Contact Map
3fucA 3 0.9603 100 0.293 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.