GREMLIN Database
YRAQ - UPF0718 protein YraQ
UniProt: P45468 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12782
Length: 346 (285)
Sequences: 1472 (953)
Seq/√Len: 56.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_C333_A5.7941.00
317_R322_A4.8221.00
313_L329_G4.5921.00
196_R327_L3.9101.00
326_W330_A3.7571.00
144_G192_Q3.5991.00
183_M339_V3.4301.00
161_L177_L3.0361.00
112_T148_A2.9691.00
289_M298_A2.9651.00
310_L314_I2.9411.00
217_F221_G2.7461.00
264_V300_A2.4211.00
201_T317_R2.3371.00
152_G184_V2.3281.00
151_M187_I2.3151.00
129_A153_N2.2841.00
239_V243_G2.2671.00
199_P323_K2.2431.00
262_M266_A2.1991.00
322_A326_W2.1841.00
116_T185_L2.0361.00
239_V244_A2.0201.00
221_G225_W1.9501.00
313_L325_L1.9441.00
287_T291_A1.9331.00
198_T323_K1.9211.00
242_L284_I1.9161.00
215_G219_R1.9001.00
216_F224_L1.8931.00
253_A256_A1.8791.00
255_G293_M1.8751.00
84_G88_G1.8681.00
187_I331_M1.8641.00
264_V344_L1.8591.00
218_S222_R1.8550.99
304_T336_G1.8520.99
179_A339_V1.7810.99
250_F255_G1.7590.99
169_G289_M1.7550.99
142_S145_G1.7460.99
285_V298_A1.7400.99
222_R226_T1.7380.99
70_A244_A1.7110.99
183_M187_I1.7020.99
300_A304_T1.6990.99
112_T144_G1.6970.99
262_M265_V1.6970.99
183_M335_S1.6730.99
147_L168_L1.6600.99
157_N160_T1.6400.99
129_A279_A1.6330.99
157_N278_T1.6330.99
176_R306_P1.6090.99
174_A178_V1.6040.98
65_A68_D1.5280.98
227_L233_P1.5090.98
116_T184_V1.4940.98
260_S263_W1.4500.97
69_Y248_W1.4470.97
103_T114_L1.4420.97
149_F153_N1.4410.97
115_G317_R1.4350.97
304_T308_V1.4240.97
286_Q290_L1.4070.97
261_L265_V1.4070.97
294_G344_L1.4010.96
162_V166_F1.3970.96
268_A337_V1.3930.96
323_K326_W1.3740.96
209_I212_A1.3630.96
228_F233_P1.3460.96
61_N64_Q1.3360.95
228_F231_T1.3340.95
130_A315_M1.3310.95
133_A146_A1.3100.95
255_G291_A1.3030.95
235_Y282_I1.2980.95
190_L237_L1.2890.94
293_M297_P1.2700.94
80_A128_C1.2620.94
234_V238_A1.2460.93
61_N68_D1.2240.93
246_R287_T1.2160.92
127_C243_G1.2110.92
221_G229_W1.2110.92
229_W233_P1.2090.92
170_W174_A1.2040.92
116_T181_L1.1960.92
176_R312_S1.1910.92
114_L299_L1.1910.92
148_A185_L1.1870.91
134_A271_G1.1770.91
225_W229_W1.1720.91
258_D261_L1.1680.91
268_A271_G1.1670.91
207_I210_P1.1610.90
178_V182_V1.1520.90
172_F295_T1.1370.90
147_L191_V1.1320.89
107_S110_R1.1200.89
129_A155_V1.1090.88
184_V187_I1.1060.88
161_L236_I1.1050.88
218_S221_G1.1040.88
118_F287_T1.0850.87
265_V269_V1.0780.87
109_F189_T1.0730.87
155_V307_A1.0690.86
91_I173_A1.0650.86
109_F113_L1.0630.86
165_G282_I1.0590.86
279_A332_V1.0580.86
106_Q110_R1.0570.86
83_L191_V1.0560.86
135_G139_Q1.0420.85
225_W233_P1.0410.85
132_V274_F1.0380.85
107_S190_L1.0370.85
202_Q321_P1.0300.84
108_R141_V1.0280.84
84_G306_P1.0270.84
267_M271_G1.0270.84
144_G188_A1.0210.84
97_R100_L1.0200.84
277_P312_S1.0200.84
200_Q205_V1.0200.84
168_L289_M1.0170.84
217_F232_I1.0160.83
282_I303_M1.0150.83
238_A241_V1.0120.83
146_A278_T1.0080.83
228_F319_A1.0070.83
69_Y73_Y1.0060.83
124_M155_V1.0050.83
238_A242_L1.0020.83
313_L317_R1.0010.83
182_V202_Q1.0000.83
294_G297_P0.9990.82
278_T281_E0.9980.82
87_L238_A0.9970.82
100_L103_T0.9950.82
164_M168_L0.9940.82
301_L305_L0.9930.82
131_P275_V0.9930.82
252_H284_I0.9880.82
208_D213_Q0.9870.82
229_W232_I0.9840.81
175_I343_A0.9810.81
182_V269_V0.9800.81
80_A120_L0.9790.81
120_L298_A0.9680.80
196_R199_P0.9670.80
67_L71_M0.9640.80
231_T234_V0.9600.80
220_W224_L0.9560.80
140_Q321_P0.9550.80
87_L241_V0.9460.79
178_V222_R0.9450.79
157_N233_P0.9420.79
149_F188_A0.9370.78
155_V309_S0.9330.78
182_V212_A0.9300.78
83_L87_L0.9160.77
252_H256_A0.9140.76
110_R193_K0.9110.76
148_A188_A0.9090.76
209_I213_Q0.9070.76
86_I218_S0.9040.76
237_L330_A0.9030.76
66_A249_L0.9020.75
243_G247_V0.9010.75
98_D193_K0.9000.75
181_L258_D0.8970.75
137_R143_M0.8960.75
126_T150_W0.8920.75
77_V153_N0.8910.75
217_F228_F0.8910.75
112_T192_Q0.8890.74
81_A320_F0.8870.74
119_S152_G0.8840.74
152_G255_G0.8840.74
224_L227_L0.8810.74
227_L231_T0.8800.74
167_V278_T0.8790.74
182_V193_K0.8790.74
261_L337_V0.8740.73
129_A305_L0.8720.73
91_I338_I0.8690.73
190_L331_M0.8680.73
221_G231_T0.8660.72
161_L307_A0.8650.72
105_G187_I0.8650.72
266_A270_A0.8600.72
342_L345_L0.8540.71
157_N282_I0.8510.71
134_A319_A0.8500.71
185_L188_A0.8490.71
111_G115_G0.8470.71
117_L121_P0.8470.71
165_G173_A0.8440.71
207_I213_Q0.8440.71
120_L181_L0.8380.70
123_M275_V0.8280.69
64_Q334_V0.8280.69
159_A167_V0.8270.69
84_G128_C0.8260.69
291_A328_T0.8240.69
197_E217_F0.8160.68
123_M273_L0.8120.68
213_Q237_L0.8110.67
214_G219_R0.8060.67
275_V328_T0.8060.67
265_V342_L0.8010.66
208_D214_G0.8010.66
212_A334_V0.7950.66
102_R106_Q0.7910.65
120_L306_P0.7910.65
275_V292_G0.7900.65
278_T306_P0.7870.65
100_L173_A0.7850.65
69_Y72_I0.7810.65
241_V244_A0.7730.64
168_L235_Y0.7710.64
126_T130_A0.7710.64
174_A211_E0.7670.63
148_A152_G0.7610.62
333_A337_V0.7610.62
210_P250_F0.7580.62
89_S93_V0.7550.62
78_W82_V0.7550.62
130_A255_G0.7550.62
194_W208_D0.7550.62
307_A313_L0.7540.62
126_T154_P0.7520.62
160_T285_V0.7510.61
96_P185_L0.7480.61
272_C342_L0.7470.61
213_Q218_S0.7470.61
172_F184_V0.7460.61
155_V183_M0.7450.61
241_V265_V0.7430.61
186_L219_R0.7430.61
206_E209_I0.7420.61
151_M184_V0.7410.60
138_R332_V0.7400.60
302_L308_V0.7380.60
111_G145_G0.7360.60
143_M147_L0.7360.60
282_I289_M0.7330.60
188_A273_L0.7320.59
126_T309_S0.7290.59
201_T322_A0.7280.59
124_M128_C0.7280.59
203_A317_R0.7260.59
157_N279_A0.7190.58
156_L160_T0.7190.58
184_V301_L0.7150.58
303_M336_G0.7150.58
165_G170_W0.7140.58
101_L139_Q0.7140.58
289_M307_A0.7140.58
66_A244_A0.7130.57
194_W327_L0.7130.57
276_I280_A0.7110.57
163_F244_A0.7070.57
277_P280_A0.7020.56
91_I95_I0.7000.56
168_L340_G0.6980.56
70_A241_V0.6970.56
142_S151_M0.6970.56
150_W158_P0.6950.56
164_M176_R0.6920.55
294_G332_V0.6910.55
159_A278_T0.6890.55
130_A275_V0.6890.55
338_I341_G0.6870.55
170_W177_L0.6860.55
63_W66_A0.6860.55
70_A240_L0.6850.54
77_V80_A0.6810.54
89_S224_L0.6810.54
262_M341_G0.6810.54
173_A177_L0.6810.54
227_L230_S0.6790.54
316_L324_A0.6750.53
163_F332_V0.6730.53
94_L235_Y0.6730.53
103_T106_Q0.6710.53
220_W227_L0.6700.53
238_A269_V0.6670.53
120_L307_A0.6670.53
207_I212_A0.6660.52
208_D338_I0.6610.52
180_G336_G0.6610.52
225_W228_F0.6580.52
209_I221_G0.6580.52
208_D212_A0.6580.52
62_P78_W0.6570.51
174_A196_R0.6560.51
160_T279_A0.6550.51
129_A156_L0.6550.51
212_A215_G0.6550.51
93_V336_G0.6550.51
218_S270_A0.6530.51
102_R334_V0.6510.51
246_R274_F0.6490.51
99_W102_R0.6480.50
308_V312_S0.6460.50
85_V225_W0.6450.50
228_F307_A0.6430.50
158_P184_V0.6400.50
102_R105_G0.6390.49
174_A256_A0.6370.49
86_I221_G0.6370.49
68_D270_A0.6370.49
271_G340_G0.6350.49
102_R110_R0.6340.49
320_F324_A0.6340.49
190_L194_W0.6340.49
90_L102_R0.6290.48
67_L198_T0.6250.48
171_G343_A0.6250.48
90_L230_S0.6250.48
251_P275_V0.6250.48
301_L308_V0.6240.48
221_G224_L0.6220.48
136_M286_Q0.6220.48
89_S117_L0.6220.48
182_V185_L0.6210.48
225_W231_T0.6210.48
131_P292_G0.6150.47
184_V188_A0.6110.46
155_V303_M0.6110.46
269_V329_G0.6110.46
66_A70_A0.6100.46
174_A341_G0.6090.46
97_R132_V0.6070.46
216_F222_R0.6060.46
124_M311_P0.6050.46
73_Y311_P0.6040.46
136_M141_V0.6040.46
186_L190_L0.6000.45
66_A245_A0.5990.45
190_L327_L0.5980.45
217_F220_W0.5980.45
240_L288_M0.5970.45
66_A170_W0.5960.45
174_A209_I0.5960.45
80_A123_M0.5930.44
180_G183_M0.5920.44
226_T245_A0.5920.44
81_A129_A0.5890.44
71_M174_A0.5840.44
166_F270_A0.5840.44
79_K83_L0.5810.43
178_V334_V0.5780.43
116_T152_G0.5760.43
258_D263_W0.5750.43
106_Q139_Q0.5740.42
89_S140_Q0.5700.42
126_T275_V0.5690.42
167_V272_C0.5680.42
156_L177_L0.5660.42
216_F231_T0.5660.42
79_K178_V0.5650.41
202_Q218_S0.5650.41
206_E238_A0.5600.41
130_A251_P0.5590.41
220_W232_I0.5570.41
117_L334_V0.5570.41
68_D83_L0.5550.40
106_Q111_G0.5540.40
199_P327_L0.5540.40
216_F226_T0.5540.40
141_V302_L0.5540.40
124_M277_P0.5540.40
102_R190_L0.5530.40
281_E306_P0.5530.40
67_L211_E0.5510.40
254_D261_L0.5500.40
84_G160_T0.5420.39
136_M303_M0.5400.39
173_A253_A0.5390.39
136_M145_G0.5370.39
294_G298_A0.5370.39
84_G277_P0.5360.38
84_G162_V0.5340.38
300_A340_G0.5330.38
282_I293_M0.5330.38
124_M132_V0.5320.38
190_L330_A0.5300.38
149_F273_L0.5300.38
113_L117_L0.5300.38
84_G312_S0.5300.38
233_P237_L0.5300.38
136_M236_I0.5290.38
240_L245_A0.5280.38
184_V282_I0.5280.38
157_N312_S0.5280.38
165_G169_G0.5260.37
127_C311_P0.5260.37
206_E210_P0.5250.37
77_V122_G0.5230.37
226_T230_S0.5230.37
85_V89_S0.5210.37
218_S226_T0.5210.37
236_I318_K0.5200.37
136_M151_M0.5190.37
277_P308_V0.5190.37
119_S148_A0.5180.37
70_A136_M0.5180.37
156_L161_L0.5170.37
102_R107_S0.5160.36
156_L309_S0.5160.36
159_A279_A0.5160.36
187_I282_I0.5160.36
154_P288_M0.5140.36
273_L297_P0.5090.36
294_G304_T0.5090.36
124_M309_S0.5060.35
205_V208_D0.5050.35
140_Q188_A0.5040.35
224_L233_P0.5040.35
100_L134_A0.5040.35
107_S327_L0.5030.35
138_R205_V0.5010.35
89_S331_M0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.8584 48.1 0.961 Contact Map
4r1iA 2 0.9393 45.6 0.962 Contact Map
4xnjA 1 0.9306 41.1 0.963 Contact Map
1pw4A 1 0.9017 37.8 0.963 Contact Map
3llqA 3 0.315 33.1 0.964 Contact Map
4tphA 2 0.8757 32.4 0.965 Contact Map
3o7qA 1 0.8497 27.5 0.966 Contact Map
3giaA 1 0.5549 23.9 0.967 Contact Map
4j05A 3 0.5434 21.3 0.968 Contact Map
4pd6A 3 0.9191 21.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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