GREMLIN Database
FRLA - Putative fructoselysine transporter FrlA
UniProt: P45539 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12908
Length: 445 (418)
Sequences: 24647 (16064)
Seq/√Len: 785.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_M338_G4.3661.00
319_C332_V4.3141.00
366_T398_I3.1741.00
53_G240_L3.1681.00
322_H332_V3.0561.00
226_K230_R2.9321.00
324_H327_Y2.9291.00
374_W377_K2.9071.00
11_G222_K2.8231.00
221_I227_T2.7491.00
77_Y313_D2.7091.00
223_N226_K2.7051.00
93_G310_M2.6191.00
311_A321_G2.6081.00
324_H331_D2.5681.00
171_G249_V2.5471.00
319_C322_H2.4921.00
16_L234_G2.4501.00
132_A342_I2.4481.00
169_G173_F2.3921.00
255_P258_K2.3881.00
279_T283_F2.3361.00
12_F234_G2.3181.00
219_G312_K2.2961.00
65_E376_R2.2751.00
220_E305_R2.2491.00
268_D271_T2.2061.00
369_F397_A2.2011.00
81_K89_A2.1791.00
308_Y312_K2.1421.00
335_I339_A2.1171.00
380_D383_P2.1081.00
140_L144_R2.1031.00
15_V221_I2.1001.00
136_I342_I2.0911.00
423_V427_G2.0761.00
143_L331_D2.0731.00
12_F227_T2.0721.00
147_E151_A2.0671.00
139_M334_I2.0601.00
395_T399_A2.0591.00
12_F16_L2.0551.00
379_D383_P2.0251.00
132_A345_I1.9761.00
131_A345_I1.9731.00
81_K86_R1.9651.00
230_R234_G1.9601.00
158_I162_I1.9331.00
84_G374_W1.9311.00
320_F336_L1.9201.00
97_F337_Q1.9121.00
258_K272_W1.9001.00
62_V369_F1.9001.00
11_G14_A1.8891.00
314_N318_K1.8871.00
176_K180_F1.8841.00
35_V45_T1.8841.00
429_P433_F1.8751.00
54_L58_P1.8291.00
136_I338_G1.7801.00
16_L238_L1.7701.00
84_G370_G1.7491.00
223_N227_T1.7231.00
80_L92_S1.7111.00
14_A154_T1.7101.00
85_S88_L1.6951.00
233_I237_L1.6911.00
392_L396_L1.6761.00
399_A403_I1.6761.00
142_H297_S1.6761.00
370_G398_I1.6701.00
190_A193_S1.6681.00
421_V425_A1.6621.00
19_A235_S1.6341.00
268_D272_W1.6231.00
413_P416_G1.6161.00
327_Y331_D1.6141.00
92_S367_L1.6091.00
262_S268_D1.6071.00
143_L335_I1.5961.00
135_I341_G1.5931.00
109_A296_L1.5881.00
48_A200_G1.5871.00
379_D382_K1.5811.00
324_H329_T1.5811.00
126_L129_F1.5671.00
94_W427_G1.5551.00
105_L341_G1.5521.00
162_I166_I1.5481.00
7_Q328_N1.5461.00
10_L14_A1.5431.00
116_L130_I1.5401.00
262_S265_P1.5201.00
308_Y323_V1.5101.00
55_I400_S1.5001.00
54_L396_L1.4981.00
84_G88_L1.4871.00
179_N182_A1.4821.00
144_R327_Y1.4761.00
307_E333_S1.4441.00
163_P287_T1.4371.00
303_Q337_Q1.4341.00
60_M236_C1.4341.00
58_P396_L1.4331.00
176_K179_N1.4221.00
414_I417_L1.4201.00
112_I289_M1.4181.00
52_G204_T1.4171.00
237_L241_V1.4151.00
370_G374_W1.4141.00
217_M301_M1.4001.00
80_L367_L1.3991.00
271_T281_G1.3891.00
224_P229_P1.3871.00
139_M335_I1.3821.00
125_L129_F1.3801.00
318_K321_G1.3781.00
332_V336_L1.3731.00
389_A393_M1.3731.00
318_K322_H1.3631.00
322_H331_D1.3631.00
177_A180_F1.3631.00
135_I338_G1.3591.00
172_I249_V1.3591.00
304_P334_I1.3491.00
282_I286_I1.3411.00
73_N219_G1.3391.00
422_I426_T1.3381.00
87_P434_W1.3331.00
112_I134_L1.3241.00
223_N230_R1.3231.00
132_A136_I1.3201.00
70_Y82_N1.3191.00
414_I418_I1.3171.00
109_A135_I1.3121.00
227_T230_R1.3111.00
59_Q369_F1.3081.00
60_M232_L1.3071.00
138_F296_L1.3041.00
14_A150_A1.2991.00
161_I165_T1.2961.00
83_A371_S1.2871.00
168_I245_L1.2711.00
12_F230_R1.2641.00
171_G253_L1.2631.00
46_V248_L1.2551.00
427_G430_A1.2531.00
123_D126_L1.2481.00
23_T239_V1.2471.00
366_T402_L1.2451.00
62_V394_T1.2391.00
10_L15_V1.2341.00
390_F394_T1.2311.00
61_C233_I1.2291.00
241_V245_L1.2271.00
78_V82_N1.2211.00
428_L432_A1.2201.00
391_G395_T1.2161.00
97_F307_E1.2101.00
413_P417_L1.2101.00
373_I395_T1.2041.00
222_K227_T1.1961.00
178_E181_A1.1901.00
175_F179_N1.1871.00
30_V111_A1.1851.00
167_V171_G1.1821.00
128_K132_A1.1751.00
15_V231_A1.1711.00
10_L150_A1.1701.00
175_F178_E1.1651.00
108_M295_S1.1641.00
63_Y76_D1.1621.00
415_P418_I1.1561.00
307_E316_F1.1531.00
402_L406_A1.1521.00
264_T268_D1.1521.00
417_L420_A1.1471.00
392_L395_T1.1461.00
13_W17_A1.1461.00
378_R381_Y1.1371.00
72_E78_V1.1301.00
9_K222_K1.1251.00
425_A429_P1.1251.00
36_A45_T1.1171.00
332_V335_I1.1151.00
141_L152_F1.1041.00
430_A434_W1.1001.00
312_K321_G1.0911.00
430_A433_F1.0811.00
152_F156_I1.0801.00
174_W180_F1.0801.00
90_F94_W1.0681.00
67_S79_Y1.0641.00
19_A214_I1.0631.00
418_I422_I1.0611.00
174_W177_A1.0591.00
133_G137_A1.0481.00
175_F252_G1.0471.00
403_I407_S1.0451.00
151_A155_L1.0441.00
20_V238_L1.0421.00
198_L403_I1.0421.00
80_L88_L1.0411.00
82_N378_R1.0411.00
139_M143_L1.0371.00
372_I394_T1.0341.00
420_A424_I1.0331.00
323_V328_N1.0321.00
153_Q297_S1.0241.00
72_E82_N1.0161.00
166_I170_L1.0151.00
423_V430_A1.0151.00
18_I217_M1.0141.00
183_P186_T1.0111.00
129_F133_G1.0111.00
65_E68_T1.0091.00
190_A197_L1.0071.00
339_A343_F1.0051.00
415_P419_C0.9991.00
418_I421_V0.9951.00
116_L289_M0.9851.00
77_Y309_A0.9851.00
113_V130_I0.9781.00
69_A381_Y0.9751.00
50_V244_T0.9731.00
398_I402_L0.9711.00
20_V239_V0.9701.00
218_T228_M0.9691.00
414_I427_G0.9651.00
136_I140_L0.9651.00
143_L329_T0.9631.00
175_F180_F0.9591.00
416_G420_A0.9501.00
414_I421_V0.9501.00
366_T401_S0.9501.00
417_L421_V0.9471.00
156_I294_G0.9461.00
276_L280_A0.9451.00
271_T278_S0.9431.00
168_I249_V0.9381.00
137_A293_L0.9371.00
146_V301_M0.9341.00
248_L252_G0.9301.00
416_G421_V0.9291.00
69_A383_P0.9261.00
265_P268_D0.9241.00
209_T361_M0.9231.00
116_L120_T0.9221.00
165_T169_G0.9201.00
17_A154_T0.9191.00
193_S196_A0.9181.00
373_I394_T0.9181.00
143_L324_H0.9121.00
234_G238_L0.9111.00
266_I269_A0.9111.00
74_G77_Y0.9031.00
300_V338_G0.8991.00
81_K313_D0.8991.00
419_C422_I0.8981.00
278_S282_I0.8971.00
178_E182_A0.8931.00
377_K380_D0.8921.00
24_V27_G0.8911.00
432_A435_A0.8911.00
331_D335_I0.8891.00
240_L244_T0.8881.00
386_R389_A0.8881.00
46_V251_S0.8861.00
212_A216_Y0.8841.00
58_P393_M0.8841.00
68_T384_L0.8841.00
107_I206_W0.8811.00
277_G280_A0.8801.00
138_F297_S0.8801.00
427_G431_Y0.8801.00
366_T370_G0.8781.00
168_I172_I0.8771.00
9_K147_E0.8761.00
69_A384_L0.8761.00
161_I242_L0.8741.00
94_W316_F0.8731.00
85_S435_A0.8701.00
320_F332_V0.8701.00
138_F300_V0.8661.00
14_A151_A0.8641.00
74_G78_V0.8611.00
265_P270_L0.8591.00
369_F398_I0.8531.00
187_A191_T0.8461.00
415_P427_G0.8441.00
112_I292_I0.8381.00
130_I133_G0.8341.00
13_W154_T0.8301.00
416_G423_V0.8271.00
107_I354_L0.8261.00
151_A154_T0.8251.00
35_V39_A0.8241.00
185_T188_I0.8201.00
359_L420_A0.8191.00
213_S302_Y0.8161.00
88_L367_L0.8111.00
124_P127_G0.8091.00
39_A42_P0.8081.00
275_A278_S0.8081.00
53_G208_Y0.8071.00
24_V29_F0.8061.00
401_S404_L0.8041.00
112_I293_L0.8031.00
194_F197_L0.8021.00
316_F320_F0.8021.00
338_G342_I0.8021.00
160_K291_V0.7911.00
135_I345_I0.7881.00
415_P421_V0.7881.00
57_I61_C0.7881.00
420_A423_V0.7881.00
87_P91_L0.7861.00
113_V131_A0.7861.00
80_L371_S0.7821.00
173_F177_A0.7811.00
172_I245_L0.7811.00
339_A342_I0.7791.00
12_F231_A0.7781.00
183_P187_A0.7751.00
431_Y435_A0.7751.00
167_V270_L0.7721.00
66_L372_I0.7711.00
428_L431_Y0.7701.00
50_V54_L0.7681.00
416_G419_C0.7671.00
173_F176_K0.7661.00
385_W388_P0.7641.00
419_C423_V0.7641.00
414_I423_V0.7581.00
57_I233_I0.7561.00
28_I246_L0.7541.00
424_I428_L0.7531.00
356_Y360_V0.7511.00
188_I191_T0.7461.00
13_W151_A0.7451.00
16_L231_A0.7411.00
255_P272_W0.7401.00
360_V364_K0.7391.00
209_T365_N0.7381.00
113_V127_G0.7351.00
87_P428_L0.7351.00
77_Y81_K0.7341.00
324_H328_N0.7331.00
110_L353_L0.7321.00
330_P333_S0.7311.00
223_N229_P0.7301.00
378_R383_P0.7291.00
405_V408_T0.7291.00
47_L197_L0.7261.00
9_K146_V0.7251.00
45_T247_A0.7241.00
229_P232_L0.7241.00
199_A203_A0.7241.00
253_L269_A0.7231.00
58_P62_V0.7221.00
113_V116_L0.7211.00
24_V160_K0.7201.00
140_L143_L0.7161.00
177_A181_A0.7161.00
42_P190_A0.7161.00
128_K345_I0.7151.00
83_A374_W0.7151.00
416_G427_G0.7141.00
144_R148_G0.7141.00
66_L79_Y0.7121.00
422_I425_A0.7111.00
104_S107_I0.7101.00
372_I376_R0.7081.00
128_K131_A0.7081.00
414_I420_A0.7071.00
421_V424_I0.7051.00
58_P397_A0.7051.00
174_W178_E0.7031.00
117_G121_P0.7021.00
225_G384_L0.7011.00
279_T282_I0.7011.00
311_A320_F0.6981.00
305_R308_Y0.6981.00
264_T267_S0.6961.00
320_F333_S0.6961.00
118_F121_P0.6941.00
397_A401_S0.6931.00
132_A346_F0.6921.00
172_I176_K0.6921.00
21_G157_T0.6901.00
300_V304_P0.6891.00
238_L242_L0.6861.00
95_A364_K0.6861.00
245_L249_V0.6861.00
415_P420_A0.6861.00
41_T251_S0.6841.00
117_G127_G0.6801.00
104_S108_M0.6791.00
371_S375_C0.6781.00
326_K331_D0.6781.00
59_Q401_S0.6771.00
426_T429_P0.6771.00
23_T235_S0.6771.00
142_H334_I0.6771.00
143_L327_Y0.6761.00
429_P432_A0.6761.00
307_E336_L0.6761.00
150_A154_T0.6751.00
47_L51_I0.6731.00
170_L277_G0.6731.00
84_G371_S0.6701.00
177_A182_A0.6701.00
142_H301_M0.6701.00
73_N308_Y0.6671.00
63_Y368_T0.6651.00
394_T398_I0.6641.00
219_G308_Y0.6641.00
418_I423_V0.6621.00
99_A361_M0.6621.00
194_F198_L0.6591.00
397_A400_S0.6581.00
304_P333_S0.6581.00
47_L50_V0.6581.00
168_I246_L0.6561.00
83_A375_C0.6551.00
77_Y93_G0.6551.00
373_I391_G0.6541.00
390_F393_M0.6531.00
196_A199_A0.6531.00
266_I270_L0.6511.00
265_P269_A0.6501.00
9_K13_W0.6481.00
104_S357_F0.6481.00
413_P421_V0.6481.00
431_Y434_W0.6481.00
96_S100_N0.6471.00
398_I401_S0.6461.00
426_T430_A0.6461.00
102_A340_L0.6431.00
42_P45_T0.6431.00
136_I139_M0.6401.00
319_C336_L0.6391.00
109_A113_V0.6391.00
143_L334_I0.6391.00
417_L431_Y0.6381.00
106_S353_L0.6371.00
403_I406_A0.6371.00
138_F293_L0.6371.00
32_V247_A0.6361.00
413_P418_I0.6361.00
401_S405_V0.6341.00
220_E323_V0.6341.00
423_V428_L0.6341.00
391_G394_T0.6321.00
56_V211_M0.6321.00
388_P392_L0.6301.00
19_A23_T0.6291.00
84_G87_P0.6291.00
42_P197_L0.6281.00
421_V430_A0.6251.00
283_F287_T0.6241.00
246_L250_I0.6231.00
46_V50_V0.6221.00
106_S344_F0.6211.00
62_V397_A0.6191.00
234_G237_L0.6191.00
220_E330_P0.6181.00
228_M232_L0.6181.00
148_G151_A0.6171.00
421_V428_L0.6171.00
49_F207_S0.6161.00
413_P420_A0.6121.00
216_Y302_Y0.6121.00
65_E388_P0.6101.00
415_P423_V0.6101.00
359_L405_V0.6101.00
390_F395_T0.6101.00
174_W179_N0.6091.00
115_N288_A0.6091.00
67_S228_M0.6091.00
266_I271_T0.6081.00
22_T299_C0.6081.00
60_M211_M0.6081.00
134_L296_L0.6081.00
22_T298_S0.6071.00
159_A287_T0.6031.00
64_A68_T0.6021.00
400_S404_L0.6011.00
31_S354_L0.6001.00
404_L408_T0.6001.00
186_T191_T0.5981.00
422_I427_G0.5971.00
66_L83_A0.5971.00
399_A402_L0.5971.00
189_G193_S0.5931.00
430_A435_A0.5931.00
417_L422_I0.5921.00
116_L134_L0.5921.00
215_C232_L0.5911.00
25_G29_F0.5901.00
184_T188_I0.5891.00
135_I342_I0.5881.00
108_M296_L0.5881.00
51_I201_I0.5871.00
87_P432_A0.5871.00
389_A392_L0.5851.00
146_V217_M0.5841.00
198_L407_S0.5821.00
414_I430_A0.5821.00
148_G152_F0.5811.00
267_S270_L0.5811.00
291_V294_G0.5791.00
108_M111_A0.5791.00
95_A363_F0.5781.00
305_R323_V0.5771.00
112_I116_L0.5761.00
100_N299_C0.5751.00
76_D212_A0.5751.00
209_T212_A0.5741.00
85_S89_A0.5731.00
425_A428_L0.5721.00
413_P423_V0.5711.00
413_P430_A0.5711.00
13_W16_L0.5701.00
413_P419_C0.5691.00
77_Y89_A0.5671.00
46_V244_T0.5651.00
249_V252_G0.5651.00
221_I228_M0.5651.00
224_P227_T0.5651.00
111_A115_N0.5651.00
267_S271_T0.5641.00
119_L286_I0.5641.00
255_P259_L0.5641.00
67_S215_C0.5631.00
139_M300_V0.5631.00
303_Q307_E0.5631.00
145_S148_G0.5631.00
125_L130_I0.5621.00
422_I433_F0.5611.00
76_D216_Y0.5601.00
150_A297_S0.5601.00
198_L202_S0.5601.00
187_A190_A0.5601.00
118_F285_A0.5591.00
256_F259_L0.5581.00
180_F251_S0.5561.00
149_G301_M0.5551.00
61_C393_M0.5531.00
20_V157_T0.5521.00
336_L340_L0.5501.00
246_L266_I0.5491.00
106_S109_A0.5481.00
15_V217_M0.5481.00
238_L241_V0.5451.00
350_L354_L0.5411.00
60_M64_A0.5411.00
319_C323_V0.5411.00
154_T158_I0.5411.00
286_I290_I0.5401.00
343_F346_F0.5391.00
35_V204_T0.5391.00
16_L19_A0.5391.00
361_M364_K0.5391.00
305_R330_P0.5381.00
127_G131_A0.5371.00
415_P430_A0.5351.00
180_F252_G0.5341.00
109_A112_I0.5331.00
417_L430_A0.5331.00
417_L427_G0.5331.00
52_G208_Y0.5331.00
103_P356_Y0.5321.00
11_G147_E0.5321.00
389_A394_T0.5321.00
375_C378_R0.5321.00
162_I165_T0.5301.00
323_V327_Y0.5291.00
423_V431_Y0.5281.00
62_V387_T0.5281.00
225_G230_R0.5271.00
133_G136_I0.5271.00
422_I429_P0.5271.00
159_A163_P0.5241.00
52_G205_S0.5231.00
120_T124_P0.5221.00
157_T160_K0.5201.00
185_T189_G0.5191.00
238_L245_L0.5191.00
108_M292_I0.5191.00
362_C401_S0.5191.00
226_K229_P0.5171.00
420_A430_A0.5161.00
176_K181_A0.5151.00
72_E219_G0.5151.00
61_C388_P0.5141.00
423_V429_P0.5141.00
80_L89_A0.5141.00
331_D334_I0.5141.00
209_T357_F0.5141.00
119_L285_A0.5131.00
186_T189_G0.5131.00
65_E69_A0.5131.00
376_R379_D0.5131.00
115_N267_S0.5111.00
189_G192_G0.5101.00
22_T213_S0.5101.00
25_G243_Y0.5101.00
416_G430_A0.5091.00
114_S127_G0.5091.00
415_P432_A0.5081.00
351_T354_L0.5071.00
49_F247_A0.5071.00
420_A425_A0.5061.00
296_L299_C0.5061.00
381_Y384_L0.5061.00
349_D352_S0.5051.00
394_T408_T0.5041.00
34_E37_K0.5041.00
394_T401_S0.5041.00
153_Q160_K0.5041.00
257_D261_N0.5031.00
106_S341_G0.5031.00
257_D260_A0.5021.00
34_E351_T0.5021.00
92_S364_K0.5011.00
95_A99_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9258 100 0.261 Contact Map
3giaA 1 0.9528 100 0.321 Contact Map
4djkA 2 0.9079 100 0.346 Contact Map
3dh4A 3 0.9326 98.7 0.863 Contact Map
2jlnA 1 0.9056 98.6 0.867 Contact Map
2xq2A 2 0.9326 98.6 0.868 Contact Map
4wgvA 2 0.8225 97.9 0.891 Contact Map
2a65A 2 0.9461 97.7 0.897 Contact Map
4xp4A 1 0.9528 97 0.908 Contact Map
4us3A 1 0.8764 96.5 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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