GREMLIN Database
NANK - N-acetylmannosamine kinase
UniProt: P45425 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12815
Length: 291 (283)
Sequences: 12555 (9652)
Seq/√Len: 573.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_P90_K3.2551.00
103_I145_T3.1681.00
27_R276_D3.0831.00
19_G23_Q3.0321.00
46_S95_L2.8411.00
219_R256_Y2.6501.00
236_C269_L2.5461.00
121_I236_C2.5411.00
16_A279_L2.4721.00
18_I283_A2.4671.00
174_V224_L2.4491.00
215_H252_L2.3321.00
119_G124_M2.3301.00
148_G233_D2.3111.00
125_V228_I2.3031.00
110_A136_G2.2241.00
68_R71_S2.2221.00
89_V93_E2.2131.00
126_F240_G2.2051.00
109_A126_F2.1461.00
58_R286_A2.1111.00
15_A48_L2.1011.00
28_R51_P1.9991.00
103_I107_Q1.9591.00
168_C173_C1.9591.00
157_T227_D1.9341.00
110_A138_V1.9241.00
186_A216_R1.9011.00
116_A284_L1.8791.00
147_P235_Q1.8671.00
103_I108_A1.8661.00
123_D235_Q1.8591.00
139_S144_L1.8581.00
43_D95_L1.8311.00
225_I237_V1.8171.00
4_L49_V1.8041.00
59_V96_T1.7811.00
26_D55_H1.7811.00
86_F91_T1.7721.00
256_Y259_Q1.7711.00
91_T94_Q1.7571.00
222_A256_Y1.7531.00
90_K94_Q1.7441.00
257_L268_L1.7301.00
166_C173_C1.7281.00
165_V171_T1.7191.00
50_S95_L1.7111.00
202_R207_D1.6751.00
236_C267_D1.6661.00
122_T235_Q1.6421.00
218_A252_L1.6411.00
112_A273_Y1.6341.00
122_T140_G1.6241.00
62_A108_A1.6201.00
195_D198_T1.6101.00
218_A222_A1.5981.00
127_I225_I1.5801.00
61_I92_L1.5561.00
201_T205_Q1.5531.00
218_A253_V1.5531.00
254_E258_A1.5521.00
114_F124_M1.5461.00
121_I235_Q1.5341.00
5_A279_L1.5031.00
33_P44_A1.4981.00
15_A52_L1.4981.00
28_R55_H1.4721.00
252_L255_T1.4691.00
158_L227_D1.4601.00
166_C169_G1.4311.00
26_D52_L1.4191.00
229_K257_L1.4141.00
129_V221_L1.4101.00
12_K29_E1.3961.00
223_R227_D1.3951.00
59_V98_L1.3921.00
183_I217_S1.3821.00
16_A24_I1.3701.00
248_G251_A1.3661.00
197_K201_T1.3531.00
124_M138_V1.3511.00
6_I15_A1.3441.00
46_S96_T1.3431.00
256_Y260_E1.3421.00
215_H256_Y1.3371.00
156_H168_C1.3221.00
103_I285_L1.3151.00
30_L48_L1.3071.00
46_S50_S1.3041.00
91_T95_L1.3031.00
204_G248_G1.2931.00
121_I124_M1.2891.00
187_A213_L1.2871.00
110_A124_M1.2791.00
115_Q284_L1.2721.00
43_D47_A1.2621.00
252_L256_Y1.2561.00
123_D139_S1.2551.00
247_E270_A1.2511.00
228_I231_T1.2431.00
133_V178_A1.2341.00
229_K237_V1.2261.00
125_V135_G1.2171.00
3_T287_Q1.2121.00
28_R48_L1.2001.00
164_P185_A1.1971.00
114_F138_V1.1941.00
42_R91_T1.1871.00
161_P223_R1.1811.00
50_S96_T1.1801.00
203_A214_I1.1641.00
18_I24_I1.1601.00
204_G249_Y1.1531.00
48_L51_P1.1431.00
62_A278_G1.1261.00
156_H166_C1.1221.00
73_L87_P1.1211.00
123_D144_L1.1191.00
30_L44_A1.1171.00
198_T201_T1.1001.00
125_V137_V1.0981.00
186_A213_L1.0981.00
135_G154_I1.0961.00
107_Q143_L1.0951.00
108_A282_A1.0921.00
101_I286_A1.0911.00
222_A260_E1.0891.00
56_A98_L1.0801.00
38_P91_T1.0651.00
6_I49_V1.0621.00
87_P91_T1.0581.00
5_A282_A1.0551.00
255_T259_Q1.0521.00
6_I45_L1.0521.00
44_A47_A1.0461.00
187_A210_A1.0431.00
30_L47_A1.0411.00
203_A211_Q1.0331.00
211_Q215_H1.0331.00
251_A254_E1.0321.00
124_M238_V1.0301.00
137_V144_L1.0231.00
164_P177_I1.0191.00
160_D223_R1.0151.00
110_A126_F1.0141.00
30_L51_P1.0131.00
37_T40_A1.0071.00
12_K180_G1.0051.00
106_A128_T1.0041.00
73_L85_H1.0021.00
14_A29_E1.0021.00
215_H255_T0.9981.00
114_F141_C0.9961.00
156_H173_C0.9921.00
39_E91_T0.9821.00
113_E117_L0.9791.00
17_L52_L0.9791.00
19_G25_R0.9721.00
258_A265_H0.9711.00
200_F214_I0.9681.00
104_N153_H0.9641.00
218_A256_Y0.9631.00
238_V269_L0.9551.00
116_A280_L0.9541.00
10_G131_T0.9511.00
223_R260_E0.9471.00
245_L275_H0.9371.00
239_V244_G0.9351.00
245_L270_A0.9321.00
124_M236_C0.9311.00
5_A60_A0.9301.00
216_R220_T0.9301.00
164_P186_A0.9241.00
122_T141_C0.9231.00
225_I239_V0.9231.00
137_V232_T0.9191.00
93_E100_T0.9181.00
47_A51_P0.9171.00
188_Q192_A0.9171.00
198_T202_R0.9161.00
251_A255_T0.9131.00
109_A278_G0.9101.00
238_V271_A0.9071.00
219_R223_R0.9041.00
40_A43_D0.9001.00
46_S91_T0.8931.00
5_A283_A0.8931.00
121_I267_D0.8921.00
123_D140_G0.8911.00
187_A199_I0.8881.00
24_I27_R0.8851.00
51_P55_H0.8831.00
164_P176_A0.8811.00
229_K266_V0.8781.00
92_L100_T0.8771.00
3_T286_A0.8741.00
200_F204_G0.8711.00
8_I45_L0.8691.00
63_S74_A0.8681.00
107_Q153_H0.8681.00
137_V152_G0.8681.00
4_L56_A0.8661.00
93_E99_P0.8651.00
125_V237_V0.8611.00
41_L83_L0.8591.00
225_I257_L0.8551.00
18_I280_L0.8461.00
201_T204_G0.8451.00
117_L120_D0.8431.00
38_P86_F0.8391.00
274_R277_A0.8371.00
186_A217_S0.8321.00
15_A28_R0.8301.00
118_D272_H0.8301.00
123_D147_P0.8291.00
247_E251_A0.8231.00
194_A198_T0.8201.00
8_I63_S0.8201.00
146_G151_A0.8191.00
93_E97_N0.8191.00
202_R210_A0.8191.00
13_L32_T0.8171.00
202_R205_Q0.8151.00
125_V234_C0.8131.00
72_L89_V0.8121.00
209_Q212_Q0.8061.00
140_G144_L0.8031.00
48_L52_L0.8011.00
14_A27_R0.8001.00
63_S67_I0.8001.00
226_A260_E0.7971.00
53_Q98_L0.7961.00
219_R260_E0.7921.00
146_G233_D0.7851.00
186_A189_G0.7841.00
207_D210_A0.7831.00
68_R75_L0.7811.00
159_A220_T0.7791.00
106_A136_G0.7791.00
222_A257_L0.7791.00
16_A27_R0.7741.00
108_A285_L0.7731.00
119_G238_V0.7711.00
212_Q216_R0.7661.00
50_S53_Q0.7661.00
72_L93_E0.7621.00
182_G185_A0.7611.00
177_I220_T0.7571.00
239_V268_L0.7541.00
76_N84_L0.7511.00
146_G152_G0.7491.00
160_D177_I0.7481.00
42_R95_L0.7461.00
173_C176_A0.7451.00
183_I243_V0.7431.00
221_L253_V0.7431.00
79_N167_G0.7431.00
184_A188_Q0.7421.00
118_D269_L0.7411.00
60_A108_A0.7371.00
208_E212_Q0.7371.00
33_P40_A0.7321.00
269_L272_H0.7311.00
111_W114_F0.7291.00
160_D164_P0.7271.00
213_L217_S0.7271.00
180_G184_A0.7221.00
226_A230_A0.7201.00
203_A206_G0.7181.00
39_E43_D0.7171.00
8_I13_L0.7141.00
126_F238_V0.7131.00
200_F246_A0.7081.00
9_G131_T0.7041.00
118_D238_V0.7041.00
40_A44_A0.7021.00
50_S54_A0.6991.00
158_L161_P0.6961.00
47_A50_S0.6931.00
222_A226_A0.6911.00
219_R259_Q0.6871.00
158_L223_R0.6861.00
89_V102_A0.6831.00
15_A30_L0.6831.00
208_E211_Q0.6821.00
273_Y280_L0.6821.00
58_R99_P0.6811.00
203_A210_A0.6811.00
116_A273_Y0.6771.00
157_T224_L0.6741.00
170_R260_E0.6731.00
174_V217_S0.6701.00
178_A217_S0.6631.00
161_P219_R0.6621.00
6_I59_V0.6621.00
166_C170_R0.6611.00
225_I253_V0.6601.00
66_I77_P0.6571.00
159_A177_I0.6571.00
60_A286_A0.6571.00
104_N132_G0.6561.00
183_I213_L0.6561.00
184_A199_I0.6551.00
44_A48_L0.6551.00
17_L56_A0.6521.00
8_I41_L0.6501.00
168_C172_G0.6501.00
159_A224_L0.6501.00
144_L232_T0.6451.00
117_L269_L0.6411.00
101_I285_L0.6401.00
169_G173_C0.6401.00
128_T278_G0.6401.00
90_K93_E0.6381.00
130_S242_S0.6361.00
213_L216_R0.6331.00
43_D46_S0.6321.00
9_G242_S0.6321.00
11_T131_T0.6321.00
181_R185_A0.6301.00
280_L283_A0.6291.00
89_V100_T0.6271.00
105_D134_G0.6271.00
254_E267_D0.6261.00
81_G84_L0.6231.00
255_T258_A0.6221.00
115_Q287_Q0.6211.00
14_A279_L0.6211.00
273_Y277_A0.6201.00
188_Q193_G0.6201.00
94_Q97_N0.6191.00
158_L170_R0.6131.00
182_G186_A0.6131.00
186_A220_T0.6051.00
247_E250_L0.6031.00
132_G153_H0.6021.00
175_E179_S0.6021.00
42_R86_F0.6001.00
226_A257_L0.6001.00
13_L30_L0.6001.00
4_L53_Q0.5991.00
183_I199_I0.5951.00
211_Q252_L0.5931.00
3_T20_A0.5911.00
151_A233_D0.5911.00
147_P233_D0.5901.00
113_E272_H0.5891.00
67_I74_A0.5881.00
132_G175_E0.5881.00
83_L86_F0.5871.00
113_E273_Y0.5861.00
160_D220_T0.5831.00
136_G143_L0.5831.00
276_D280_L0.5821.00
147_P234_C0.5811.00
38_P83_L0.5811.00
156_H169_G0.5761.00
92_L96_T0.5741.00
113_E271_A0.5741.00
127_I154_I0.5731.00
170_R173_C0.5731.00
166_C176_A0.5711.00
127_I135_G0.5680.99
187_A202_R0.5650.99
196_A200_F0.5640.99
127_I228_I0.5630.99
234_C237_V0.5620.99
3_T57_Q0.5610.99
112_A284_L0.5610.99
97_N100_T0.5600.99
109_A240_G0.5600.99
46_S92_L0.5600.99
8_I61_I0.5590.99
276_D279_L0.5580.99
253_V257_L0.5560.99
266_V270_A0.5560.99
72_L90_K0.5550.99
240_G271_A0.5550.99
69_D145_T0.5530.99
3_T18_I0.5510.99
233_D266_V0.5490.99
77_P80_L0.5440.99
191_L194_A0.5430.99
180_G243_V0.5420.99
159_A174_V0.5420.99
284_L287_Q0.5400.99
206_G211_Q0.5390.99
60_A285_L0.5320.99
162_H219_R0.5310.99
81_G85_H0.5310.99
203_A218_A0.5270.99
66_I150_L0.5260.99
184_A196_A0.5250.99
109_A128_T0.5240.99
4_L17_L0.5230.99
13_L45_L0.5220.99
157_T228_I0.5220.99
45_L92_L0.5210.99
158_L163_G0.5210.99
14_A276_D0.5190.99
53_Q96_T0.5180.99
207_D211_Q0.5170.99
219_R252_L0.5170.99
24_I280_L0.5140.99
49_V96_T0.5140.99
58_R98_L0.5140.99
199_I203_A0.5130.99
59_V92_L0.5120.99
104_N107_Q0.5120.99
64_T79_N0.5120.99
126_F130_S0.5110.99
111_W285_L0.5110.99
138_V143_L0.5110.99
53_Q56_A0.5080.99
224_L229_K0.5080.99
61_I88_L0.5070.99
147_P265_H0.5070.99
190_E193_G0.5070.99
178_A221_L0.5030.99
51_P54_A0.5030.99
105_D128_T0.5010.99
154_I228_I0.5010.99
69_D149_G0.5010.99
75_L85_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aa4A 2 0.9931 100 0.16 Contact Map
1z05A 2 0.9897 100 0.182 Contact Map
1z6rA 3 0.9931 100 0.186 Contact Map
3vovA 3 0.9863 100 0.19 Contact Map
2qm1A 2 0.9966 100 0.199 Contact Map
4htlA 4 0.9828 100 0.2 Contact Map
3vglA 3 0.9828 100 0.201 Contact Map
2yhwA 2 0.9725 100 0.205 Contact Map
2ap1A 2 0.9863 100 0.207 Contact Map
4db3A 2 0.9863 100 0.219 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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