GREMLIN Database
YHCH - Uncharacterized protein YhcH
UniProt: P45424 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12814
Length: 154 (149)
Sequences: 1163 (902)
Seq/√Len: 73.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_Q44_N3.2141.00
44_N149_K3.1151.00
35_P51_T2.9211.00
4_G8_S2.8771.00
20_D41_Q2.6591.00
51_T142_K2.6491.00
23_T27_A2.5901.00
47_M144_V2.5571.00
55_Q60_K2.4991.00
46_F68_Y2.3481.00
29_R32_E2.3231.00
53_N140_E2.1591.00
39_E43_D2.0241.00
50_M145_V1.9971.00
82_L112_A1.9431.00
67_Q149_K1.9401.00
5_E119_M1.9161.00
52_F132_G1.8581.00
71_I148_V1.8021.00
52_F141_I1.7901.00
69_I124_M1.7441.00
72_Q123_F1.7381.00
37_R43_D1.7111.00
74_L117_P1.6861.00
130_K133_C1.6611.00
134_V138_P1.6391.00
115_L121_A1.6251.00
38_Y49_V1.5940.99
34_A38_Y1.5840.99
89_A128_P1.5800.99
40_L47_M1.5790.99
54_T138_P1.5590.99
67_Q97_H1.5570.99
90_R105_S1.5540.99
78_E116_K1.5400.99
81_I115_L1.4990.99
71_I122_V1.4920.99
76_N117_P1.4790.99
103_L131_P1.4700.99
21_A146_V1.4680.99
64_L102_Q1.4480.99
18_L22_L1.4330.99
64_L104_C1.4270.99
66_E86_A1.4150.99
80_R114_I1.4000.99
62_A110_E1.3920.98
42_G68_Y1.3610.98
61_K93_E1.3340.98
12_A19_Q1.3330.98
37_R46_F1.3280.98
24_L47_M1.3280.98
55_Q59_E1.3200.98
56_S59_E1.3190.98
61_K103_L1.3030.98
39_E42_G1.2990.98
4_G120_F1.2890.97
49_V142_K1.2790.97
9_L22_L1.2670.97
18_L71_I1.2390.97
51_T140_E1.2330.97
64_L128_P1.2330.97
78_E139_G1.2170.96
96_H99_D1.1920.96
17_A45_I1.1870.96
116_K119_M1.1680.95
72_Q81_I1.1390.95
95_F102_Q1.1340.95
62_A128_P1.1130.94
37_R48_N1.1120.94
2_M124_M1.1080.94
81_I123_F1.1010.94
11_S126_G1.0920.93
66_E102_Q1.0880.93
75_L144_V1.0800.93
50_M132_G1.0770.93
33_K49_V1.0520.92
55_Q132_G1.0460.92
60_K132_G1.0310.91
21_A71_I1.0260.91
81_I121_A1.0100.90
22_L73_L1.0050.90
57_P112_A1.0030.90
24_L28_A0.9930.90
64_L86_A0.9900.90
50_M72_Q0.9790.89
64_L127_E0.9780.89
74_L77_G0.9540.88
35_P38_Y0.9480.87
114_I135_V0.9220.86
15_H18_L0.9100.85
93_E103_L0.9070.85
53_N138_P0.9020.85
25_A73_L0.9010.85
99_D142_K0.8920.84
79_E115_L0.8870.84
19_Q23_T0.8820.83
30_P33_K0.8790.83
17_A117_P0.8730.83
82_L110_E0.8600.82
72_Q131_P0.8560.82
54_T81_I0.8550.81
47_M73_L0.8380.80
13_G19_Q0.8380.80
10_P26_L0.8310.80
4_G126_G0.8290.79
49_V72_Q0.8100.78
60_K130_K0.8050.77
23_T26_L0.7970.77
54_T141_I0.7890.76
66_E95_F0.7770.75
113_I123_F0.7740.75
20_D23_T0.7700.74
99_D103_L0.7690.74
67_Q105_S0.7630.74
92_C105_S0.7600.73
9_L12_A0.7550.73
104_C127_E0.7410.71
132_G141_I0.7410.71
62_A130_K0.7320.70
49_V144_V0.7290.70
24_L40_L0.7290.70
83_F123_F0.7280.70
61_K72_Q0.7270.70
46_F50_M0.7260.70
36_G49_V0.7260.70
2_M8_S0.7230.69
78_E114_I0.7190.69
56_S134_V0.7190.69
93_E96_H0.7160.69
66_E97_H0.7150.69
80_R112_A0.7100.68
54_T74_L0.7060.68
72_Q121_A0.7030.67
45_I148_V0.6960.67
14_L18_L0.6950.66
9_L144_V0.6920.66
61_K92_C0.6850.65
29_R33_K0.6840.65
69_I125_P0.6820.65
18_L148_V0.6770.64
4_G15_H0.6740.64
69_I72_Q0.6740.64
40_L68_Y0.6690.63
4_G9_L0.6680.63
54_T77_G0.6640.63
9_L71_I0.6610.63
115_L141_I0.6600.62
41_Q68_Y0.6600.62
36_G131_P0.6460.61
43_D149_K0.6420.60
72_Q145_V0.6400.60
143_K147_K0.6350.59
82_L130_K0.6280.59
92_C102_Q0.6250.58
37_R64_L0.6240.58
26_L34_A0.6220.58
113_I121_A0.6150.57
7_Q90_R0.6090.56
42_G46_F0.6080.56
52_F74_L0.6080.56
36_G142_K0.6060.56
84_G104_C0.6020.55
54_T79_E0.5990.55
35_P142_K0.5980.55
127_E150_A0.5930.54
3_M108_D0.5920.54
74_L145_V0.5900.54
122_V148_V0.5880.54
66_E94_E0.5880.54
28_A33_K0.5860.53
19_Q44_N0.5840.53
94_E102_Q0.5820.53
77_G141_I0.5810.53
78_E115_L0.5790.53
7_Q10_P0.5740.52
90_R97_H0.5670.51
63_E70_D0.5630.51
6_V73_L0.5630.51
17_A44_N0.5620.50
62_A103_L0.5600.50
65_H129_H0.5580.50
94_E97_H0.5580.50
65_H70_D0.5560.50
40_L45_I0.5560.50
1_M14_L0.5560.50
93_E102_Q0.5550.50
30_P75_L0.5540.49
10_P19_Q0.5520.49
25_A75_L0.5510.49
60_K133_C0.5490.49
74_L141_I0.5450.48
71_I117_P0.5430.48
48_N89_A0.5430.48
40_L46_F0.5400.48
23_T67_Q0.5380.47
71_I110_E0.5360.47
59_E76_N0.5360.47
121_A127_E0.5310.47
12_A139_G0.5310.47
16_P20_D0.5280.46
98_E112_A0.5250.46
74_L115_L0.5250.46
28_A146_V0.5230.46
117_P141_I0.5230.46
26_L131_P0.5220.45
3_M16_P0.5180.45
43_D68_Y0.5170.45
28_A31_Q0.5170.45
20_D137_E0.5150.45
52_F64_L0.5130.44
67_Q140_E0.5130.44
69_I123_F0.5130.44
58_V76_N0.5120.44
115_L123_F0.5110.44
123_F141_I0.5110.44
129_H147_K0.5100.44
83_F121_A0.5100.44
70_D147_K0.5090.44
55_Q58_V0.5090.44
25_A47_M0.5090.44
42_G149_K0.5090.44
52_F62_A0.5050.43
44_N67_Q0.5010.43
72_Q120_F0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s4cA 2 0.987 100 0.07 Contact Map
4tsdB 2 1 100 0.121 Contact Map
2gu9A 2 0.6623 45.6 0.926 Contact Map
3gbgA 1 0.5649 38.6 0.929 Contact Map
4e2gA 2 0.7727 34.8 0.931 Contact Map
1vj2A 2 0.7143 27.8 0.934 Contact Map
1o4tA 2 0.6558 25.2 0.935 Contact Map
4mv2A 2 0.7273 24.9 0.935 Contact Map
2vpvA 5 0.5649 21.9 0.937 Contact Map
3cewA 2 0.6883 21.1 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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