GREMLIN Database
YHFY - Uncharacterized protein YhfY
UniProt: P45551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12920
Length: 120 (97)
Sequences: 4714 (3980)
Seq/√Len: 404.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_L96_E3.7181.00
32_E84_Q3.7141.00
24_Q92_E2.9331.00
28_V88_V2.6701.00
78_H110_Y2.5501.00
66_D103_G2.4121.00
83_V102_E2.3341.00
82_V106_L2.3191.00
54_M58_R2.2931.00
25_V85_L2.2591.00
86_H102_E2.1711.00
30_E36_P2.1681.00
28_V84_Q2.1291.00
29_L109_L1.7551.00
33_C81_A1.7321.00
82_V102_E1.7231.00
80_Q83_V1.5961.00
53_L57_R1.5461.00
48_H108_N1.5231.00
59_G95_L1.5151.00
68_E72_E1.4911.00
56_S98_N1.4471.00
42_G46_M1.3881.00
66_D70_L1.3711.00
67_N71_A1.3491.00
78_H82_V1.3381.00
88_V92_E1.2671.00
55_R101_E1.2621.00
78_H109_L1.2501.00
28_V32_E1.2421.00
77_S80_Q1.1481.00
21_G93_F1.1251.00
23_M27_N1.1241.00
55_R62_I1.1221.00
29_L81_A1.1191.00
50_A54_M1.1061.00
27_N31_T1.1021.00
79_W106_L1.0851.00
83_V99_P1.0841.00
70_L73_L1.0521.00
22_M26_V1.0481.00
86_H97_V1.0381.00
18_I22_M1.0371.00
22_M49_M1.0181.00
87_Q90_L1.0181.00
70_L99_P1.0091.00
83_V87_Q1.0041.00
44_M111_G0.9981.00
110_Y113_W0.9971.00
22_M46_M0.9921.00
85_L109_L0.9831.00
20_K24_Q0.9621.00
65_L70_L0.9391.00
51_S60_E0.9381.00
16_K20_K0.9321.00
63_E103_G0.9321.00
32_E81_A0.9281.00
37_V109_L0.9211.00
70_L79_W0.8901.00
86_H90_L0.8871.00
81_A85_L0.8841.00
18_I50_A0.8821.00
23_M42_G0.8711.00
52_A108_N0.8691.00
69_L73_L0.8691.00
21_G92_E0.8091.00
40_E44_M0.8091.00
69_L107_A0.8031.00
21_G25_V0.8011.00
82_V109_L0.7961.00
98_N101_E0.7911.00
37_V112_L0.7821.00
29_L45_A0.7781.00
44_M108_N0.7761.00
20_K92_E0.7701.00
86_H105_L0.7691.00
85_L88_V0.7681.00
79_W83_V0.7581.00
24_Q28_V0.7541.00
69_L106_L0.7531.00
43_T46_M0.7491.00
17_D20_K0.7441.00
44_M112_L0.7411.00
18_I53_L0.7361.00
79_W99_P0.7321.00
87_Q96_E0.7281.00
53_L93_F0.7251.00
30_E39_S0.7201.00
65_L108_N0.7171.00
84_Q88_V0.7131.00
30_E33_C0.7091.00
22_M25_V0.6991.00
78_H106_L0.6951.00
67_N70_L0.6931.00
24_Q88_V0.6921.00
102_E106_L0.6881.00
78_H113_W0.6871.00
35_L113_W0.6760.99
64_P68_E0.6670.99
103_G106_L0.6640.99
84_Q87_Q0.6450.99
57_R95_L0.6430.99
33_C84_Q0.6420.99
82_V105_L0.6420.99
56_S61_E0.6290.99
69_L103_G0.6260.99
76_S80_Q0.6250.99
99_P102_E0.6230.99
47_T51_S0.6210.99
47_T54_M0.6160.99
33_C113_W0.6150.99
24_Q27_N0.6130.99
87_Q91_K0.6120.99
83_V86_H0.6120.99
41_Q112_L0.6110.99
52_A97_V0.6090.99
29_L33_C0.6040.99
19_C42_G0.5990.99
73_L76_S0.5970.99
80_Q84_Q0.5960.99
53_L97_V0.5950.99
45_A103_G0.5910.99
61_E98_N0.5890.99
79_W102_E0.5850.98
26_V41_Q0.5840.98
21_G88_V0.5800.98
65_L73_L0.5790.98
88_V91_K0.5740.98
89_L95_L0.5670.98
62_I104_Y0.5650.98
100_C103_G0.5630.98
64_P72_E0.5580.98
89_L97_V0.5570.98
66_D99_P0.5550.98
66_D73_L0.5530.98
68_E73_L0.5460.98
52_A56_S0.5410.97
61_E100_C0.5400.97
20_K23_M0.5360.97
19_C43_T0.5300.97
65_L69_L0.5250.97
63_E100_C0.5210.97
32_E77_S0.5070.96
34_H77_S0.5050.96
52_A60_E0.5000.96
21_G57_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rioA 1 0.9417 99.6 0.279 Contact Map
1h99A 2 0.975 99.5 0.348 Contact Map
3ufeA 2 0.8667 99.5 0.361 Contact Map
4r6iA 2 0.9667 99.3 0.413 Contact Map
3sqnA 2 0.9333 98.6 0.557 Contact Map
3nufA 2 0.9167 97.3 0.678 Contact Map
3ldzA 1 0.7667 20 0.874 Contact Map
1elkA 1 0.8 9.4 0.891 Contact Map
2vlaA 1 0.9333 4.8 0.905 Contact Map
1x5bA 1 0.875 4.5 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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