GREMLIN Database
YHCG - Uncharacterized protein YhcG
UniProt: P45423 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12813
Length: 375 (343)
Sequences: 413 (327)
Seq/√Len: 17.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_K108_G7.1311.00
103_H109_E6.1851.00
105_T142_S4.4911.00
104_Q108_G4.3881.00
88_R103_H4.1421.00
88_R109_E4.0571.00
262_D327_G3.8291.00
232_E256_Q3.8111.00
259_L268_V3.6301.00
258_R265_W3.4671.00
107_S142_S3.3340.99
217_L235_L3.0550.99
306_K340_N3.0450.99
264_N289_K2.9910.99
68_K84_A2.9180.99
284_D298_M2.7850.98
264_N327_G2.7260.98
331_A344_A2.6990.98
102_I109_E2.6480.97
293_S297_Q2.6000.97
84_A88_R2.5390.96
292_Y300_M2.4290.95
102_I110_L2.3870.95
298_M321_V2.3370.94
23_V41_T2.2830.93
289_K325_E2.2810.93
12_Y73_D2.2270.93
282_I305_A2.1390.91
89_Q104_Q2.1130.90
139_L163_T2.0690.89
155_A183_E2.0020.88
280_L317_P1.9900.88
310_T313_D1.9590.87
82_F90_M1.9260.86
85_K88_R1.9200.86
288_G294_D1.9050.85
302_L317_P1.8630.84
306_K336_A1.8520.83
71_S83_S1.8410.83
38_M42_Y1.8000.82
306_K317_P1.7820.81
50_V95_L1.7700.80
284_D321_V1.7630.80
96_F156_R1.7610.80
142_S170_V1.7560.80
43_Q177_I1.7250.79
136_S144_Y1.7150.78
320_L331_A1.7050.78
16_H70_L1.7020.78
275_R280_L1.7010.78
294_D297_Q1.6860.77
308_H333_Y1.6840.77
263_D327_G1.6700.76
107_S170_V1.6500.75
179_T184_R1.6450.75
214_P243_M1.6320.75
307_E332_H1.5990.73
254_G257_R1.5940.73
14_Q17_D1.5830.72
266_F307_E1.5810.72
307_E333_Y1.5530.71
299_N338_L1.5510.71
105_T170_V1.5450.70
355_K359_D1.5360.70
162_E168_W1.5150.69
103_H108_G1.5080.68
91_R95_L1.5080.68
88_R212_R1.4850.67
30_T34_V1.4680.66
299_N337_G1.4560.66
84_A103_H1.4390.65
238_H241_D1.4390.65
89_Q108_G1.4350.64
337_G340_N1.4230.64
104_Q145_V1.4180.63
303_N336_A1.4120.63
246_L272_F1.4100.63
273_F314_E1.4090.63
253_V275_R1.4080.63
275_R314_E1.4040.63
256_Q285_L1.3840.62
20_I77_R1.3760.61
150_V177_I1.3730.61
353_D356_R1.3700.61
271_L282_I1.3510.60
249_D311_L1.3450.59
268_V282_I1.3390.59
249_D273_F1.3350.59
239_L242_F1.3350.59
278_R313_D1.3340.59
88_R91_R1.3280.58
295_A302_L1.3250.58
332_H354_E1.3050.57
232_E285_L1.2990.57
150_V155_A1.2970.56
362_V365_Q1.2940.56
297_Q300_M1.2860.56
93_F96_F1.2840.56
288_G321_V1.2810.55
145_V148_L1.2570.54
299_N334_A1.2560.54
83_S86_N1.2540.54
248_D267_R1.2520.54
50_V91_R1.2500.54
85_K92_L1.2440.53
307_E336_A1.2440.53
278_R314_E1.2360.53
53_E62_Y1.2300.52
22_L41_T1.2280.52
165_R211_I1.2250.52
271_L305_A1.2190.52
84_A108_G1.2160.51
24_D77_R1.2010.51
88_R108_G1.1930.50
299_N336_A1.1850.50
168_W181_F1.1830.49
251_A331_A1.1800.49
84_A109_E1.1780.49
321_V367_V1.1690.49
325_E346_E1.1680.49
106_M110_L1.1670.49
104_Q107_S1.1570.48
302_L342_V1.1570.48
24_D78_Y1.1560.48
67_I84_A1.1480.47
147_L156_R1.1340.46
68_K88_R1.1280.46
86_N90_M1.1270.46
16_H73_D1.1250.46
71_S88_R1.1220.46
320_L332_H1.1140.45
280_L305_A1.1120.45
92_L96_F1.1100.45
258_R267_R1.1050.45
303_N337_G1.0870.44
259_L333_Y1.0790.43
15_I48_R1.0770.43
188_S193_A1.0700.43
156_R322_L1.0680.43
282_I317_P1.0520.42
215_F230_D1.0450.41
19_I45_I1.0430.41
223_K227_S1.0380.41
211_I238_H1.0360.41
274_H293_S1.0300.40
234_A347_Y1.0290.40
306_K310_T1.0260.40
290_F295_A1.0240.40
144_Y147_L1.0200.40
137_F177_I1.0180.40
93_F147_L1.0120.39
42_Y253_V0.9950.38
266_F330_E0.9950.38
364_T368_L0.9900.38
50_V78_Y0.9890.38
67_I294_D0.9760.37
41_T45_I0.9750.37
330_E334_A0.9740.37
264_N330_E0.9720.37
37_L90_M0.9720.37
222_L231_F0.9630.36
249_D314_E0.9570.36
47_R51_E0.9570.36
22_L27_R0.9570.36
217_L298_M0.9500.36
73_D254_G0.9500.36
280_L321_V0.9470.36
306_K339_P0.9460.35
85_K103_H0.9450.35
232_E255_R0.9380.35
253_V310_T0.9350.35
217_L261_I0.9350.35
293_S300_M0.9340.35
215_F289_K0.9330.35
11_G315_N0.9320.35
289_K327_G0.9300.35
262_D326_K0.9280.34
152_N183_E0.9250.34
152_N155_A0.9150.34
290_F302_L0.9110.34
235_L246_L0.9060.33
152_N238_H0.9050.33
229_S354_E0.9010.33
257_R271_L0.9000.33
251_A314_E0.8970.33
294_D344_A0.8960.33
18_G48_R0.8950.33
185_T194_M0.8950.33
302_L335_L0.8940.33
303_N307_E0.8930.33
365_Q368_L0.8930.33
102_I105_T0.8930.33
253_V280_L0.8930.33
29_E37_L0.8880.32
328_A332_H0.8860.32
213_D217_L0.8830.32
267_R281_L0.8820.32
33_S37_L0.8810.32
171_R174_E0.8780.32
162_E165_R0.8770.32
238_H312_P0.8740.32
302_L324_A0.8690.31
343_L346_E0.8660.31
222_L230_D0.8660.31
310_T317_P0.8640.31
186_L299_N0.8630.31
240_M255_R0.8630.31
273_F280_L0.8610.31
158_F181_F0.8590.31
355_K358_A0.8580.31
26_A44_E0.8580.31
85_K104_Q0.8580.31
275_R309_W0.8550.31
280_L314_E0.8530.30
276_R311_L0.8520.30
291_S294_D0.8520.30
85_K89_Q0.8520.30
82_F224_D0.8500.30
93_F322_L0.8460.30
75_C79_K0.8450.30
62_Y240_M0.8440.30
42_Y213_D0.8420.30
212_R313_D0.8420.30
60_A66_L0.8410.30
82_F315_N0.8360.30
300_M332_H0.8340.29
300_M330_E0.8310.29
261_I327_G0.8310.29
295_A299_N0.8250.29
213_D235_L0.8230.29
360_E364_T0.8220.29
280_L302_L0.8210.29
129_W132_L0.8210.29
86_N254_G0.8200.29
309_W331_A0.8190.29
345_S349_M0.8190.29
290_F334_A0.8180.29
302_L349_M0.8170.29
49_I162_E0.8120.28
141_R280_L0.8120.28
213_D325_E0.8120.28
205_I217_L0.8100.28
196_Q237_N0.8080.28
196_Q200_P0.8070.28
146_R174_E0.8000.28
274_H277_L0.7990.28
293_S299_N0.7950.28
233_E237_N0.7930.27
38_M327_G0.7890.27
144_Y344_A0.7890.27
159_Y285_L0.7880.27
215_F250_F0.7810.27
230_D357_L0.7790.27
86_N89_Q0.7780.27
176_Q197_Q0.7750.27
299_N307_E0.7740.27
244_L288_G0.7740.27
249_D276_R0.7740.27
249_D343_L0.7730.26
285_L322_L0.7710.26
351_L362_V0.7710.26
209_Q299_N0.7640.26
251_A280_L0.7610.26
93_F156_R0.7600.26
139_L168_W0.7540.26
65_Q211_I0.7510.25
240_M282_I0.7510.25
278_R311_L0.7500.25
19_I167_G0.7490.25
38_M41_T0.7490.25
140_P169_S0.7480.25
71_S87_L0.7470.25
251_A275_R0.7470.25
35_N213_D0.7470.25
72_K111_T0.7460.25
240_M243_M0.7410.25
60_A67_I0.7410.25
71_S158_F0.7390.25
176_Q184_R0.7340.25
81_G285_L0.7330.25
195_L362_V0.7300.25
136_S235_L0.7290.24
60_A64_A0.7260.24
62_Y110_L0.7260.24
50_V252_F0.7260.24
64_A109_E0.7260.24
302_L322_L0.7260.24
103_H358_A0.7240.24
159_Y256_Q0.7240.24
62_Y292_Y0.7190.24
217_L273_F0.7180.24
314_E349_M0.7180.24
22_L44_E0.7170.24
79_K186_L0.7150.24
147_L160_E0.7140.24
83_S88_R0.7140.24
78_Y141_R0.7100.24
19_I169_S0.7100.24
45_I156_R0.7080.24
156_R177_I0.7080.24
75_C136_S0.7060.23
268_V318_I0.7030.23
147_L158_F0.6970.23
266_F300_M0.6960.23
306_K337_G0.6870.23
260_R265_W0.6870.23
104_Q154_D0.6860.23
86_N148_L0.6810.22
49_I60_A0.6810.22
261_I287_V0.6800.22
257_R309_W0.6770.22
259_L273_F0.6770.22
294_D298_M0.6760.22
354_E362_V0.6750.22
27_R82_F0.6750.22
217_L284_D0.6750.22
200_P312_P0.6750.22
34_V38_M0.6740.22
249_D280_L0.6700.22
219_F272_F0.6670.22
256_Q303_N0.6660.22
48_R320_L0.6660.22
53_E61_A0.6650.22
105_T171_R0.6650.22
261_I334_A0.6650.22
97_F249_D0.6640.22
23_V267_R0.6630.22
49_I87_L0.6620.22
139_L160_E0.6610.22
219_F242_F0.6610.22
61_A80_R0.6590.21
299_N303_N0.6580.21
234_A238_H0.6540.21
211_I232_E0.6530.21
22_L297_Q0.6520.21
27_R229_S0.6510.21
140_P170_V0.6510.21
295_A354_E0.6500.21
359_D362_V0.6500.21
274_H278_R0.6490.21
317_P321_V0.6490.21
336_A340_N0.6470.21
43_Q314_E0.6460.21
31_V78_Y0.6460.21
332_H340_N0.6460.21
342_V358_A0.6430.21
105_T109_E0.6430.21
172_Q175_R0.6420.21
34_V98_Q0.6410.21
302_L334_A0.6400.21
30_T320_L0.6390.21
67_I259_L0.6390.21
165_R276_R0.6380.21
284_D300_M0.6380.21
305_A317_P0.6380.21
307_E354_E0.6360.21
30_T43_Q0.6360.21
252_F266_F0.6340.20
28_T106_M0.6330.20
79_K82_F0.6320.20
82_F323_C0.6310.20
23_V42_Y0.6300.20
337_G342_V0.6270.20
334_A338_L0.6260.20
182_Y263_D0.6260.20
168_W243_M0.6240.20
165_R182_Y0.6240.20
179_T356_R0.6230.20
159_Y232_E0.6230.20
44_E47_R0.6210.20
97_F273_F0.6210.20
334_A337_G0.6200.20
97_F246_L0.6190.20
147_L298_M0.6190.20
84_A91_R0.6190.20
27_R79_K0.6180.20
181_F185_T0.6170.20
235_L250_F0.6160.20
89_Q103_H0.6150.20
67_I92_L0.6130.20
299_N304_Y0.6100.19
166_C181_F0.6100.19
217_L314_E0.6070.19
69_R73_D0.6070.19
38_M274_H0.6060.19
135_K316_P0.6050.19
68_K92_L0.6050.19
162_E181_F0.6040.19
98_Q318_I0.6040.19
256_Q338_L0.6040.19
46_G63_G0.6030.19
290_F344_A0.6030.19
82_F216_V0.6030.19
152_N320_L0.6020.19
214_P283_V0.6010.19
261_I304_Y0.5990.19
38_M84_A0.5980.19
12_Y16_H0.5970.19
39_T227_S0.5960.19
292_Y297_Q0.5940.19
40_A356_R0.5930.19
50_V94_Y0.5930.19
19_I95_L0.5930.19
223_K281_L0.5920.19
16_H20_I0.5920.19
94_Y315_N0.5910.19
253_V357_L0.5900.19
168_W214_P0.5890.19
181_F324_A0.5880.19
295_A334_A0.5860.19
26_A158_F0.5850.19
302_L321_V0.5830.18
43_Q98_Q0.5820.18
332_H335_L0.5820.18
158_F267_R0.5810.18
213_D345_S0.5800.18
152_N259_L0.5790.18
42_Y254_G0.5780.18
97_F144_Y0.5750.18
246_L252_F0.5750.18
232_E299_N0.5730.18
141_R344_A0.5730.18
86_N151_K0.5710.18
155_A300_M0.5710.18
231_F234_A0.5700.18
315_N325_E0.5700.18
31_V238_H0.5700.18
243_M345_S0.5690.18
315_N364_T0.5690.18
234_A280_L0.5680.18
274_H295_A0.5670.18
45_I65_Q0.5670.18
238_H357_L0.5670.18
34_V216_V0.5660.18
258_R274_H0.5660.18
303_N334_A0.5660.18
25_S110_L0.5640.18
230_D321_V0.5640.18
78_Y243_M0.5630.18
33_S234_A0.5620.18
45_I90_M0.5620.18
304_Y308_H0.5620.18
179_T214_P0.5590.18
257_R305_A0.5570.18
184_R214_P0.5570.18
274_H338_L0.5570.18
97_F302_L0.5560.18
106_M127_K0.5560.18
217_L321_V0.5550.17
187_L275_R0.5540.17
14_Q318_I0.5540.17
37_L41_T0.5510.17
305_A309_W0.5510.17
358_A363_R0.5510.17
211_I256_Q0.5500.17
19_I30_T0.5480.17
291_S297_Q0.5480.17
40_A49_I0.5470.17
124_P127_K0.5460.17
280_L349_M0.5450.17
255_R317_P0.5440.17
171_R175_R0.5440.17
86_N104_Q0.5440.17
290_F299_N0.5440.17
297_Q336_A0.5430.17
180_Q183_E0.5420.17
238_H251_A0.5410.17
93_F258_R0.5410.17
195_L207_P0.5380.17
256_Q307_E0.5380.17
126_A133_S0.5370.17
335_L353_D0.5370.17
183_E187_L0.5370.17
284_D290_F0.5360.17
19_I66_L0.5360.17
111_T114_G0.5350.17
67_I81_G0.5340.17
275_R331_A0.5340.17
155_A307_E0.5300.17
297_Q304_Y0.5280.17
219_F274_H0.5280.17
317_P331_A0.5270.17
274_H337_G0.5260.16
90_M181_F0.5260.16
273_F278_R0.5250.16
194_M343_L0.5240.16
113_L124_P0.5240.16
175_R352_P0.5240.16
33_S238_H0.5220.16
328_A342_V0.5200.16
78_Y91_R0.5180.16
68_K109_E0.5170.16
27_R106_M0.5170.16
16_H238_H0.5150.16
296_G323_C0.5150.16
75_C138_P0.5120.16
156_R252_F0.5120.16
114_G312_P0.5110.16
140_P143_T0.5100.16
293_S304_Y0.5100.16
141_R214_P0.5100.16
242_F316_P0.5100.16
170_V174_E0.5090.16
311_L314_E0.5090.16
137_F314_E0.5080.16
145_V252_F0.5070.16
38_M47_R0.5070.16
144_Y160_E0.5070.16
62_Y194_M0.5060.16
251_A306_K0.5050.16
298_M325_E0.5030.16
251_A290_F0.5000.16
15_I52_F0.5000.16
182_Y297_Q0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vldA 2 0.488 100 0.808 Contact Map
3h1tA 1 0.3547 82.5 0.968 Contact Map
3l0aA 3 0.5333 34.8 0.977 Contact Map
4umkA 2 0.352 32.4 0.978 Contact Map
4qbnA 2 0.224 32 0.978 Contact Map
2jv8A 1 0.1653 26.1 0.979 Contact Map
4ic1A 5 0.456 19.2 0.98 Contact Map
1vz0A 3 0.336 19.2 0.98 Contact Map
3kkwA 1 0.3787 12.1 0.982 Contact Map
4tllA 1 0.1707 11.6 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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