GREMLIN Database
PHP - Phosphotriesterase homology protein
UniProt: P45548 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12917
Length: 292 (287)
Sequences: 936 (648)
Seq/√Len: 38.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_L48_V3.9371.00
270_R276_Q3.5521.00
169_L204_A3.5341.00
275_S278_D3.2081.00
68_D72_E3.0311.00
148_H177_V2.9811.00
106_V147_A2.9701.00
67_L71_R2.9491.00
107_D111_Q2.8731.00
170_A202_L2.7711.00
157_T168_Q2.7641.00
120_A153_R2.7271.00
197_L232_R2.6811.00
276_Q280_D2.6161.00
211_I265_F2.4781.00
280_D284_R2.4671.00
142_I175_H2.4661.00
235_L281_V2.4231.00
266_I270_R2.3631.00
236_N281_V2.3581.00
44_M49_R2.3481.00
138_E142_I2.2961.00
109_I153_R2.2931.00
173_Q202_L2.2470.99
280_D285_E2.2090.99
123_I144_A2.2070.99
78_V121_G2.1750.99
106_V151_T2.1280.99
37_C73_T2.1080.99
135_P138_E2.1030.99
33_Y68_D2.0930.99
50_N76_N2.0930.99
198_K201_D2.0600.99
156_S185_G2.0450.99
240_L282_M2.0210.99
158_H243_D1.9790.99
46_R263_T1.9600.99
102_A106_V1.9520.98
106_V150_Q1.9150.98
146_L175_H1.8670.98
227_H231_D1.8360.98
128_T168_Q1.8320.98
285_E288_S1.8060.97
179_L182_V1.7690.97
228_A232_R1.7580.97
186_H243_D1.7580.97
6_T50_N1.7490.97
183_T290_F1.7070.96
230_R274_F1.6970.96
205_Y239_M1.6920.96
228_A231_D1.6910.96
102_A146_L1.6800.96
266_I283_L1.6290.95
158_H186_H1.6210.95
101_L143_A1.6120.95
41_N44_M1.6050.95
235_L278_D1.5750.94
224_A272_S1.5750.94
173_Q179_L1.5690.94
40_M69_V1.5690.94
281_V285_E1.5170.93
122_I156_S1.5020.93
166_L202_L1.4770.92
37_C72_E1.4650.92
142_I146_L1.4460.91
86_D134_T1.4390.91
41_N45_T1.4370.91
166_L198_K1.4260.91
126_I144_A1.3970.90
169_L184_V1.3820.89
103_Q107_D1.3810.89
114_D117_E1.3640.89
165_G199_M1.3630.89
201_D234_L1.3620.89
148_H155_I1.3600.88
259_D263_T1.3550.88
128_T157_T1.3430.88
230_R238_V1.3360.88
170_A174_A1.3300.87
169_L202_L1.3280.87
145_A172_L1.3190.87
230_R235_L1.3120.87
8_Y262_L1.2970.86
56_N125_E1.2920.86
205_Y289_Q1.2640.84
125_E243_D1.2580.84
269_L274_F1.2530.84
37_C69_V1.2480.84
157_T184_V1.2380.83
274_F278_D1.2370.83
48_V262_L1.2360.83
223_I268_Q1.2350.83
54_M156_S1.2240.83
125_E158_H1.2040.81
11_A239_M1.2020.81
46_R262_L1.1900.81
212_G219_D1.1860.80
237_R289_Q1.1850.80
168_Q184_V1.1810.80
54_M80_C1.1790.80
79_A113_I1.1730.80
61_R108_E1.1640.79
223_I272_S1.1510.78
142_I174_A1.1470.78
39_E254_G1.1430.78
143_A147_A1.1430.78
93_V139_K1.1350.77
9_T50_N1.1250.77
26_V247_R1.1250.77
165_G195_N1.1210.77
39_E255_G1.1170.76
200_I234_L1.1090.76
254_G257_G1.1040.75
39_E257_G1.0970.75
108_E120_A1.0930.75
128_T133_I1.0880.74
15_L77_V1.0850.74
98_V146_L1.0840.74
125_E244_I1.0820.74
62_N65_F1.0810.74
239_M286_N1.0810.74
66_M79_A1.0810.74
109_I120_A1.0750.73
198_K202_L1.0740.73
230_R282_M1.0700.73
147_A153_R1.0660.73
113_I116_T1.0560.72
34_A37_C1.0550.72
43_L75_I1.0540.72
15_L40_M1.0530.72
80_C125_E1.0310.70
169_L173_Q1.0300.70
238_V282_M1.0280.70
205_Y286_N1.0180.69
81_T105_M1.0040.68
159_T168_Q1.0030.68
274_F282_M0.9990.68
209_D243_D0.9980.68
67_L117_E0.9910.67
10_L262_L0.9860.67
13_E241_S0.9830.67
235_L274_F0.9830.67
239_M290_F0.9790.66
128_T141_F0.9760.66
127_G255_G0.9730.66
34_A72_E0.9680.65
189_L210_T0.9670.65
191_D221_K0.9670.65
97_S100_E0.9610.65
33_Y69_V0.9490.64
83_Y92_H0.9480.64
196_I208_F0.9470.64
57_R83_Y0.9460.64
138_E175_H0.9450.63
113_I117_E0.9450.63
63_A113_I0.9410.63
190_K196_I0.9400.63
10_L241_S0.9390.63
63_A66_M0.9370.63
67_L118_L0.9350.63
173_Q182_V0.9330.62
68_D119_K0.9290.62
110_E150_Q0.9280.62
171_L175_H0.9270.62
133_I167_E0.9220.61
121_G153_R0.9210.61
9_T96_R0.9210.61
205_Y290_F0.9180.61
42_D46_R0.9140.61
84_Y242_M0.9100.60
96_R100_E0.9100.60
123_I126_I0.9070.60
40_M73_T0.9040.60
186_H209_D0.8980.59
98_V102_A0.8950.59
158_H209_D0.8940.59
188_D210_T0.8920.59
172_L177_V0.8910.59
197_L201_D0.8790.58
208_F229_L0.8780.58
262_L266_I0.8760.58
149_N175_H0.8740.57
40_M75_I0.8700.57
188_D222_R0.8660.57
8_Y48_V0.8630.56
277_A285_E0.8620.56
11_A52_I0.8620.56
11_A283_L0.8610.56
107_D110_E0.8550.56
81_T108_E0.8550.56
111_Q120_A0.8510.55
13_E212_G0.8510.55
155_I185_G0.8490.55
210_T245_T0.8490.55
63_A79_A0.8480.55
19_L125_E0.8430.55
157_T172_L0.8410.54
16_H65_F0.8380.54
14_H186_H0.8360.54
260_Y265_F0.8350.54
44_M75_I0.8350.54
245_T249_H0.8310.54
199_M204_A0.8300.53
169_L179_L0.8260.53
42_D251_K0.8170.52
149_N177_V0.8150.52
9_T76_N0.8150.52
133_I171_L0.8130.52
3_F291_F0.8120.52
155_I172_L0.8120.52
48_V75_I0.8120.52
53_E195_N0.8080.51
171_L174_A0.8080.51
84_Y125_E0.8070.51
125_E186_H0.8060.51
45_T103_Q0.8030.51
125_E210_T0.7960.50
187_C199_M0.7940.50
78_V178_D0.7880.50
123_I148_H0.7850.49
19_L59_M0.7830.49
61_R112_G0.7820.49
14_H158_H0.7810.49
16_H69_V0.7800.49
52_I78_V0.7770.49
49_R76_N0.7750.49
12_H243_D0.7750.49
70_M75_I0.7720.48
10_L13_E0.7630.47
56_N240_L0.7630.47
138_E171_L0.7590.47
188_D291_F0.7570.47
84_Y243_D0.7550.47
157_T200_I0.7550.47
229_L238_V0.7520.46
63_A115_G0.7500.46
98_V142_I0.7490.46
12_H158_H0.7490.46
156_S207_Q0.7430.46
8_Y283_L0.7400.45
56_N84_Y0.7380.45
138_E167_E0.7380.45
105_M144_A0.7380.45
54_M122_I0.7310.45
84_Y213_K0.7290.44
133_I164_M0.7280.44
41_N73_T0.7280.44
129_S137_E0.7240.44
157_T182_V0.7180.43
196_I225_M0.7180.43
154_P290_F0.7140.43
159_T291_F0.7130.43
108_E114_D0.7100.43
58_Y84_Y0.7080.43
227_H230_R0.7070.42
213_K216_Y0.7070.42
83_Y101_L0.7060.42
161_F260_Y0.7060.42
100_E103_Q0.7050.42
213_K246_R0.7040.42
146_L149_N0.7040.42
106_V110_E0.7040.42
239_M282_M0.7040.42
266_I279_V0.7030.42
128_T187_C0.7000.42
141_F157_T0.6990.42
164_M167_E0.6980.42
6_T288_S0.6960.42
5_P282_M0.6960.42
12_H186_H0.6940.41
18_D90_P0.6930.41
192_N195_N0.6930.41
39_E258_Y0.6910.41
126_I140_V0.6900.41
267_P270_R0.6860.41
166_L199_M0.6860.41
80_C245_T0.6840.40
52_I73_T0.6820.40
212_G241_S0.6820.40
177_V181_R0.6810.40
270_R279_V0.6810.40
64_Q77_V0.6800.40
68_D238_V0.6780.40
27_D168_Q0.6780.40
78_V259_D0.6770.40
126_I141_F0.6750.40
230_R278_D0.6740.40
141_F206_V0.6680.39
17_I245_T0.6680.39
54_M185_G0.6640.39
99_Q103_Q0.6620.39
170_A173_Q0.6610.39
99_Q150_Q0.6610.39
183_T207_Q0.6540.38
140_V153_R0.6530.38
131_G164_M0.6490.37
98_V175_H0.6490.37
219_D250_L0.6470.37
253_N257_G0.6470.37
15_L66_M0.6460.37
221_K224_A0.6430.37
131_G163_T0.6430.37
172_L182_V0.6430.37
63_A114_D0.6380.37
238_V281_V0.6370.36
98_V139_K0.6370.36
81_T109_I0.6370.36
148_H204_A0.6370.36
211_I260_Y0.6360.36
178_D232_R0.6350.36
246_R249_H0.6340.36
242_M261_L0.6330.36
10_L242_M0.6320.36
14_H243_D0.6320.36
64_Q95_T0.6310.36
109_I147_A0.6290.36
18_D125_E0.6270.36
211_I214_N0.6270.36
129_S134_T0.6260.36
8_Y280_D0.6260.36
159_T184_V0.6250.36
27_D248_S0.6230.35
123_I147_A0.6230.35
105_M147_A0.6200.35
80_C122_I0.6200.35
86_D137_E0.6180.35
41_N72_E0.6160.35
142_I171_L0.6120.34
7_G47_G0.6110.34
161_F189_L0.6070.34
219_D260_Y0.6060.34
59_M84_Y0.6060.34
122_I157_T0.6050.34
149_N237_R0.6030.34
200_I204_A0.6000.33
156_S183_T0.5960.33
193_L228_A0.5960.33
170_A184_V0.5930.33
83_Y104_E0.5930.33
284_R288_S0.5930.33
172_L179_L0.5890.33
4_D197_L0.5890.33
62_N289_Q0.5890.33
5_P76_N0.5880.33
51_V258_Y0.5880.33
4_D289_Q0.5870.32
217_Y221_K0.5860.32
226_L262_L0.5860.32
53_E182_V0.5850.32
74_G77_V0.5830.32
58_Y118_L0.5820.32
37_C41_N0.5800.32
224_A276_Q0.5780.32
60_G192_N0.5780.32
17_I59_M0.5750.32
163_T198_K0.5740.31
239_M268_Q0.5740.31
206_V225_M0.5730.31
20_S23_K0.5710.31
48_V261_L0.5710.31
211_I222_R0.5700.31
30_L65_F0.5700.31
108_E154_P0.5700.31
178_D182_V0.5700.31
205_Y237_R0.5690.31
120_A127_G0.5690.31
81_T113_I0.5680.31
246_R265_F0.5660.31
70_M73_T0.5660.31
115_G172_L0.5650.31
100_E201_D0.5630.31
227_H274_F0.5620.31
166_L169_L0.5570.30
6_T110_E0.5550.30
179_L204_A0.5550.30
120_A147_A0.5530.30
181_R270_R0.5520.30
208_F265_F0.5510.30
138_E146_L0.5500.30
210_T213_K0.5470.29
61_R123_I0.5460.29
33_Y65_F0.5440.29
68_D71_R0.5420.29
52_I109_I0.5410.29
57_R104_E0.5410.29
174_A181_R0.5400.29
47_G287_P0.5380.29
194_D198_K0.5370.29
182_V185_G0.5360.29
127_G257_G0.5340.28
11_A119_K0.5320.28
10_L43_L0.5300.28
162_S190_K0.5300.28
260_Y264_T0.5280.28
30_L254_G0.5280.28
240_L283_L0.5270.28
226_L238_V0.5270.28
125_E258_Y0.5270.28
85_Q242_M0.5260.28
180_S234_L0.5250.28
78_V103_Q0.5250.28
71_R206_V0.5250.28
155_I177_V0.5230.28
81_T120_A0.5230.28
242_M262_L0.5220.28
159_T190_K0.5220.28
16_H36_I0.5210.27
250_L253_N0.5200.27
77_V133_I0.5200.27
40_M200_I0.5190.27
178_D181_R0.5180.27
114_D253_N0.5170.27
211_I223_I0.5160.27
80_C140_V0.5160.27
244_I250_L0.5160.27
96_R104_E0.5150.27
169_L182_V0.5140.27
222_R265_F0.5130.27
82_G158_H0.5110.27
105_M123_I0.5110.27
183_T239_M0.5110.27
79_A104_E0.5080.27
160_S245_T0.5060.26
189_L249_H0.5040.26
76_N288_S0.5030.26
68_D224_A0.5020.26
11_A207_Q0.5020.26
185_G222_R0.5010.26
9_T49_R0.5010.26
193_L238_V0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k2gA 3 0.9966 100 0.419 Contact Map
3rhgA 2 0.9932 100 0.439 Contact Map
3pnzA 4 0.9966 100 0.561 Contact Map
3gtxA 2 0.9966 100 0.58 Contact Map
1bf6A 1 0.9966 100 0.581 Contact Map
3ovgA 4 0.9966 100 0.585 Contact Map
3tn4A 2 0.9966 100 0.589 Contact Map
4kezA 2 0.9966 100 0.592 Contact Map
4if2A 2 0.9966 100 0.596 Contact Map
2ob3A 2 0.9829 100 0.606 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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