GREMLIN Database
FRLD - Fructoselysine kinase
UniProt: P45543 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12912
Length: 261 (253)
Sequences: 22411 (16720)
Seq/√Len: 1051.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_I232_C3.1851.00
57_K72_T2.6061.00
42_G66_D2.5101.00
119_H141_A2.5021.00
193_L199_I2.4811.00
5_A115_Y2.4141.00
200_A244_I2.3951.00
233_G238_M2.3211.00
198_S226_F2.1831.00
49_D74_H2.1741.00
131_P159_H2.1041.00
239_T242_Q2.0981.00
54_T72_T2.0701.00
182_V201_W2.0031.00
46_W73_K1.9991.00
34_C39_I1.9451.00
207_W241_P1.9451.00
233_G246_Q1.9351.00
167_A193_L1.9231.00
6_T31_A1.9001.00
36_R63_M1.8841.00
32_V63_M1.8641.00
141_A231_L1.8451.00
164_F227_I1.8131.00
175_R206_F1.8091.00
61_A67_I1.8051.00
133_L138_K1.8031.00
130_F140_T1.7851.00
225_S250_C1.7851.00
117_I139_L1.7811.00
33_Y228_A1.7621.00
139_L161_D1.7461.00
200_A207_W1.7401.00
178_M201_W1.7361.00
46_W106_E1.7241.00
199_I208_R1.7211.00
238_M242_Q1.6881.00
161_D187_G1.6721.00
59_D62_R1.6501.00
198_S248_T1.6461.00
180_A184_R1.6191.00
222_A255_I1.6011.00
162_F188_T1.5911.00
127_E155_T1.5871.00
57_K61_A1.5841.00
212_E249_A1.5751.00
230_F243_A1.5741.00
251_A255_I1.5651.00
58_Q62_R1.5611.00
117_I141_A1.5591.00
241_P245_A1.5581.00
229_G250_C1.5511.00
188_T202_D1.5341.00
190_I230_F1.5171.00
193_L208_R1.5151.00
21_A55_K1.5091.00
34_C232_C1.4941.00
128_D131_P1.4931.00
4_L34_C1.4811.00
128_D132_Q1.4761.00
193_L196_N1.4721.00
10_N45_T1.4681.00
200_A240_L1.4631.00
209_Q244_I1.4551.00
117_I231_L1.4541.00
180_A183_A1.4371.00
229_G246_Q1.4251.00
49_D54_T1.4141.00
132_Q136_A1.4021.00
202_D205_Q1.3971.00
54_T58_Q1.3851.00
14_I19_N1.3661.00
23_S56_L1.3641.00
143_D192_T1.3511.00
132_Q135_A1.3471.00
139_L162_F1.3401.00
28_V60_L1.3391.00
134_H161_D1.3341.00
134_H159_H1.3301.00
127_E131_P1.3301.00
212_E245_A1.3171.00
144_F165_A1.3061.00
175_R179_K1.3051.00
179_K183_A1.2991.00
23_S59_D1.2761.00
209_Q248_T1.2641.00
49_D72_T1.2581.00
113_A136_A1.2561.00
40_Q66_D1.2561.00
59_D63_M1.2541.00
104_L128_D1.2511.00
53_G77_T1.2441.00
193_L197_G1.2361.00
160_L163_A1.2291.00
103_A106_E1.2271.00
232_C236_A1.2211.00
57_K70_V1.2181.00
188_T240_L1.2061.00
173_T176_L1.2031.00
188_T234_W1.2001.00
201_W206_F1.1981.00
214_V256_Q1.1961.00
198_S244_I1.1871.00
12_V55_K1.1781.00
253_K257_Y1.1581.00
229_G247_G1.1561.00
154_Q184_R1.1551.00
55_K58_Q1.1541.00
164_F192_T1.1441.00
179_K201_W1.1431.00
230_F234_W1.1251.00
139_L187_G1.1191.00
192_T226_F1.1161.00
233_G243_A1.1101.00
216_V255_I1.1041.00
37_Y229_G1.1011.00
188_T230_F1.0991.00
54_T57_K1.0981.00
242_Q245_A1.0891.00
112_L115_Y1.0891.00
230_F247_G1.0881.00
253_K256_Q1.0871.00
170_E191_V1.0861.00
51_D54_T1.0861.00
35_T65_V1.0841.00
212_E248_T1.0811.00
212_E252_A1.0791.00
119_H231_L1.0751.00
30_V119_H1.0681.00
214_V255_I1.0681.00
179_K206_F1.0661.00
120_A140_T1.0641.00
31_A41_P1.0611.00
39_I236_A1.0601.00
162_F234_W1.0491.00
58_Q61_A1.0491.00
14_I21_A1.0431.00
188_T200_A1.0421.00
162_F230_F1.0421.00
108_D128_D1.0411.00
10_N56_L1.0381.00
131_P135_A1.0291.00
34_C41_P1.0251.00
35_T64_G1.0211.00
233_G236_A1.0181.00
216_V219_T1.0171.00
33_Y225_S1.0161.00
118_V133_L1.0141.00
10_N43_C1.0111.00
32_V36_R1.0101.00
176_L179_K0.9851.00
39_I235_S0.9781.00
166_S169_Q0.9751.00
230_F240_L0.9741.00
248_T251_A0.9741.00
42_G111_W0.9671.00
119_H227_I0.9631.00
245_A249_A0.9621.00
167_A196_N0.9611.00
142_F160_L0.9611.00
42_G115_Y0.9601.00
225_S254_T0.9551.00
55_K59_D0.9541.00
164_F230_F0.9531.00
42_G69_H0.9461.00
10_N28_V0.9451.00
118_V138_K0.9441.00
90_V93_D0.9431.00
23_S55_K0.9411.00
170_E177_K0.9391.00
211_P248_T0.9291.00
167_A171_D0.9251.00
50_D77_T0.9201.00
243_A247_G0.9141.00
67_I70_V0.9031.00
124_G128_D0.8961.00
6_T27_A0.8951.00
47_V57_K0.8931.00
47_V70_V0.8921.00
92_G95_T0.8881.00
37_Y250_C0.8871.00
110_A113_A0.8861.00
178_M191_V0.8831.00
232_C246_Q0.8801.00
216_V256_Q0.8761.00
7_I118_V0.8761.00
34_C228_A0.8751.00
209_Q245_A0.8741.00
14_I79_Q0.8741.00
15_Y22_F0.8741.00
143_D164_F0.8731.00
47_V53_G0.8731.00
71_H106_E0.8711.00
115_Y138_K0.8691.00
215_T256_Q0.8681.00
57_K67_I0.8661.00
48_G77_T0.8631.00
158_P185_G0.8561.00
5_A44_I0.8541.00
14_I52_Y0.8481.00
56_L77_T0.8471.00
120_A130_F0.8451.00
30_V227_I0.8441.00
234_W243_A0.8411.00
35_T40_Q0.8411.00
176_L180_A0.8391.00
16_P92_G0.8321.00
155_T158_P0.8271.00
197_G211_P0.8181.00
196_N208_R0.8171.00
73_K101_D0.8141.00
46_W71_H0.8091.00
165_A170_E0.8061.00
125_H129_A0.8031.00
205_Q241_P0.8031.00
238_M246_Q0.8021.00
150_S154_Q0.8011.00
157_V160_L0.8011.00
131_P155_T0.8001.00
11_C78_A0.7981.00
239_T243_A0.7931.00
202_D240_L0.7921.00
122_I142_F0.7891.00
226_F248_T0.7881.00
225_S251_A0.7861.00
209_Q241_P0.7821.00
50_D53_G0.7781.00
31_A43_C0.7741.00
47_V72_T0.7731.00
7_I129_A0.7711.00
214_V252_A0.7711.00
35_T41_P0.7711.00
5_A42_G0.7691.00
112_L138_K0.7681.00
229_G233_G0.7621.00
249_A253_K0.7611.00
120_A126_A0.7591.00
57_K71_H0.7581.00
218_D259_G0.7531.00
143_D165_A0.7481.00
225_S229_G0.7481.00
207_W244_I0.7471.00
21_A52_Y0.7421.00
4_L235_S0.7411.00
178_M189_V0.7291.00
174_L177_K0.7291.00
111_W115_Y0.7291.00
199_I206_F0.7281.00
12_V21_A0.7251.00
248_T252_A0.7181.00
217_I258_H0.7151.00
202_D207_W0.7131.00
90_V94_Y0.7121.00
42_G68_S0.7091.00
127_E159_H0.7081.00
37_Y246_Q0.7051.00
26_N145_S0.7021.00
106_E109_Y0.7011.00
179_K182_V0.7001.00
117_I235_S0.6991.00
82_V220_M0.6971.00
102_F107_E0.6951.00
89_R93_D0.6921.00
98_V101_D0.6841.00
91_F95_T0.6811.00
195_E213_P0.6781.00
182_V202_D0.6781.00
178_M182_V0.6781.00
182_V203_G0.6781.00
5_A111_W0.6771.00
141_A164_F0.6761.00
83_E90_V0.6671.00
226_F247_G0.6651.00
130_F159_H0.6651.00
226_F251_A0.6641.00
12_V52_Y0.6611.00
82_V91_F0.6601.00
177_K181_I0.6561.00
175_R201_W0.6541.00
197_G208_R0.6531.00
226_F244_I0.6481.00
99_M102_F0.6461.00
37_Y232_C0.6461.00
251_A254_T0.6431.00
175_R208_R0.6421.00
52_Y79_Q0.6421.00
13_D24_G0.6391.00
141_A227_I0.6391.00
51_D55_K0.6391.00
127_E130_F0.6351.00
88_D91_F0.6341.00
151_P154_Q0.6291.00
88_D94_Y0.6261.00
175_R178_M0.6231.00
78_A83_E0.6211.00
141_A162_F0.6191.00
31_A65_V0.6141.00
124_G127_E0.6131.00
190_I200_A0.6131.00
69_H111_W0.6131.00
105_S109_Y0.6111.00
105_S108_D0.6091.00
83_E92_G0.6041.00
238_M243_A0.6041.00
20_K258_H0.6031.00
85_H88_D0.6031.00
94_Y97_G0.6021.00
174_L193_L0.6011.00
158_P184_R0.5981.00
69_H72_T0.5971.00
190_I226_F0.5961.00
174_L178_M0.5921.00
170_E181_I0.5911.00
104_L124_G0.5911.00
129_A133_L0.5891.00
175_R199_I0.5821.00
154_Q158_P0.5821.00
118_V129_A0.5821.00
111_W114_Q0.5801.00
9_D145_S0.5791.00
178_M206_F0.5771.00
28_V43_C0.5751.00
173_T177_K0.5741.00
244_I248_T0.5741.00
104_L125_H0.5691.00
164_F190_I0.5671.00
89_R95_T0.5661.00
45_T70_V0.5641.00
151_P155_T0.5641.00
24_G29_N0.5611.00
126_A129_A0.5571.00
14_I81_Q0.5561.00
51_D58_Q0.5561.00
242_Q246_Q0.5521.00
40_Q116_D0.5521.00
209_Q212_E0.5521.00
88_D92_G0.5511.00
6_T34_C0.5491.00
26_N123_W0.5481.00
35_T63_M0.5461.00
4_L117_I0.5451.00
167_A194_G0.5441.00
140_T160_L0.5441.00
116_D138_K0.5431.00
34_C231_L0.5431.00
54_T61_A0.5421.00
198_S209_Q0.5401.00
228_A232_C0.5391.00
89_R92_G0.5361.00
37_Y228_A0.5361.00
172_E176_L0.5361.00
163_A189_V0.5301.00
161_D188_T0.5251.00
4_L39_I0.5241.00
102_F106_E0.5241.00
80_T83_E0.5241.00
142_F156_L0.5241.00
133_L137_G0.5231.00
240_L243_A0.5221.00
90_V95_T0.5201.00
49_D75_G0.5191.00
88_D93_D0.5191.00
68_S71_H0.5181.00
109_Y132_Q0.5171.00
237_G243_A0.5161.00
178_M181_I0.5161.00
170_E174_L0.5141.00
80_T123_W0.5141.00
28_V32_V0.5131.00
104_L108_D0.5131.00
246_Q250_C0.5121.00
30_V231_L0.5111.00
9_D123_W0.5081.00
190_I244_I0.5061.00
80_T93_D0.5041.00
68_S111_W0.5031.00
152_L155_T0.5031.00
117_I234_W0.5031.00
97_G100_A0.5021.00
240_L244_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbcA 2 0.9923 100 0.175 Contact Map
3hj6A 2 0.9425 100 0.182 Contact Map
3iq0A 2 0.9962 100 0.184 Contact Map
3ljsA 2 0.9885 100 0.19 Contact Map
4k8kA 2 0.9923 100 0.193 Contact Map
1tyyA 2 0.9655 100 0.196 Contact Map
3vasA 1 0.9962 100 0.196 Contact Map
4du5A 2 0.9464 100 0.197 Contact Map
4gm6A 5 0.9923 100 0.201 Contact Map
2qcvA 3 0.9847 100 0.201 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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