GREMLIN Database
YHFW - Uncharacterized protein YhfW
UniProt: P45549 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12918
Length: 408 (378)
Sequences: 1410 (867)
Seq/√Len: 44.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_N326_A4.6061.00
276_D319_N3.5771.00
113_Q117_S3.2641.00
143_N146_A3.2141.00
135_N144_L3.1931.00
124_R194_R3.1211.00
238_Q260_P3.0071.00
119_G170_G2.9051.00
278_T292_T2.8601.00
35_H38_S2.8591.00
137_A147_D2.7241.00
220_G223_V2.7001.00
119_G192_S2.6981.00
264_S284_T2.6861.00
135_N148_L2.6851.00
218_D223_V2.6141.00
120_W132_L2.6141.00
150_Q154_I2.6001.00
347_H351_T2.5511.00
107_V201_S2.5501.00
319_N322_R2.5171.00
241_Y263_V2.5021.00
151_V157_N2.4621.00
217_Y220_G2.4571.00
231_D260_P2.4231.00
240_L386_F2.3891.00
91_I378_V2.3411.00
31_N57_L2.3281.00
31_N34_G2.3071.00
221_F224_V2.2841.00
272_Q276_D2.2731.00
134_V151_V2.1741.00
144_L148_L2.1581.00
84_T256_I2.1551.00
118_A124_R2.1481.00
218_D222_Q2.1181.00
74_V371_V2.1151.00
132_L157_N2.1151.00
234_V242_E2.1061.00
21_T28_A2.1031.00
153_N178_Q2.0300.99
143_N147_D2.0220.99
218_D221_F2.0130.99
21_T24_R1.9940.99
85_F229_G1.9770.99
152_Y213_R1.9650.99
372_R377_D1.9430.99
359_V397_F1.9080.99
153_N220_G1.8970.99
47_T50_T1.8910.99
118_A123_E1.8700.99
275_M323_L1.8430.99
236_V383_C1.8300.99
5_V290_I1.8130.99
361_Q364_M1.8090.98
124_R191_D1.8020.98
116_V133_W1.7940.98
250_V281_E1.7910.98
304_E351_T1.7730.98
71_T364_M1.7720.98
45_L313_L1.7470.98
73_G370_G1.7350.98
158_L188_L1.7350.98
187_G190_T1.7310.98
75_A357_V1.7250.98
272_Q319_N1.7160.98
277_I280_N1.7160.98
139_A144_L1.7030.98
151_V154_I1.7030.98
273_R277_I1.7000.98
35_H344_T1.6970.98
300_A312_R1.6800.98
306_V344_T1.6760.98
373_T395_R1.6750.97
50_T69_S1.6740.97
18_K354_V1.6480.97
144_L147_D1.6440.97
115_L201_S1.6420.97
254_A259_N1.6330.97
218_D224_V1.6310.97
190_T228_Y1.6280.97
158_L179_V1.6170.97
282_F323_L1.6070.97
345_I351_T1.5980.97
220_G224_V1.5910.97
304_E345_I1.5890.97
330_D363_G1.5880.97
234_V239_K1.5830.96
384_E396_S1.5780.96
47_T321_A1.5770.96
226_M267_N1.5690.96
30_A345_I1.5610.96
134_V157_N1.5510.96
139_A148_L1.5410.96
139_A147_D1.5350.96
16_A29_G1.5350.96
135_N139_A1.5340.96
231_D258_N1.5310.96
76_E373_T1.5310.96
272_Q315_V1.5200.96
238_Q241_Y1.5120.95
304_E347_H1.4910.95
76_E354_V1.4850.95
305_D311_E1.4720.95
40_L310_A1.4690.95
45_L53_L1.4620.94
187_G191_D1.4620.94
74_V354_V1.4600.94
249_L262_G1.4260.94
372_R397_F1.3970.93
385_F398_L1.3890.93
238_Q242_E1.3860.93
170_G196_L1.3850.93
334_V359_V1.3850.93
150_Q220_G1.3660.92
219_N223_V1.3410.91
116_V120_W1.3390.91
153_N217_Y1.3390.91
30_A347_H1.3360.91
245_V287_T1.3340.91
275_M321_A1.3340.91
75_A378_V1.3280.91
133_W160_V1.3210.91
286_P290_I1.3020.90
380_A391_P1.2960.90
329_P362_Q1.2790.89
75_A372_R1.2600.89
240_L245_V1.2510.88
120_W133_W1.2470.88
17_M76_E1.2420.88
40_L307_A1.2350.88
30_A351_T1.2340.88
332_C385_F1.2290.87
146_A219_N1.2290.87
279_L282_F1.2280.87
275_M294_I1.2270.87
31_N61_P1.2270.87
150_Q218_D1.2260.87
216_A220_G1.2240.87
150_Q217_Y1.2220.87
377_D397_F1.2200.87
75_A355_V1.2160.87
5_V282_F1.2140.87
12_F313_L1.2130.87
177_V216_A1.2060.86
49_E63_D1.2020.86
275_M319_N1.1990.86
307_A311_E1.1940.86
55_N68_D1.1890.86
20_V30_A1.1860.85
304_E346_G1.1700.85
51_L70_A1.1660.84
236_V391_P1.1640.84
237_P262_G1.1600.84
37_L61_P1.1570.84
355_V378_V1.1490.84
250_V292_T1.1420.83
196_L206_F1.1330.83
272_Q275_M1.1310.83
94_T233_K1.1310.83
276_D322_R1.1260.82
333_L360_Y1.1150.82
24_R80_E1.1150.82
73_G397_F1.1130.82
6_V91_I1.1110.81
45_L314_Q1.1020.81
175_E215_G1.1000.81
134_V148_L1.0890.80
11_S309_Y1.0870.80
25_P80_E1.0700.79
115_L195_I1.0680.79
49_E55_N1.0680.79
179_V188_L1.0670.79
131_F158_L1.0660.79
334_V378_V1.0640.78
334_V357_V1.0580.78
272_Q322_R1.0570.78
71_T361_Q1.0540.78
243_A388_A1.0400.77
51_L324_V1.0350.77
271_S315_V1.0280.76
2_A287_T1.0270.76
86_M104_F1.0270.76
240_L388_A1.0220.76
92_L379_G1.0160.75
270_D299_L1.0110.75
49_E54_I1.0090.75
246_P264_S1.0090.75
17_M354_V1.0060.74
249_L254_A1.0050.74
117_S123_E1.0050.74
115_L196_L0.9950.74
125_R158_L0.9920.73
6_V289_F0.9810.73
9_I335_V0.9800.72
6_V92_L0.9770.72
152_Y158_L0.9740.72
16_A354_V0.9740.72
311_E315_V0.9690.72
4_F385_F0.9690.72
247_T263_V0.9680.72
254_A265_W0.9650.71
217_Y223_V0.9640.71
103_P107_V0.9570.71
43_L314_Q0.9460.70
12_F33_C0.9450.70
91_I257_V0.9440.70
250_V278_T0.9440.70
219_N222_Q0.9420.69
77_L375_L0.9380.69
359_V369_L0.9370.69
257_V291_C0.9320.69
6_V378_V0.9320.69
135_N147_D0.9310.69
41_P307_A0.9300.68
248_V281_E0.9290.68
266_Q281_E0.9290.68
139_A143_N0.9180.67
268_L274_I0.9130.67
119_G160_V0.9110.67
71_T369_L0.9040.66
16_A345_I0.9010.66
43_L310_A0.8950.65
214_S221_F0.8900.65
33_C53_L0.8900.65
3_R328_Q0.8900.65
239_K391_P0.8850.65
59_Y62_G0.8780.64
73_G369_L0.8760.64
51_L69_S0.8740.64
226_M254_A0.8740.64
84_T309_Y0.8740.64
70_A358_L0.8690.63
37_L43_L0.8650.63
235_Q238_Q0.8650.63
191_D194_R0.8630.63
5_V327_M0.8600.62
279_L322_R0.8590.62
315_V318_R0.8580.62
35_H351_T0.8460.61
78_Q95_R0.8440.61
332_C359_V0.8420.61
374_T395_R0.8320.60
33_C45_L0.8310.60
39_Q307_A0.8310.60
71_T367_T0.8310.60
16_A28_A0.8300.60
146_A217_Y0.8240.59
14_V57_L0.8190.59
195_I200_E0.8160.58
382_V386_F0.8150.58
236_V379_G0.8140.58
248_V286_P0.8140.58
285_H288_A0.8130.58
119_G188_L0.8100.58
170_G206_F0.8080.58
71_T366_A0.8080.58
179_V213_R0.8070.57
2_A330_D0.8040.57
58_G64_M0.8020.57
249_L265_W0.7970.56
38_S60_A0.7920.56
321_A325_E0.7900.56
86_M96_P0.7880.56
78_Q393_N0.7840.55
134_V158_L0.7800.55
152_Y179_V0.7750.54
2_A385_F0.7720.54
271_S312_R0.7700.54
18_K76_E0.7660.54
279_L319_N0.7660.54
254_A262_G0.7610.53
44_Q314_Q0.7600.53
36_I306_V0.7600.53
241_Y247_T0.7570.53
177_V214_S0.7560.53
239_K380_A0.7550.52
14_V56_A0.7540.52
307_A310_A0.7510.52
8_V336_M0.7500.52
383_C388_A0.7480.52
153_N216_A0.7470.52
59_Y74_V0.7410.51
54_I62_G0.7410.51
40_L306_V0.7390.51
12_F45_L0.7380.51
103_P109_D0.7370.51
270_D296_E0.7360.51
245_V386_F0.7340.50
65_Q68_D0.7330.50
282_F326_A0.7320.50
246_P263_V0.7320.50
257_V379_G0.7320.50
45_L48_L0.7310.50
6_V291_C0.7290.50
45_L49_E0.7290.50
26_Q346_G0.7280.50
123_E373_T0.7270.50
314_Q318_R0.7240.49
125_R188_L0.7220.49
30_A304_E0.7220.49
94_T235_Q0.7220.49
6_V382_V0.7210.49
190_T267_N0.7170.49
125_R191_D0.7130.48
219_N224_V0.7130.48
236_V239_K0.7110.48
6_V334_V0.7110.48
250_V257_V0.7110.48
357_V369_L0.7100.48
116_V132_L0.7100.48
85_F258_N0.7090.48
55_N64_M0.7080.48
113_Q123_E0.7080.48
103_P108_I0.7070.48
274_I294_I0.7010.47
376_S393_N0.6990.47
239_K388_A0.6960.47
384_E398_L0.6930.46
247_T262_G0.6920.46
269_V273_R0.6920.46
300_A315_V0.6900.46
282_F327_M0.6880.46
18_K60_A0.6870.46
278_T290_I0.6870.46
150_Q153_N0.6860.46
169_I173_V0.6860.46
124_R192_S0.6850.46
105_R202_K0.6850.46
264_S281_E0.6850.46
171_R175_E0.6840.46
171_R174_R0.6830.45
36_I309_Y0.6780.45
131_F179_V0.6780.45
9_I316_V0.6750.45
73_G357_V0.6730.45
217_Y221_F0.6720.44
199_A202_K0.6710.44
160_V170_G0.6710.44
107_V110_R0.6680.44
324_V333_L0.6640.44
72_W358_L0.6630.44
57_L368_Q0.6630.44
91_I355_V0.6620.43
254_A267_N0.6590.43
76_E371_V0.6580.43
178_Q216_A0.6580.43
304_E341_N0.6560.43
104_F383_C0.6550.43
281_E290_I0.6540.43
285_H328_Q0.6540.43
75_A377_D0.6520.43
379_G390_P0.6510.42
275_M316_V0.6510.42
169_I174_R0.6500.42
153_N175_E0.6500.42
202_K230_V0.6490.42
169_I172_I0.6490.42
4_F382_V0.6490.42
275_M282_F0.6490.42
117_S120_W0.6480.42
280_N284_T0.6480.42
381_T397_F0.6470.42
281_E284_T0.6470.42
234_V260_P0.6450.42
49_E358_L0.6430.42
42_H306_V0.6430.42
270_D273_R0.6410.41
131_F188_L0.6400.41
12_F335_V0.6400.41
237_P249_L0.6380.41
217_Y222_Q0.6370.41
12_F53_L0.6370.41
69_S360_Y0.6360.41
2_A328_Q0.6350.41
279_L326_A0.6350.41
361_Q385_F0.6340.41
233_K392_Q0.6340.41
105_R110_R0.6320.41
354_V371_V0.6320.41
231_D238_Q0.6310.41
273_R276_D0.6310.41
72_W366_A0.6300.40
42_H61_P0.6300.40
217_Y224_V0.6270.40
246_P288_A0.6270.40
381_T394_G0.6260.40
337_A356_P0.6260.40
37_L54_I0.6260.40
124_R195_I0.6240.40
49_E65_Q0.6230.40
139_A145_E0.6210.40
323_L327_M0.6210.40
5_V323_L0.6200.40
19_D352_R0.6200.40
114_A200_E0.6200.40
337_A355_V0.6190.39
146_A220_G0.6190.39
379_G392_Q0.6190.39
275_M322_R0.6170.39
8_V355_V0.6160.39
35_H347_H0.6130.39
114_A201_S0.6130.39
33_C313_L0.6120.39
190_T194_R0.6100.39
248_V264_S0.6070.38
174_R185_F0.6060.38
332_C398_L0.6050.38
14_V53_L0.6040.38
24_R387_R0.6030.38
310_A314_Q0.6020.38
152_Y155_T0.6010.38
171_R176_Q0.5990.38
104_F292_T0.5990.38
202_K229_G0.5990.38
91_I382_V0.5990.38
105_R201_S0.5970.37
383_C391_P0.5960.37
116_V160_V0.5950.37
368_Q371_V0.5940.37
332_C361_Q0.5940.37
324_V360_Y0.5930.37
333_L358_L0.5930.37
216_A219_N0.5920.37
296_E299_L0.5910.37
67_S387_R0.5900.37
7_L294_I0.5890.37
119_G196_L0.5890.37
380_A392_Q0.5890.37
58_G70_A0.5870.37
104_F344_T0.5850.36
377_D380_A0.5850.36
17_M45_L0.5850.36
221_F299_L0.5840.36
110_R136_Q0.5840.36
245_V289_F0.5830.36
153_N221_F0.5820.36
174_R179_V0.5810.36
3_R331_D0.5810.36
16_A56_A0.5800.36
248_V288_A0.5790.36
289_F379_G0.5790.36
72_W368_Q0.5790.36
288_A380_A0.5790.36
49_E62_G0.5770.36
96_P229_G0.5770.36
68_D366_A0.5770.36
197_D230_V0.5760.36
102_M200_E0.5750.35
330_D362_Q0.5750.35
103_P138_V0.5750.35
386_F391_P0.5740.35
320_L333_L0.5740.35
17_M20_V0.5730.35
7_L316_V0.5720.35
91_I94_T0.5720.35
25_P347_H0.5720.35
131_F156_A0.5700.35
53_L358_L0.5700.35
318_R321_A0.5690.35
197_D203_E0.5680.35
17_M355_V0.5680.35
75_A374_T0.5670.35
330_D382_V0.5660.35
275_M279_L0.5630.34
142_D303_A0.5630.34
237_P247_T0.5620.34
106_D138_V0.5620.34
383_C390_P0.5620.34
248_V266_Q0.5620.34
118_A191_D0.5610.34
5_V331_D0.5610.34
384_E399_S0.5600.34
330_D333_L0.5600.34
250_V279_L0.5590.34
105_R109_D0.5580.34
282_F333_L0.5550.34
107_V115_L0.5540.34
259_N265_W0.5540.34
91_I306_V0.5530.34
275_M320_L0.5520.33
41_P60_A0.5510.33
36_I204_G0.5490.33
268_L277_I0.5490.33
236_V289_F0.5490.33
226_M265_W0.5480.33
200_E203_E0.5480.33
104_F314_Q0.5470.33
120_W160_V0.5470.33
181_R213_R0.5470.33
287_T386_F0.5450.33
105_R229_G0.5450.33
70_A361_Q0.5440.33
169_I175_E0.5420.33
120_W131_F0.5420.33
25_P304_E0.5410.32
30_A346_G0.5400.32
20_V28_A0.5400.32
9_I337_A0.5390.32
204_G229_G0.5380.32
56_A74_V0.5380.32
67_S70_A0.5380.32
152_Y188_L0.5380.32
279_L283_N0.5370.32
278_T323_L0.5360.32
49_E64_M0.5350.32
137_A143_N0.5350.32
228_Y260_P0.5340.32
148_L151_V0.5340.32
12_F309_Y0.5330.32
86_M95_R0.5320.32
240_L289_F0.5310.32
297_T316_V0.5310.32
262_G265_W0.5310.32
161_I169_I0.5300.32
152_Y173_V0.5300.32
238_Q257_V0.5290.31
25_P351_T0.5280.31
150_Q221_F0.5270.31
48_L219_N0.5270.31
108_I138_V0.5260.31
246_P286_P0.5260.31
29_G345_I0.5240.31
58_G61_P0.5240.31
37_L62_G0.5220.31
70_A395_R0.5220.31
266_Q277_I0.5220.31
361_Q365_I0.5220.31
11_S256_I0.5180.31
5_V292_T0.5180.31
153_N223_V0.5170.30
169_I176_Q0.5170.30
125_R133_W0.5170.30
73_G372_R0.5170.30
181_R185_F0.5160.30
170_G370_G0.5160.30
322_R325_E0.5160.30
107_V200_E0.5160.30
134_V152_Y0.5160.30
115_L144_L0.5160.30
47_T324_V0.5150.30
51_L382_V0.5150.30
25_P345_I0.5140.30
182_V190_T0.5130.30
306_V310_A0.5130.30
55_N65_Q0.5130.30
243_A387_R0.5130.30
105_R258_N0.5120.30
94_T238_Q0.5120.30
323_L326_A0.5110.30
278_T341_N0.5100.30
193_Q197_D0.5100.30
145_E197_D0.5090.30
330_D385_F0.5090.30
73_G170_G0.5080.30
37_L40_L0.5070.30
58_G371_V0.5060.30
199_A341_N0.5040.29
282_F325_E0.5040.29
113_Q284_T0.5040.29
119_G125_R0.5040.29
85_F204_G0.5030.29
34_G38_S0.5030.29
236_V334_V0.5020.29
115_L199_A0.5010.29
241_Y246_P0.5010.29
174_R178_Q0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ot9A 1 0.9412 100 0.382 Contact Map
3m7vA 1 0.9387 100 0.384 Contact Map
3kd8A 1 0.7966 100 0.785 Contact Map
2zktA 3 0.8015 100 0.841 Contact Map
1zedA 2 0.8554 100 0.845 Contact Map
2x98A 4 0.7892 99.9 0.856 Contact Map
1o98A 1 0.9485 99.9 0.859 Contact Map
1k7hA 2 0.8554 99.9 0.859 Contact Map
3igzB 1 0.9485 99.9 0.865 Contact Map
3a52A 2 0.7426 99.9 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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