GREMLIN Database
FRLC - Protein FrlC
UniProt: P45541 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12910
Length: 276 (241)
Sequences: 17071 (12233)
Seq/√Len: 788.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_K137_Y3.1251.00
177_F204_R3.0231.00
20_R59_Y2.7201.00
128_A170_L2.7151.00
53_K57_Q2.6711.00
227_P230_E2.5961.00
197_D234_D2.4011.00
144_D204_R2.3691.00
97_D141_I2.3111.00
29_G243_Y2.2951.00
210_D222_G2.2741.00
54_A58_T2.2311.00
16_E55_L2.1631.00
144_D177_F2.1151.00
100_K141_I2.0591.00
89_L133_E2.0431.00
97_D137_Y2.0421.00
14_P17_H2.0421.00
146_I204_R2.0241.00
124_W166_H1.9741.00
165_L198_K1.9451.00
166_H170_L1.9191.00
106_Y146_I1.9011.00
261_R265_E1.8511.00
136_E173_S1.8251.00
55_L59_Y1.7821.00
165_L169_A1.7791.00
234_D237_E1.7491.00
55_L58_T1.7311.00
20_R24_E1.7121.00
86_R90_D1.6711.00
125_G170_L1.6381.00
48_G51_Q1.6251.00
23_S59_Y1.6041.00
46_A101_E1.5941.00
96_M141_I1.5921.00
56_A63_I1.5881.00
146_I179_M1.5841.00
124_W170_L1.5841.00
50_K101_E1.5831.00
84_M87_E1.5731.00
137_Y140_N1.5541.00
194_S198_K1.5501.00
99_A104_A1.5491.00
197_D237_E1.5481.00
135_C176_L1.5251.00
128_A132_S1.5211.00
49_I101_E1.5081.00
85_R130_N1.5071.00
21_D24_E1.5071.00
229_R233_R1.5061.00
90_D94_L1.5041.00
139_E175_R1.4921.00
137_Y141_I1.4761.00
193_M230_E1.4671.00
125_G129_E1.4441.00
122_V125_G1.4421.00
196_F200_G1.4311.00
210_D224_G1.4301.00
191_P194_S1.4271.00
255_E258_L1.4211.00
96_M138_A1.4161.00
223_E262_Q1.4031.00
51_Q54_A1.4001.00
126_R129_E1.3971.00
106_Y144_D1.3931.00
94_L97_D1.3891.00
129_E132_S1.3891.00
206_L235_I1.3691.00
119_P122_V1.3661.00
20_R55_L1.3561.00
177_F202_K1.3341.00
16_E58_T1.3321.00
17_H20_R1.3201.00
136_E140_N1.3141.00
233_R237_E1.3111.00
234_D238_R1.3061.00
21_D257_R1.2821.00
193_M197_D1.2661.00
182_I231_L1.2661.00
51_Q55_L1.2531.00
93_K133_E1.2501.00
135_C171_V1.2451.00
19_F59_Y1.2361.00
160_N163_D1.2341.00
25_L264_L1.2321.00
200_G238_R1.2281.00
159_C163_D1.2161.00
166_H169_A1.2141.00
195_Y199_L1.2081.00
162_N198_K1.2031.00
149_P185_P1.1981.00
54_A57_Q1.1971.00
96_M137_Y1.1951.00
89_L93_K1.1841.00
180_V185_P1.1801.00
93_K97_D1.1761.00
212_D219_Y1.1701.00
50_K54_A1.1591.00
258_L262_Q1.1531.00
142_G175_R1.1491.00
16_E51_Q1.1351.00
164_V178_S1.1351.00
90_D93_K1.1311.00
23_S60_Q1.1261.00
133_E136_E1.1171.00
19_F55_L1.1171.00
29_G62_P1.1101.00
21_D25_L1.1041.00
128_A171_V1.1011.00
96_M143_M1.1001.00
165_L202_K1.0941.00
153_Y156_N1.0941.00
16_E20_R1.0931.00
53_K101_E1.0911.00
97_D101_E1.0901.00
81_D84_M1.0891.00
230_E234_D1.0891.00
132_S171_V1.0861.00
86_R133_E1.0841.00
120_P163_D1.0801.00
46_A50_K1.0761.00
139_E173_S1.0751.00
169_A202_K1.0711.00
194_S197_D1.0681.00
82_E86_R1.0651.00
124_W128_A1.0591.00
220_I223_E1.0451.00
22_A27_Y1.0431.00
165_L199_L1.0351.00
138_A145_L1.0331.00
92_I134_L1.0301.00
197_D238_R1.0271.00
29_G64_I1.0261.00
19_F56_A1.0241.00
93_K140_N1.0091.00
27_Y264_L1.0071.00
87_E90_D1.0021.00
89_L130_N0.9981.00
132_S172_P0.9831.00
262_Q265_E0.9821.00
121_N166_H0.9741.00
106_Y204_R0.9721.00
85_R129_E0.9691.00
97_D100_K0.9691.00
139_E174_P0.9681.00
27_Y246_V0.9651.00
31_E65_G0.9621.00
136_E139_E0.9521.00
129_E133_E0.9501.00
56_A61_M0.9421.00
232_M236_I0.9371.00
45_K48_G0.9331.00
47_G51_Q0.9211.00
132_S136_E0.9191.00
181_D247_E0.9191.00
186_Y225_K0.9181.00
226_M231_L0.9171.00
105_G144_D0.9131.00
56_A59_Y0.9091.00
257_R261_R0.9081.00
235_I238_R0.9061.00
49_I98_M0.9061.00
99_A107_T0.9041.00
49_I53_K0.9021.00
135_C175_R0.9011.00
121_N125_G0.9011.00
64_I243_Y0.9001.00
218_H221_P0.8971.00
32_I63_I0.8951.00
135_C173_S0.8941.00
162_N166_H0.8941.00
193_M234_D0.8901.00
66_Y99_A0.8891.00
120_P123_I0.8871.00
124_W163_D0.8851.00
122_V126_R0.8761.00
196_F238_R0.8751.00
148_E247_E0.8751.00
13_L21_D0.8741.00
93_K141_I0.8741.00
79_L84_M0.8701.00
108_L179_M0.8701.00
230_E233_R0.8671.00
23_S28_D0.8641.00
31_E205_H0.8611.00
168_L202_K0.8591.00
161_A198_K0.8571.00
184_A209_V0.8481.00
258_L261_R0.8431.00
259_Y262_Q0.8431.00
24_E257_R0.8411.00
178_S199_L0.8371.00
22_A30_I0.8361.00
219_Y223_E0.8321.00
131_L176_L0.8271.00
132_S173_S0.8221.00
168_L178_S0.8211.00
221_P263_A0.8201.00
85_R126_R0.8161.00
53_K103_N0.8101.00
50_K53_K0.8051.00
91_M94_L0.8051.00
100_K143_M0.7991.00
183_C209_V0.7961.00
8_C11_Q0.7961.00
144_D175_R0.7931.00
98_M102_M0.7911.00
260_A264_L0.7901.00
126_R130_N0.7901.00
206_L244_C0.7891.00
62_P105_G0.7881.00
171_V176_L0.7841.00
212_D225_K0.7841.00
212_D217_T0.7831.00
130_N133_E0.7791.00
196_F234_D0.7731.00
208_I228_L0.7701.00
77_M130_N0.7701.00
63_I104_A0.7671.00
254_N258_L0.7591.00
20_R58_T0.7511.00
213_G225_K0.7381.00
85_R89_L0.7371.00
83_H87_E0.7371.00
197_D200_G0.7351.00
94_L98_M0.7321.00
186_Y226_M0.7311.00
228_L232_M0.7301.00
259_Y263_A0.7291.00
49_I102_M0.7281.00
256_P259_Y0.7281.00
163_D166_H0.7251.00
260_A263_A0.7241.00
195_Y200_G0.7221.00
172_P175_R0.7171.00
253_M256_P0.7171.00
28_D62_P0.7141.00
196_F199_L0.7131.00
100_K142_G0.7121.00
239_G242_G0.7121.00
209_V249_V0.7101.00
158_V164_V0.7091.00
161_A190_E0.7081.00
132_S170_L0.7061.00
62_P243_Y0.6991.00
123_I126_R0.6991.00
183_C211_S0.6941.00
19_F23_S0.6941.00
168_L176_L0.6891.00
18_A22_A0.6891.00
205_H245_T0.6871.00
67_T110_S0.6861.00
133_E137_Y0.6841.00
31_E245_T0.6831.00
182_I228_L0.6811.00
209_V218_H0.6801.00
13_L17_H0.6761.00
208_I244_C0.6721.00
95_A107_T0.6711.00
127_L167_A0.6711.00
158_V167_A0.6671.00
99_A143_M0.6671.00
17_H21_D0.6671.00
25_L261_R0.6671.00
107_T138_A0.6621.00
135_C145_L0.6601.00
195_Y198_K0.6551.00
19_F30_I0.6551.00
131_L167_A0.6531.00
20_R23_S0.6481.00
23_S61_M0.6461.00
179_M205_H0.6461.00
82_E126_R0.6461.00
149_P164_V0.6451.00
193_M196_F0.6441.00
148_E207_H0.6411.00
125_G128_A0.6401.00
106_Y205_H0.6371.00
200_G203_L0.6281.00
82_E85_R0.6251.00
200_G234_D0.6161.00
180_V195_Y0.6141.00
85_R133_E0.6141.00
66_Y104_A0.6141.00
124_W167_A0.6131.00
135_C139_E0.6121.00
136_E175_R0.6101.00
127_L131_L0.6081.00
232_M244_C0.6071.00
105_G142_G0.6071.00
196_F203_L0.6051.00
89_L137_Y0.6051.00
180_V196_F0.6051.00
128_A167_A0.6041.00
161_A194_S0.5971.00
27_Y260_A0.5971.00
52_I55_L0.5951.00
83_H86_R0.5951.00
87_E91_M0.5911.00
186_Y192_V0.5911.00
138_A143_M0.5901.00
109_I145_L0.5881.00
86_R89_L0.5871.00
236_I244_C0.5841.00
161_A165_L0.5821.00
246_V263_A0.5811.00
88_S91_M0.5801.00
201_D238_R0.5731.00
182_I208_I0.5721.00
253_M259_Y0.5711.00
256_P260_A0.5711.00
19_F52_I0.5701.00
69_E95_A0.5701.00
57_Q103_N0.5681.00
178_S203_L0.5651.00
19_F61_M0.5631.00
134_L145_L0.5581.00
89_L134_L0.5571.00
118_T126_R0.5551.00
138_A141_I0.5541.00
76_N79_L0.5511.00
185_P195_Y0.5511.00
115_G119_P0.5471.00
53_K56_A0.5461.00
127_L130_N0.5431.00
146_I177_F0.5421.00
173_S176_L0.5411.00
261_R264_L0.5391.00
180_V203_L0.5391.00
255_E259_Y0.5391.00
118_T123_I0.5371.00
53_K102_M0.5351.00
220_I259_Y0.5331.00
187_V211_S0.5321.00
16_E59_Y0.5311.00
65_G108_L0.5291.00
205_H243_Y0.5281.00
183_C218_H0.5271.00
65_G245_T0.5261.00
172_P202_K0.5251.00
148_E184_A0.5231.00
168_L172_P0.5221.00
96_M107_T0.5211.00
149_P158_V0.5211.00
235_I240_Y0.5211.00
181_D209_V0.5191.00
68_P95_A0.5191.00
167_A171_V0.5191.00
229_R232_M0.5151.00
75_Y78_M0.5141.00
128_A166_H0.5111.00
157_V160_N0.5101.00
18_A21_D0.5091.00
236_I239_G0.5081.00
108_L205_H0.5071.00
28_D60_Q0.5071.00
165_L168_L0.5061.00
24_E261_R0.5021.00
66_Y69_E0.5021.00
228_L231_L0.5021.00
10_H21_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i60A 1 0.971 100 0.204 Contact Map
3wqoA 2 0.9493 100 0.207 Contact Map
3cqjA 2 0.9855 100 0.21 Contact Map
2zdsA 5 0.9855 100 0.215 Contact Map
3vniA 4 0.9493 100 0.225 Contact Map
3kwsA 2 0.9312 100 0.226 Contact Map
2qulA 2 0.9457 100 0.227 Contact Map
3dx5A 2 0.9239 100 0.229 Contact Map
2hk0A 3 0.9457 100 0.23 Contact Map
3u0hA 3 0.9638 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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