GREMLIN Database
FKBA - FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
UniProt: P45523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12900
Length: 270 (212)
Sequences: 1452 (1161)
Seq/√Len: 79.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_Q216_K4.3531.00
180_E186_T3.4621.00
172_K180_E3.4511.00
160_A210_K3.2461.00
214_K244_E3.1791.00
135_F149_V2.9681.00
172_K185_Y2.8401.00
205_G217_L2.7831.00
175_L179_K2.7601.00
234_P237_S2.7601.00
216_K242_D2.6651.00
126_A130_E2.5711.00
227_K236_N2.5131.00
211_K247_D2.4891.00
168_V247_D2.4341.00
210_K213_G2.3951.00
211_K248_V2.2911.00
169_V202_W2.2321.00
194_R197_G2.2251.00
205_G215_I2.2241.00
125_E129_K2.1621.00
129_K133_E2.1341.00
168_V192_S2.1211.00
151_Q218_V2.0641.00
94_S97_E2.0591.00
209_I215_I2.0501.00
214_K242_D2.0311.00
195_L205_G1.9901.00
217_L243_V1.9811.00
148_L223_L1.8711.00
229_G235_P1.8561.00
143_T149_V1.8541.00
221_P236_N1.8411.00
153_V216_K1.8101.00
172_K242_D1.7901.00
128_G238_T1.7831.00
184_S187_R1.7591.00
146_T204_E1.7441.00
161_P245_L1.7041.00
131_Y218_V1.6931.00
124_N128_G1.6761.00
163_D207_K1.6651.00
123_D127_K1.6611.00
229_G237_S1.6211.00
173_G181_F1.6211.00
164_S196_D1.6151.00
134_K138_E1.6061.00
122_A126_A1.5951.00
130_E134_K1.5661.00
176_I240_V1.5601.00
190_P246_L1.5150.99
168_V249_K1.4640.99
144_S215_I1.4250.99
152_V215_I1.4200.99
126_A129_K1.4080.99
170_N246_L1.3970.99
175_L234_P1.3890.99
121_A236_N1.3870.99
208_N215_I1.3150.98
170_N244_E1.3060.98
180_E185_Y1.3010.98
148_L204_E1.2990.98
166_T194_R1.2970.98
138_E151_Q1.2960.98
198_V202_W1.2880.98
155_A213_G1.2560.98
119_K123_D1.2430.97
162_K196_D1.2380.97
170_N185_Y1.2360.97
200_P203_T1.2340.97
176_I238_T1.2230.97
168_V190_P1.2230.97
135_F138_E1.2190.97
180_E183_N1.2170.97
135_F143_T1.2130.97
146_T223_L1.2060.97
84_Q88_A1.2030.97
195_L206_L1.1960.97
152_V209_I1.1800.97
183_N187_R1.1720.96
159_E211_K1.1710.96
209_I213_G1.1680.96
124_N234_P1.1680.96
199_I224_A1.1550.96
181_F241_F1.1400.96
136_A143_T1.1390.96
55_S59_Y1.1260.96
170_N190_P1.1200.95
115_A119_K1.1180.95
206_L217_L1.1080.95
160_A213_G1.1080.95
218_V240_V1.1050.95
44_D47_K1.1030.95
93_L97_E1.0850.94
82_G86_A1.0840.94
209_I245_L1.0720.94
210_K215_I1.0640.94
170_N184_S1.0560.94
46_Q75_D1.0560.94
138_E149_V1.0520.94
192_S249_K1.0440.93
125_E236_N1.0420.93
204_E223_L1.0390.93
195_L207_K1.0330.93
132_R135_F1.0230.93
114_Q118_E1.0100.92
196_D203_T0.9900.91
230_V235_P0.9780.91
144_S204_E0.9740.91
201_G219_I0.9690.90
97_E100_Q0.9660.90
166_T192_S0.9620.90
41_F46_Q0.9610.90
76_K80_I0.9590.90
154_E214_K0.9560.90
153_V214_K0.9440.89
152_V155_A0.9430.89
199_I202_W0.9420.89
51_A98_I0.9250.88
182_D243_V0.9190.88
141_V149_V0.9190.88
165_D248_V0.9180.88
58_R95_D0.9140.88
127_K130_E0.9120.88
144_S208_N0.8900.86
72_I75_D0.8780.85
77_D84_Q0.8710.85
148_L217_L0.8680.85
118_E122_A0.8580.84
182_D193_F0.8560.84
102_L105_F0.8530.84
111_S115_A0.8500.84
174_T180_E0.8500.84
229_G232_G0.8450.83
155_A210_K0.8340.82
134_K137_K0.8340.82
182_D241_F0.8180.81
170_N187_R0.8170.81
60_M83_V0.8170.81
163_D196_D0.8060.80
185_Y244_E0.8040.80
172_K186_T0.8010.80
107_A111_S0.7990.80
153_V242_D0.7980.80
57_G86_A0.7960.79
205_G243_V0.7950.79
157_K210_K0.7870.79
51_A55_S0.7840.78
142_K145_S0.7840.78
171_Y201_G0.7830.78
203_T207_K0.7750.78
78_Q82_G0.7670.77
54_A98_I0.7580.76
175_L233_I0.7580.76
132_R149_V0.7560.76
198_V243_V0.7530.75
144_S148_L0.7510.75
173_G241_F0.7480.75
78_Q81_A0.7400.74
205_G213_G0.7390.74
152_V213_G0.7380.74
112_S116_K0.7360.74
171_Y182_D0.7350.74
161_P248_V0.7320.73
158_G210_K0.7270.73
176_I218_V0.7260.73
202_W233_I0.7250.73
34_A38_K0.7250.73
218_V238_T0.7230.72
150_Y223_L0.7200.72
106_E110_K0.7120.71
174_T242_D0.7080.71
202_W245_L0.7050.71
205_G208_N0.7000.70
166_T249_K0.6950.69
191_L234_P0.6940.69
103_Q107_A0.6930.69
111_S114_Q0.6910.69
161_P195_L0.6900.69
135_F141_V0.6880.69
199_I239_L0.6880.69
103_Q106_E0.6870.69
34_A37_S0.6860.68
177_D237_S0.6830.68
159_E210_K0.6830.68
143_T148_L0.6800.68
193_F198_V0.6790.68
170_N183_N0.6780.68
98_I101_T0.6750.67
116_K120_D0.6730.67
54_A59_Y0.6720.67
148_L208_N0.6720.67
115_A118_E0.6690.67
43_N46_Q0.6670.66
169_V245_L0.6650.66
50_Y82_G0.6650.66
44_D108_R0.6630.66
154_E157_K0.6620.66
198_V203_T0.6610.66
129_K132_R0.6600.66
147_G220_P0.6540.65
181_F201_G0.6500.64
142_K152_V0.6490.64
93_L101_T0.6460.64
181_F199_I0.6440.64
153_V209_I0.6420.63
169_V197_G0.6400.63
222_E227_K0.6400.63
187_R246_L0.6390.63
202_W207_K0.6380.63
166_T197_G0.6370.63
135_F218_V0.6350.63
233_I241_F0.6320.62
125_E128_G0.6300.62
49_A74_L0.6260.61
111_S130_E0.6250.61
98_I106_E0.6230.61
156_G210_K0.6230.61
173_G182_D0.6220.61
54_A124_N0.6160.60
113_A116_K0.6160.60
157_K211_K0.6150.60
58_R61_E0.6090.59
205_G224_A0.6090.59
100_Q103_Q0.6070.59
121_A125_E0.6050.59
182_D198_V0.6040.59
160_A208_N0.6040.59
124_N127_K0.6000.58
127_K177_D0.5960.58
123_D136_A0.5920.57
119_K122_A0.5920.57
130_E133_E0.5910.57
125_E222_E0.5910.57
153_V244_E0.5900.57
81_A92_K0.5900.57
168_V246_L0.5870.57
76_K84_Q0.5860.56
128_G176_I0.5860.56
131_Y150_Y0.5860.56
116_K119_K0.5860.56
233_I237_S0.5850.56
125_E221_P0.5840.56
132_R221_P0.5840.56
136_A149_V0.5810.56
193_F203_T0.5790.56
199_I241_F0.5770.55
167_V206_L0.5770.55
225_Y241_F0.5740.55
169_V195_L0.5700.54
142_K151_Q0.5700.54
109_V116_K0.5680.54
137_K143_T0.5670.54
74_L77_D0.5660.54
149_V218_V0.5660.54
95_D100_Q0.5650.54
139_K157_K0.5650.54
174_T186_T0.5630.53
185_Y242_D0.5630.53
112_S115_A0.5620.53
116_K133_E0.5620.53
39_A42_K0.5600.53
173_G239_L0.5600.53
85_D93_L0.5600.53
104_A108_R0.5580.53
184_S198_V0.5560.53
96_Q99_E0.5560.53
110_K113_A0.5530.52
156_G217_L0.5530.52
173_G201_G0.5510.52
53_G82_G0.5510.52
185_Y214_K0.5500.52
131_Y176_I0.5500.52
181_F239_L0.5480.52
50_Y53_G0.5480.52
48_S74_L0.5440.51
81_A85_D0.5440.51
182_D201_G0.5440.51
193_F239_L0.5420.51
210_K219_I0.5410.51
158_G209_I0.5370.50
123_D126_A0.5350.50
172_K183_N0.5290.49
146_T208_N0.5280.49
141_V150_Y0.5260.49
144_S223_L0.5250.49
171_Y181_F0.5250.49
43_N52_L0.5240.48
97_E101_T0.5230.48
49_A75_D0.5210.48
38_K108_R0.5210.48
195_L215_I0.5210.48
232_G237_S0.5190.48
233_I239_L0.5180.48
201_G241_F0.5170.48
38_K118_E0.5170.48
56_L83_V0.5170.48
149_V176_I0.5160.47
160_A163_D0.5160.47
219_I224_A0.5160.47
135_F176_I0.5150.47
142_K155_A0.5110.47
182_D233_I0.5090.46
33_T36_D0.5080.46
169_V240_V0.5080.46
101_T108_R0.5080.46
140_G151_Q0.5070.46
38_K62_N0.5070.46
131_Y135_F0.5060.46
127_K237_S0.5050.46
182_D239_L0.5050.46
229_G234_P0.5050.46
98_I102_L0.5030.46
51_A57_G0.5020.46
99_E102_L0.5010.45
38_K44_D0.5010.45
202_W217_L0.5010.45
212_G241_F0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q6hA 2 0.7778 100 0.296 Contact Map
1fd9A 2 0.7481 100 0.309 Contact Map
3oe2A 1 0.4889 100 0.337 Contact Map
1jvwA 1 0.5815 100 0.467 Contact Map
2f4eA 1 0.4556 100 0.498 Contact Map
2mf9A 1 0.5259 100 0.507 Contact Map
2mphA 1 0.7852 100 0.511 Contact Map
3uf8A 1 0.6889 100 0.519 Contact Map
4bf8A 1 0.4259 100 0.533 Contact Map
2lgoA 1 0.4667 100 0.544 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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