GREMLIN Database
YHBV - Uncharacterized protein YhbV
UniProt: P45475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12791
Length: 292 (270)
Sequences: 4317 (2835)
Seq/√Len: 172.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_R265_N3.9091.00
112_A132_M3.5401.00
11_Y264_E3.5131.00
100_V132_M3.2181.00
58_A90_F3.0361.00
25_A62_K2.8701.00
92_I108_L2.6631.00
13_P257_L2.5731.00
150_L242_D2.5491.00
34_L64_I2.5131.00
21_Y53_M2.4811.00
46_K49_D2.4601.00
147_V151_N2.4281.00
150_L164_V2.3511.00
237_M244_V2.2861.00
25_A56_S2.2771.00
124_L135_W2.2661.00
57_L64_I2.2361.00
128_L161_Q2.2151.00
9_L268_A2.1761.00
66_L89_E2.1441.00
26_T56_S2.0841.00
112_A116_L2.0701.00
22_Q56_S2.0651.00
109_P133_M2.0321.00
54_A89_E1.9811.00
81_L99_V1.9631.00
230_L233_E1.9541.00
51_L55_K1.9351.00
27_S254_F1.9201.00
258_D262_A1.9191.00
9_L238_Q1.8631.00
17_L20_F1.8561.00
233_E283_R1.8531.00
18_E52_E1.8071.00
233_E279_N1.7531.00
137_M146_L1.7481.00
231_G263_N1.7351.00
134_R163_E1.7131.00
153_C161_Q1.7091.00
166_V237_M1.7071.00
236_S283_R1.7041.00
169_Y260_F1.6721.00
121_A152_Q1.6691.00
147_V239_G1.6641.00
18_E22_Q1.6641.00
55_K59_G1.6471.00
18_E53_M1.6451.00
47_V87_N1.6441.00
234_L267_A1.6271.00
101_N105_E1.5931.00
56_S60_S1.5611.00
233_E236_S1.5591.00
125_K128_L1.5271.00
279_N283_R1.5181.00
25_A57_L1.5091.00
52_E55_K1.5061.00
54_A64_I1.5021.00
148_N152_Q1.4671.00
128_L162_F1.4671.00
25_A60_S1.4641.00
8_V268_A1.4521.00
238_Q264_E1.4391.00
230_L282_W1.4361.00
166_V241_V1.4301.00
85_V103_C1.4151.00
112_A127_L1.4131.00
146_L166_V1.4131.00
22_Q52_E1.4041.00
143_R240_L1.4001.00
118_C123_T1.3941.00
180_C193_C1.3941.00
34_L50_W1.3911.00
65_V91_L1.3871.00
126_I130_Q1.3851.00
22_Q26_T1.3761.00
36_E84_Y1.3691.00
235_A239_G1.3651.00
144_D147_V1.3411.00
57_L62_K1.3411.00
238_Q267_A1.3351.00
82_K86_E1.3121.00
35_G40_S1.2931.00
118_C127_L1.2911.00
94_A99_V1.2851.00
12_W243_V1.2851.00
213_Q216_V1.2841.00
30_D62_K1.2441.00
86_E106_R1.2391.00
91_L111_V1.2221.00
83_R86_E1.2211.00
246_L257_L1.2191.00
122_V125_K1.2181.00
166_V282_W1.2071.00
125_K129_K1.2011.00
38_V80_E1.1981.00
103_C110_F1.1971.00
102_M106_R1.1961.00
31_V243_V1.1921.00
80_E85_V1.1851.00
17_L43_R1.1841.00
24_A32_I1.1821.00
143_R230_L1.1821.00
24_A253_T1.1721.00
180_C197_C1.1671.00
21_Y32_I1.1671.00
137_M166_V1.1611.00
231_G259_A1.1591.00
26_T60_S1.1591.00
21_Y57_L1.1561.00
235_A238_Q1.1561.00
141_L149_L1.1491.00
255_A272_L1.1321.00
79_G82_K1.1251.00
94_A100_V1.1231.00
150_L153_C1.1231.00
238_Q244_V1.1191.00
235_A267_A1.1161.00
142_S145_W1.1141.00
206_V209_Q1.1071.00
229_N232_N1.0951.00
74_A121_A1.0911.00
13_P246_L1.0881.00
83_R87_N1.0871.00
110_F132_M1.0861.00
94_A110_F1.0861.00
124_L149_L1.0841.00
124_L162_F1.0791.00
103_C108_L1.0651.00
141_L145_W1.0651.00
143_R282_W1.0541.00
165_E245_R1.0470.99
229_N277_D1.0370.99
128_L153_C1.0370.99
238_Q268_A1.0350.99
97_L127_L1.0300.99
58_A64_I1.0270.99
146_L240_L1.0270.99
209_Q212_Q1.0220.99
12_W31_V1.0160.99
236_S239_G1.0140.99
11_Y261_R1.0130.99
266_G269_P1.0080.99
82_K102_M1.0070.99
137_M164_V1.0060.99
147_V236_S1.0050.99
206_V210_E1.0030.99
125_K152_Q1.0020.99
51_L87_N0.9950.99
52_E56_S0.9930.99
78_L102_M0.9900.99
196_C201_P0.9850.99
82_K106_R0.9840.99
92_I103_C0.9790.99
34_L66_L0.9760.99
54_A58_A0.9750.99
253_T257_L0.9710.99
23_Q27_S0.9550.99
261_R264_E0.9540.99
100_V110_F0.9470.99
234_L264_E0.9410.99
254_F258_D0.9390.99
68_T99_V0.9290.99
143_R236_S0.9260.99
134_R243_V0.9240.99
78_L81_L0.9230.99
230_L283_R0.9200.99
84_Y87_N0.9190.99
163_E242_D0.9180.99
53_M64_I0.9170.99
81_L85_V0.9160.99
10_W63_Q0.9110.99
117_N179_R0.9070.99
116_L127_L0.9020.98
121_A148_N0.9020.98
240_L244_V0.8930.98
168_S244_V0.8900.98
172_L228_Y0.8850.98
168_S230_L0.8850.98
27_S257_L0.8840.98
117_N138_P0.8790.98
229_N260_F0.8780.98
31_V63_Q0.8750.98
232_N279_N0.8640.98
94_A103_C0.8630.98
23_Q254_F0.8600.98
205_N211_N0.8580.98
228_Y278_C0.8510.98
112_A118_C0.8480.98
71_L95_S0.8440.98
148_N151_N0.8410.98
31_V134_R0.8410.98
77_E190_K0.8390.98
193_C197_C0.8380.98
166_V240_L0.8370.97
124_L164_V0.8350.97
140_E170_G0.8290.97
39_C80_E0.8250.97
109_P163_E0.8160.97
153_C162_F0.8140.97
68_T84_Y0.8110.97
31_V65_V0.8010.97
150_L161_Q0.7970.97
119_Y138_P0.7950.97
68_T85_V0.7920.97
49_D52_E0.7900.96
9_L242_D0.7890.96
137_M149_L0.7890.96
168_S246_L0.7870.96
230_L279_N0.7860.96
118_C124_L0.7850.96
80_E83_R0.7830.96
133_M163_E0.7790.96
123_T127_L0.7690.96
48_G51_L0.7680.96
47_V51_L0.7680.96
63_Q109_P0.7680.96
15_E21_Y0.7660.96
194_E199_K0.7660.96
207_L212_Q0.7650.96
172_L278_C0.7640.96
78_L82_K0.7630.96
264_E267_A0.7630.96
33_Y165_E0.7630.96
23_Q26_T0.7620.96
209_Q215_F0.7620.96
73_Q184_R0.7620.96
220_I223_M0.7610.96
232_N235_A0.7580.96
34_L45_T0.7560.95
140_E177_S0.7550.95
47_V50_W0.7540.95
121_A125_K0.7530.95
82_K99_V0.7510.95
274_A277_D0.7510.95
145_W148_N0.7440.95
244_V264_E0.7420.95
262_A266_G0.7410.95
100_V112_A0.7330.95
41_K70_A0.7280.94
73_Q145_W0.7270.94
79_G83_R0.7240.94
113_G245_R0.7230.94
97_L126_I0.7190.94
164_V241_V0.7150.94
37_A46_K0.7150.94
20_F23_Q0.7120.94
255_A259_A0.7110.94
82_K105_E0.7110.94
273_T277_D0.7110.94
204_R223_M0.7090.94
8_V264_E0.7080.94
139_V172_L0.7020.93
186_E194_E0.6990.93
97_L100_V0.6930.93
256_M260_F0.6880.93
27_S258_D0.6850.92
263_N266_G0.6840.92
169_Y229_N0.6810.92
204_R207_L0.6800.92
239_G267_A0.6790.92
259_A263_N0.6740.92
9_L264_E0.6730.92
48_G52_E0.6730.92
166_V230_L0.6690.92
230_L237_M0.6690.92
187_D190_K0.6670.91
147_V240_L0.6670.91
203_G222_T0.6650.91
264_E268_A0.6630.91
166_V244_V0.6610.91
85_V99_V0.6600.91
93_E136_C0.6540.91
8_V17_L0.6530.91
169_Y227_V0.6530.91
125_K161_Q0.6520.90
85_V102_M0.6520.90
136_C165_E0.6500.90
198_I201_P0.6500.90
171_H227_V0.6490.90
26_T254_F0.6490.90
245_R248_P0.6480.90
47_V83_R0.6470.90
68_T81_L0.6460.90
279_N285_L0.6450.90
205_N212_Q0.6430.90
72_V78_L0.6420.90
169_Y251_T0.6410.90
44_A250_G0.6410.90
246_L253_T0.6400.90
270_L277_D0.6370.89
139_V167_L0.6360.89
10_W31_V0.6360.89
92_I110_F0.6340.89
234_L263_N0.6330.89
119_Y179_R0.6320.89
32_I64_I0.6310.89
88_G108_L0.6300.89
10_W243_V0.6280.89
80_E84_Y0.6280.89
124_L153_C0.6270.89
212_Q216_V0.6270.89
21_Y45_T0.6260.89
195_T198_I0.6250.89
73_Q174_L0.6240.88
200_Y207_L0.6230.88
11_Y256_M0.6230.88
237_M240_L0.6220.88
262_A267_A0.6220.88
209_Q214_V0.6190.88
104_A110_F0.6180.88
53_M56_S0.6160.88
143_R283_R0.6160.88
54_A57_L0.6130.88
150_L241_V0.6110.87
118_C138_P0.6100.87
281_Y284_R0.6080.87
234_L238_Q0.6050.87
37_A44_A0.6030.87
197_C201_P0.6010.87
49_D53_M0.6010.87
233_E282_W0.6010.87
206_V212_Q0.6010.87
21_Y25_A0.5970.86
174_L225_G0.5970.86
208_S212_Q0.5950.86
280_G283_R0.5940.86
18_E45_T0.5940.86
30_D261_R0.5920.86
105_E125_K0.5890.85
152_Q161_Q0.5890.85
270_L274_A0.5870.85
206_V211_N0.5850.85
72_V81_L0.5850.85
69_L245_R0.5840.85
179_R219_G0.5780.84
18_E34_L0.5780.84
259_A262_A0.5780.84
114_H251_T0.5750.84
89_E108_L0.5750.84
205_N208_S0.5750.84
173_P245_R0.5740.84
135_W164_V0.5730.84
144_D236_S0.5720.84
226_Y278_C0.5680.83
53_M57_L0.5680.83
218_N221_Q0.5650.83
97_L101_N0.5650.83
11_Y260_F0.5640.83
103_C107_K0.5600.83
72_V99_V0.5590.82
138_P141_L0.5580.82
208_S214_V0.5580.82
169_Y256_M0.5570.82
46_K52_E0.5560.82
276_S279_N0.5540.82
105_E129_K0.5520.82
37_A49_D0.5500.81
150_L240_L0.5500.81
55_K88_G0.5500.81
256_M259_A0.5480.81
100_V130_Q0.5480.81
38_V47_V0.5470.81
271_P274_A0.5450.81
195_T199_K0.5450.81
209_Q216_V0.5440.81
167_L247_S0.5430.81
143_R237_M0.5370.80
236_S240_L0.5360.80
18_E21_Y0.5340.79
40_S67_S0.5310.79
171_H195_T0.5310.79
136_C245_R0.5300.79
184_R187_D0.5300.79
241_V244_V0.5270.79
102_M105_E0.5240.78
136_C167_L0.5230.78
115_A189_P0.5230.78
172_L253_T0.5220.78
104_A129_K0.5200.78
181_F280_G0.5190.78
67_S93_E0.5180.77
139_V173_P0.5180.77
115_A139_V0.5180.77
121_A149_L0.5160.77
52_E59_G0.5150.77
104_A133_M0.5150.77
129_K161_Q0.5140.77
36_E50_W0.5130.77
95_S113_G0.5130.77
279_N284_R0.5130.77
37_A47_V0.5110.76
271_P280_G0.5090.76
69_L173_P0.5090.76
76_S83_R0.5090.76
235_A240_L0.5090.76
80_E87_N0.5080.76
8_V269_P0.5080.76
100_V127_L0.5080.76
182_T222_T0.5070.76
199_K221_Q0.5050.76
226_Y276_S0.5050.76
252_D260_F0.5020.75
72_V77_E0.5000.75
208_S215_F0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bdqA 2 0.6062 97.1 0.899 Contact Map
3iwpA 3 0.7226 95.9 0.912 Contact Map
4u28A 1 0.4932 95.6 0.914 Contact Map
1wa3A 3 0.4863 95.4 0.915 Contact Map
1h5yA 1 0.5068 95.2 0.916 Contact Map
2y88A 1 0.4829 95.1 0.917 Contact Map
3tsmA 2 0.4692 95.1 0.917 Contact Map
1thfD 2 0.5171 94.6 0.919 Contact Map
3f4wA 2 0.5034 94.5 0.92 Contact Map
3c2eA 5 0.2603 94.3 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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