YHFK - ECOLI - GREMLIN Contacts

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YHFK - Uncharacterized protein YhfK

UniProt:	P45537	Sequences: MFPPMWRRLIYHPDINYALRQTLVLCLPVAVGLMLGELRFGLLFSLVPACCNIAGLDTPHKRFFKRLIIGASLFATCSLLTQLLLAKDVPLPFLLTGLTLVLGVTAELGPLHAKLLPASLLAAIFTLSLAGYMPVWEPLLIYALGTLWYGLFNWFWFWIWREQPLRESLSLLYRELADYCEAKYSLLTQHTDPEKALPPLLVRQQKAVDLITQCYQQMHMLSAQNNTDYKRMLRIFQEALDLQEHISVSLHQPEEVQKLVERSHAEEVIRWNAQTVAARLRVLADDILYHRLPTRFTMEKQIGALEKIARQHPDNPVGQFCYWHFSRIARVLRTQKPLYARDLLADKQRRMPLLPALKSYLSLKSPALRNAGRLSVMLSVASLMGTALHLPKSYWILMTVLLVTQNGYGATRLRIVNRSVGTVVGLIIAGVALHFKIPEGYTLTLMLITTLASYLILRKNYGWATVGFTITAVYTLQLLWLNGEQYILPRLIDTIIGCLIAFGGTVWLWPQWQSGLLRKNAHDALEAYQEAIRLILSEDPQPTPLAWQRMRVNQAHNTLYNSLNQAMQEPAFNSHYLADMKLWVTHSQFIVEHINAMTTLAREHRALPPELAQEYLQSCEIAIQRCQQRLEYDEPGSSGDANIMDAPEMQPHEGAAGTLEQHLQRVIGHLNTMHTISSMAWRQRPHHGIWLSRKLRDSKA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12906
Length:	700 (614)
Sequences:	2222 (1762)
Seq/√Len:	71.1

ECOLI - YHFK YCCS MDTO
BACSU - YVAC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
619_C	623_I	4.266	1.00
181_E	281_R	4.123	1.00
381_A	400_V	3.925	1.00
245_H	248_V	3.363	1.00
93_F	97_G	3.358	1.00
96_T	375_S	3.304	1.00
324_H	328_I	3.249	1.00
377_M	400_V	3.240	1.00
377_M	500_I	3.215	1.00
96_T	379_S	3.141	1.00
272_N	276_V	2.899	1.00
329_A	332_L	2.831	1.00
24_V	152_F	2.824	1.00
513_Q	565_Q	2.820	1.00
214_C	217_Q	2.770	1.00
236_F	240_L	2.709	1.00
140_L	144_L	2.707	1.00
283_L	287_I	2.667	1.00
211_I	214_C	2.656	1.00
46_L	49_A	2.656	1.00
377_M	504_G	2.636	1.00
151_L	155_F	2.614	1.00
280_L	284_A	2.577	1.00
395_W	422_T	2.574	1.00
283_L	286_D	2.574	1.00
299_E	302_I	2.388	1.00
235_I	238_E	2.307	1.00
497_G	501_A	2.295	1.00
173_Y	176_L	2.274	1.00
212_T	215_Y	2.235	1.00
240_L	244_E	2.233	1.00
335_Q	339_Y	2.214	1.00
321_C	324_H	2.206	1.00
240_L	246_I	2.159	1.00
396_I	493_D	2.157	1.00
225_N	228_D	2.155	1.00
324_H	331_V	2.150	1.00
301_Q	305_L	2.149	1.00
100_L	368_L	2.144	1.00
324_H	327_R	2.105	1.00
444_T	448_I	2.050	1.00
396_I	496_I	2.046	1.00
324_H	329_A	2.045	1.00
612_A	615_Y	2.035	1.00
222_S	226_N	2.031	1.00
234_R	238_E	2.030	1.00
235_I	244_E	2.018	1.00
336_K	339_Y	2.012	1.00
294_T	309_A	2.010	1.00
329_A	339_Y	1.987	1.00
320_F	323_W	1.984	1.00
100_L	375_S	1.984	1.00
192_D	195_K	1.977	1.00
329_A	335_Q	1.959	1.00
403_V	461_Y	1.958	1.00
28_P	148_W	1.952	1.00
295_R	302_I	1.942	1.00
529_Q	620_E	1.931	1.00
399_T	494_T	1.930	1.00
331_V	334_T	1.927	1.00
305_L	308_I	1.874	1.00
58_T	62_R	1.874	1.00
151_L	154_W	1.857	1.00
240_L	243_Q	1.842	1.00
136_W	139_L	1.841	1.00
177_A	495_I	1.833	1.00
99_T	378_L	1.833	1.00
305_L	309_A	1.831	1.00
322_Y	326_S	1.831	1.00
381_A	500_I	1.818	1.00
615_Y	623_I	1.806	1.00
284_A	288_L	1.793	1.00
28_P	41_G	1.767	1.00
528_Y	587_S	1.752	1.00
327_R	333_R	1.751	1.00
276_V	280_L	1.750	1.00
408_Y	570_P	1.726	1.00
384_M	500_I	1.725	1.00
75_A	143_A	1.722	1.00
320_F	324_H	1.707	1.00
22_T	447_L	1.705	1.00
355_P	358_K	1.705	1.00
392_K	395_W	1.702	1.00
109_G	112_H	1.696	1.00
220_M	223_A	1.695	1.00
395_W	497_G	1.690	1.00
222_S	225_N	1.689	1.00
18_A	451_L	1.680	1.00
472_A	476_L	1.678	1.00
449_T	452_A	1.676	1.00
545_L	548_Q	1.666	1.00
324_H	335_Q	1.664	1.00
611_L	614_E	1.656	1.00
295_R	318_G	1.650	0.99
414_R	461_Y	1.647	0.99
303_G	306_E	1.640	0.99
322_Y	325_F	1.639	0.99
449_T	470_I	1.629	0.99
45_S	49_A	1.626	0.99
301_Q	304_A	1.615	0.99
450_T	453_S	1.612	0.99
92_P	379_S	1.604	0.99
221_L	224_Q	1.601	0.99
293_P	297_T	1.593	0.99
384_M	496_I	1.590	0.99
213_Q	217_Q	1.584	0.99
322_Y	329_A	1.581	0.99
95_L	123_A	1.580	0.99
351_M	354_L	1.579	0.99
299_E	303_G	1.577	0.99
328_I	331_V	1.573	0.99
326_S	330_R	1.569	0.99
233_L	239_A	1.564	0.99
382_S	397_L	1.561	0.99
277_A	280_L	1.558	0.99
67_L	150_G	1.554	0.99
370_N	406_N	1.553	0.99
560_Y	588_Q	1.549	0.99
301_Q	308_I	1.546	0.99
229_Y	233_L	1.536	0.99
22_T	26_C	1.529	0.99
50_C	53_I	1.528	0.99
373_R	395_W	1.527	0.99
302_I	308_I	1.527	0.99
223_A	226_N	1.525	0.99
616_L	620_E	1.525	0.99
181_E	277_A	1.523	0.99
615_Y	619_C	1.521	0.99
257_Q	261_E	1.510	0.99
294_T	297_T	1.510	0.99
231_R	236_F	1.503	0.99
219_H	222_S	1.500	0.99
533_R	620_E	1.488	0.99
282_V	287_I	1.485	0.99
255_E	259_L	1.483	0.99
175_E	178_D	1.482	0.99
423_V	427_I	1.482	0.99
89_V	93_F	1.481	0.99
330_R	424_V	1.478	0.99
46_L	50_C	1.471	0.99
439_E	442_T	1.468	0.99
241_D	245_H	1.467	0.99
83_L	87_K	1.463	0.99
323_W	326_S	1.454	0.99
358_K	361_L	1.452	0.99
208_V	211_I	1.443	0.99
396_I	500_I	1.441	0.99
223_A	227_T	1.440	0.99
235_I	243_Q	1.421	0.98
28_P	32_G	1.420	0.98
177_A	277_A	1.413	0.98
306_E	310_R	1.408	0.98
369_R	509_W	1.406	0.98
207_A	218_M	1.400	0.98
360_Y	365_S	1.400	0.98
99_T	104_V	1.397	0.98
210_L	214_C	1.390	0.98
277_A	281_R	1.390	0.98
303_G	307_K	1.389	0.98
304_A	308_I	1.389	0.98
293_P	302_I	1.385	0.98
378_L	401_L	1.381	0.98
619_C	622_A	1.380	0.98
422_T	469_T	1.377	0.98
615_Y	622_A	1.370	0.98
422_T	494_T	1.369	0.98
449_T	453_S	1.355	0.98
72_S	76_T	1.352	0.98
235_I	240_L	1.350	0.98
635_P	638_S	1.349	0.98
231_R	240_L	1.346	0.98
527_A	555_A	1.345	0.98
273_A	284_A	1.344	0.98
295_R	305_L	1.344	0.98
296_F	306_E	1.342	0.98
423_V	491_L	1.342	0.98
233_L	236_F	1.339	0.98
329_A	336_K	1.339	0.98
103_G	374_L	1.337	0.98
235_I	241_D	1.335	0.98
312_H	318_G	1.327	0.98
327_R	337_P	1.327	0.98
204_Q	208_V	1.322	0.98
221_L	226_N	1.319	0.98
315_N	318_G	1.317	0.97
20_R	158_W	1.317	0.97
328_I	332_L	1.314	0.97
272_N	283_L	1.313	0.97
324_H	338_L	1.311	0.97
229_Y	234_R	1.308	0.97
612_A	619_C	1.305	0.97
84_L	94_L	1.296	0.97
221_L	225_N	1.296	0.97
320_F	327_R	1.295	0.97
490_R	497_G	1.293	0.97
634_E	637_S	1.293	0.97
281_R	284_A	1.292	0.97
242_L	249_S	1.292	0.97
220_M	224_Q	1.291	0.97
84_L	92_P	1.290	0.97
145_G	283_L	1.290	0.97
232_M	238_E	1.285	0.97
447_L	454_Y	1.285	0.97
484_E	488_L	1.281	0.97
512_W	570_P	1.278	0.97
404_T	422_T	1.273	0.97
100_L	104_V	1.272	0.97
454_Y	457_L	1.272	0.97
320_F	332_L	1.271	0.97
92_P	95_L	1.270	0.97
396_I	399_T	1.269	0.97
331_V	335_Q	1.269	0.97
353_L	356_A	1.260	0.97
383_L	387_A	1.256	0.97
243_Q	247_S	1.252	0.97
622_A	629_R	1.244	0.96
312_H	317_V	1.239	0.96
352_P	360_Y	1.235	0.96
450_T	455_L	1.234	0.96
321_C	328_I	1.233	0.96
439_E	444_T	1.231	0.96
276_V	281_R	1.230	0.96
576_Y	580_M	1.229	0.96
242_L	245_H	1.224	0.96
465_T	468_F	1.224	0.96
424_V	466_V	1.223	0.96
476_L	486_Y	1.218	0.96
94_L	98_L	1.215	0.96
406_N	513_Q	1.204	0.96
451_L	456_I	1.200	0.96
99_T	103_G	1.199	0.96
241_D	244_E	1.198	0.96
631_E	634_E	1.197	0.96
363_L	508_L	1.193	0.95
541_Q	544_P	1.192	0.95
271_W	275_T	1.191	0.95
435_F	442_T	1.191	0.95
37_E	41_G	1.186	0.95
260_V	264_H	1.186	0.95
421_G	490_R	1.183	0.95
496_I	499_L	1.182	0.95
103_G	107_E	1.181	0.95
571_A	574_S	1.179	0.95
166_R	177_A	1.178	0.95
231_R	238_E	1.175	0.95
306_E	309_A	1.170	0.95
322_Y	327_R	1.166	0.95
208_V	212_T	1.163	0.95
456_I	463_W	1.161	0.95
614_E	622_A	1.161	0.95
295_R	308_I	1.160	0.95
625_R	628_Q	1.160	0.95
293_P	299_E	1.159	0.95
308_I	318_G	1.159	0.95
408_Y	512_W	1.156	0.95
624_Q	627_Q	1.154	0.95
93_F	144_L	1.150	0.94
446_M	455_L	1.145	0.94
324_H	336_K	1.144	0.94
219_H	224_Q	1.143	0.94
95_L	103_G	1.140	0.94
230_K	236_F	1.140	0.94
556_H	560_Y	1.140	0.94
294_T	300_K	1.134	0.94
98_L	123_A	1.133	0.94
292_L	295_R	1.133	0.94
549_R	553_N	1.130	0.94
613_Q	617_Q	1.129	0.94
20_R	576_Y	1.125	0.94
454_Y	458_R	1.122	0.94
231_R	235_I	1.115	0.94
70_G	115_L	1.115	0.94
24_V	28_P	1.113	0.93
611_L	615_Y	1.111	0.93
618_S	628_Q	1.108	0.93
221_L	227_T	1.108	0.93
135_V	139_L	1.104	0.93
332_L	335_Q	1.103	0.93
624_Q	637_S	1.100	0.93
296_F	300_K	1.099	0.93
278_A	282_V	1.097	0.93
399_T	418_R	1.095	0.93
323_W	334_T	1.093	0.93
331_V	339_Y	1.090	0.93
48_P	52_N	1.089	0.93
306_E	311_Q	1.088	0.93
373_R	498_C	1.084	0.93
488_L	492_I	1.079	0.92
236_F	245_H	1.079	0.92
334_T	339_Y	1.076	0.92
534_L	537_S	1.073	0.92
624_Q	635_P	1.070	0.92
413_L	417_N	1.069	0.92
617_Q	636_G	1.068	0.92
450_T	454_Y	1.067	0.92
426_L	487_I	1.062	0.92
451_L	458_R	1.062	0.92
239_A	243_Q	1.055	0.91
294_T	298_M	1.052	0.91
324_H	334_T	1.052	0.91
273_A	277_A	1.052	0.91
328_I	337_P	1.050	0.91
311_Q	315_N	1.050	0.91
105_T	389_H	1.049	0.91
403_V	426_L	1.049	0.91
454_Y	467_G	1.049	0.91
447_L	451_L	1.046	0.91
327_R	334_T	1.043	0.91
629_R	634_E	1.042	0.91
446_M	453_S	1.037	0.91
624_Q	629_R	1.035	0.91
18_A	22_T	1.033	0.91
272_N	282_V	1.031	0.91
73_L	77_C	1.031	0.91
428_I	466_V	1.030	0.90
418_R	461_Y	1.029	0.90
449_T	454_Y	1.024	0.90
321_C	332_L	1.020	0.90
323_W	329_A	1.018	0.90
621_I	626_C	1.017	0.90
295_R	298_M	1.016	0.90
213_Q	216_Q	1.016	0.90
204_Q	210_L	1.011	0.90
102_L	106_A	1.009	0.90
60_H	157_F	1.007	0.89
604_H	607_L	1.007	0.89
44_F	48_P	1.006	0.89
206_K	210_L	1.006	0.89
75_A	139_L	1.005	0.89
407_G	410_A	1.004	0.89
616_L	623_I	0.997	0.89
299_E	310_R	0.996	0.89
178_D	182_A	0.995	0.89
297_T	301_Q	0.993	0.89
612_A	622_A	0.992	0.89
268_V	279_R	0.990	0.89
327_R	335_Q	0.989	0.89
618_S	629_R	0.987	0.88
258_K	264_H	0.985	0.88
329_A	338_L	0.982	0.88
229_Y	235_I	0.982	0.88
125_F	494_T	0.979	0.88
304_A	311_Q	0.977	0.88
71_A	146_T	0.974	0.88
319_Q	324_H	0.973	0.88
405_Q	414_R	0.972	0.88
377_M	415_I	0.971	0.88
233_L	240_L	0.967	0.87
632_Y	636_G	0.967	0.87
305_L	318_G	0.966	0.87
385_G	493_D	0.963	0.87
219_H	223_A	0.962	0.87
45_S	526_E	0.961	0.87
274_Q	278_A	0.961	0.87
211_I	218_M	0.954	0.87
330_R	337_P	0.953	0.87
201_L	204_Q	0.953	0.87
370_N	402_L	0.952	0.87
322_Y	334_T	0.951	0.87
213_Q	218_M	0.949	0.86
326_S	333_R	0.949	0.86
133_M	136_W	0.945	0.86
23_L	376_V	0.945	0.86
269_I	283_L	0.943	0.86
55_G	58_T	0.942	0.86
324_H	332_L	0.937	0.86
542_P	545_L	0.935	0.86
323_W	327_R	0.934	0.86
177_A	281_R	0.933	0.86
404_T	501_A	0.930	0.85
204_Q	215_Y	0.930	0.85
58_T	74_F	0.928	0.85
633_D	638_S	0.928	0.85
297_T	302_I	0.926	0.85
82_Q	138_P	0.923	0.85
371_A	375_S	0.916	0.84
629_R	637_S	0.914	0.84
271_W	274_Q	0.913	0.84
220_M	233_L	0.910	0.84
137_E	428_I	0.910	0.84
370_N	501_A	0.909	0.84
204_Q	214_C	0.907	0.84
178_D	278_A	0.907	0.84
304_A	309_A	0.904	0.84
472_A	494_T	0.903	0.84
168_S	214_C	0.901	0.83
327_R	331_V	0.901	0.83
327_R	332_L	0.900	0.83
380_V	383_L	0.898	0.83
276_V	282_V	0.898	0.83
307_K	310_R	0.897	0.83
266_E	280_L	0.895	0.83
31_V	35_L	0.890	0.83
492_I	496_I	0.889	0.83
582_L	586_H	0.889	0.83
174_R	288_L	0.889	0.83
142_Y	400_V	0.888	0.83
259_L	262_R	0.888	0.83
566_A	586_H	0.887	0.83
299_E	304_A	0.887	0.83
112_H	115_L	0.884	0.82
298_M	306_E	0.884	0.82
90_P	94_L	0.883	0.82
212_T	216_Q	0.882	0.82
148_W	152_F	0.882	0.82
264_H	268_V	0.881	0.82
461_Y	497_G	0.880	0.82
446_M	454_Y	0.880	0.82
395_W	469_T	0.880	0.82
260_V	265_A	0.878	0.82
403_V	497_G	0.878	0.82
270_R	282_V	0.878	0.82
237_Q	243_Q	0.877	0.82
202_V	206_K	0.876	0.82
230_K	242_L	0.873	0.82
464_A	468_F	0.872	0.81
524_A	552_V	0.870	0.81
237_Q	242_L	0.869	0.81
61_K	65_K	0.868	0.81
373_R	553_N	0.866	0.81
294_T	310_R	0.865	0.81
240_L	245_H	0.864	0.81
193_P	196_A	0.863	0.81
394_Y	493_D	0.863	0.81
634_E	638_S	0.857	0.80
298_M	301_Q	0.857	0.80
276_V	284_A	0.851	0.80
612_A	623_I	0.849	0.80
240_L	247_S	0.846	0.79
431_V	499_L	0.845	0.79
617_Q	620_E	0.844	0.79
461_Y	465_T	0.843	0.79
443_L	455_L	0.838	0.79
554_Q	558_T	0.837	0.79
381_A	396_I	0.837	0.79
66_R	73_L	0.836	0.79
39_R	97_G	0.835	0.79
210_L	217_Q	0.834	0.78
18_A	455_L	0.834	0.78
375_S	379_S	0.834	0.78
260_V	263_S	0.832	0.78
275_T	278_A	0.831	0.78
43_L	50_C	0.831	0.78
185_S	199_P	0.830	0.78
45_S	50_C	0.830	0.78
242_L	247_S	0.828	0.78
237_Q	244_E	0.828	0.78
106_A	113_A	0.827	0.78
408_Y	494_T	0.827	0.78
618_S	622_A	0.827	0.78
308_I	311_Q	0.826	0.78
80_L	98_L	0.825	0.78
297_T	300_K	0.824	0.78
18_A	566_A	0.824	0.78
232_M	235_I	0.824	0.78
334_T	338_L	0.822	0.77
234_R	237_Q	0.822	0.77
612_A	616_L	0.822	0.77
205_Q	218_M	0.821	0.77
45_S	475_T	0.818	0.77
265_A	270_R	0.815	0.77
207_A	211_I	0.814	0.77
324_H	339_Y	0.813	0.77
18_A	26_C	0.811	0.76
494_T	512_W	0.811	0.76
280_L	287_I	0.809	0.76
177_A	376_V	0.808	0.76
526_E	631_E	0.807	0.76
353_L	357_L	0.807	0.76
455_L	458_R	0.805	0.76
25_L	68_I	0.803	0.76
287_I	333_R	0.802	0.76
326_S	338_L	0.799	0.75
496_I	558_T	0.799	0.75
276_V	283_L	0.797	0.75
295_R	306_E	0.797	0.75
275_T	285_D	0.797	0.75
211_I	217_Q	0.797	0.75
200_L	211_I	0.796	0.75
212_T	218_M	0.795	0.75
124_I	524_A	0.795	0.75
241_D	249_S	0.795	0.75
373_R	569_E	0.795	0.75
95_L	102_L	0.794	0.75
436_K	445_L	0.794	0.75
447_L	458_R	0.794	0.75
467_G	517_L	0.792	0.75
625_R	629_R	0.791	0.75
239_A	499_L	0.788	0.74
326_S	334_T	0.788	0.74
489_P	493_D	0.787	0.74
20_R	152_F	0.787	0.74
273_A	280_L	0.787	0.74
443_L	498_C	0.787	0.74
612_A	618_S	0.785	0.74
535_I	594_I	0.785	0.74
125_F	394_Y	0.785	0.74
45_S	48_P	0.784	0.74
237_Q	245_H	0.784	0.74
395_W	494_T	0.783	0.74
620_E	624_Q	0.783	0.74
280_L	288_L	0.782	0.74
84_L	90_P	0.781	0.74
319_Q	325_F	0.780	0.74
300_K	308_I	0.780	0.74
406_N	531_A	0.780	0.74
352_P	356_A	0.780	0.74
503_G	564_N	0.776	0.73
544_P	548_Q	0.776	0.73
466_V	469_T	0.774	0.73
52_N	56_L	0.774	0.73
447_L	455_L	0.773	0.73
207_A	217_Q	0.773	0.73
620_E	627_Q	0.772	0.73
370_N	409_G	0.772	0.73
397_L	476_L	0.770	0.73
341_R	350_R	0.770	0.73
424_V	427_I	0.766	0.72
28_P	165_L	0.765	0.72
325_F	331_V	0.765	0.72
305_L	312_H	0.764	0.72
78_S	126_T	0.764	0.72
319_Q	333_R	0.764	0.72
296_F	309_A	0.763	0.72
190_H	194_E	0.763	0.72
484_E	487_I	0.762	0.72
415_I	502_F	0.759	0.72
307_K	311_Q	0.758	0.72
268_V	271_W	0.758	0.72
325_F	332_L	0.757	0.71
621_I	625_R	0.756	0.71
335_Q	338_L	0.756	0.71
628_Q	634_E	0.754	0.71
261_E	420_V	0.753	0.71
433_L	493_D	0.753	0.71
43_L	47_V	0.750	0.71
41_G	45_S	0.747	0.70
400_V	504_G	0.747	0.70
238_E	243_Q	0.746	0.70
220_M	225_N	0.743	0.70
113_A	429_A	0.742	0.70
616_L	632_Y	0.742	0.70
240_L	249_S	0.741	0.70
447_L	453_S	0.740	0.70
566_A	574_S	0.740	0.70
86_A	617_Q	0.739	0.70
588_Q	591_V	0.738	0.69
80_L	94_L	0.738	0.69
113_A	120_L	0.735	0.69
238_E	241_D	0.734	0.69
357_L	371_A	0.734	0.69
275_T	301_Q	0.733	0.69
151_L	318_G	0.733	0.69
322_Y	340_A	0.732	0.69
275_T	287_I	0.731	0.69
622_A	625_R	0.731	0.69
615_Y	636_G	0.730	0.69
331_V	338_L	0.729	0.69
273_A	281_R	0.728	0.68
22_T	32_G	0.727	0.68
320_F	335_Q	0.727	0.68
544_P	547_W	0.725	0.68
398_M	465_T	0.725	0.68
230_K	234_R	0.723	0.68
105_T	155_F	0.723	0.68
255_E	258_K	0.722	0.68
29_V	32_G	0.721	0.68
397_L	486_Y	0.720	0.68
429_A	473_V	0.719	0.67
446_M	474_Y	0.719	0.67
137_E	140_L	0.718	0.67
56_L	60_H	0.717	0.67
179_Y	183_K	0.716	0.67
316_P	319_Q	0.716	0.67
87_K	90_P	0.716	0.67
393_S	397_L	0.716	0.67
306_E	341_R	0.715	0.67
372_G	427_I	0.714	0.67
164_P	373_R	0.714	0.67
377_M	517_L	0.712	0.67
633_D	636_G	0.711	0.67
239_A	247_S	0.710	0.67
373_R	508_L	0.710	0.67
615_Y	618_S	0.710	0.67
369_R	411_T	0.708	0.66
587_S	591_V	0.707	0.66
89_V	372_G	0.707	0.66
331_V	336_K	0.707	0.66
235_I	242_L	0.706	0.66
231_R	234_R	0.706	0.66
158_W	427_I	0.705	0.66
202_V	211_I	0.705	0.66
205_Q	209_D	0.704	0.66
625_R	633_D	0.702	0.66
322_Y	335_Q	0.699	0.65
319_Q	329_A	0.698	0.65
387_A	431_V	0.698	0.65
49_A	53_I	0.697	0.65
370_N	512_W	0.696	0.65
319_Q	323_W	0.695	0.65
380_V	384_M	0.695	0.65
279_R	282_V	0.693	0.65
417_N	460_N	0.693	0.65
271_W	282_V	0.692	0.65
196_A	200_L	0.692	0.65
125_F	475_T	0.692	0.65
475_T	502_F	0.691	0.64
428_I	431_V	0.690	0.64
248_V	372_G	0.688	0.64
360_Y	368_L	0.688	0.64
152_F	156_W	0.686	0.64
49_A	584_V	0.685	0.64
611_L	617_Q	0.685	0.64
298_M	309_A	0.684	0.64
68_I	503_G	0.684	0.64
426_L	491_L	0.684	0.64
40_F	161_R	0.682	0.63
628_Q	632_Y	0.682	0.63
297_T	354_L	0.680	0.63
395_W	501_A	0.678	0.63
42_L	46_L	0.677	0.63
270_R	548_Q	0.677	0.63
27_L	31_V	0.675	0.63
228_D	231_R	0.675	0.63
244_E	248_V	0.675	0.63
373_R	509_W	0.675	0.63
449_T	456_I	0.674	0.62
301_Q	503_G	0.673	0.62
149_Y	382_S	0.673	0.62
51_C	440_G	0.673	0.62
403_V	498_C	0.671	0.62
296_F	308_I	0.670	0.62
364_K	372_G	0.669	0.62
614_E	618_S	0.669	0.62
44_F	49_A	0.669	0.62
399_T	408_Y	0.668	0.62
618_S	630_L	0.668	0.62
431_V	435_F	0.667	0.62
208_V	214_C	0.666	0.62
327_R	338_L	0.665	0.61
584_V	619_C	0.665	0.61
267_E	284_A	0.664	0.61
321_C	334_T	0.664	0.61
294_T	308_I	0.663	0.61
170_S	174_R	0.662	0.61
42_L	45_S	0.662	0.61
126_T	411_T	0.662	0.61
158_W	161_R	0.661	0.61
280_L	404_T	0.661	0.61
616_L	630_L	0.660	0.61
321_C	327_R	0.660	0.61
399_T	403_V	0.660	0.61
174_R	285_D	0.660	0.61
124_I	127_L	0.660	0.61
623_I	632_Y	0.659	0.61
40_F	44_F	0.658	0.61
614_E	624_Q	0.657	0.61
140_L	284_A	0.657	0.61
449_T	491_L	0.657	0.61
445_L	449_T	0.656	0.60
588_Q	593_H	0.655	0.60
327_R	339_Y	0.655	0.60
237_Q	249_S	0.653	0.60
111_L	114_K	0.651	0.60
114_K	122_A	0.651	0.60
334_T	337_P	0.651	0.60
420_V	424_V	0.651	0.60
27_L	152_F	0.650	0.60
386_T	583_W	0.650	0.60
466_V	474_Y	0.649	0.60
403_V	418_R	0.649	0.60
381_A	532_I	0.648	0.59
414_R	418_R	0.648	0.59
32_G	445_L	0.648	0.59
476_L	494_T	0.647	0.59
329_A	334_T	0.646	0.59
356_A	360_Y	0.646	0.59
445_L	614_E	0.646	0.59
114_K	473_V	0.646	0.59
615_Y	628_Q	0.645	0.59
592_E	595_N	0.645	0.59
228_D	281_R	0.644	0.59
173_Y	239_A	0.644	0.59
586_H	623_I	0.643	0.59
431_V	496_I	0.642	0.59
239_A	242_L	0.642	0.59
173_Y	218_M	0.641	0.59
300_K	309_A	0.640	0.59
321_C	333_R	0.640	0.59
266_E	269_I	0.640	0.59
325_F	328_I	0.640	0.59
178_D	185_S	0.639	0.58
106_A	405_Q	0.638	0.58
625_R	634_E	0.637	0.58
211_I	215_Y	0.637	0.58
349_R	352_P	0.636	0.58
236_F	247_S	0.635	0.58
106_A	409_G	0.632	0.58
324_H	333_R	0.632	0.58
355_P	360_Y	0.631	0.57
320_F	330_R	0.628	0.57
46_L	54_A	0.628	0.57
535_I	539_D	0.628	0.57
470_I	506_V	0.628	0.57
141_I	473_V	0.627	0.57
322_Y	328_I	0.627	0.57
453_S	497_G	0.626	0.57
182_A	203_R	0.625	0.57
37_E	40_F	0.625	0.57
403_V	414_R	0.621	0.56
297_T	303_G	0.620	0.56
453_S	456_I	0.619	0.56
563_L	580_M	0.619	0.56
58_T	145_G	0.619	0.56
365_S	368_L	0.618	0.56
269_I	280_L	0.618	0.56
245_H	264_H	0.617	0.56
28_P	31_V	0.617	0.56
614_E	620_E	0.616	0.56
206_K	213_Q	0.616	0.56
325_F	335_Q	0.615	0.56
490_R	510_P	0.613	0.55
225_N	233_L	0.613	0.55
322_Y	331_V	0.613	0.55
274_Q	619_C	0.612	0.55
371_A	411_T	0.610	0.55
100_L	111_L	0.610	0.55
237_Q	240_L	0.610	0.55
112_H	116_L	0.609	0.55
274_Q	282_V	0.609	0.55
269_I	284_A	0.609	0.55
340_A	619_C	0.608	0.55
53_I	57_D	0.608	0.55
582_L	587_S	0.608	0.55
200_L	266_E	0.608	0.55
101_V	445_L	0.607	0.55
622_A	630_L	0.607	0.55
495_I	499_L	0.607	0.55
303_G	311_Q	0.606	0.54
243_Q	249_S	0.606	0.54
395_W	490_R	0.605	0.54
267_E	270_R	0.604	0.54
219_H	225_N	0.604	0.54
169_L	500_I	0.604	0.54
297_T	310_R	0.604	0.54
632_Y	635_P	0.604	0.54
436_K	473_V	0.603	0.54
543_T	546_A	0.603	0.54
429_A	497_G	0.602	0.54
209_D	376_V	0.601	0.54
60_H	63_F	0.601	0.54
233_L	237_Q	0.599	0.54
327_R	330_R	0.598	0.53
524_A	587_S	0.597	0.53
119_S	124_I	0.597	0.53
244_E	247_S	0.597	0.53
197_L	200_L	0.595	0.53
142_Y	179_Y	0.594	0.53
617_Q	638_S	0.594	0.53
200_L	629_R	0.593	0.53
113_A	374_L	0.593	0.53
97_G	101_V	0.592	0.53
618_S	633_D	0.592	0.53
543_T	547_W	0.592	0.53
49_A	52_N	0.590	0.52
258_K	261_E	0.589	0.52
369_R	401_L	0.588	0.52
423_V	495_I	0.588	0.52
48_P	81_T	0.587	0.52
74_F	142_Y	0.587	0.52
518_R	574_S	0.586	0.52
492_I	626_C	0.585	0.52
300_K	304_A	0.584	0.52
107_E	112_H	0.583	0.52
621_I	633_D	0.582	0.51
320_F	333_R	0.581	0.51
155_F	606_A	0.581	0.51
57_D	368_L	0.581	0.51
269_I	273_A	0.580	0.51
377_M	509_W	0.580	0.51
267_E	271_W	0.580	0.51
298_M	329_A	0.579	0.51
299_E	503_G	0.578	0.51
385_G	395_W	0.578	0.51
433_L	443_L	0.578	0.51
54_A	57_D	0.578	0.51
77_C	142_Y	0.576	0.51
479_L	483_G	0.575	0.51
117_P	398_M	0.574	0.51
203_R	206_K	0.574	0.51
293_P	303_G	0.573	0.50
522_H	529_Q	0.572	0.50
236_F	241_D	0.571	0.50
406_N	501_A	0.571	0.50
84_L	211_I	0.570	0.50
625_R	630_L	0.569	0.50
32_G	152_F	0.569	0.50
230_K	233_L	0.568	0.50
178_D	306_E	0.568	0.50
72_S	376_V	0.568	0.50
302_I	318_G	0.567	0.50
320_F	328_I	0.567	0.50
124_I	141_I	0.566	0.50
393_S	421_G	0.566	0.50
454_Y	552_V	0.565	0.49
279_R	283_L	0.564	0.49
630_L	635_P	0.564	0.49
293_P	499_L	0.564	0.49
472_A	528_Y	0.564	0.49
153_N	498_C	0.563	0.49
374_L	531_A	0.563	0.49
133_M	137_E	0.562	0.49
93_F	295_R	0.561	0.49
177_A	284_A	0.560	0.49
615_Y	625_R	0.559	0.49
232_M	243_Q	0.558	0.49
632_Y	638_S	0.557	0.48
618_S	623_I	0.557	0.48
403_V	518_R	0.556	0.48
614_E	617_Q	0.555	0.48
289_Y	292_L	0.555	0.48
367_A	411_T	0.554	0.48
130_A	138_P	0.554	0.48
209_D	214_C	0.552	0.48
26_C	444_T	0.552	0.48
430_G	434_H	0.550	0.48
613_Q	633_D	0.550	0.48
630_L	637_S	0.549	0.47
394_Y	494_T	0.548	0.47
153_N	159_I	0.547	0.47
395_W	404_T	0.547	0.47
190_H	325_F	0.547	0.47
231_R	247_S	0.547	0.47
17_Y	20_R	0.546	0.47
201_L	213_Q	0.546	0.47
407_G	570_P	0.546	0.47
273_A	602_R	0.544	0.47
444_T	447_L	0.544	0.47
293_P	296_F	0.543	0.47
405_Q	508_L	0.543	0.47
308_I	312_H	0.542	0.47
199_P	448_I	0.541	0.46
15_I	18_A	0.539	0.46
223_A	235_I	0.539	0.46
54_A	60_H	0.538	0.46
58_T	61_K	0.538	0.46
63_F	373_R	0.536	0.46
253_P	260_V	0.535	0.46
264_H	267_E	0.535	0.46
341_R	347_K	0.535	0.46
327_R	336_K	0.535	0.46
266_E	277_A	0.534	0.46
233_L	249_S	0.534	0.46
302_I	306_E	0.532	0.45
208_V	402_L	0.531	0.45
50_C	125_F	0.531	0.45
617_Q	621_I	0.530	0.45
329_A	337_P	0.530	0.45
301_Q	309_A	0.529	0.45
309_A	318_G	0.528	0.45
118_A	125_F	0.527	0.45
176_L	426_L	0.527	0.45
379_S	383_L	0.526	0.45
620_E	629_R	0.526	0.45
249_S	252_Q	0.524	0.44
231_R	242_L	0.524	0.44
258_K	262_R	0.524	0.44
443_L	447_L	0.524	0.44
294_T	299_E	0.524	0.44
233_L	238_E	0.523	0.44
312_H	315_N	0.523	0.44
625_R	632_Y	0.523	0.44
356_A	359_S	0.523	0.44
620_E	628_Q	0.522	0.44
101_V	305_L	0.522	0.44
319_Q	336_K	0.521	0.44
395_W	493_D	0.521	0.44
63_F	403_V	0.519	0.44
628_Q	638_S	0.519	0.44
621_I	629_R	0.518	0.44
332_L	339_Y	0.518	0.44
285_D	288_L	0.517	0.44
145_G	491_L	0.516	0.43
16_N	26_C	0.516	0.43
298_M	311_Q	0.516	0.43
118_A	429_A	0.516	0.43
272_N	523_D	0.516	0.43
152_F	155_F	0.514	0.43
235_I	239_A	0.514	0.43
235_I	246_I	0.514	0.43
355_P	359_S	0.513	0.43
429_A	510_P	0.513	0.43
621_I	627_Q	0.513	0.43
99_T	107_E	0.512	0.43
268_V	285_D	0.511	0.43
23_L	522_H	0.511	0.43
460_N	466_V	0.510	0.43
429_A	486_Y	0.509	0.43
205_Q	216_Q	0.509	0.43
409_G	514_S	0.509	0.43
354_L	358_K	0.509	0.43
309_A	427_I	0.508	0.43
357_L	360_Y	0.508	0.43
612_A	620_E	0.507	0.42
398_M	487_I	0.506	0.42
48_P	322_Y	0.506	0.42
25_L	28_P	0.505	0.42
296_F	303_G	0.505	0.42
266_E	276_V	0.505	0.42
43_L	378_L	0.504	0.42
24_V	56_L	0.504	0.42
614_E	625_R	0.503	0.42
63_F	370_N	0.503	0.42
339_Y	503_G	0.503	0.42
207_A	210_L	0.502	0.42
404_T	473_V	0.502	0.42
259_L	263_S	0.501	0.42
165_L	407_G	0.501	0.42
487_I	491_L	0.501	0.42
155_F	341_R	0.500	0.42
236_F	242_L	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cgkA	3	0.25	33	0.971	Contact Map
4q4gX	1	0	23.5	0.973	Contact Map
4ltoA	3	0.1914	22.4	0.973	Contact Map
2f95B	2	0.0686	22.2	0.973	Contact Map
2ksfA	1	0.1386	19.6	0.974	Contact Map
4j2cA	1	0.1357	19.1	0.974	Contact Map
4cbcA	3	0.1243	15	0.975	Contact Map
1tr2A	1	0.2643	14.3	0.976	Contact Map
4ea3A	2	0.0829	12.8	0.976	Contact Map
2c5kT	1	0.1271	12.8	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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