GREMLIN Database
YHET - Putative esterase YheT
UniProt: P45524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12904
Length: 340 (313)
Sequences: 1867 (1378)
Seq/√Len: 77.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_I272_T4.0891.00
75_L97_A4.0151.00
163_L175_A3.8701.00
28_H199_Y3.7451.00
161_C264_M3.4871.00
301_Q326_R3.2401.00
161_C165_K3.2331.00
47_W61_A3.2321.00
313_G325_S3.0231.00
53_P133_W3.0181.00
254_D258_Q2.9551.00
51_E118_R2.9401.00
149_A159_L2.9201.00
94_V104_G2.8981.00
250_A254_D2.7861.00
160_A272_T2.7841.00
49_R59_D2.7481.00
149_A172_V2.6791.00
59_D113_S2.6411.00
176_V331_L2.4641.00
132_S166_E2.4521.00
60_L105_V2.4011.00
61_A85_L2.3951.00
278_K304_E2.3901.00
128_T165_K2.3291.00
77_V90_A2.2951.00
128_T161_C2.2461.00
76_V135_L2.2241.00
48_Q141_E2.2191.00
48_Q62_W2.0921.00
160_A177_I2.0751.00
148_A331_L2.0091.00
59_D115_E1.9921.00
240_D251_D1.9761.00
49_R115_E1.9751.00
180_A261_A1.9431.00
100_R332_T1.9411.00
124_H249_Y1.9041.00
132_S136_R1.8991.00
176_V327_I1.8871.00
157_N261_A1.8601.00
239_D256_Y1.8451.00
163_L270_K1.8101.00
249_Y258_Q1.7661.00
314_G317_L1.7601.00
234_R237_E1.7491.00
157_N161_C1.7081.00
175_A270_K1.7071.00
52_L58_V1.6951.00
57_F118_R1.6931.00
78_F109_F1.6881.00
179_S311_F1.6851.00
49_R113_S1.6701.00
121_R127_E1.6581.00
62_W105_V1.6541.00
31_T307_G1.6461.00
236_R253_I1.6411.00
18_F21_M1.6381.00
161_C164_A1.6031.00
205_N208_K1.6001.00
177_I180_A1.5811.00
55_G119_M1.5540.99
103_L145_A1.5530.99
137_W141_E1.5520.99
49_R57_F1.5420.99
82_E210_N1.5350.99
195_F198_V1.5310.99
185_E253_I1.5280.99
78_F131_A1.5240.99
178_V327_I1.5220.99
207_L238_F1.5180.99
84_S87_S1.5160.99
52_L133_W1.5130.99
192_E236_R1.4620.99
156_G180_A1.4560.99
192_E200_Q1.4560.99
72_K103_L1.4440.99
131_A158_M1.4420.99
73_P146_P1.4390.99
78_F158_M1.4220.99
79_H112_C1.4190.99
183_M186_A1.3930.99
239_D243_T1.3910.99
168_N269_A1.3880.99
167_G170_L1.3860.99
100_R329_D1.3850.99
78_F159_L1.3750.99
92_G324_E1.3720.99
186_A284_D1.3660.99
132_S162_L1.3440.98
97_A104_G1.3110.98
240_D252_A1.3000.98
160_A274_I1.2900.98
30_Q279_D1.2850.98
148_A174_A1.2830.98
74_R145_A1.2830.98
125_S184_L1.2820.98
170_L270_K1.2800.98
164_A264_M1.2780.98
38_R92_G1.2680.98
178_V275_I1.2560.97
175_A272_T1.2460.97
20_P305_H1.2450.97
48_Q137_W1.2400.97
225_N228_Q1.2320.97
212_A230_K1.2200.97
105_V138_L1.2190.97
290_K302_L1.2010.97
77_V94_V1.1980.97
204_L208_K1.1950.97
85_L106_V1.1940.97
183_M262_M1.1930.97
146_P173_D1.1920.97
63_S98_Q1.1850.96
182_F274_I1.1770.96
109_F123_Y1.1760.96
307_G310_G1.1670.96
56_D60_L1.1670.96
160_A261_A1.1670.96
244_A252_A1.1410.96
95_E99_K1.1350.95
274_I298_V1.1340.95
61_A106_V1.1320.95
25_S305_H1.1310.95
229_L232_V1.1300.95
278_K302_L1.1280.95
81_L207_L1.1280.95
56_D59_D1.1280.95
283_M287_V1.1240.95
51_E55_G1.1240.95
78_F107_M1.1200.95
57_F115_E1.1180.95
38_R324_E1.1180.95
273_L301_Q1.1100.95
159_L163_L1.1090.95
163_L170_L1.1080.95
228_Q241_L1.1060.95
73_P102_W1.1030.95
85_L108_H1.1010.95
111_G116_P1.1000.95
82_E112_C1.0990.95
80_G89_Y1.0880.94
303_T311_F1.0870.94
126_G259_C1.0860.94
161_C261_A1.0830.94
96_A100_R1.0760.94
186_A286_Q1.0560.93
25_S29_L1.0450.93
150_V327_I1.0430.93
139_Q173_D1.0400.93
139_Q171_P1.0370.93
57_F113_S1.0350.93
54_D58_V1.0340.93
190_H196_S1.0330.92
81_L203_L1.0330.92
24_F29_L1.0200.92
24_F33_L1.0170.92
109_F158_M1.0100.92
98_Q104_G0.9990.91
152_Y309_V0.9950.91
54_D62_W0.9900.91
18_F30_Q0.9890.91
232_V241_L0.9870.91
132_S165_K0.9840.91
35_R202_Y0.9810.90
76_V107_M0.9800.90
97_A328_P0.9790.90
86_N91_H0.9730.90
190_H193_K0.9720.90
47_W85_L0.9580.89
121_R129_E0.9540.89
125_S154_L0.9500.89
156_G177_I0.9430.89
136_R171_P0.9420.89
242_I246_I0.9370.88
117_N214_K0.9330.88
93_L178_V0.9330.88
263_P266_N0.9310.88
50_L133_W0.9220.87
321_M324_E0.9220.87
48_Q105_V0.9150.87
181_P184_L0.9130.87
176_V273_L0.9080.87
154_L260_S0.9040.86
226_L229_L0.9040.86
236_R252_A0.9020.86
278_K285_H0.9010.86
323_L327_I0.8950.86
57_F119_M0.8870.85
94_V242_I0.8850.85
184_L260_S0.8840.85
74_R103_L0.8830.85
200_Q235_I0.8810.85
79_H274_I0.8760.85
76_V138_L0.8750.85
125_S255_Y0.8750.85
147_T171_P0.8680.84
211_A229_L0.8660.84
185_E257_R0.8650.84
167_G269_A0.8620.84
74_R138_L0.8560.83
160_A180_A0.8530.83
226_L230_K0.8510.83
72_K145_A0.8480.83
56_D117_N0.8480.83
77_V152_Y0.8410.82
249_Y259_C0.8400.82
47_W59_D0.8360.82
82_E203_L0.8360.82
90_A106_V0.8350.82
16_A329_D0.8340.82
148_A173_D0.8250.81
188_S235_I0.8110.80
47_W106_V0.8030.79
120_H246_I0.8000.79
125_S214_K0.7980.79
111_G210_N0.7930.78
58_V107_M0.7920.78
251_D254_D0.7900.78
16_A301_Q0.7870.78
45_P106_V0.7860.78
215_L218_Y0.7850.78
275_I322_W0.7790.77
164_A268_I0.7780.77
81_L239_D0.7760.77
46_Y64_E0.7750.77
62_W137_W0.7730.76
211_A242_I0.7720.76
45_P85_L0.7720.76
288_I302_L0.7670.76
74_R105_V0.7630.76
147_T172_V0.7610.75
73_P145_A0.7600.75
126_G165_K0.7590.75
45_P94_V0.7570.75
137_W140_R0.7560.75
99_K231_S0.7520.74
109_F157_N0.7500.74
135_L147_T0.7480.74
109_F247_H0.7480.74
27_C276_H0.7440.74
151_G155_G0.7430.74
93_L150_V0.7430.74
71_H144_H0.7420.73
157_N164_A0.7390.73
21_M24_F0.7350.73
179_S309_V0.7340.73
45_P61_A0.7330.73
189_Y236_R0.7320.72
160_A268_I0.7320.72
157_N165_K0.7310.72
62_W138_L0.7300.72
97_A327_I0.7250.72
51_E57_F0.7230.72
154_L255_Y0.7220.71
157_N264_M0.7220.71
50_L58_V0.7220.71
177_I272_T0.7180.71
105_V150_V0.7170.71
179_S276_H0.7150.71
96_A325_S0.7140.71
273_L330_W0.7140.71
233_R237_E0.7080.70
102_W148_A0.7070.70
127_E247_H0.7070.70
58_V134_F0.7030.69
99_K150_V0.7010.69
54_D121_R0.7000.69
314_G319_P0.7000.69
157_N184_L0.6990.69
276_H288_I0.6970.69
153_S306_G0.6950.69
84_S113_S0.6930.68
22_R25_S0.6920.68
215_L229_L0.6890.68
185_E189_Y0.6840.67
129_E165_K0.6840.67
203_L206_L0.6840.67
52_L56_D0.6780.67
182_F261_A0.6770.67
232_V237_E0.6750.66
139_Q147_T0.6750.66
243_T256_Y0.6690.66
60_L134_F0.6680.65
159_L172_V0.6680.65
245_R248_G0.6680.65
80_G153_S0.6660.65
79_H83_G0.6660.65
329_D333_T0.6620.65
74_R147_T0.6600.65
45_P91_H0.6600.65
42_K99_K0.6590.64
269_A297_Q0.6580.64
32_M185_E0.6570.64
107_M134_F0.6560.64
292_E295_P0.6550.64
212_A229_L0.6550.64
325_S329_D0.6540.64
153_S308_H0.6520.64
183_M263_P0.6470.63
107_M130_D0.6470.63
109_F125_S0.6460.63
178_V333_T0.6460.63
72_K76_V0.6440.63
243_T260_S0.6440.63
131_A162_L0.6420.62
61_A113_S0.6400.62
80_G154_L0.6380.62
230_K237_E0.6370.62
152_Y178_V0.6360.62
52_L55_G0.6360.62
120_H281_P0.6340.61
193_K257_R0.6340.61
126_G258_Q0.6320.61
129_E177_I0.6320.61
200_Q203_L0.6290.61
210_N214_K0.6280.61
250_A258_Q0.6280.61
125_S157_N0.6280.61
289_P300_Y0.6270.61
281_P322_W0.6250.60
239_D244_A0.6240.60
142_F145_A0.6240.60
80_G108_H0.6220.60
47_W114_G0.6210.60
82_E206_L0.6200.60
102_W332_T0.6200.60
192_E234_R0.6200.60
140_R168_N0.6180.59
176_V275_I0.6180.59
291_P294_L0.6160.59
87_S311_F0.6150.59
220_G225_N0.6140.59
135_L139_Q0.6120.59
227_A230_K0.6120.59
21_M25_S0.6110.59
203_L214_K0.6110.59
79_H109_F0.6110.59
48_Q60_L0.6100.59
280_D306_G0.6060.58
62_W172_V0.6040.58
53_P101_G0.6040.58
312_I321_M0.6030.58
190_H284_D0.6030.58
54_D61_A0.6030.58
138_L147_T0.6020.58
28_H195_F0.6010.57
303_T322_W0.6000.57
30_Q281_P0.6000.57
112_C123_Y0.5990.57
123_Y154_L0.5990.57
273_L326_R0.5980.57
266_N295_P0.5960.57
29_L33_L0.5920.56
124_H247_H0.5910.56
257_R294_L0.5910.56
38_R321_M0.5880.56
154_L199_Y0.5860.55
96_A99_K0.5850.55
184_L187_C0.5850.55
37_F312_I0.5820.55
41_V91_H0.5810.55
76_V237_E0.5790.55
81_L124_H0.5780.54
154_L307_G0.5760.54
26_N29_L0.5750.54
41_V95_E0.5730.54
19_I26_N0.5720.54
93_L152_Y0.5720.54
149_A175_A0.5710.54
40_Q43_F0.5700.53
109_F154_L0.5690.53
110_R130_D0.5690.53
116_P119_M0.5690.53
211_A228_Q0.5690.53
259_C263_P0.5690.53
31_T239_D0.5660.53
82_E111_G0.5640.53
205_N213_R0.5620.52
133_W137_W0.5600.52
57_F214_K0.5600.52
203_L219_P0.5590.52
216_A219_P0.5590.52
222_L225_N0.5580.52
97_A145_A0.5580.52
118_R160_A0.5580.52
99_K332_T0.5550.52
213_R217_A0.5540.51
87_S112_C0.5540.51
275_I301_Q0.5530.51
94_V106_V0.5520.51
181_P243_T0.5520.51
33_L37_F0.5520.51
162_L262_M0.5510.51
107_M279_D0.5510.51
280_D308_H0.5500.51
50_L192_E0.5500.51
150_V331_L0.5490.51
62_W74_R0.5480.51
161_C256_Y0.5440.50
60_L251_D0.5430.50
156_G261_A0.5430.50
275_I302_L0.5430.50
52_L119_M0.5410.50
49_R56_D0.5410.50
219_P222_L0.5400.50
21_M314_G0.5400.50
74_R142_F0.5390.50
54_D57_F0.5380.49
216_A253_I0.5380.49
106_V117_N0.5380.49
164_A267_R0.5350.49
168_N296_P0.5350.49
47_W113_S0.5350.49
45_P62_W0.5340.49
83_G87_S0.5340.49
79_H124_H0.5320.49
126_G264_M0.5320.49
229_L329_D0.5310.48
64_E103_L0.5310.48
162_L170_L0.5300.48
82_E108_H0.5300.48
211_A215_L0.5290.48
171_P270_K0.5290.48
56_D62_W0.5290.48
32_M320_Q0.5280.48
82_E204_L0.5270.48
189_Y286_Q0.5270.48
235_I256_Y0.5260.48
167_G267_R0.5260.48
156_G298_V0.5250.48
70_Q241_L0.5240.48
56_D118_R0.5240.48
127_E158_M0.5240.48
311_F326_R0.5220.47
83_G255_Y0.5220.47
114_G123_Y0.5210.47
244_A251_D0.5210.47
108_H127_E0.5200.47
279_D302_L0.5180.47
87_S126_G0.5170.47
150_V284_D0.5160.47
32_M40_Q0.5140.46
247_H258_Q0.5130.46
257_R297_Q0.5130.46
270_K331_L0.5130.46
69_A72_K0.5130.46
164_A330_W0.5120.46
191_M206_L0.5110.46
24_F281_P0.5110.46
110_R113_S0.5110.46
139_Q144_H0.5110.46
231_S267_R0.5090.46
39_R129_E0.5080.46
18_F244_A0.5070.45
107_M131_A0.5060.45
31_T310_G0.5060.45
92_G321_M0.5060.45
136_R220_G0.5050.45
213_R216_A0.5050.45
294_L302_L0.5040.45
207_L259_C0.5040.45
17_E269_A0.5040.45
266_N290_K0.5030.45
211_A231_S0.5030.45
100_R328_P0.5030.45
276_H303_T0.5020.45
242_I276_H0.5020.45
198_V255_Y0.5010.45
113_S238_F0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e15A 1 0.7853 100 0.735 Contact Map
3iiiA 1 0.8735 100 0.74 Contact Map
1lnsA 2 0.9529 100 0.744 Contact Map
3hjuA 2 0.8294 99.9 0.749 Contact Map
1k8qA 1 0.9176 99.9 0.751 Contact Map
3k6kA 2 0.8029 99.9 0.759 Contact Map
2wtmA 2 0.7294 99.9 0.762 Contact Map
3i2kA 2 0.8676 99.9 0.763 Contact Map
2hdwA 2 0.8765 99.9 0.764 Contact Map
1thtA 2 0.75 99.9 0.766 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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