GREMLIN Database
TTDR - HTH-type transcriptional activator TtdR
UniProt: P45463 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12694
Length: 310 (288)
Sequences: 79782 (58104)
Seq/√Len: 3423.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_E79_Q3.5241.00
20_S29_T3.3621.00
160_H293_A2.6911.00
101_G143_I2.5481.00
72_H86_D2.4031.00
235_A242_M2.3061.00
166_K246_E2.2271.00
175_Y191_H2.2061.00
117_E295_W2.1951.00
164_K270_N2.1761.00
16_E29_T2.1501.00
161_L164_K2.1351.00
19_H74_L2.1331.00
25_A28_A2.1291.00
97_M128_H2.1061.00
97_M126_Q2.0531.00
161_L270_N2.0341.00
184_S187_E2.0331.00
15_V70_Y1.9931.00
232_L252_F1.9931.00
50_T65_S1.9791.00
13_V40_R1.9771.00
164_K268_S1.9611.00
99_R128_H1.9561.00
72_H79_Q1.9301.00
117_E291_F1.9091.00
194_L240_G1.9001.00
76_I80_Y1.8921.00
23_F41_I1.8901.00
15_V74_L1.8861.00
16_E19_H1.8861.00
13_V37_V1.8841.00
18_V62_L1.8701.00
15_V19_H1.8411.00
16_E20_S1.8391.00
236_L257_K1.8111.00
236_L252_F1.8071.00
70_Y74_L1.7981.00
168_I246_E1.7851.00
134_R146_D1.7681.00
54_N61_A1.7281.00
69_C83_L1.7211.00
192_D222_H1.6731.00
118_L288_C1.6601.00
68_R86_D1.6531.00
180_P187_E1.6431.00
159_A272_W1.6351.00
171_A261_V1.6221.00
19_H29_T1.6081.00
14_L70_Y1.5811.00
137_D142_N1.5711.00
18_V70_Y1.5701.00
15_V73_A1.5641.00
13_V32_Q1.5501.00
20_S25_A1.5421.00
158_I277_E1.5371.00
24_S34_P1.5231.00
118_L125_L1.5131.00
93_R124_E1.5111.00
64_E67_Q1.5041.00
10_D40_R1.4831.00
168_I260_Q1.4801.00
10_D47_T1.4661.00
33_T36_F1.4571.00
205_I209_G1.4571.00
7_L10_D1.4511.00
15_V77_L1.4431.00
160_H275_Y1.4301.00
51_T54_N1.4301.00
281_R285_L1.4251.00
136_I140_Q1.4221.00
22_S25_A1.4121.00
10_D43_I1.4101.00
16_E30_L1.3951.00
72_H75_E1.3931.00
289_V293_A1.3891.00
148_R274_V1.3751.00
158_I275_Y1.3721.00
150_N272_W1.3711.00
76_I83_L1.3671.00
72_H82_R1.3561.00
139_V156_Y1.3351.00
108_R229_E1.3321.00
95_E124_E1.3321.00
8_A80_Y1.3301.00
117_E121_N1.3291.00
273_A289_V1.3261.00
145_L285_L1.3201.00
275_Y289_V1.3011.00
287_V290_E1.3011.00
99_R130_E1.2831.00
138_L146_D1.2761.00
137_D143_I1.2711.00
191_H241_I1.2711.00
165_N247_W1.2651.00
145_L273_A1.2641.00
171_A241_I1.2641.00
212_Q217_V1.2601.00
119_M222_H1.2531.00
231_V242_M1.2511.00
69_C84_V1.2451.00
56_S61_A1.2421.00
67_Q71_E1.2371.00
173_P257_K1.2311.00
246_E250_L1.2301.00
42_Q46_N1.2271.00
79_Q82_R1.2131.00
121_N291_F1.2051.00
194_L231_V1.1951.00
71_E75_E1.1921.00
233_Q236_L1.1911.00
176_L191_H1.1841.00
72_H83_L1.1831.00
252_F257_K1.1761.00
117_E120_R1.1691.00
116_T120_R1.1681.00
181_Q259_V1.1681.00
68_R71_E1.1671.00
119_M192_D1.1641.00
250_L254_E1.1631.00
47_T84_V1.1631.00
14_L53_L1.1591.00
161_L272_W1.1511.00
98_I288_C1.1451.00
246_E260_Q1.1321.00
32_Q36_F1.1301.00
14_L52_L1.1291.00
159_A274_V1.1271.00
12_Q81_Q1.1201.00
39_K42_Q1.1181.00
14_L18_V1.1181.00
17_I26_A1.1041.00
257_K261_V1.1011.00
38_T42_Q1.0991.00
118_L291_F1.0911.00
23_F60_V1.0901.00
39_K43_I1.0871.00
290_E293_A1.0801.00
192_D220_S1.0801.00
128_H224_S1.0791.00
75_E82_R1.0771.00
291_F295_W1.0731.00
116_T237_E1.0721.00
225_S231_V1.0711.00
122_Y287_V1.0661.00
11_L73_A1.0631.00
286_R290_E1.0611.00
9_K12_Q1.0611.00
6_P47_T1.0561.00
76_I79_Q1.0521.00
62_L66_G1.0521.00
16_E26_A1.0501.00
172_A238_G1.0501.00
114_A292_L1.0441.00
40_R43_I1.0341.00
232_L236_L1.0181.00
68_R72_H1.0171.00
139_V154_P1.0031.00
160_H289_V0.9991.00
169_L241_I0.9981.00
233_Q237_E0.9971.00
183_Q187_E0.9951.00
113_P237_E0.9941.00
81_Q85_D0.9921.00
166_K268_S0.9911.00
84_V88_T0.9891.00
13_V30_L0.9841.00
101_G134_R0.9831.00
18_V53_L0.9821.00
81_Q84_V0.9801.00
173_P259_V0.9801.00
32_Q37_V0.9781.00
121_N294_A0.9741.00
175_Y178_K0.9731.00
170_C249_V0.9691.00
14_L62_L0.9591.00
118_L122_Y0.9591.00
251_P255_S0.9551.00
171_A175_Y0.9521.00
17_I23_F0.9481.00
262_L265_Y0.9381.00
175_Y192_D0.9361.00
137_D140_Q0.9351.00
291_F294_A0.9351.00
69_C73_A0.9341.00
78_T82_R0.9301.00
195_V221_G0.9261.00
53_L60_V0.9251.00
156_Y277_E0.9241.00
225_S234_W0.9211.00
257_K260_Q0.9201.00
50_T87_V0.9181.00
282_S285_L0.9171.00
18_V66_G0.9171.00
114_A291_F0.9131.00
126_Q220_S0.9081.00
260_Q263_P0.8991.00
26_A37_V0.8951.00
14_L44_L0.8941.00
143_I146_D0.8931.00
175_Y179_Y0.8831.00
43_I46_N0.8811.00
101_G148_R0.8801.00
206_W209_G0.8771.00
171_A176_L0.8751.00
71_E74_L0.8751.00
276_R279_L0.8741.00
25_A29_T0.8671.00
150_N270_N0.8591.00
100_I145_L0.8581.00
130_E137_D0.8561.00
157_Y274_V0.8541.00
290_E294_A0.8501.00
24_S28_A0.8481.00
170_C242_M0.8481.00
125_L284_K0.8471.00
104_F227_S0.8471.00
170_C260_Q0.8421.00
17_I41_I0.8411.00
21_G61_A0.8401.00
187_E190_R0.8401.00
179_Y192_D0.8351.00
192_D221_G0.8351.00
176_L181_Q0.8311.00
56_S59_G0.8271.00
30_L37_V0.8261.00
208_L212_Q0.8211.00
185_L265_Y0.8201.00
177_Q191_H0.8181.00
9_K40_R0.8181.00
75_E78_T0.8171.00
166_K266_A0.8161.00
249_V252_F0.8051.00
101_G146_D0.8041.00
8_A77_L0.8011.00
65_S87_V0.7991.00
14_L69_C0.7981.00
42_Q51_T0.7981.00
18_V21_G0.7971.00
158_I161_L0.7961.00
281_R286_R0.7961.00
17_I53_L0.7941.00
135_Q139_V0.7871.00
21_G67_Q0.7851.00
94_P122_Y0.7851.00
172_A239_K0.7841.00
96_G284_K0.7781.00
174_E178_K0.7781.00
130_E143_I0.7751.00
205_I224_S0.7741.00
252_F255_S0.7731.00
19_H70_Y0.7711.00
186_Q189_S0.7691.00
80_Y83_L0.7671.00
116_T239_K0.7651.00
34_P38_T0.7641.00
79_Q83_L0.7621.00
145_L288_C0.7581.00
6_P84_V0.7541.00
20_S26_A0.7541.00
234_W239_K0.7531.00
21_G59_G0.7491.00
121_N287_V0.7491.00
62_L67_Q0.7471.00
68_R90_I0.7471.00
65_S90_I0.7471.00
88_T91_K0.7461.00
170_C244_R0.7451.00
82_R86_D0.7421.00
117_E294_A0.7391.00
283_M287_V0.7381.00
61_A67_Q0.7371.00
253_L260_Q0.7351.00
170_C253_L0.7341.00
147_I292_L0.7341.00
256_G260_Q0.7331.00
211_G215_K0.7321.00
99_R143_I0.7301.00
186_Q215_K0.7281.00
189_S217_V0.7281.00
10_D13_V0.7261.00
193_C219_V0.7261.00
119_M239_K0.7241.00
139_V157_Y0.7211.00
80_Y84_V0.7211.00
114_A295_W0.7191.00
23_F37_V0.7161.00
65_S68_R0.7151.00
249_V253_L0.7121.00
83_L87_V0.7121.00
73_A76_I0.7111.00
253_L256_G0.7101.00
245_S248_D0.7101.00
17_I37_V0.7091.00
118_L287_V0.7081.00
171_A177_Q0.7071.00
210_N213_E0.7051.00
12_Q16_E0.7051.00
54_N63_T0.7021.00
102_C107_G0.7011.00
36_F40_R0.6991.00
190_R220_S0.6971.00
172_A175_Y0.6961.00
23_F59_G0.6951.00
96_G125_L0.6911.00
223_L234_W0.6871.00
99_R144_D0.6851.00
144_D285_L0.6761.00
205_I208_L0.6751.00
54_N59_G0.6751.00
65_S69_C0.6751.00
45_E50_T0.6741.00
206_W210_N0.6741.00
98_I284_K0.6711.00
227_S230_I0.6701.00
74_L78_T0.6701.00
73_A77_L0.6681.00
196_T231_V0.6671.00
82_R85_D0.6641.00
102_C111_I0.6641.00
78_T81_Q0.6631.00
126_Q224_S0.6581.00
138_L274_V0.6581.00
64_E68_R0.6521.00
26_A30_L0.6511.00
197_K224_S0.6451.00
45_E55_R0.6431.00
193_C241_I0.6421.00
210_N214_K0.6411.00
174_E177_Q0.6411.00
209_G213_E0.6391.00
17_I22_S0.6381.00
67_Q70_Y0.6371.00
69_C87_V0.6351.00
176_L179_Y0.6331.00
211_G214_K0.6321.00
287_V291_F0.6301.00
174_E238_G0.6281.00
41_I45_E0.6251.00
28_A31_G0.6241.00
208_L211_G0.6231.00
141_D276_R0.6231.00
251_P254_E0.6211.00
68_R87_V0.6201.00
171_A259_V0.6201.00
262_L266_A0.6191.00
72_H76_I0.6171.00
288_C292_L0.6161.00
163_T271_I0.6141.00
169_L193_C0.6131.00
9_K43_I0.6131.00
180_P183_Q0.6121.00
212_Q219_V0.6111.00
169_L188_L0.6101.00
207_E211_G0.6071.00
231_V235_A0.6061.00
12_Q15_V0.6031.00
111_I114_A0.6031.00
234_W240_G0.5991.00
62_L70_Y0.5991.00
206_W211_G0.5971.00
204_G207_E0.5951.00
98_I145_L0.5951.00
108_R233_Q0.5951.00
177_Q180_P0.5931.00
197_K226_N0.5931.00
177_Q183_Q0.5921.00
184_S264_E0.5911.00
279_L282_S0.5901.00
283_M286_R0.5891.00
145_L289_V0.5891.00
165_N269_A0.5881.00
158_I278_P0.5881.00
107_G131_L0.5881.00
169_L243_L0.5881.00
85_D89_Q0.5861.00
167_R243_L0.5851.00
95_E126_Q0.5851.00
173_P256_G0.5811.00
138_L157_Y0.5811.00
48_L87_V0.5811.00
134_R141_D0.5801.00
33_T39_K0.5781.00
275_Y286_R0.5751.00
35_A39_K0.5741.00
149_I269_A0.5721.00
48_L69_C0.5721.00
9_K13_V0.5681.00
209_G212_Q0.5631.00
256_G261_V0.5631.00
53_L62_L0.5601.00
36_F39_K0.5601.00
176_L180_P0.5601.00
178_K259_V0.5591.00
113_P117_E0.5591.00
41_I53_L0.5581.00
50_T54_N0.5571.00
198_E224_S0.5541.00
71_E86_D0.5511.00
113_P116_T0.5491.00
48_L51_T0.5491.00
106_F110_H0.5481.00
228_G245_S0.5481.00
77_L80_Y0.5481.00
225_S230_I0.5471.00
171_A178_K0.5461.00
12_Q77_L0.5451.00
96_G122_Y0.5441.00
244_R249_V0.5431.00
115_I127_V0.5431.00
175_Y241_I0.5411.00
73_A80_Y0.5401.00
13_V41_I0.5391.00
147_I273_A0.5391.00
263_P266_A0.5341.00
77_L81_Q0.5261.00
152_E155_D0.5261.00
51_T65_S0.5251.00
23_F55_R0.5251.00
182_P187_E0.5241.00
162_L273_A0.5241.00
204_G208_L0.5231.00
96_G124_E0.5211.00
72_H87_V0.5201.00
258_L261_V0.5181.00
150_N159_A0.5161.00
13_V26_A0.5151.00
174_E259_V0.5111.00
285_L289_V0.5101.00
23_F34_P0.5081.00
85_D88_T0.5021.00
103_S106_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uthA 2 0.7194 100 0.128 Contact Map
2esnA 3 0.9452 100 0.133 Contact Map
3szpA 3 0.9323 100 0.136 Contact Map
1ixcA 4 0.9387 100 0.137 Contact Map
3hhgA 3 0.9484 100 0.144 Contact Map
3fxqA 3 0.9323 100 0.145 Contact Map
3fzvA 4 0.9194 100 0.147 Contact Map
1al3A 1 0.7 100 0.152 Contact Map
2h98A 2 0.6806 100 0.153 Contact Map
4x6gA 4 0.9742 100 0.154 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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