FRLC - ECOLI - GREMLIN Contacts

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FRLC - Protein FrlC

UniProt:	P45541	Sequences: MKTGMFTCGHQRLPIEHAFRDASELGYDGIEIWGGRPHAFAPDLKAGGIKQIKALAQTYQMPIIGYTPETNGYPYNMMLGDEHMRRESLDMIKLAMDMAKEMNAGYTLISAAHAGYLTPPNVIWGRLAENLSELCEYAENIGMDLILEPLTPYESNVVCNANDVLHALALVPSPRLFSMVDICAPYVQAEPVMSYFDKLGDKLRHLHIVDSDGASDTHYIPGEGKMPLRELMRDIIERGYEGYCTVELVTMYMNEPRLYARQALERFRALLPEDER	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12910
Length:	276 (241)
Sequences:	17071 (12233)
Seq/√Len:	788.0

ECOLI - FRLC ULAE SGBU YCJR HYI YGBM YIHM END4
BACSU - IOLI IOLH YFIH IOLE END4
HALSA - END4
SULSO - Q97UI8 Q97UG9 Q97UI3 Q7LX49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
93_K	137_Y	3.125	1.00
177_F	204_R	3.023	1.00
20_R	59_Y	2.720	1.00
128_A	170_L	2.715	1.00
53_K	57_Q	2.671	1.00
227_P	230_E	2.596	1.00
197_D	234_D	2.401	1.00
144_D	204_R	2.369	1.00
97_D	141_I	2.311	1.00
29_G	243_Y	2.295	1.00
210_D	222_G	2.274	1.00
54_A	58_T	2.231	1.00
16_E	55_L	2.163	1.00
144_D	177_F	2.115	1.00
100_K	141_I	2.059	1.00
89_L	133_E	2.043	1.00
97_D	137_Y	2.042	1.00
14_P	17_H	2.042	1.00
146_I	204_R	2.024	1.00
124_W	166_H	1.974	1.00
165_L	198_K	1.945	1.00
166_H	170_L	1.919	1.00
106_Y	146_I	1.901	1.00
261_R	265_E	1.851	1.00
136_E	173_S	1.825	1.00
55_L	59_Y	1.782	1.00
165_L	169_A	1.779	1.00
234_D	237_E	1.749	1.00
55_L	58_T	1.731	1.00
20_R	24_E	1.712	1.00
86_R	90_D	1.671	1.00
125_G	170_L	1.638	1.00
48_G	51_Q	1.625	1.00
23_S	59_Y	1.604	1.00
46_A	101_E	1.594	1.00
96_M	141_I	1.592	1.00
56_A	63_I	1.588	1.00
146_I	179_M	1.584	1.00
124_W	170_L	1.584	1.00
50_K	101_E	1.583	1.00
84_M	87_E	1.573	1.00
137_Y	140_N	1.554	1.00
194_S	198_K	1.550	1.00
99_A	104_A	1.549	1.00
197_D	237_E	1.548	1.00
135_C	176_L	1.525	1.00
128_A	132_S	1.521	1.00
49_I	101_E	1.508	1.00
85_R	130_N	1.507	1.00
21_D	24_E	1.507	1.00
229_R	233_R	1.506	1.00
90_D	94_L	1.504	1.00
139_E	175_R	1.492	1.00
137_Y	141_I	1.476	1.00
193_M	230_E	1.467	1.00
125_G	129_E	1.444	1.00
122_V	125_G	1.442	1.00
196_F	200_G	1.431	1.00
210_D	224_G	1.430	1.00
191_P	194_S	1.427	1.00
255_E	258_L	1.421	1.00
96_M	138_A	1.416	1.00
223_E	262_Q	1.403	1.00
51_Q	54_A	1.400	1.00
126_R	129_E	1.397	1.00
106_Y	144_D	1.393	1.00
94_L	97_D	1.389	1.00
129_E	132_S	1.389	1.00
206_L	235_I	1.369	1.00
119_P	122_V	1.366	1.00
20_R	55_L	1.356	1.00
177_F	202_K	1.334	1.00
16_E	58_T	1.332	1.00
17_H	20_R	1.320	1.00
136_E	140_N	1.314	1.00
233_R	237_E	1.311	1.00
234_D	238_R	1.306	1.00
21_D	257_R	1.282	1.00
193_M	197_D	1.266	1.00
182_I	231_L	1.266	1.00
51_Q	55_L	1.253	1.00
93_K	133_E	1.250	1.00
135_C	171_V	1.245	1.00
19_F	59_Y	1.236	1.00
160_N	163_D	1.234	1.00
25_L	264_L	1.232	1.00
200_G	238_R	1.228	1.00
159_C	163_D	1.216	1.00
166_H	169_A	1.214	1.00
195_Y	199_L	1.208	1.00
162_N	198_K	1.203	1.00
149_P	185_P	1.198	1.00
54_A	57_Q	1.197	1.00
96_M	137_Y	1.195	1.00
89_L	93_K	1.184	1.00
180_V	185_P	1.180	1.00
93_K	97_D	1.176	1.00
212_D	219_Y	1.170	1.00
50_K	54_A	1.159	1.00
258_L	262_Q	1.153	1.00
142_G	175_R	1.149	1.00
16_E	51_Q	1.135	1.00
164_V	178_S	1.135	1.00
90_D	93_K	1.131	1.00
23_S	60_Q	1.126	1.00
133_E	136_E	1.117	1.00
19_F	55_L	1.117	1.00
29_G	62_P	1.110	1.00
21_D	25_L	1.104	1.00
128_A	171_V	1.101	1.00
96_M	143_M	1.100	1.00
165_L	202_K	1.094	1.00
153_Y	156_N	1.094	1.00
16_E	20_R	1.093	1.00
53_K	101_E	1.091	1.00
97_D	101_E	1.090	1.00
81_D	84_M	1.089	1.00
230_E	234_D	1.089	1.00
132_S	171_V	1.086	1.00
86_R	133_E	1.084	1.00
120_P	163_D	1.080	1.00
46_A	50_K	1.076	1.00
139_E	173_S	1.075	1.00
169_A	202_K	1.071	1.00
194_S	197_D	1.068	1.00
82_E	86_R	1.065	1.00
124_W	128_A	1.059	1.00
220_I	223_E	1.045	1.00
22_A	27_Y	1.043	1.00
165_L	199_L	1.035	1.00
138_A	145_L	1.033	1.00
92_I	134_L	1.030	1.00
197_D	238_R	1.027	1.00
29_G	64_I	1.026	1.00
19_F	56_A	1.024	1.00
93_K	140_N	1.009	1.00
27_Y	264_L	1.007	1.00
87_E	90_D	1.002	1.00
89_L	130_N	0.998	1.00
132_S	172_P	0.983	1.00
262_Q	265_E	0.982	1.00
121_N	166_H	0.974	1.00
106_Y	204_R	0.972	1.00
85_R	129_E	0.969	1.00
97_D	100_K	0.969	1.00
139_E	174_P	0.968	1.00
27_Y	246_V	0.965	1.00
31_E	65_G	0.962	1.00
136_E	139_E	0.952	1.00
129_E	133_E	0.950	1.00
56_A	61_M	0.942	1.00
232_M	236_I	0.937	1.00
45_K	48_G	0.933	1.00
47_G	51_Q	0.921	1.00
132_S	136_E	0.919	1.00
181_D	247_E	0.919	1.00
186_Y	225_K	0.918	1.00
226_M	231_L	0.917	1.00
105_G	144_D	0.913	1.00
56_A	59_Y	0.909	1.00
257_R	261_R	0.908	1.00
235_I	238_R	0.906	1.00
49_I	98_M	0.906	1.00
99_A	107_T	0.904	1.00
49_I	53_K	0.902	1.00
135_C	175_R	0.901	1.00
121_N	125_G	0.901	1.00
64_I	243_Y	0.900	1.00
218_H	221_P	0.897	1.00
32_I	63_I	0.895	1.00
135_C	173_S	0.894	1.00
162_N	166_H	0.894	1.00
193_M	234_D	0.890	1.00
66_Y	99_A	0.889	1.00
120_P	123_I	0.887	1.00
124_W	163_D	0.885	1.00
122_V	126_R	0.876	1.00
196_F	238_R	0.875	1.00
148_E	247_E	0.875	1.00
13_L	21_D	0.874	1.00
93_K	141_I	0.874	1.00
79_L	84_M	0.870	1.00
108_L	179_M	0.870	1.00
230_E	233_R	0.867	1.00
23_S	28_D	0.864	1.00
31_E	205_H	0.861	1.00
168_L	202_K	0.859	1.00
161_A	198_K	0.857	1.00
184_A	209_V	0.848	1.00
258_L	261_R	0.843	1.00
259_Y	262_Q	0.843	1.00
24_E	257_R	0.841	1.00
178_S	199_L	0.837	1.00
22_A	30_I	0.836	1.00
219_Y	223_E	0.832	1.00
131_L	176_L	0.827	1.00
132_S	173_S	0.822	1.00
168_L	178_S	0.821	1.00
221_P	263_A	0.820	1.00
85_R	126_R	0.816	1.00
53_K	103_N	0.810	1.00
50_K	53_K	0.805	1.00
91_M	94_L	0.805	1.00
100_K	143_M	0.799	1.00
183_C	209_V	0.796	1.00
8_C	11_Q	0.796	1.00
144_D	175_R	0.793	1.00
98_M	102_M	0.791	1.00
260_A	264_L	0.790	1.00
126_R	130_N	0.790	1.00
206_L	244_C	0.789	1.00
62_P	105_G	0.788	1.00
171_V	176_L	0.784	1.00
212_D	225_K	0.784	1.00
212_D	217_T	0.783	1.00
130_N	133_E	0.779	1.00
196_F	234_D	0.773	1.00
208_I	228_L	0.770	1.00
77_M	130_N	0.770	1.00
63_I	104_A	0.767	1.00
254_N	258_L	0.759	1.00
20_R	58_T	0.751	1.00
213_G	225_K	0.738	1.00
85_R	89_L	0.737	1.00
83_H	87_E	0.737	1.00
197_D	200_G	0.735	1.00
94_L	98_M	0.732	1.00
186_Y	226_M	0.731	1.00
228_L	232_M	0.730	1.00
259_Y	263_A	0.729	1.00
49_I	102_M	0.728	1.00
256_P	259_Y	0.728	1.00
163_D	166_H	0.725	1.00
260_A	263_A	0.724	1.00
195_Y	200_G	0.722	1.00
172_P	175_R	0.717	1.00
253_M	256_P	0.717	1.00
28_D	62_P	0.714	1.00
196_F	199_L	0.713	1.00
100_K	142_G	0.712	1.00
239_G	242_G	0.712	1.00
209_V	249_V	0.710	1.00
158_V	164_V	0.709	1.00
161_A	190_E	0.708	1.00
132_S	170_L	0.706	1.00
62_P	243_Y	0.699	1.00
123_I	126_R	0.699	1.00
183_C	211_S	0.694	1.00
19_F	23_S	0.694	1.00
168_L	176_L	0.689	1.00
18_A	22_A	0.689	1.00
205_H	245_T	0.687	1.00
67_T	110_S	0.686	1.00
133_E	137_Y	0.684	1.00
31_E	245_T	0.683	1.00
182_I	228_L	0.681	1.00
209_V	218_H	0.680	1.00
13_L	17_H	0.676	1.00
208_I	244_C	0.672	1.00
95_A	107_T	0.671	1.00
127_L	167_A	0.671	1.00
158_V	167_A	0.667	1.00
99_A	143_M	0.667	1.00
17_H	21_D	0.667	1.00
25_L	261_R	0.667	1.00
107_T	138_A	0.662	1.00
135_C	145_L	0.660	1.00
195_Y	198_K	0.655	1.00
19_F	30_I	0.655	1.00
131_L	167_A	0.653	1.00
20_R	23_S	0.648	1.00
23_S	61_M	0.646	1.00
179_M	205_H	0.646	1.00
82_E	126_R	0.646	1.00
149_P	164_V	0.645	1.00
193_M	196_F	0.644	1.00
148_E	207_H	0.641	1.00
125_G	128_A	0.640	1.00
106_Y	205_H	0.637	1.00
200_G	203_L	0.628	1.00
82_E	85_R	0.625	1.00
200_G	234_D	0.616	1.00
180_V	195_Y	0.614	1.00
85_R	133_E	0.614	1.00
66_Y	104_A	0.614	1.00
124_W	167_A	0.613	1.00
135_C	139_E	0.612	1.00
136_E	175_R	0.610	1.00
127_L	131_L	0.608	1.00
232_M	244_C	0.607	1.00
105_G	142_G	0.607	1.00
196_F	203_L	0.605	1.00
89_L	137_Y	0.605	1.00
180_V	196_F	0.605	1.00
128_A	167_A	0.604	1.00
161_A	194_S	0.597	1.00
27_Y	260_A	0.597	1.00
52_I	55_L	0.595	1.00
83_H	86_R	0.595	1.00
87_E	91_M	0.591	1.00
186_Y	192_V	0.591	1.00
138_A	143_M	0.590	1.00
109_I	145_L	0.588	1.00
86_R	89_L	0.587	1.00
236_I	244_C	0.584	1.00
161_A	165_L	0.582	1.00
246_V	263_A	0.581	1.00
88_S	91_M	0.580	1.00
201_D	238_R	0.573	1.00
182_I	208_I	0.572	1.00
253_M	259_Y	0.571	1.00
256_P	260_A	0.571	1.00
19_F	52_I	0.570	1.00
69_E	95_A	0.570	1.00
57_Q	103_N	0.568	1.00
178_S	203_L	0.565	1.00
19_F	61_M	0.563	1.00
134_L	145_L	0.558	1.00
89_L	134_L	0.557	1.00
118_T	126_R	0.555	1.00
138_A	141_I	0.554	1.00
76_N	79_L	0.551	1.00
185_P	195_Y	0.551	1.00
115_G	119_P	0.547	1.00
53_K	56_A	0.546	1.00
127_L	130_N	0.543	1.00
146_I	177_F	0.542	1.00
173_S	176_L	0.541	1.00
261_R	264_L	0.539	1.00
180_V	203_L	0.539	1.00
255_E	259_Y	0.539	1.00
118_T	123_I	0.537	1.00
53_K	102_M	0.535	1.00
220_I	259_Y	0.533	1.00
187_V	211_S	0.532	1.00
16_E	59_Y	0.531	1.00
65_G	108_L	0.529	1.00
205_H	243_Y	0.528	1.00
183_C	218_H	0.527	1.00
65_G	245_T	0.526	1.00
172_P	202_K	0.525	1.00
148_E	184_A	0.523	1.00
168_L	172_P	0.522	1.00
96_M	107_T	0.521	1.00
149_P	158_V	0.521	1.00
235_I	240_Y	0.521	1.00
181_D	209_V	0.519	1.00
68_P	95_A	0.519	1.00
167_A	171_V	0.519	1.00
229_R	232_M	0.515	1.00
75_Y	78_M	0.514	1.00
128_A	166_H	0.511	1.00
157_V	160_N	0.510	1.00
18_A	21_D	0.509	1.00
236_I	239_G	0.508	1.00
108_L	205_H	0.507	1.00
28_D	60_Q	0.507	1.00
165_L	168_L	0.506	1.00
24_E	261_R	0.502	1.00
66_Y	69_E	0.502	1.00
228_L	231_L	0.502	1.00
10_H	21_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i60A	1	0.971	100	0.204	Contact Map
3wqoA	2	0.9493	100	0.207	Contact Map
3cqjA	2	0.9855	100	0.21	Contact Map
2zdsA	5	0.9855	100	0.215	Contact Map
3vniA	4	0.9493	100	0.225	Contact Map
3kwsA	2	0.9312	100	0.226	Contact Map
2qulA	2	0.9457	100	0.227	Contact Map
3dx5A	2	0.9239	100	0.229	Contact Map
2hk0A	3	0.9457	100	0.23	Contact Map
3u0hA	3	0.9638	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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