GREMLIN Database
FRLR - HTH-type transcriptional regulator FrlR
UniProt: P45544 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12913
Length: 243 (192)
Sequences: 28604 (22493)
Seq/√Len: 1623.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_D28_V4.0301.00
30_Q33_Q3.9751.00
23_D44_Q3.5271.00
17_R58_D3.4621.00
21_L62_D3.2921.00
66_I76_Q2.8961.00
38_E49_R2.8891.00
187_D190_A2.8791.00
16_V47_V2.8031.00
19_R23_D2.6921.00
67_R73_T2.4841.00
16_V45_Y2.4421.00
17_R62_D2.3591.00
68_W71_K2.2561.00
22_D26_Q2.2011.00
34_Q74_F2.1471.00
10_Q18_Q2.1221.00
135_M143_F1.9901.00
19_R45_Y1.9311.00
17_R21_L1.9051.00
60_V67_R1.8551.00
39_N43_T1.8481.00
54_K57_S1.8131.00
37_T40_E1.7731.00
15_T19_R1.7411.00
71_K74_F1.7071.00
21_L25_A1.6671.00
23_D29_Y1.6541.00
40_E44_Q1.6331.00
19_R22_D1.6081.00
192_T196_A1.6041.00
182_D190_A1.6011.00
12_L15_T1.5991.00
41_L52_I1.5971.00
192_T195_Q1.5751.00
131_L147_S1.5561.00
68_W74_F1.5561.00
60_V65_L1.5431.00
190_A194_P1.4931.00
21_L64_V1.4861.00
118_E121_N1.4831.00
132_C135_M1.4671.00
66_I74_F1.4611.00
65_L73_T1.4511.00
144_I148_W1.4291.00
141_P152_S1.4281.00
188_I192_T1.4201.00
57_S67_R1.4131.00
58_D61_A1.4031.00
13_Y58_D1.4011.00
56_I65_L1.3911.00
24_I75_V1.3901.00
38_E53_R1.3651.00
29_Y75_V1.3591.00
193_R197_K1.3561.00
104_K136_Y1.3431.00
10_Q15_T1.3071.00
131_L135_M1.2871.00
99_K103_E1.2861.00
40_E43_T1.2821.00
130_H146_S1.2651.00
57_S61_A1.2621.00
125_N128_V1.2431.00
134_V146_S1.2391.00
23_D45_Y1.2331.00
180_V184_K1.2271.00
132_C136_Y1.2161.00
31_A77_S1.2061.00
11_L14_A1.2011.00
47_V52_I1.1961.00
68_W72_G1.1841.00
169_Q173_E1.1731.00
57_S60_V1.1711.00
56_I73_T1.1681.00
34_Q72_G1.1631.00
130_H176_D1.1501.00
177_T181_S1.1351.00
133_R183_K1.1021.00
128_V132_C1.0971.00
23_D27_G1.0941.00
107_E132_C1.0911.00
25_A64_V1.0911.00
58_D62_D1.0901.00
102_K136_Y1.0811.00
172_Q178_R1.0751.00
98_G102_K1.0701.00
181_S185_T1.0701.00
109_E112_S1.0661.00
14_A58_D1.0651.00
14_A18_Q1.0501.00
190_A193_R1.0421.00
116_F148_W1.0411.00
196_A200_K1.0391.00
168_Y172_Q1.0341.00
29_Y33_Q1.0331.00
173_E201_C1.0201.00
48_S51_T0.9971.00
111_V130_H0.9951.00
123_P126_S0.9871.00
96_S99_K0.9861.00
105_V192_T0.9691.00
178_R194_P0.9671.00
143_F147_S0.9581.00
185_T190_A0.9491.00
20_L41_L0.9361.00
132_C146_S0.9141.00
144_I195_Q0.9121.00
107_E130_H0.9101.00
99_K102_K0.9071.00
97_Q101_T0.8951.00
12_L51_T0.8931.00
105_V108_Q0.8911.00
145_D148_W0.8901.00
34_Q37_T0.8891.00
141_P144_I0.8861.00
166_S169_Q0.8761.00
32_G66_I0.8701.00
129_F180_V0.8691.00
41_L56_I0.8641.00
107_E110_R0.8631.00
137_L143_F0.8611.00
70_G73_T0.8591.00
105_V112_S0.8551.00
13_Y17_R0.8431.00
120_L123_P0.8351.00
32_G77_S0.8341.00
86_T140_E0.8301.00
10_Q14_A0.8241.00
54_K58_D0.8221.00
181_S184_K0.8221.00
98_G101_T0.8181.00
105_V109_E0.8171.00
42_C52_I0.8171.00
102_K105_V0.8161.00
88_S91_T0.8121.00
104_K112_S0.8111.00
89_G92_D0.8101.00
182_D187_D0.8061.00
127_E151_L0.8041.00
18_Q21_L0.8031.00
92_D200_K0.8021.00
179_V195_Q0.7991.00
95_V98_G0.7961.00
38_E67_R0.7901.00
28_V44_Q0.7861.00
92_D96_S0.7821.00
35_I65_L0.7811.00
97_Q100_A0.7801.00
13_Y54_K0.7701.00
166_S170_L0.7701.00
93_F97_Q0.7651.00
110_R114_A0.7631.00
115_P119_K0.7611.00
106_I110_R0.7611.00
178_R181_S0.7591.00
191_A201_C0.7541.00
95_V99_K0.7531.00
16_V19_R0.7531.00
102_K106_I0.7531.00
94_G99_K0.7491.00
100_A103_E0.7451.00
189_F192_T0.7451.00
23_D26_Q0.7451.00
96_S100_A0.7431.00
179_V194_P0.7341.00
111_V114_A0.7261.00
107_E114_A0.7261.00
79_K83_A0.7241.00
19_R44_Q0.7231.00
101_T105_V0.7181.00
18_Q22_D0.7171.00
109_E130_H0.7131.00
193_R196_A0.7071.00
131_L150_P0.7061.00
189_F195_Q0.7051.00
31_A76_Q0.7051.00
189_F193_R0.7041.00
89_G139_K0.7021.00
167_T171_F0.7001.00
39_N42_C0.6981.00
104_K108_Q0.6971.00
178_R190_A0.6951.00
38_E73_T0.6871.00
43_T46_N0.6871.00
121_N124_G0.6851.00
194_P197_K0.6851.00
108_Q112_S0.6851.00
116_F119_K0.6781.00
110_R151_L0.6781.00
56_I60_V0.6741.00
97_Q102_K0.6731.00
29_Y35_I0.6731.00
197_K201_C0.6691.00
132_C194_P0.6661.00
86_T139_K0.6651.00
195_Q198_W0.6651.00
119_K122_I0.6641.00
152_S155_P0.6621.00
126_S152_S0.6601.00
120_L184_K0.6571.00
131_L143_F0.6561.00
141_P145_D0.6551.00
167_T170_L0.6541.00
92_D196_A0.6521.00
102_K139_K0.6521.00
157_F160_I0.6501.00
94_G98_G0.6421.00
195_Q199_L0.6381.00
127_E150_P0.6371.00
159_E162_V0.6341.00
45_Y52_I0.6321.00
109_E113_A0.6301.00
158_D161_Y0.6301.00
157_F161_Y0.6291.00
110_R113_A0.6261.00
107_E111_V0.6241.00
86_T91_T0.6191.00
177_T180_V0.6171.00
83_A141_P0.6171.00
170_L173_E0.6161.00
134_V150_P0.6161.00
127_E154_Y0.6161.00
90_F145_D0.6111.00
51_T55_A0.6071.00
16_V52_I0.6021.00
98_G103_E0.5961.00
17_R55_A0.5961.00
150_P153_R0.5941.00
37_T70_G0.5931.00
20_L29_Y0.5921.00
126_S130_H0.5901.00
126_S176_D0.5901.00
106_I109_E0.5861.00
81_E85_L0.5831.00
130_H198_W0.5831.00
91_T95_V0.5821.00
137_L142_L0.5821.00
9_H15_T0.5811.00
42_C49_R0.5811.00
87_V91_T0.5781.00
127_E131_L0.5771.00
42_C45_Y0.5741.00
39_N49_R0.5741.00
16_V55_A0.5731.00
111_V116_F0.5721.00
94_G97_Q0.5691.00
171_F177_T0.5671.00
119_K123_P0.5671.00
88_S92_D0.5651.00
182_D194_P0.5641.00
57_S73_T0.5641.00
154_Y158_D0.5611.00
108_Q111_V0.5611.00
93_F101_T0.5601.00
99_K138_D0.5591.00
104_K111_V0.5571.00
191_A195_Q0.5541.00
74_F77_S0.5531.00
69_Q72_G0.5531.00
42_C50_I0.5481.00
93_F98_G0.5471.00
104_K109_E0.5451.00
109_E184_K0.5431.00
179_V191_A0.5431.00
101_T104_K0.5421.00
176_D198_W0.5421.00
86_T89_G0.5391.00
178_R197_K0.5331.00
146_S195_Q0.5321.00
108_Q129_F0.5301.00
95_V102_K0.5301.00
178_R182_D0.5301.00
22_D28_V0.5271.00
51_T54_K0.5261.00
112_S127_E0.5221.00
60_V73_T0.5191.00
100_A104_K0.5181.00
128_V131_L0.5181.00
169_Q172_Q0.5171.00
93_F96_S0.5171.00
50_I54_K0.5161.00
41_L45_Y0.5121.00
34_Q71_K0.5081.00
95_V101_T0.5071.00
136_Y139_K0.5061.00
147_S150_P0.5061.00
160_I163_E0.5001.00
124_G128_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0wA 2 0.9918 100 0.165 Contact Map
2ra5A 2 0.6049 100 0.184 Contact Map
3f8mA 2 0.9342 100 0.198 Contact Map
3eetA 2 0.9547 100 0.221 Contact Map
3edpA 2 0.9053 100 0.227 Contact Map
3bwgA 2 0.9342 100 0.227 Contact Map
1hw1A 2 0.8313 100 0.399 Contact Map
2di3A 2 0.8313 100 0.411 Contact Map
3sxyA 2 0.786 100 0.413 Contact Map
2hs5A 1 0.8148 100 0.413 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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