GREMLIN Database
YRAN - UPF0102 protein YraN
UniProt: P45465 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12779
Length: 131 (111)
Sequences: 3473 (2748)
Seq/√Len: 260.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_R79_S2.9491.00
80_V112_V2.7211.00
28_R41_A2.5011.00
38_F54_M2.4801.00
23_W67_Y2.4311.00
77_A114_A2.2221.00
62_F92_A2.2141.00
25_A41_A2.1611.00
28_R52_L2.1371.00
28_R38_F2.0821.00
17_K21_D2.0161.00
92_A110_F1.9401.00
76_A114_A1.8791.00
56_E124_K1.8641.00
27_A113_V1.8121.00
75_G78_A1.7691.00
54_M63_V1.7421.00
113_V122_W1.7041.00
36_L54_M1.7041.00
19_T67_Y1.6791.00
36_L122_W1.6771.00
61_I109_R1.6731.00
68_R79_S1.5551.00
34_K124_K1.4091.00
28_R32_E1.3971.00
48_G91_T1.3431.00
43_V94_L1.3191.00
40_A99_H1.3181.00
55_R106_V1.2931.00
30_W34_K1.2891.00
30_W120_V1.2481.00
48_G87_K1.2391.00
87_K91_T1.2191.00
82_R86_H1.2171.00
21_D42_N1.2061.00
37_R55_R1.2051.00
80_V114_A1.2031.00
40_A95_W1.1921.00
112_V126_A1.1911.00
45_E91_T1.1871.00
81_T84_K1.1781.00
89_L93_R1.1711.00
110_F127_F1.1651.00
62_F108_C1.1511.00
50_I53_I1.1351.00
60_T95_W1.1131.00
45_E94_L1.1131.00
36_L56_E1.1121.00
61_I122_W1.1111.00
23_W115_F1.1051.00
115_F120_V1.1041.00
26_Q115_F1.0801.00
29_R32_E1.0771.00
123_I126_A1.0721.00
36_L61_I1.0641.00
39_I55_R1.0551.00
96_L108_C1.0531.00
28_R54_M1.0501.00
26_Q29_R1.0471.00
39_I60_T1.0341.00
114_A121_E1.0131.00
101_G106_V1.0101.00
53_I62_F1.0041.00
43_V98_R1.0001.00
56_E61_I0.9991.00
42_N49_E0.9891.00
77_A121_E0.9891.00
55_R58_R0.9871.00
41_A52_L0.9841.00
47_G90_Q0.9811.00
38_F41_A0.9651.00
83_S86_H0.9481.00
88_L127_F0.9451.00
22_A26_Q0.9311.00
25_A29_R0.9291.00
95_W99_H0.9201.00
85_Q110_F0.9121.00
85_Q126_A0.9081.00
93_R97_A0.9001.00
70_S74_G0.8951.00
25_A28_R0.8951.00
17_K44_N0.8901.00
17_K42_N0.8741.00
77_A123_I0.8741.00
80_V84_K0.8711.00
113_V120_V0.8641.00
36_L63_V0.8581.00
56_E59_T0.8470.99
59_T109_R0.8370.99
27_A115_F0.8340.99
56_E109_R0.8160.99
47_G91_T0.8120.99
86_H90_Q0.8100.99
45_E48_G0.8090.99
32_E38_F0.8020.99
43_V95_W0.7860.99
82_R85_Q0.7830.99
31_L36_L0.7620.99
40_A43_V0.7560.99
100_N106_V0.7470.99
31_L63_V0.7330.99
22_A25_A0.7280.98
34_K122_W0.7280.98
59_T107_D0.7260.98
86_H89_L0.7180.98
101_G105_T0.7180.98
47_G94_L0.7170.98
31_L122_W0.7030.98
15_T18_Q0.7030.98
88_L91_T0.7030.98
94_L98_R0.6990.98
52_L65_V0.6890.98
74_G78_A0.6860.98
50_I62_F0.6860.98
29_R33_G0.6850.98
31_L54_M0.6830.98
92_A108_C0.6760.97
58_R107_D0.6710.97
88_L110_F0.6690.97
85_Q127_F0.6690.97
99_H106_V0.6690.97
46_R94_L0.6570.97
30_W113_V0.6500.97
19_T23_W0.6500.97
62_F96_L0.6480.97
89_L127_F0.6460.97
43_V53_I0.6340.96
50_I91_T0.6290.96
21_D25_A0.6270.96
39_I95_W0.6260.96
88_L125_D0.6130.96
85_Q89_L0.6050.95
99_H105_T0.6010.95
83_S87_K0.5890.94
40_A53_I0.5730.94
47_G87_K0.5710.94
18_Q22_A0.5690.93
101_G104_D0.5680.93
27_A122_W0.5640.93
18_Q21_D0.5620.93
50_I88_L0.5560.93
67_Y115_F0.5560.93
95_W101_G0.5520.92
53_I95_W0.5490.92
71_A74_G0.5470.92
76_A116_T0.5450.92
88_L92_A0.5440.92
50_I92_A0.5410.92
38_F52_L0.5330.91
66_R84_K0.5320.91
89_L96_L0.5290.91
87_K90_Q0.5250.90
29_R120_V0.5230.90
30_W122_W0.5210.90
16_T66_R0.5190.90
59_T108_C0.5170.90
43_V48_G0.5150.90
61_I111_D0.5130.89
66_R80_V0.5110.89
26_Q118_N0.5080.89
85_Q88_L0.5030.88
43_V91_T0.5030.88
20_G24_E0.5010.88
85_Q112_V0.5010.88
33_G37_R0.5000.88
26_Q120_V0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fovA 2 0.771 100 0.144 Contact Map
1gefA 2 0.8015 99.9 0.404 Contact Map
1hh1A 2 0.7481 99.9 0.413 Contact Map
2eo0A 2 0.7481 99.9 0.434 Contact Map
1ob8A 1 0.8092 99.9 0.446 Contact Map
2wcwA 2 0.8015 99.9 0.485 Contact Map
2ostA 4 0.7939 99.5 0.649 Contact Map
1y88A 5 0.855 99.2 0.698 Contact Map
2vldA 2 0.8244 91.1 0.88 Contact Map
3dnxA 2 0.8473 82.5 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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