GREMLIN Database
YHBO - Protein YhbO
UniProt: P45470 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12784
Length: 172 (161)
Sequences: 14461 (9772)
Seq/√Len: 770.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_E168_R2.6571.00
4_K31_E2.6391.00
6_A66_F2.5531.00
145_V169_L2.5521.00
33_I66_F2.3841.00
6_A35_I2.3551.00
119_R147_K2.3491.00
120_K139_Y2.3191.00
116_I121_L2.2351.00
4_K33_I2.0721.00
42_T53_T2.0421.00
119_R146_D2.0401.00
33_I56_K2.0091.00
145_V165_E1.9091.00
24_E167_L1.8921.00
120_K141_Q1.8391.00
117_R137_E1.8351.00
28_A167_L1.8211.00
128_I132_K1.7661.00
94_V149_Q1.7551.00
22_A26_R1.7511.00
120_K137_E1.7161.00
119_R150_L1.6281.00
94_V100_V1.5821.00
145_V151_V1.5811.00
93_F98_K1.5721.00
44_K51_S1.5521.00
130_D134_A1.5231.00
99_P169_L1.5011.00
102_A152_T1.4981.00
37_K83_D1.4791.00
101_F166_A1.4771.00
15_D19_T1.4711.00
68_A99_P1.4691.00
57_S60_E1.4401.00
153_S158_D1.4161.00
59_D85_R1.4091.00
88_T92_D1.4051.00
7_V70_L1.4031.00
151_V169_L1.3971.00
120_K146_D1.3921.00
89_F93_F1.3901.00
7_V22_A1.3801.00
87_V91_R1.3781.00
130_D133_N1.3751.00
102_A110_L1.3711.00
42_T51_S1.3561.00
36_E39_A1.3521.00
45_G48_G1.3061.00
131_V136_A1.3031.00
92_D96_S1.2951.00
88_T91_R1.2931.00
84_N88_T1.2881.00
121_L138_F1.2871.00
145_V149_Q1.2771.00
13_F18_F1.2701.00
94_V115_V1.2511.00
112_S134_A1.2441.00
94_V150_L1.2351.00
13_F45_G1.2271.00
97_G149_Q1.2261.00
85_R88_T1.2241.00
165_E169_L1.2181.00
131_V140_D1.2151.00
51_S55_D1.2151.00
101_F162_F1.2121.00
119_R149_Q1.2091.00
25_F163_N1.2021.00
5_I68_A1.1621.00
9_I34_T1.1621.00
23_D27_K1.1531.00
87_V113_A1.1471.00
20_S160_P1.1341.00
56_K60_E1.1271.00
16_S20_S1.1271.00
97_G100_V1.1251.00
11_D44_K1.1231.00
18_F34_T1.1161.00
142_E161_A1.0951.00
128_I140_D1.0861.00
105_H127_I1.0811.00
9_I18_F1.0751.00
20_S23_D1.0721.00
108_Q130_D1.0711.00
82_G112_S1.0701.00
70_L162_F1.0661.00
92_D95_N1.0651.00
91_R95_N1.0571.00
120_K144_V1.0561.00
22_A34_T1.0521.00
67_D98_K1.0501.00
114_D117_R1.0451.00
8_L86_F1.0431.00
151_V162_F1.0411.00
94_V97_G1.0311.00
45_G49_E1.0251.00
39_A57_S1.0221.00
111_I138_F1.0111.00
20_S163_N0.9981.00
93_F96_S0.9951.00
143_V165_E0.9791.00
153_S162_F0.9761.00
99_P149_Q0.9611.00
102_A107_P0.9531.00
24_E163_N0.9471.00
37_K85_R0.9441.00
7_V32_V0.9441.00
81_R112_S0.9381.00
154_R158_D0.9301.00
124_V155_T0.9291.00
71_L90_T0.9241.00
56_K61_V0.9111.00
129_I133_N0.9101.00
99_P151_V0.9021.00
21_P70_L0.8981.00
35_I56_K0.8981.00
5_I30_H0.8861.00
30_H68_A0.8811.00
71_L109_L0.8801.00
160_P164_R0.8741.00
23_D26_R0.8671.00
151_V166_A0.8641.00
21_P159_L0.8621.00
112_S135_G0.8491.00
20_S159_L0.8471.00
127_I130_D0.8461.00
87_V112_S0.8331.00
30_H167_L0.8271.00
107_P123_A0.8271.00
70_L101_F0.8261.00
22_A32_V0.8221.00
18_F22_A0.8221.00
68_A166_A0.8061.00
64_A92_D0.8021.00
35_I61_V0.8021.00
71_L106_G0.7991.00
9_I13_F0.7991.00
24_E164_R0.7951.00
71_L86_F0.7931.00
129_I132_K0.7921.00
131_V135_G0.7881.00
89_F92_D0.7821.00
36_E54_I0.7801.00
68_A101_F0.7781.00
15_D45_G0.7741.00
13_F52_V0.7741.00
132_K142_E0.7731.00
11_D38_Q0.7721.00
25_F166_A0.7701.00
15_D49_E0.7701.00
91_R113_A0.7681.00
69_L93_F0.7661.00
13_F72_P0.7641.00
83_D86_F0.7641.00
99_P166_A0.7511.00
151_V165_E0.7501.00
103_I159_L0.7361.00
66_F93_F0.7271.00
7_V18_F0.7251.00
87_V90_T0.7151.00
37_K58_I0.7071.00
122_T144_V0.6991.00
117_R135_G0.6931.00
42_T54_I0.6911.00
15_D47_K0.6851.00
161_A164_R0.6781.00
118_G137_E0.6721.00
90_T109_L0.6681.00
24_E28_A0.6611.00
79_Y82_G0.6601.00
61_V66_F0.6571.00
102_A106_G0.6551.00
84_N87_V0.6551.00
90_T113_A0.6521.00
87_V109_L0.6521.00
39_A54_I0.6511.00
108_Q127_I0.6411.00
24_E27_K0.6371.00
110_L113_A0.6341.00
25_F30_H0.6331.00
123_A138_F0.6311.00
121_L136_A0.6301.00
103_I162_F0.6211.00
9_I43_V0.6191.00
124_V127_I0.6151.00
94_V119_R0.6091.00
17_E73_G0.6091.00
6_A61_V0.6081.00
65_E96_S0.6051.00
26_R32_V0.6051.00
116_I122_T0.6011.00
5_I25_F0.6011.00
135_G138_F0.6011.00
161_A165_E0.6001.00
17_E156_P0.5931.00
111_I131_V0.5921.00
100_V149_Q0.5891.00
123_A127_I0.5891.00
164_R168_R0.5881.00
64_A96_S0.5881.00
44_K48_G0.5851.00
6_A89_F0.5851.00
46_K49_E0.5821.00
159_L163_N0.5811.00
20_S24_E0.5761.00
121_L131_V0.5741.00
128_I142_E0.5721.00
80_L83_D0.5681.00
36_E55_D0.5671.00
76_S80_L0.5621.00
66_F69_L0.5611.00
4_K67_D0.5601.00
14_E23_D0.5571.00
15_D52_V0.5561.00
82_G87_V0.5551.00
139_Y144_V0.5441.00
143_V151_V0.5421.00
141_Q144_V0.5411.00
54_I57_S0.5401.00
91_R115_V0.5401.00
78_D82_G0.5401.00
33_I55_D0.5361.00
101_F151_V0.5341.00
24_E160_P0.5321.00
107_P131_V0.5321.00
100_V150_L0.5291.00
74_G109_L0.5271.00
122_T138_F0.5271.00
111_I116_I0.5261.00
7_V21_P0.5241.00
70_L153_S0.5241.00
61_V89_F0.5221.00
125_K155_T0.5161.00
8_L69_L0.5141.00
143_V162_F0.5141.00
136_A140_D0.5131.00
18_F72_P0.5131.00
44_K55_D0.5071.00
14_E46_K0.5061.00
40_G43_V0.5021.00
110_L150_L0.5001.00
12_E44_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oi4A 2 0.9884 100 0.14 Contact Map
3ewnA 2 0.9767 100 0.164 Contact Map
3noqA 2 0.9709 100 0.164 Contact Map
3fseA 2 0.9826 100 0.167 Contact Map
3l18A 2 0.9767 100 0.172 Contact Map
2rk3A 2 0.9826 100 0.173 Contact Map
2vrnA 2 0.9826 100 0.174 Contact Map
4e08A 2 0.9826 100 0.174 Contact Map
3mgkA 2 0.9651 100 0.175 Contact Map
4oggA 3 0.9767 100 0.18 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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