GREMLIN Database
DCUD - Putative cryptic C4-dicarboxylate transporter DcuD
UniProt: P45428 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12818
Length: 455 (437)
Sequences: 393 (271)
Seq/√Len: 13.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_S441_V8.5841.00
212_H216_Q4.9961.00
207_S441_V4.5731.00
172_G193_F4.5391.00
243_Y287_V4.5201.00
10_V31_A4.4061.00
207_S445_V4.3051.00
279_L283_V3.6790.99
188_K191_T3.3290.98
63_N66_L2.9920.97
255_M323_G2.9920.97
288_E291_R2.9060.96
66_L272_H2.8810.96
14_M31_A2.8620.95
217_R221_K2.8260.95
72_R324_E2.8110.95
23_K303_Q2.6780.93
218_A222_K2.5270.91
165_T212_H2.4630.90
368_M413_I2.4500.90
69_L321_V2.4340.90
440_A444_V2.4170.89
253_I444_V2.3980.89
215_V437_I2.3650.88
132_T273_L2.3550.88
157_L415_A2.3420.88
319_L415_A2.3210.87
305_F308_G2.3050.87
7_S335_T2.2990.87
202_S206_I2.2890.86
323_G418_V2.2390.85
362_A407_A2.2220.85
154_V159_A2.2180.85
421_S431_V2.2160.85
164_A431_V2.1790.83
134_A416_V2.1460.83
138_G416_V2.1410.82
362_A415_A2.1400.82
100_V134_A2.1280.82
216_Q220_D2.1260.82
171_W402_F2.1160.82
102_L242_L2.1110.81
396_M422_G2.1070.81
83_V172_G2.0210.78
405_T415_A2.0080.78
98_A245_A1.9890.77
124_G166_T1.9790.77
94_G212_H1.9750.77
193_F413_I1.9400.75
414_T418_V1.9370.75
229_E246_I1.9130.74
177_N372_N1.9070.74
254_L279_L1.8970.74
6_I38_C1.8520.72
5_I33_I1.8370.71
176_T376_M1.8330.71
87_A270_E1.8250.71
113_P319_L1.8170.70
76_L86_Y1.8050.70
278_L363_I1.7800.69
161_A212_H1.7710.68
146_F421_S1.7560.68
167_M171_W1.7320.67
307_D311_T1.7310.66
172_G419_V1.7300.66
113_P372_N1.7270.66
76_L120_T1.7230.66
96_S152_L1.7190.66
104_S345_H1.7010.65
18_I330_L1.7000.65
101_S115_I1.6930.65
35_L435_T1.6880.64
390_H414_T1.6700.64
10_V35_L1.6600.63
169_I205_I1.6600.63
184_V298_T1.6590.63
409_A442_G1.6250.61
374_P377_S1.6120.61
246_I442_G1.6110.61
144_T330_L1.5780.59
5_I9_I1.5600.58
10_V34_F1.5600.58
121_Y128_A1.5580.58
29_A325_I1.5530.58
161_A216_Q1.5520.58
337_D341_R1.5170.56
183_Q186_G1.5110.56
117_L158_S1.5090.56
8_V34_F1.5070.55
292_K297_E1.5010.55
206_I210_I1.4940.55
165_T169_I1.4930.55
99_M320_V1.4800.54
35_L329_G1.4800.54
145_L333_I1.4760.54
273_L423_I1.4750.54
255_M367_V1.4550.53
9_I41_W1.4480.52
92_R304_A1.4470.52
222_K282_T1.4440.52
252_L403_A1.4410.52
209_A212_H1.4330.52
257_G268_Q1.4240.51
341_R344_E1.4230.51
272_H275_V1.4170.51
126_I230_Q1.4070.50
70_S74_A1.4040.50
250_M321_V1.3900.49
286_F352_G1.3890.49
167_M319_L1.3860.49
255_M403_A1.3600.48
359_L440_A1.3540.47
141_L163_I1.3510.47
134_A319_L1.3480.47
12_I286_F1.3480.47
196_Y254_L1.3380.47
81_M313_F1.3300.46
102_L286_F1.3220.46
215_V219_F1.3140.45
314_A318_T1.3120.45
122_V126_I1.3040.45
197_Q201_A1.3030.45
135_S377_S1.2950.44
355_I447_M1.2840.44
392_P444_V1.2610.43
65_I325_I1.2510.42
24_P86_Y1.2480.42
151_S183_Q1.2390.42
123_I312_Q1.2330.41
62_Y278_L1.2270.41
80_I100_V1.2120.40
241_P383_P1.2110.40
124_G165_T1.2020.40
208_V442_G1.2010.40
171_W420_T1.1870.39
32_G329_G1.1850.39
169_I406_L1.1830.39
246_I441_V1.1780.38
358_A391_V1.1720.38
130_F177_N1.1710.38
184_V323_G1.1580.37
149_L154_V1.1550.37
77_G399_P1.1550.37
172_G177_N1.1540.37
108_K253_I1.1530.37
320_V426_V1.1490.37
14_M377_S1.1490.37
294_N298_T1.1470.37
62_Y282_T1.1460.37
422_G439_M1.1360.36
329_G428_P1.1320.36
180_F420_T1.1310.36
207_S286_F1.1300.36
374_P414_T1.1250.36
128_A409_A1.1220.36
69_L143_V1.1210.36
323_G368_M1.1190.36
116_I196_Y1.1150.35
250_M442_G1.1150.35
54_S63_N1.1120.35
109_L352_G1.1120.35
192_Y401_H1.1110.35
122_V286_F1.1100.35
191_T210_I1.1000.35
294_N297_E1.0940.34
171_W415_A1.0930.34
6_I169_I1.0920.34
207_S211_S1.0820.34
153_G355_I1.0810.34
288_E292_K1.0770.34
127_M149_L1.0760.34
166_T418_V1.0760.34
122_V210_I1.0720.33
15_G421_S1.0680.33
55_G361_I1.0600.33
14_M234_K1.0600.33
86_Y136_G1.0540.33
39_G94_G1.0510.32
296_R336_V1.0430.32
54_S156_R1.0410.32
128_A215_V1.0310.31
107_L250_M1.0310.31
24_P385_I1.0290.31
63_N186_G1.0250.31
364_C368_M1.0240.31
319_L372_N1.0230.31
323_G413_I1.0220.31
243_Y444_V1.0220.31
370_S378_F1.0210.31
9_I228_H1.0160.31
266_L271_L1.0160.31
249_V345_H1.0150.31
279_L431_V1.0130.31
161_A165_T1.0120.31
224_K269_S1.0080.30
141_L435_T1.0020.30
315_N323_G0.9960.30
403_A430_A0.9950.30
84_G139_M0.9940.30
210_I338_A0.9940.30
277_M373_A0.9910.30
118_S178_S0.9900.30
69_L127_M0.9900.30
75_G336_V0.9880.30
332_T390_H0.9860.29
128_A168_S0.9850.29
33_I414_T0.9840.29
229_E233_Q0.9820.29
76_L136_G0.9760.29
318_T323_G0.9750.29
148_T444_V0.9740.29
24_P139_M0.9670.29
22_Y107_L0.9640.29
321_V415_A0.9620.28
252_L323_G0.9610.28
244_Y288_E0.9610.28
177_N379_A0.9600.28
120_T185_A0.9530.28
362_A366_I0.9480.28
125_Q175_E0.9480.28
144_T435_T0.9480.28
94_G216_Q0.9460.28
165_T216_Q0.9450.28
101_S240_P0.9420.28
190_A389_L0.9410.28
104_S152_L0.9410.28
66_L275_V0.9390.27
19_L65_I0.9370.27
99_M276_V0.9330.27
366_I442_G0.9330.27
19_L431_V0.9320.27
425_G433_K0.9310.27
130_F324_E0.9280.27
8_V225_N0.9250.27
287_V396_M0.9240.27
172_G405_T0.9230.27
54_S298_T0.9210.27
235_A267_M0.9210.27
12_I15_G0.9200.27
116_I152_L0.9180.27
280_S389_L0.9140.26
307_D314_A0.9130.26
76_L379_A0.9120.26
122_V209_A0.9100.26
79_S423_I0.9100.26
387_A429_F0.9100.26
286_F351_I0.9080.26
284_T287_V0.9040.26
273_L374_P0.9040.26
126_I250_M0.9030.26
209_A357_M0.8990.26
36_M325_I0.8980.26
87_A266_L0.8960.26
202_S226_I0.8960.26
12_I235_A0.8940.26
106_P155_S0.8940.26
172_G175_E0.8940.26
223_D433_K0.8930.26
317_V419_V0.8890.25
30_A421_S0.8880.25
158_S442_G0.8860.25
164_A417_V0.8860.25
231_A440_A0.8860.25
206_I224_K0.8850.25
62_Y279_L0.8840.25
142_M323_G0.8830.25
328_K331_T0.8830.25
39_G335_T0.8830.25
77_G95_A0.8800.25
124_G252_L0.8790.25
80_I86_Y0.8780.25
250_M279_L0.8770.25
13_T444_V0.8760.25
190_A256_L0.8730.25
100_V404_T0.8710.25
170_E406_L0.8700.25
128_A169_I0.8690.25
103_L118_S0.8690.25
355_I451_I0.8680.25
6_I256_L0.8640.24
408_R411_S0.8630.24
126_I183_Q0.8620.24
146_F280_S0.8600.24
256_L265_G0.8580.24
174_L177_N0.8570.24
326_F424_A0.8530.24
381_L400_M0.8520.24
200_V209_A0.8500.24
152_L318_T0.8490.24
271_L364_C0.8490.24
116_I211_S0.8450.24
165_T168_S0.8430.24
77_G319_L0.8430.24
193_F419_V0.8420.24
29_A417_V0.8420.24
391_V433_K0.8400.24
417_V432_V0.8390.24
43_G285_M0.8380.23
332_T414_T0.8380.23
275_V355_I0.8380.23
313_F401_H0.8340.23
257_G265_G0.8330.23
157_L306_F0.8330.23
389_L402_F0.8310.23
84_G255_M0.8280.23
177_N377_S0.8270.23
253_I410_V0.8240.23
364_C413_I0.8230.23
136_G378_F0.8230.23
171_W175_E0.8210.23
206_I286_F0.8210.23
18_I413_I0.8190.23
290_F294_N0.8150.23
155_S417_V0.8140.23
320_V421_S0.8130.23
77_G317_V0.8100.22
23_K316_V0.8090.22
7_S307_D0.8090.22
356_I413_I0.8080.22
146_F160_V0.8080.22
353_V413_I0.8060.22
86_Y418_V0.8050.22
100_V403_A0.8040.22
132_T401_H0.8030.22
26_V335_T0.8030.22
121_Y313_F0.7980.22
87_A384_N0.7970.22
176_T432_V0.7950.22
271_L430_A0.7930.22
35_L333_I0.7930.22
99_M405_T0.7910.22
148_T158_S0.7890.22
180_F379_A0.7880.22
74_A182_A0.7860.22
105_R221_K0.7820.21
73_I396_M0.7820.21
183_Q270_E0.7810.21
85_G323_G0.7770.21
125_Q170_E0.7770.21
105_R108_K0.7770.21
297_E377_S0.7770.21
77_G81_M0.7770.21
202_S210_I0.7740.21
118_S152_L0.7730.21
282_T286_F0.7720.21
87_A327_A0.7710.21
99_M172_G0.7710.21
319_L370_S0.7690.21
143_V361_I0.7680.21
18_I343_A0.7680.21
126_I202_S0.7670.21
69_L139_M0.7660.21
161_A439_M0.7650.21
80_I134_A0.7620.21
342_G409_A0.7620.21
5_I29_A0.7610.21
21_N224_K0.7590.21
157_L426_V0.7580.21
169_I175_E0.7570.21
64_E266_L0.7560.21
86_Y380_S0.7550.21
297_E301_D0.7530.20
403_A410_V0.7520.20
7_S348_L0.7510.20
423_I431_V0.7480.20
323_G414_T0.7480.20
427_S448_I0.7480.20
230_Q233_Q0.7460.20
194_F198_L0.7450.20
129_Q359_L0.7440.20
417_V421_S0.7430.20
79_S142_M0.7420.20
138_G284_T0.7420.20
91_E154_V0.7410.20
186_G284_T0.7400.20
254_L283_V0.7400.20
189_I331_T0.7370.20
374_P418_V0.7370.20
66_L342_G0.7330.20
21_N252_L0.7330.20
191_T246_I0.7320.20
76_L130_F0.7320.20
161_A323_G0.7310.20
14_M269_S0.7310.20
74_A337_D0.7300.20
416_V446_N0.7300.20
137_L405_T0.7260.20
154_V322_A0.7250.20
18_I203_C0.7220.19
288_E435_T0.7220.19
188_K256_L0.7210.19
77_G376_M0.7200.19
83_V177_N0.7170.19
15_G18_I0.7170.19
214_F290_F0.7120.19
82_A326_F0.7110.19
121_Y158_S0.7110.19
116_I143_V0.7070.19
205_I209_A0.7070.19
33_I300_D0.7060.19
266_L269_S0.7060.19
386_A428_P0.7040.19
136_G140_L0.7020.19
330_L422_G0.7010.19
225_N286_F0.7010.19
142_M423_I0.7000.19
99_M174_L0.7000.19
17_L381_L0.6990.19
201_A210_I0.6980.19
166_T172_G0.6980.19
372_N383_P0.6970.19
28_L319_L0.6960.19
74_A131_I0.6920.18
137_L220_D0.6910.18
32_G378_F0.6900.18
231_A278_L0.6890.18
287_V425_G0.6880.18
253_I387_A0.6870.18
353_V382_I0.6850.18
195_H256_L0.6810.18
36_M42_L0.6790.18
177_N193_F0.6780.18
318_T430_A0.6780.18
214_F363_I0.6770.18
23_K36_M0.6760.18
296_R427_S0.6750.18
59_V319_L0.6750.18
158_S339_V0.6750.18
243_Y286_F0.6730.18
77_G244_Y0.6730.18
25_Q277_M0.6730.18
134_A166_T0.6730.18
125_Q171_W0.6720.18
316_V354_M0.6710.18
389_L396_M0.6710.18
14_M391_V0.6710.18
151_S376_M0.6680.18
362_A377_S0.6670.18
286_F289_F0.6660.18
120_T162_V0.6660.18
316_V363_I0.6660.18
37_M61_I0.6650.18
145_L243_Y0.6620.18
102_L106_P0.6610.17
351_I359_L0.6610.17
83_V406_L0.6580.17
284_T363_I0.6580.17
33_I138_G0.6570.17
321_V365_A0.6560.17
10_V123_I0.6560.17
96_S118_S0.6540.17
31_A157_L0.6540.17
55_G400_M0.6530.17
145_L284_T0.6520.17
139_M276_V0.6500.17
187_M294_N0.6490.17
371_G377_S0.6490.17
139_M177_N0.6470.17
252_L361_I0.6460.17
93_I100_V0.6450.17
234_K237_D0.6450.17
18_I276_V0.6440.17
380_S422_G0.6440.17
96_S361_I0.6430.17
154_V409_A0.6410.17
371_G408_R0.6390.17
240_P243_Y0.6370.17
165_T435_T0.6370.17
26_V302_V0.6350.17
210_I237_D0.6330.17
377_S396_M0.6310.17
314_A322_A0.6310.17
132_T256_L0.6300.17
78_L123_I0.6300.17
331_T435_T0.6280.17
139_M143_V0.6280.17
104_S116_I0.6270.16
20_K444_V0.6270.16
194_F441_V0.6260.16
15_G330_L0.6260.16
179_I208_V0.6260.16
8_V229_E0.6240.16
117_L178_S0.6230.16
33_I61_I0.6220.16
31_A55_G0.6220.16
154_V442_G0.6210.16
332_T380_S0.6200.16
31_A387_A0.6180.16
162_V426_V0.6180.16
13_T31_A0.6180.16
17_L391_V0.6160.16
77_G247_L0.6160.16
271_L280_S0.6150.16
331_T442_G0.6130.16
297_E396_M0.6120.16
120_T265_G0.6120.16
130_F146_F0.6110.16
326_F421_S0.6110.16
91_E416_V0.6100.16
38_C195_H0.6090.16
81_M241_P0.6080.16
174_L407_A0.6080.16
189_I280_S0.6080.16
118_S397_I0.6070.16
178_S365_A0.6060.16
39_G300_D0.6050.16
135_S306_F0.6050.16
56_Y324_E0.6030.16
323_G374_P0.6020.16
87_A123_I0.6020.16
7_S355_I0.6010.16
99_M424_A0.6010.16
115_I202_S0.5980.16
9_I345_H0.5980.16
285_M301_D0.5980.16
123_I295_L0.5980.16
5_I75_G0.5980.16
206_I268_Q0.5960.16
88_R203_C0.5940.16
170_E413_I0.5890.15
130_F372_N0.5860.15
256_L330_L0.5860.15
160_V177_N0.5840.15
137_L304_A0.5830.15
217_R231_A0.5830.15
162_V309_M0.5830.15
90_M164_A0.5790.15
136_G329_G0.5790.15
71_N227_N0.5780.15
54_S360_V0.5780.15
175_E178_S0.5760.15
68_M324_E0.5760.15
335_T450_T0.5760.15
152_L404_T0.5760.15
183_Q288_E0.5750.15
295_L299_M0.5730.15
21_N249_V0.5730.15
163_I192_Y0.5720.15
218_A279_L0.5720.15
83_V96_S0.5710.15
256_L441_V0.5700.15
21_N404_T0.5700.15
205_I284_T0.5700.15
9_I223_D0.5680.15
128_A165_T0.5670.15
14_M418_V0.5660.15
11_L325_I0.5660.15
62_Y401_H0.5650.15
224_K336_V0.5650.15
150_V353_V0.5600.15
73_I318_T0.5600.15
18_I376_M0.5600.15
121_Y212_H0.5590.15
313_F407_A0.5590.15
288_E438_P0.5580.15
28_L159_A0.5560.15
125_Q401_H0.5560.15
370_S373_A0.5550.15
94_G209_A0.5550.15
229_E237_D0.5550.15
29_A322_A0.5550.15
204_V395_V0.5540.14
24_P323_G0.5520.14
137_L165_T0.5520.14
63_N67_R0.5510.14
91_E151_S0.5510.14
87_A368_M0.5500.14
368_M396_M0.5500.14
115_I191_T0.5480.14
77_G114_Y0.5470.14
93_I140_L0.5470.14
81_M95_A0.5470.14
34_F185_A0.5470.14
215_V436_A0.5460.14
40_V232_E0.5450.14
44_F318_T0.5450.14
128_A167_M0.5450.14
31_A82_A0.5440.14
252_L398_M0.5440.14
128_A134_A0.5440.14
192_Y398_M0.5430.14
7_S322_A0.5420.14
83_V99_M0.5420.14
316_V427_S0.5410.14
76_L166_T0.5410.14
327_A368_M0.5410.14
154_V305_F0.5410.14
60_D90_M0.5410.14
143_V431_V0.5380.14
9_I13_T0.5380.14
402_F414_T0.5380.14
317_V355_I0.5380.14
124_G141_L0.5370.14
117_L128_A0.5360.14
82_A420_T0.5350.14
168_S174_L0.5340.14
8_V445_V0.5340.14
103_L435_T0.5340.14
121_Y317_V0.5330.14
319_L401_H0.5330.14
108_K410_V0.5330.14
87_A432_V0.5320.14
219_F223_D0.5310.14
320_V413_I0.5300.14
33_I108_K0.5300.14
11_L21_N0.5300.14
149_L234_K0.5290.14
162_V435_T0.5280.14
25_Q172_G0.5270.14
82_A336_V0.5260.14
312_Q380_S0.5260.14
134_A402_F0.5260.14
160_V345_H0.5260.14
34_F228_H0.5250.14
77_G309_M0.5240.14
211_S253_I0.5240.14
96_S177_N0.5240.14
202_S311_T0.5220.14
182_A189_I0.5200.14
171_W443_F0.5200.14
370_S374_P0.5200.14
8_V440_A0.5200.14
79_S364_C0.5180.14
10_V14_M0.5170.14
125_Q193_F0.5170.14
15_G183_Q0.5160.14
219_F437_I0.5160.14
157_L418_V0.5150.14
56_Y414_T0.5150.14
210_I441_V0.5130.13
433_K436_A0.5130.13
28_L308_G0.5130.13
168_S171_W0.5130.13
231_A425_G0.5120.13
164_A375_F0.5110.13
314_A413_I0.5110.13
18_I252_L0.5100.13
9_I387_A0.5100.13
17_L431_V0.5090.13
160_V420_T0.5070.13
5_I17_L0.5070.13
108_K187_M0.5070.13
93_I323_G0.5070.13
176_T205_I0.5070.13
84_G136_G0.5060.13
139_M376_M0.5060.13
23_K139_M0.5050.13
8_V356_I0.5040.13
285_M415_A0.5040.13
87_A139_M0.5040.13
9_I227_N0.5020.13
177_N320_V0.5020.13
19_L160_V0.5020.13
155_S163_I0.5010.13
73_I87_A0.5010.13
111_R222_K0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8725 99.9 0.831 Contact Map
4r1iA 2 0.9495 99.9 0.832 Contact Map
4r0cA 3 0.9187 99.9 0.836 Contact Map
3qnqA 2 0.3868 32.1 0.979 Contact Map
3giaA 1 0.4659 18.8 0.981 Contact Map
2kv5A 1 0.0725 9.9 0.983 Contact Map
2cfqA 1 0.389 8.7 0.984 Contact Map
3l1lA 2 0.444 7.7 0.984 Contact Map
4ikvA 1 0.3978 7.5 0.984 Contact Map
1pw4A 1 0.4681 7.3 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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