NANK - ECOLI - GREMLIN Contacts

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NANK - N-acetylmannosamine kinase

UniProt:	P45425	Sequences: MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNLGGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEFQALDGDITDMVFITVSTGVGGGVVSGCKLLTGPGGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADAKTIFTRAGQGDEQAQQLIHRSARTLARLIADIKATTDCQCVVVGGSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12815
Length:	291 (283)
Sequences:	12555 (9652)
Seq/√Len:	573.7

ECOLI - NANK MLC MAK NAGK YPHH NAGC ALSK
BACSU - GLK XYLR SCRK
HALSA - Q9HMA7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
87_P	90_K	3.255	1.00
103_I	145_T	3.168	1.00
27_R	276_D	3.083	1.00
19_G	23_Q	3.032	1.00
46_S	95_L	2.841	1.00
219_R	256_Y	2.650	1.00
236_C	269_L	2.546	1.00
121_I	236_C	2.541	1.00
16_A	279_L	2.472	1.00
18_I	283_A	2.467	1.00
174_V	224_L	2.449	1.00
215_H	252_L	2.332	1.00
119_G	124_M	2.330	1.00
148_G	233_D	2.311	1.00
125_V	228_I	2.303	1.00
110_A	136_G	2.224	1.00
68_R	71_S	2.222	1.00
89_V	93_E	2.213	1.00
126_F	240_G	2.205	1.00
109_A	126_F	2.146	1.00
58_R	286_A	2.111	1.00
15_A	48_L	2.101	1.00
28_R	51_P	1.999	1.00
103_I	107_Q	1.959	1.00
168_C	173_C	1.959	1.00
157_T	227_D	1.934	1.00
110_A	138_V	1.924	1.00
186_A	216_R	1.901	1.00
116_A	284_L	1.879	1.00
147_P	235_Q	1.867	1.00
103_I	108_A	1.866	1.00
123_D	235_Q	1.859	1.00
139_S	144_L	1.858	1.00
43_D	95_L	1.831	1.00
225_I	237_V	1.817	1.00
4_L	49_V	1.804	1.00
59_V	96_T	1.781	1.00
26_D	55_H	1.781	1.00
86_F	91_T	1.772	1.00
256_Y	259_Q	1.771	1.00
91_T	94_Q	1.757	1.00
222_A	256_Y	1.753	1.00
90_K	94_Q	1.744	1.00
257_L	268_L	1.730	1.00
166_C	173_C	1.728	1.00
165_V	171_T	1.719	1.00
50_S	95_L	1.711	1.00
202_R	207_D	1.675	1.00
236_C	267_D	1.666	1.00
122_T	235_Q	1.642	1.00
218_A	252_L	1.641	1.00
112_A	273_Y	1.634	1.00
122_T	140_G	1.624	1.00
62_A	108_A	1.620	1.00
195_D	198_T	1.610	1.00
218_A	222_A	1.598	1.00
127_I	225_I	1.580	1.00
61_I	92_L	1.556	1.00
201_T	205_Q	1.553	1.00
218_A	253_V	1.553	1.00
254_E	258_A	1.552	1.00
114_F	124_M	1.546	1.00
121_I	235_Q	1.534	1.00
5_A	279_L	1.503	1.00
33_P	44_A	1.498	1.00
15_A	52_L	1.498	1.00
28_R	55_H	1.472	1.00
252_L	255_T	1.469	1.00
158_L	227_D	1.460	1.00
166_C	169_G	1.431	1.00
26_D	52_L	1.419	1.00
229_K	257_L	1.414	1.00
129_V	221_L	1.410	1.00
12_K	29_E	1.396	1.00
223_R	227_D	1.395	1.00
59_V	98_L	1.392	1.00
183_I	217_S	1.382	1.00
16_A	24_I	1.370	1.00
248_G	251_A	1.366	1.00
197_K	201_T	1.353	1.00
124_M	138_V	1.351	1.00
6_I	15_A	1.344	1.00
46_S	96_T	1.343	1.00
256_Y	260_E	1.342	1.00
215_H	256_Y	1.337	1.00
156_H	168_C	1.322	1.00
103_I	285_L	1.315	1.00
30_L	48_L	1.307	1.00
46_S	50_S	1.304	1.00
91_T	95_L	1.303	1.00
204_G	248_G	1.293	1.00
121_I	124_M	1.289	1.00
187_A	213_L	1.287	1.00
110_A	124_M	1.279	1.00
115_Q	284_L	1.272	1.00
43_D	47_A	1.262	1.00
252_L	256_Y	1.256	1.00
123_D	139_S	1.255	1.00
247_E	270_A	1.251	1.00
228_I	231_T	1.243	1.00
133_V	178_A	1.234	1.00
229_K	237_V	1.226	1.00
125_V	135_G	1.217	1.00
3_T	287_Q	1.212	1.00
28_R	48_L	1.200	1.00
164_P	185_A	1.197	1.00
114_F	138_V	1.194	1.00
42_R	91_T	1.187	1.00
161_P	223_R	1.181	1.00
50_S	96_T	1.180	1.00
203_A	214_I	1.164	1.00
18_I	24_I	1.160	1.00
204_G	249_Y	1.153	1.00
48_L	51_P	1.143	1.00
62_A	278_G	1.126	1.00
156_H	166_C	1.122	1.00
73_L	87_P	1.121	1.00
123_D	144_L	1.119	1.00
30_L	44_A	1.117	1.00
198_T	201_T	1.100	1.00
125_V	137_V	1.098	1.00
186_A	213_L	1.098	1.00
135_G	154_I	1.096	1.00
107_Q	143_L	1.095	1.00
108_A	282_A	1.092	1.00
101_I	286_A	1.091	1.00
222_A	260_E	1.089	1.00
56_A	98_L	1.080	1.00
38_P	91_T	1.065	1.00
6_I	49_V	1.062	1.00
87_P	91_T	1.058	1.00
5_A	282_A	1.055	1.00
255_T	259_Q	1.052	1.00
6_I	45_L	1.052	1.00
44_A	47_A	1.046	1.00
187_A	210_A	1.043	1.00
30_L	47_A	1.041	1.00
203_A	211_Q	1.033	1.00
211_Q	215_H	1.033	1.00
251_A	254_E	1.032	1.00
124_M	238_V	1.030	1.00
137_V	144_L	1.023	1.00
164_P	177_I	1.019	1.00
160_D	223_R	1.015	1.00
110_A	126_F	1.014	1.00
30_L	51_P	1.013	1.00
37_T	40_A	1.007	1.00
12_K	180_G	1.005	1.00
106_A	128_T	1.004	1.00
73_L	85_H	1.002	1.00
14_A	29_E	1.002	1.00
215_H	255_T	0.998	1.00
114_F	141_C	0.996	1.00
156_H	173_C	0.992	1.00
39_E	91_T	0.982	1.00
113_E	117_L	0.979	1.00
17_L	52_L	0.979	1.00
19_G	25_R	0.972	1.00
258_A	265_H	0.971	1.00
200_F	214_I	0.968	1.00
104_N	153_H	0.964	1.00
218_A	256_Y	0.963	1.00
238_V	269_L	0.955	1.00
116_A	280_L	0.954	1.00
10_G	131_T	0.951	1.00
223_R	260_E	0.947	1.00
245_L	275_H	0.937	1.00
239_V	244_G	0.935	1.00
245_L	270_A	0.932	1.00
124_M	236_C	0.931	1.00
5_A	60_A	0.930	1.00
216_R	220_T	0.930	1.00
164_P	186_A	0.924	1.00
122_T	141_C	0.923	1.00
225_I	239_V	0.923	1.00
137_V	232_T	0.919	1.00
93_E	100_T	0.918	1.00
47_A	51_P	0.917	1.00
188_Q	192_A	0.917	1.00
198_T	202_R	0.916	1.00
251_A	255_T	0.913	1.00
109_A	278_G	0.910	1.00
238_V	271_A	0.907	1.00
219_R	223_R	0.904	1.00
40_A	43_D	0.900	1.00
46_S	91_T	0.893	1.00
5_A	283_A	0.893	1.00
121_I	267_D	0.892	1.00
123_D	140_G	0.891	1.00
187_A	199_I	0.888	1.00
24_I	27_R	0.885	1.00
51_P	55_H	0.883	1.00
164_P	176_A	0.881	1.00
229_K	266_V	0.878	1.00
92_L	100_T	0.877	1.00
3_T	286_A	0.874	1.00
200_F	204_G	0.871	1.00
8_I	45_L	0.869	1.00
63_S	74_A	0.868	1.00
107_Q	153_H	0.868	1.00
137_V	152_G	0.868	1.00
4_L	56_A	0.866	1.00
93_E	99_P	0.865	1.00
125_V	237_V	0.861	1.00
41_L	83_L	0.859	1.00
225_I	257_L	0.855	1.00
18_I	280_L	0.846	1.00
201_T	204_G	0.845	1.00
117_L	120_D	0.843	1.00
38_P	86_F	0.839	1.00
274_R	277_A	0.837	1.00
186_A	217_S	0.832	1.00
15_A	28_R	0.830	1.00
118_D	272_H	0.830	1.00
123_D	147_P	0.829	1.00
247_E	251_A	0.823	1.00
194_A	198_T	0.820	1.00
8_I	63_S	0.820	1.00
146_G	151_A	0.819	1.00
93_E	97_N	0.819	1.00
202_R	210_A	0.819	1.00
13_L	32_T	0.817	1.00
202_R	205_Q	0.815	1.00
125_V	234_C	0.813	1.00
72_L	89_V	0.812	1.00
209_Q	212_Q	0.806	1.00
140_G	144_L	0.803	1.00
48_L	52_L	0.801	1.00
14_A	27_R	0.800	1.00
63_S	67_I	0.800	1.00
226_A	260_E	0.797	1.00
53_Q	98_L	0.796	1.00
219_R	260_E	0.792	1.00
146_G	233_D	0.785	1.00
186_A	189_G	0.784	1.00
207_D	210_A	0.783	1.00
68_R	75_L	0.781	1.00
159_A	220_T	0.779	1.00
106_A	136_G	0.779	1.00
222_A	257_L	0.779	1.00
16_A	27_R	0.774	1.00
108_A	285_L	0.773	1.00
119_G	238_V	0.771	1.00
212_Q	216_R	0.766	1.00
50_S	53_Q	0.766	1.00
72_L	93_E	0.762	1.00
182_G	185_A	0.761	1.00
177_I	220_T	0.757	1.00
239_V	268_L	0.754	1.00
76_N	84_L	0.751	1.00
146_G	152_G	0.749	1.00
160_D	177_I	0.748	1.00
42_R	95_L	0.746	1.00
173_C	176_A	0.745	1.00
183_I	243_V	0.743	1.00
221_L	253_V	0.743	1.00
79_N	167_G	0.743	1.00
184_A	188_Q	0.742	1.00
118_D	269_L	0.741	1.00
60_A	108_A	0.737	1.00
208_E	212_Q	0.737	1.00
33_P	40_A	0.732	1.00
269_L	272_H	0.731	1.00
111_W	114_F	0.729	1.00
160_D	164_P	0.727	1.00
213_L	217_S	0.727	1.00
180_G	184_A	0.722	1.00
226_A	230_A	0.720	1.00
203_A	206_G	0.718	1.00
39_E	43_D	0.717	1.00
8_I	13_L	0.714	1.00
126_F	238_V	0.713	1.00
200_F	246_A	0.708	1.00
9_G	131_T	0.704	1.00
118_D	238_V	0.704	1.00
40_A	44_A	0.702	1.00
50_S	54_A	0.699	1.00
158_L	161_P	0.696	1.00
47_A	50_S	0.693	1.00
222_A	226_A	0.691	1.00
219_R	259_Q	0.687	1.00
158_L	223_R	0.686	1.00
89_V	102_A	0.683	1.00
15_A	30_L	0.683	1.00
208_E	211_Q	0.682	1.00
273_Y	280_L	0.682	1.00
58_R	99_P	0.681	1.00
203_A	210_A	0.681	1.00
116_A	273_Y	0.677	1.00
157_T	224_L	0.674	1.00
170_R	260_E	0.673	1.00
174_V	217_S	0.670	1.00
178_A	217_S	0.663	1.00
161_P	219_R	0.662	1.00
6_I	59_V	0.662	1.00
166_C	170_R	0.661	1.00
225_I	253_V	0.660	1.00
66_I	77_P	0.657	1.00
159_A	177_I	0.657	1.00
60_A	286_A	0.657	1.00
104_N	132_G	0.656	1.00
183_I	213_L	0.656	1.00
184_A	199_I	0.655	1.00
44_A	48_L	0.655	1.00
17_L	56_A	0.652	1.00
8_I	41_L	0.650	1.00
168_C	172_G	0.650	1.00
159_A	224_L	0.650	1.00
144_L	232_T	0.645	1.00
117_L	269_L	0.641	1.00
101_I	285_L	0.640	1.00
169_G	173_C	0.640	1.00
128_T	278_G	0.640	1.00
90_K	93_E	0.638	1.00
130_S	242_S	0.636	1.00
213_L	216_R	0.633	1.00
43_D	46_S	0.632	1.00
9_G	242_S	0.632	1.00
11_T	131_T	0.632	1.00
181_R	185_A	0.630	1.00
280_L	283_A	0.629	1.00
89_V	100_T	0.627	1.00
105_D	134_G	0.627	1.00
254_E	267_D	0.626	1.00
81_G	84_L	0.623	1.00
255_T	258_A	0.622	1.00
115_Q	287_Q	0.621	1.00
14_A	279_L	0.621	1.00
273_Y	277_A	0.620	1.00
188_Q	193_G	0.620	1.00
94_Q	97_N	0.619	1.00
158_L	170_R	0.613	1.00
182_G	186_A	0.613	1.00
186_A	220_T	0.605	1.00
247_E	250_L	0.603	1.00
132_G	153_H	0.602	1.00
175_E	179_S	0.602	1.00
42_R	86_F	0.600	1.00
226_A	257_L	0.600	1.00
13_L	30_L	0.600	1.00
4_L	53_Q	0.599	1.00
183_I	199_I	0.595	1.00
211_Q	252_L	0.593	1.00
3_T	20_A	0.591	1.00
151_A	233_D	0.591	1.00
147_P	233_D	0.590	1.00
113_E	272_H	0.589	1.00
67_I	74_A	0.588	1.00
132_G	175_E	0.588	1.00
83_L	86_F	0.587	1.00
113_E	273_Y	0.586	1.00
160_D	220_T	0.583	1.00
136_G	143_L	0.583	1.00
276_D	280_L	0.582	1.00
147_P	234_C	0.581	1.00
38_P	83_L	0.581	1.00
156_H	169_G	0.576	1.00
92_L	96_T	0.574	1.00
113_E	271_A	0.574	1.00
127_I	154_I	0.573	1.00
170_R	173_C	0.573	1.00
166_C	176_A	0.571	1.00
127_I	135_G	0.568	0.99
187_A	202_R	0.565	0.99
196_A	200_F	0.564	0.99
127_I	228_I	0.563	0.99
234_C	237_V	0.562	0.99
3_T	57_Q	0.561	0.99
112_A	284_L	0.561	0.99
97_N	100_T	0.560	0.99
109_A	240_G	0.560	0.99
46_S	92_L	0.560	0.99
8_I	61_I	0.559	0.99
276_D	279_L	0.558	0.99
253_V	257_L	0.556	0.99
266_V	270_A	0.556	0.99
72_L	90_K	0.555	0.99
240_G	271_A	0.555	0.99
69_D	145_T	0.553	0.99
3_T	18_I	0.551	0.99
233_D	266_V	0.549	0.99
77_P	80_L	0.544	0.99
191_L	194_A	0.543	0.99
180_G	243_V	0.542	0.99
159_A	174_V	0.542	0.99
284_L	287_Q	0.540	0.99
206_G	211_Q	0.539	0.99
60_A	285_L	0.532	0.99
162_H	219_R	0.531	0.99
81_G	85_H	0.531	0.99
203_A	218_A	0.527	0.99
66_I	150_L	0.526	0.99
184_A	196_A	0.525	0.99
109_A	128_T	0.524	0.99
4_L	17_L	0.523	0.99
13_L	45_L	0.522	0.99
157_T	228_I	0.522	0.99
45_L	92_L	0.521	0.99
158_L	163_G	0.521	0.99
14_A	276_D	0.519	0.99
53_Q	96_T	0.518	0.99
207_D	211_Q	0.517	0.99
219_R	252_L	0.517	0.99
24_I	280_L	0.514	0.99
49_V	96_T	0.514	0.99
58_R	98_L	0.514	0.99
199_I	203_A	0.513	0.99
59_V	92_L	0.512	0.99
104_N	107_Q	0.512	0.99
64_T	79_N	0.512	0.99
126_F	130_S	0.511	0.99
111_W	285_L	0.511	0.99
138_V	143_L	0.511	0.99
53_Q	56_A	0.508	0.99
224_L	229_K	0.508	0.99
61_I	88_L	0.507	0.99
147_P	265_H	0.507	0.99
190_E	193_G	0.507	0.99
178_A	221_L	0.503	0.99
51_P	54_A	0.503	0.99
105_D	128_T	0.501	0.99
154_I	228_I	0.501	0.99
69_D	149_G	0.501	0.99
75_L	85_H	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2aa4A	2	0.9931	100	0.16	Contact Map
1z05A	2	0.9897	100	0.182	Contact Map
1z6rA	3	0.9931	100	0.186	Contact Map
3vovA	3	0.9863	100	0.19	Contact Map
2qm1A	2	0.9966	100	0.199	Contact Map
4htlA	4	0.9828	100	0.2	Contact Map
3vglA	3	0.9828	100	0.201	Contact Map
2yhwA	2	0.9725	100	0.205	Contact Map
2ap1A	2	0.9863	100	0.207	Contact Map
4db3A	2	0.9863	100	0.219	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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