GREMLIN Database
YHCF - Uncharacterized protein YhcF
UniProt: P45422 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12812
Length: 238 (202)
Sequences: 551 (449)
Seq/√Len: 31.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_R228_D5.6051.00
89_T230_K4.9961.00
86_A123_F4.0111.00
132_K220_G3.5381.00
161_G170_K3.0471.00
202_V205_A2.9611.00
49_F213_A2.8821.00
148_A154_T2.7441.00
83_A188_Y2.6541.00
221_G225_I2.5411.00
58_S63_T2.4740.99
49_F65_I2.4240.99
57_L63_T2.3740.99
85_T234_S2.2430.99
143_S208_P2.2330.99
49_F227_L2.2140.99
87_R234_S2.1350.98
83_A236_V2.1260.98
89_T232_V2.0840.98
128_T131_N2.0470.98
56_R235_V2.0340.98
60_Q217_N1.9740.97
127_K133_N1.9110.97
128_T132_K1.9050.97
75_T204_N1.9010.97
201_P223_E1.8910.96
125_L213_A1.8650.96
139_V209_L1.8310.96
88_D123_F1.8070.95
69_N208_P1.7790.95
47_V70_I1.7380.94
137_Y231_A1.7370.94
191_F202_V1.7190.94
90_R227_L1.6840.93
220_G223_E1.6800.93
25_S230_K1.6690.93
20_A26_I1.6620.93
202_V235_V1.6590.93
81_G201_P1.6450.92
41_L45_G1.6240.92
148_A202_V1.5920.91
79_A203_T1.5720.91
173_W199_P1.5710.91
41_L233_I1.5360.90
148_A157_V1.5340.90
28_V32_L1.5270.89
42_S84_I1.5170.89
49_F68_R1.4670.87
220_G234_S1.4670.87
155_L195_G1.4190.85
124_G229_G1.3990.85
148_A200_T1.3980.85
95_T136_S1.3950.84
65_I213_A1.3920.84
41_L209_L1.3810.84
157_V192_V1.3690.83
134_I156_A1.3570.83
123_F231_A1.3450.82
57_L215_I1.3440.82
57_L219_L1.3100.80
47_V65_I1.3050.80
215_I222_S1.3050.80
155_L197_T1.3010.80
163_D170_K1.2930.80
82_I202_V1.2790.79
78_S204_N1.2510.77
154_T200_T1.2290.76
58_S61_H1.2140.75
51_S224_K1.2140.75
10_G13_F1.2130.75
147_S190_T1.2100.75
7_L15_A1.2100.75
96_T136_S1.1960.74
68_R216_A1.1940.74
47_V72_M1.1920.74
9_A14_F1.1900.74
72_M209_L1.1860.73
92_D127_K1.1750.73
7_L14_F1.1730.73
11_S14_F1.1580.72
82_I235_V1.1480.71
126_G228_D1.1300.70
12_A16_M1.0970.67
24_V39_P1.0970.67
26_I89_T1.0950.67
83_A199_P1.0910.67
93_S131_N1.0740.66
8_I14_F1.0700.65
72_M207_I1.0550.64
98_K190_T1.0230.62
36_A173_W1.0160.61
24_V224_K1.0140.61
42_S71_N1.0120.61
162_A187_Y0.9990.60
157_V190_T0.9920.59
227_L233_I0.9910.59
22_D51_S0.9910.59
130_D152_S0.9880.59
81_G235_V0.9700.58
53_S56_R0.9690.58
10_G15_A0.9580.57
155_L192_V0.9550.56
49_F212_S0.9520.56
215_I219_L0.9490.56
7_L10_G0.9290.54
93_S188_Y0.9260.54
59_T217_N0.9260.54
192_V197_T0.9210.54
30_V33_E0.9210.54
144_N207_I0.9060.52
35_A80_T0.8990.52
7_L231_A0.8940.52
8_I13_F0.8930.51
142_D208_P0.8920.51
37_C76_C0.8860.51
12_A17_S0.8820.51
27_D218_D0.8770.50
93_S197_T0.8760.50
84_I233_I0.8720.50
216_A221_G0.8540.48
19_Q140_L0.8490.48
49_F66_G0.8420.47
6_L19_Q0.8390.47
31_T198_T0.8360.47
93_S127_K0.8350.47
72_M233_I0.8320.46
26_I88_D0.8310.46
98_K178_A0.8310.46
93_S124_G0.8240.46
40_I59_T0.8230.46
55_N162_A0.8230.46
38_T82_I0.8190.45
212_S217_N0.8150.45
9_A47_V0.8120.45
11_S19_Q0.8110.45
18_A73_T0.8090.45
41_L70_I0.8080.45
73_T211_V0.8020.44
24_V58_S0.8010.44
64_Q97_G0.8000.44
74_I82_I0.7900.43
58_S217_N0.7850.43
84_I215_I0.7830.43
17_S21_A0.7760.42
84_I207_I0.7730.42
47_V149_S0.7690.41
177_T196_E0.7690.41
74_I176_L0.7660.41
85_T91_M0.7620.41
25_S28_V0.7580.41
21_A29_K0.7560.40
49_F211_V0.7560.40
213_A227_L0.7540.40
34_A63_T0.7530.40
121_R190_T0.7520.40
21_A30_V0.7490.40
191_F217_N0.7450.40
28_V68_R0.7390.39
88_D135_G0.7380.39
84_I205_A0.7370.39
67_T210_Q0.7330.39
128_T220_G0.7330.39
44_G68_R0.7320.39
35_A42_S0.7310.38
177_T193_K0.7280.38
77_E203_T0.7280.38
64_Q214_S0.7200.38
138_A216_A0.7200.38
63_T215_I0.7200.38
41_L47_V0.7190.38
82_I190_T0.7190.38
15_A139_V0.7170.37
212_S218_D0.7160.37
16_M194_P0.7130.37
42_S70_I0.7040.36
63_T225_I0.7030.36
52_H215_I0.6990.36
39_P173_W0.6990.36
129_K134_I0.6990.36
23_R204_N0.6930.36
7_L12_A0.6920.35
128_T230_K0.6900.35
169_Q226_E0.6900.35
93_S98_K0.6890.35
219_L228_D0.6880.35
190_T199_P0.6850.35
149_S152_S0.6840.35
157_V191_F0.6840.35
171_R217_N0.6830.35
40_I72_M0.6790.35
62_Y136_S0.6770.34
34_A84_I0.6770.34
20_A31_T0.6760.34
43_N61_H0.6680.34
8_I123_F0.6560.33
63_T219_L0.6530.33
49_F52_H0.6520.33
225_I236_V0.6520.33
33_E226_E0.6520.33
137_Y211_V0.6510.32
56_R92_D0.6510.32
34_A220_G0.6500.32
43_N174_Q0.6480.32
231_A236_V0.6470.32
19_Q26_I0.6460.32
78_S221_G0.6460.32
93_S151_G0.6450.32
39_P47_V0.6450.32
52_H136_S0.6340.31
149_S170_K0.6300.31
27_D72_M0.6300.31
185_Q212_S0.6270.31
9_A174_Q0.6260.31
90_R124_G0.6260.31
194_P222_S0.6260.31
6_L11_S0.6230.31
39_P42_S0.6180.30
80_T133_N0.6170.30
95_T206_I0.6170.30
178_A187_Y0.6140.30
125_L225_I0.6100.30
58_S211_V0.6080.29
94_M190_T0.6080.29
26_I38_T0.6060.29
157_V173_W0.6060.29
207_I233_I0.6000.29
183_V231_A0.5990.29
90_R229_G0.5950.29
125_L227_L0.5930.28
191_F205_A0.5930.28
19_Q77_E0.5910.28
54_V131_N0.5910.28
211_V228_D0.5900.28
65_I227_L0.5890.28
47_V213_A0.5880.28
39_P57_L0.5870.28
86_A231_A0.5860.28
156_A205_A0.5850.28
147_S206_I0.5780.27
44_G157_V0.5770.27
76_C135_G0.5750.27
37_C135_G0.5750.27
6_L17_S0.5730.27
79_A234_S0.5710.27
220_G230_K0.5710.27
44_G201_P0.5700.27
35_A199_P0.5680.27
36_A199_P0.5660.27
36_A205_A0.5650.27
35_A55_N0.5640.27
36_A83_A0.5630.27
82_I144_N0.5620.26
66_G92_D0.5600.26
134_I221_G0.5590.26
72_M202_V0.5590.26
89_T126_G0.5560.26
88_D224_K0.5480.26
132_K223_E0.5470.26
42_S233_I0.5460.25
71_N208_P0.5440.25
157_V199_P0.5440.25
35_A77_E0.5420.25
96_T123_F0.5410.25
144_N192_V0.5410.25
139_V225_I0.5410.25
49_F137_Y0.5380.25
26_I231_A0.5340.25
162_A179_Y0.5330.25
45_G84_I0.5310.25
125_L135_G0.5310.25
158_S233_I0.5270.24
64_Q140_L0.5270.24
179_Y233_I0.5250.24
74_I151_G0.5250.24
42_S72_M0.5240.24
39_P238_L0.5240.24
40_I140_L0.5240.24
32_L141_I0.5230.24
36_A75_T0.5230.24
39_P44_G0.5190.24
97_G201_P0.5180.24
83_A238_L0.5180.24
139_V169_Q0.5170.24
88_D218_D0.5160.24
25_S231_A0.5150.24
211_V225_I0.5140.24
155_L175_T0.5120.23
41_L72_M0.5120.23
26_I47_V0.5110.23
175_T193_K0.5100.23
6_L42_S0.5100.23
15_A19_Q0.5090.23
199_P215_I0.5090.23
27_D230_K0.5080.23
41_L237_Y0.5070.23
31_T154_T0.5070.23
32_L125_L0.5060.23
128_T216_A0.5050.23
49_F54_V0.5050.23
199_P237_Y0.5040.23
73_T144_N0.5030.23
178_A184_D0.5020.23
29_K35_A0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xg5B 1 0.5714 97.9 0.857 Contact Map
2jtyA 1 0.6513 97.6 0.864 Contact Map
2jmrA 1 0.6387 97.4 0.869 Contact Map
2uy6B 2 0.6008 97.1 0.875 Contact Map
5afoA 1 0.7269 96.5 0.885 Contact Map
2w07B 1 0.4958 96.3 0.888 Contact Map
1pdkB 1 0.5924 96 0.891 Contact Map
4dwhB 1 0.563 90.7 0.912 Contact Map
3bwuF 1 0.5252 86.5 0.919 Contact Map
1n12A 1 0.5588 83 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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