FRLD - ECOLI - GREMLIN Contacts

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FRLD - Fructoselysine kinase

UniProt:	P45543	Sequences: MKTLATIGDNCVDIYPQLNKAFSGGNAVNVAVYCTRYGIQPGCITWVGDDDYGTKLKQDLARMGVDISHVHTKHGVTAQTQVELHDNDRVFGDYTEGVMADFALSEEDYAWLAQYDIVHAAIWGHAEDAFPQLHAAGKLTAFDFSDKWDSPLWQTLVPHLDFAFASAPQEDETLRLKMKAIVARGAGTVIVTLGENGSIAWDGAQFWRQAPEPVTVIDTMGAGDSFIAGFLCGWSAGMTLPQAIAQGTACAAKTIQYHGAW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12912
Length:	261 (253)
Sequences:	22411 (16720)
Seq/√Len:	1051.2

ECOLI - FRLD SQUV RBSK KDGK YDJH PSUK YEII YEGV K1PF PFKB HLDE INGK
BACSU - FRLD YDJE IOLC KDGK RBSK K1PF
HALSA - Q9HMJ3 Q9HP13 Q9HSM7
SULSO - KDGK Q981E2 Q97W01 Q980X6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_I	232_C	3.185	1.00
57_K	72_T	2.606	1.00
42_G	66_D	2.510	1.00
119_H	141_A	2.502	1.00
193_L	199_I	2.481	1.00
5_A	115_Y	2.414	1.00
200_A	244_I	2.395	1.00
233_G	238_M	2.321	1.00
198_S	226_F	2.183	1.00
49_D	74_H	2.174	1.00
131_P	159_H	2.104	1.00
239_T	242_Q	2.098	1.00
54_T	72_T	2.070	1.00
182_V	201_W	2.003	1.00
46_W	73_K	1.999	1.00
34_C	39_I	1.945	1.00
207_W	241_P	1.945	1.00
233_G	246_Q	1.935	1.00
167_A	193_L	1.923	1.00
6_T	31_A	1.900	1.00
36_R	63_M	1.884	1.00
32_V	63_M	1.864	1.00
141_A	231_L	1.845	1.00
164_F	227_I	1.813	1.00
175_R	206_F	1.809	1.00
61_A	67_I	1.805	1.00
133_L	138_K	1.803	1.00
130_F	140_T	1.785	1.00
225_S	250_C	1.785	1.00
117_I	139_L	1.781	1.00
33_Y	228_A	1.762	1.00
139_L	161_D	1.746	1.00
200_A	207_W	1.740	1.00
178_M	201_W	1.736	1.00
46_W	106_E	1.724	1.00
199_I	208_R	1.721	1.00
238_M	242_Q	1.688	1.00
161_D	187_G	1.672	1.00
59_D	62_R	1.650	1.00
198_S	248_T	1.646	1.00
180_A	184_R	1.619	1.00
222_A	255_I	1.601	1.00
162_F	188_T	1.591	1.00
127_E	155_T	1.587	1.00
57_K	61_A	1.584	1.00
212_E	249_A	1.575	1.00
230_F	243_A	1.574	1.00
251_A	255_I	1.565	1.00
58_Q	62_R	1.561	1.00
117_I	141_A	1.559	1.00
241_P	245_A	1.558	1.00
229_G	250_C	1.551	1.00
188_T	202_D	1.534	1.00
190_I	230_F	1.517	1.00
193_L	208_R	1.515	1.00
21_A	55_K	1.509	1.00
34_C	232_C	1.494	1.00
128_D	131_P	1.493	1.00
4_L	34_C	1.481	1.00
128_D	132_Q	1.476	1.00
193_L	196_N	1.472	1.00
10_N	45_T	1.468	1.00
200_A	240_L	1.463	1.00
209_Q	244_I	1.455	1.00
117_I	231_L	1.454	1.00
180_A	183_A	1.437	1.00
229_G	246_Q	1.425	1.00
49_D	54_T	1.414	1.00
132_Q	136_A	1.402	1.00
202_D	205_Q	1.397	1.00
54_T	58_Q	1.385	1.00
14_I	19_N	1.366	1.00
23_S	56_L	1.364	1.00
143_D	192_T	1.351	1.00
132_Q	135_A	1.347	1.00
139_L	162_F	1.340	1.00
28_V	60_L	1.339	1.00
134_H	161_D	1.334	1.00
134_H	159_H	1.330	1.00
127_E	131_P	1.330	1.00
212_E	245_A	1.317	1.00
144_F	165_A	1.306	1.00
175_R	179_K	1.305	1.00
179_K	183_A	1.299	1.00
23_S	59_D	1.276	1.00
209_Q	248_T	1.264	1.00
49_D	72_T	1.258	1.00
113_A	136_A	1.256	1.00
40_Q	66_D	1.256	1.00
59_D	63_M	1.254	1.00
104_L	128_D	1.251	1.00
53_G	77_T	1.244	1.00
193_L	197_G	1.236	1.00
160_L	163_A	1.229	1.00
103_A	106_E	1.227	1.00
232_C	236_A	1.221	1.00
57_K	70_V	1.218	1.00
188_T	240_L	1.206	1.00
173_T	176_L	1.203	1.00
188_T	234_W	1.200	1.00
201_W	206_F	1.198	1.00
214_V	256_Q	1.196	1.00
198_S	244_I	1.187	1.00
12_V	55_K	1.178	1.00
253_K	257_Y	1.158	1.00
229_G	247_G	1.156	1.00
154_Q	184_R	1.155	1.00
55_K	58_Q	1.154	1.00
164_F	192_T	1.144	1.00
179_K	201_W	1.143	1.00
230_F	234_W	1.125	1.00
139_L	187_G	1.119	1.00
192_T	226_F	1.116	1.00
233_G	243_A	1.110	1.00
216_V	255_I	1.104	1.00
37_Y	229_G	1.101	1.00
188_T	230_F	1.099	1.00
54_T	57_K	1.098	1.00
242_Q	245_A	1.089	1.00
112_L	115_Y	1.089	1.00
230_F	247_G	1.088	1.00
253_K	256_Q	1.087	1.00
170_E	191_V	1.086	1.00
51_D	54_T	1.086	1.00
35_T	65_V	1.084	1.00
212_E	248_T	1.081	1.00
212_E	252_A	1.079	1.00
119_H	231_L	1.075	1.00
30_V	119_H	1.068	1.00
214_V	255_I	1.068	1.00
179_K	206_F	1.066	1.00
120_A	140_T	1.064	1.00
31_A	41_P	1.061	1.00
39_I	236_A	1.060	1.00
162_F	234_W	1.049	1.00
58_Q	61_A	1.049	1.00
14_I	21_A	1.043	1.00
188_T	200_A	1.042	1.00
162_F	230_F	1.042	1.00
108_D	128_D	1.041	1.00
10_N	56_L	1.038	1.00
131_P	135_A	1.029	1.00
34_C	41_P	1.025	1.00
35_T	64_G	1.021	1.00
233_G	236_A	1.018	1.00
216_V	219_T	1.017	1.00
33_Y	225_S	1.016	1.00
118_V	133_L	1.014	1.00
10_N	43_C	1.011	1.00
32_V	36_R	1.010	1.00
176_L	179_K	0.985	1.00
39_I	235_S	0.978	1.00
166_S	169_Q	0.975	1.00
230_F	240_L	0.974	1.00
248_T	251_A	0.974	1.00
42_G	111_W	0.967	1.00
119_H	227_I	0.963	1.00
245_A	249_A	0.962	1.00
167_A	196_N	0.961	1.00
142_F	160_L	0.961	1.00
42_G	115_Y	0.960	1.00
225_S	254_T	0.955	1.00
55_K	59_D	0.954	1.00
164_F	230_F	0.953	1.00
42_G	69_H	0.946	1.00
10_N	28_V	0.945	1.00
118_V	138_K	0.944	1.00
90_V	93_D	0.943	1.00
23_S	55_K	0.941	1.00
170_E	177_K	0.939	1.00
211_P	248_T	0.929	1.00
167_A	171_D	0.925	1.00
50_D	77_T	0.920	1.00
243_A	247_G	0.914	1.00
67_I	70_V	0.903	1.00
124_G	128_D	0.896	1.00
6_T	27_A	0.895	1.00
47_V	57_K	0.893	1.00
47_V	70_V	0.892	1.00
92_G	95_T	0.888	1.00
37_Y	250_C	0.887	1.00
110_A	113_A	0.886	1.00
178_M	191_V	0.883	1.00
232_C	246_Q	0.880	1.00
216_V	256_Q	0.876	1.00
7_I	118_V	0.876	1.00
34_C	228_A	0.875	1.00
209_Q	245_A	0.874	1.00
14_I	79_Q	0.874	1.00
15_Y	22_F	0.874	1.00
143_D	164_F	0.873	1.00
47_V	53_G	0.873	1.00
71_H	106_E	0.871	1.00
115_Y	138_K	0.869	1.00
215_T	256_Q	0.868	1.00
57_K	67_I	0.866	1.00
48_G	77_T	0.863	1.00
158_P	185_G	0.856	1.00
5_A	44_I	0.854	1.00
14_I	52_Y	0.848	1.00
56_L	77_T	0.847	1.00
120_A	130_F	0.845	1.00
30_V	227_I	0.844	1.00
234_W	243_A	0.841	1.00
35_T	40_Q	0.841	1.00
176_L	180_A	0.839	1.00
16_P	92_G	0.832	1.00
155_T	158_P	0.827	1.00
197_G	211_P	0.818	1.00
196_N	208_R	0.817	1.00
73_K	101_D	0.814	1.00
46_W	71_H	0.809	1.00
165_A	170_E	0.806	1.00
125_H	129_A	0.803	1.00
205_Q	241_P	0.803	1.00
238_M	246_Q	0.802	1.00
150_S	154_Q	0.801	1.00
157_V	160_L	0.801	1.00
131_P	155_T	0.800	1.00
11_C	78_A	0.798	1.00
239_T	243_A	0.793	1.00
202_D	240_L	0.792	1.00
122_I	142_F	0.789	1.00
226_F	248_T	0.788	1.00
225_S	251_A	0.786	1.00
209_Q	241_P	0.782	1.00
50_D	53_G	0.778	1.00
31_A	43_C	0.774	1.00
47_V	72_T	0.773	1.00
7_I	129_A	0.771	1.00
214_V	252_A	0.771	1.00
35_T	41_P	0.771	1.00
5_A	42_G	0.769	1.00
112_L	138_K	0.768	1.00
229_G	233_G	0.762	1.00
249_A	253_K	0.761	1.00
120_A	126_A	0.759	1.00
57_K	71_H	0.758	1.00
218_D	259_G	0.753	1.00
143_D	165_A	0.748	1.00
225_S	229_G	0.748	1.00
207_W	244_I	0.747	1.00
21_A	52_Y	0.742	1.00
4_L	235_S	0.741	1.00
178_M	189_V	0.729	1.00
174_L	177_K	0.729	1.00
111_W	115_Y	0.729	1.00
199_I	206_F	0.728	1.00
12_V	21_A	0.725	1.00
248_T	252_A	0.718	1.00
217_I	258_H	0.715	1.00
202_D	207_W	0.713	1.00
90_V	94_Y	0.712	1.00
42_G	68_S	0.709	1.00
127_E	159_H	0.708	1.00
37_Y	246_Q	0.705	1.00
26_N	145_S	0.702	1.00
106_E	109_Y	0.701	1.00
179_K	182_V	0.700	1.00
117_I	235_S	0.699	1.00
82_V	220_M	0.697	1.00
102_F	107_E	0.695	1.00
89_R	93_D	0.692	1.00
98_V	101_D	0.684	1.00
91_F	95_T	0.681	1.00
195_E	213_P	0.678	1.00
182_V	202_D	0.678	1.00
178_M	182_V	0.678	1.00
182_V	203_G	0.678	1.00
5_A	111_W	0.677	1.00
141_A	164_F	0.676	1.00
83_E	90_V	0.667	1.00
226_F	247_G	0.665	1.00
130_F	159_H	0.665	1.00
226_F	251_A	0.664	1.00
12_V	52_Y	0.661	1.00
82_V	91_F	0.660	1.00
177_K	181_I	0.656	1.00
175_R	201_W	0.654	1.00
197_G	208_R	0.653	1.00
226_F	244_I	0.648	1.00
99_M	102_F	0.646	1.00
37_Y	232_C	0.646	1.00
251_A	254_T	0.643	1.00
175_R	208_R	0.642	1.00
52_Y	79_Q	0.642	1.00
13_D	24_G	0.639	1.00
141_A	227_I	0.639	1.00
51_D	55_K	0.639	1.00
127_E	130_F	0.635	1.00
88_D	91_F	0.634	1.00
151_P	154_Q	0.629	1.00
88_D	94_Y	0.626	1.00
175_R	178_M	0.623	1.00
78_A	83_E	0.621	1.00
141_A	162_F	0.619	1.00
31_A	65_V	0.614	1.00
124_G	127_E	0.613	1.00
190_I	200_A	0.613	1.00
69_H	111_W	0.613	1.00
105_S	109_Y	0.611	1.00
105_S	108_D	0.609	1.00
83_E	92_G	0.604	1.00
238_M	243_A	0.604	1.00
20_K	258_H	0.603	1.00
85_H	88_D	0.603	1.00
94_Y	97_G	0.602	1.00
174_L	193_L	0.601	1.00
158_P	184_R	0.598	1.00
69_H	72_T	0.597	1.00
190_I	226_F	0.596	1.00
174_L	178_M	0.592	1.00
170_E	181_I	0.591	1.00
104_L	124_G	0.591	1.00
129_A	133_L	0.589	1.00
175_R	199_I	0.582	1.00
154_Q	158_P	0.582	1.00
118_V	129_A	0.582	1.00
111_W	114_Q	0.580	1.00
9_D	145_S	0.579	1.00
178_M	206_F	0.577	1.00
28_V	43_C	0.575	1.00
173_T	177_K	0.574	1.00
244_I	248_T	0.574	1.00
104_L	125_H	0.569	1.00
164_F	190_I	0.567	1.00
89_R	95_T	0.566	1.00
45_T	70_V	0.564	1.00
151_P	155_T	0.564	1.00
24_G	29_N	0.561	1.00
126_A	129_A	0.557	1.00
14_I	81_Q	0.556	1.00
51_D	58_Q	0.556	1.00
242_Q	246_Q	0.552	1.00
40_Q	116_D	0.552	1.00
209_Q	212_E	0.552	1.00
88_D	92_G	0.551	1.00
6_T	34_C	0.549	1.00
26_N	123_W	0.548	1.00
35_T	63_M	0.546	1.00
4_L	117_I	0.545	1.00
167_A	194_G	0.544	1.00
140_T	160_L	0.544	1.00
116_D	138_K	0.543	1.00
34_C	231_L	0.543	1.00
54_T	61_A	0.542	1.00
198_S	209_Q	0.540	1.00
228_A	232_C	0.539	1.00
89_R	92_G	0.536	1.00
37_Y	228_A	0.536	1.00
172_E	176_L	0.536	1.00
163_A	189_V	0.530	1.00
161_D	188_T	0.525	1.00
4_L	39_I	0.524	1.00
102_F	106_E	0.524	1.00
80_T	83_E	0.524	1.00
142_F	156_L	0.524	1.00
133_L	137_G	0.523	1.00
240_L	243_A	0.522	1.00
90_V	95_T	0.520	1.00
49_D	75_G	0.519	1.00
88_D	93_D	0.519	1.00
68_S	71_H	0.518	1.00
109_Y	132_Q	0.517	1.00
237_G	243_A	0.516	1.00
178_M	181_I	0.516	1.00
170_E	174_L	0.514	1.00
80_T	123_W	0.514	1.00
28_V	32_V	0.513	1.00
104_L	108_D	0.513	1.00
246_Q	250_C	0.512	1.00
30_V	231_L	0.511	1.00
9_D	123_W	0.508	1.00
190_I	244_I	0.506	1.00
80_T	93_D	0.504	1.00
68_S	111_W	0.503	1.00
152_L	155_T	0.503	1.00
117_I	234_W	0.503	1.00
97_G	100_A	0.502	1.00
240_L	244_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rbcA	2	0.9923	100	0.175	Contact Map
3hj6A	2	0.9425	100	0.182	Contact Map
3iq0A	2	0.9962	100	0.184	Contact Map
3ljsA	2	0.9885	100	0.19	Contact Map
4k8kA	2	0.9923	100	0.193	Contact Map
1tyyA	2	0.9655	100	0.196	Contact Map
3vasA	1	0.9962	100	0.196	Contact Map
4du5A	2	0.9464	100	0.197	Contact Map
4gm6A	5	0.9923	100	0.201	Contact Map
2qcvA	3	0.9847	100	0.201	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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