GREMLIN Database
KDSD - Arabinose 5-phosphate isomerase KdsD
UniProt: P45395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12803
Length: 328 (314)
Sequences: 2110 (1396)
Seq/√Len: 78.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_I168_L4.1131.00
108_E136_S3.6841.00
128_C141_A3.4341.00
282_I300_R3.2711.00
18_E180_K3.1401.00
57_M84_G3.0541.00
253_F273_I3.0261.00
241_V306_M2.8861.00
228_A273_I2.8351.00
20_L169_V2.7921.00
231_E235_K2.6801.00
54_V64_G2.6591.00
52_V76_T2.6521.00
33_Y146_C2.6311.00
222_T274_A2.6221.00
147_V170_M2.5961.00
221_K250_E2.5761.00
70_T175_A2.5721.00
244_D248_M2.4541.00
21_A31_D2.4521.00
147_V167_T2.4411.00
49_K97_Q2.4301.00
24_R28_A2.3931.00
284_V288_I2.3921.00
48_C99_V2.3691.00
67_M71_F2.3601.00
52_V101_I2.3451.00
272_S275_D2.3391.00
55_M102_A2.3311.00
103_I167_T2.3161.00
306_M313_L2.2991.00
24_R27_L2.2931.00
57_M83_P2.2541.00
44_K143_V2.2311.00
41_A127_I2.2131.00
51_K95_T2.1901.00
207_N287_G2.1571.00
41_A143_V2.1401.00
13_Q34_I2.0831.00
24_R31_D1.9891.00
68_A78_S1.9761.00
249_I313_L1.9661.00
100_V119_L1.9501.00
309_D312_H1.9071.00
295_N299_S1.8951.00
46_F181_A1.8711.00
81_V94_V1.8261.00
16_G38_F1.8241.00
303_T318_H1.8121.00
25_E28_A1.8101.00
24_R169_V1.8031.00
21_A25_E1.7811.00
44_K125_P1.7661.00
228_A240_T1.7551.00
45_M52_V1.7361.00
55_M100_V1.7281.00
26_C162_S1.6821.00
130_T144_H1.6661.00
54_V101_I1.6421.00
284_V305_V1.5981.00
22_I162_S1.5911.00
131_G146_C1.5771.00
237_L316_V1.5650.99
13_Q39_T1.5630.99
46_F182_R1.5560.99
120_K142_D1.5460.99
12_F181_A1.5370.99
219_V242_I1.5360.99
138_A144_H1.5330.99
218_H241_V1.5210.99
72_A93_M1.5190.99
29_E150_A1.5160.99
15_A19_V1.5100.99
15_A180_K1.4980.99
45_M99_V1.4960.99
286_P314_L1.4940.99
255_D259_R1.4940.99
288_I292_E1.4900.99
110_S114_A1.4840.99
211_H321_D1.4560.99
249_I306_M1.4430.99
125_P142_D1.4150.99
64_G103_I1.4070.99
43_E47_W1.3990.99
82_H85_E1.3960.99
12_F39_T1.3940.99
161_T176_V1.3810.99
239_M316_V1.3750.99
267_D270_Q1.3610.99
133_P146_C1.3590.99
221_K274_A1.3220.98
33_Y148_K1.3210.98
209_I317_L1.3090.98
207_N286_P1.3010.98
129_I170_M1.2900.98
206_V293_A1.2840.98
221_K279_P1.2760.98
248_M312_H1.2760.98
261_V276_V1.2730.98
220_K245_D1.2500.97
286_P309_D1.2470.97
282_I302_I1.2430.97
211_H237_L1.2420.97
247_M313_L1.2260.97
68_A72_A1.2120.97
271_L275_D1.2010.97
145_L170_M1.1940.97
19_V177_A1.1890.97
13_Q17_K1.1850.97
67_M101_I1.1790.96
79_F93_M1.1570.96
101_I129_I1.1510.96
241_V313_L1.1500.96
30_L166_A1.1480.96
103_I129_I1.1410.96
231_E234_R1.1380.96
67_M103_I1.1370.96
284_V293_A1.1350.96
285_R309_D1.1260.95
130_T138_A1.1240.95
221_K244_D1.1210.95
64_G80_F1.1170.95
209_I290_A1.1160.95
44_K99_V1.1130.95
12_F43_E1.1120.95
87_A195_G1.1090.95
128_C137_M1.1070.95
284_V307_V1.1060.95
122_L192_S1.0860.94
253_F258_L1.0830.94
51_K93_M1.0790.94
248_M311_D1.0760.94
37_N40_L1.0760.94
213_G235_K1.0760.94
133_P144_H1.0730.94
94_V100_V1.0710.94
45_M71_F1.0670.94
241_V249_I1.0560.93
134_E139_R1.0550.93
219_V223_A1.0450.93
28_A32_Q1.0410.93
53_V79_F1.0410.93
231_E240_T1.0350.93
223_A227_D1.0340.93
18_E151_K1.0310.93
131_G170_M1.0270.92
128_C144_H1.0260.92
74_T178_L1.0220.92
15_A18_E1.0210.92
239_M304_S1.0040.92
52_V71_F1.0030.92
239_M252_I1.0020.92
129_I147_V0.9990.91
21_A28_A0.9970.91
21_A24_R0.9960.91
45_M76_T0.9950.91
292_E295_N0.9880.91
72_A79_F0.9880.91
53_V94_V0.9850.91
133_P138_A0.9790.91
244_D250_E0.9790.91
20_L30_L0.9670.90
304_S318_H0.9660.90
18_E22_I0.9640.90
22_I151_K0.9560.90
293_A305_V0.9540.89
283_R308_A0.9520.89
225_L228_A0.9490.89
64_G167_T0.9470.89
40_L43_E0.9410.89
228_A253_F0.9410.89
112_I137_M0.9380.89
219_V240_T0.9300.88
233_T259_R0.9290.88
285_R311_D0.9290.88
36_Q40_L0.9290.88
253_F276_V0.9260.88
246_N312_H0.9260.88
42_C174_L0.9260.88
218_H247_M0.9170.87
190_A200_R0.9170.87
221_K245_D0.9080.87
216_I313_L0.9000.86
26_C29_E0.8910.86
229_L262_F0.8910.86
131_G147_V0.8910.86
131_G149_V0.8900.86
99_V125_P0.8900.86
12_F42_C0.8880.86
155_P179_L0.8820.85
62_H86_A0.8770.85
40_L44_K0.8720.85
29_E33_Y0.8660.84
17_K21_A0.8610.84
206_V284_V0.8590.84
285_R310_G0.8590.84
226_R263_D0.8530.83
16_G39_T0.8530.83
218_H313_L0.8520.83
247_M250_E0.8520.83
17_K31_D0.8460.83
113_T136_S0.8440.83
243_C250_E0.8420.83
28_A31_D0.8370.82
251_G277_M0.8350.82
321_D324_R0.8330.82
68_A79_F0.8330.82
121_R289_L0.8320.82
109_S112_I0.8300.82
285_R288_I0.8290.82
33_Y131_G0.8280.82
39_T43_E0.8200.81
45_M48_C0.8190.81
296_L300_R0.8190.81
87_A114_A0.8190.81
51_K77_P0.8160.81
222_T273_I0.8150.80
74_T179_L0.8140.80
77_P95_T0.8110.80
127_I143_V0.8090.80
19_V167_T0.8080.80
303_T319_M0.8010.79
23_E153_A0.7980.79
26_C150_A0.7960.79
25_E150_A0.7930.79
253_F261_V0.7920.79
102_A126_L0.7850.78
225_L253_F0.7850.78
189_F198_L0.7810.78
29_E32_Q0.7810.78
85_E93_M0.7790.77
15_A177_A0.7730.77
42_C177_A0.7720.77
61_G83_P0.7720.77
221_K243_C0.7720.77
67_M171_G0.7700.77
234_R263_D0.7660.76
220_K223_A0.7640.76
40_L125_P0.7570.75
145_L174_L0.7520.75
43_E181_A0.7510.75
162_S166_A0.7500.75
219_V231_E0.7490.75
200_R325_A0.7490.75
45_M101_I0.7470.74
149_V162_S0.7450.74
57_M85_E0.7410.74
36_Q39_T0.7410.74
155_P158_L0.7390.74
241_V316_V0.7320.73
118_V122_L0.7310.73
132_R149_V0.7310.73
54_V103_I0.7280.73
61_G72_A0.7270.72
112_I115_L0.7260.72
290_A322_L0.7240.72
20_L31_D0.7200.72
37_N143_V0.7190.72
303_T323_L0.7190.72
224_S227_D0.7180.71
216_I241_V0.7160.71
108_E197_A0.7150.71
149_V166_A0.7140.71
293_A317_L0.7120.71
256_G260_R0.7120.71
204_L294_L0.7090.71
94_V119_L0.7090.71
118_V191_L0.7080.70
209_I325_A0.7060.70
73_S189_F0.7040.70
282_I296_L0.7040.70
146_C149_V0.7020.70
121_R298_Q0.6970.69
49_K312_H0.6970.69
61_G68_A0.6940.69
99_V127_I0.6930.69
218_H243_C0.6930.69
266_V271_L0.6870.68
122_L191_L0.6870.68
151_K157_G0.6840.68
156_L179_L0.6820.68
25_E29_E0.6790.67
230_L233_T0.6790.67
62_H65_R0.6790.67
81_V86_A0.6770.67
247_M312_H0.6770.67
222_T272_S0.6770.67
54_V69_A0.6750.67
125_P143_V0.6740.67
62_H271_L0.6730.67
158_L202_L0.6710.66
301_H324_R0.6700.66
23_E165_T0.6690.66
266_V270_Q0.6650.66
178_L184_F0.6630.65
40_L143_V0.6620.65
105_N297_M0.6610.65
105_N148_K0.6590.65
105_N157_G0.6580.65
20_L24_R0.6560.65
205_R252_I0.6560.65
27_L30_L0.6550.64
190_A203_L0.6540.64
154_C159_A0.6540.64
256_G259_R0.6530.64
162_S169_V0.6530.64
274_A279_P0.6530.64
16_G19_V0.6510.64
108_E139_R0.6500.64
192_S253_F0.6470.63
224_S273_I0.6470.63
298_Q320_H0.6460.63
250_E279_P0.6460.63
14_Q17_K0.6460.63
39_T42_C0.6440.63
54_V141_A0.6430.63
117_P190_A0.6410.63
20_L162_S0.6400.63
229_L233_T0.6380.62
19_V176_V0.6370.62
42_C181_A0.6370.62
103_I147_V0.6330.62
131_G148_K0.6300.61
217_P318_H0.6300.61
210_M315_G0.6280.61
205_R208_D0.6270.61
250_E313_L0.6260.61
303_T320_H0.6260.61
55_M81_V0.6240.61
155_P159_A0.6240.61
211_H324_R0.6240.61
30_L170_M0.6230.61
62_H85_E0.6230.61
260_R263_D0.6220.60
67_M233_T0.6220.60
105_N131_G0.6130.59
265_G269_R0.6120.59
143_V167_T0.6080.59
200_R204_L0.6040.58
116_I140_A0.6030.58
41_A99_V0.6030.58
17_K35_N0.6020.58
206_V288_I0.6010.58
242_I250_E0.6010.58
242_I273_I0.6000.58
37_N133_P0.5990.58
225_L273_I0.5990.58
233_T304_S0.5970.57
74_T154_C0.5960.57
218_H240_T0.5940.57
110_S195_G0.5930.57
249_I278_T0.5920.57
23_E173_A0.5920.57
153_A161_T0.5910.57
222_T227_D0.5910.57
156_L186_A0.5910.57
74_T184_F0.5900.56
42_C192_S0.5880.56
207_N317_L0.5870.56
14_Q18_E0.5860.56
245_D270_Q0.5860.56
81_V87_A0.5850.56
207_N285_R0.5850.56
17_K34_I0.5830.56
222_T245_D0.5830.56
27_L150_A0.5820.55
166_A170_M0.5810.55
242_I277_M0.5800.55
244_D312_H0.5790.55
207_N311_D0.5790.55
154_C198_L0.5780.55
226_R230_L0.5770.55
149_V298_Q0.5760.55
154_C176_V0.5760.55
105_N156_L0.5740.54
283_R306_M0.5730.54
223_A228_A0.5730.54
225_L269_R0.5730.54
225_L271_L0.5730.54
62_H81_V0.5720.54
12_F177_A0.5710.54
71_F178_L0.5710.54
211_H323_L0.5710.54
38_F166_A0.5700.54
38_F42_C0.5690.54
14_Q222_T0.5690.54
216_I240_T0.5690.54
307_V314_L0.5690.54
236_N255_D0.5690.54
141_A144_H0.5680.54
109_S201_K0.5680.54
217_P255_D0.5670.54
67_M320_H0.5650.53
14_Q310_G0.5650.53
94_V124_V0.5650.53
223_A274_A0.5640.53
215_E235_K0.5640.53
261_V264_M0.5630.53
138_A146_C0.5630.53
115_L124_V0.5610.53
128_C138_A0.5600.53
55_M112_I0.5590.52
226_R266_V0.5590.52
63_I67_M0.5580.52
156_L198_L0.5550.52
177_A181_A0.5530.52
63_I133_P0.5530.52
112_I197_A0.5510.51
99_V143_V0.5510.51
119_L124_V0.5510.51
85_E203_L0.5490.51
197_A201_K0.5480.51
237_L303_T0.5470.51
63_I212_T0.5460.51
74_T159_A0.5460.51
104_S128_C0.5450.51
114_A192_S0.5450.51
224_S272_S0.5450.51
16_G170_M0.5430.50
252_I279_P0.5420.50
110_S200_R0.5420.50
72_A203_L0.5400.50
271_L276_V0.5390.50
24_R162_S0.5380.50
42_C281_G0.5370.50
303_T316_V0.5370.50
26_C177_A0.5370.50
76_T178_L0.5360.50
288_I296_L0.5360.50
47_W310_G0.5350.49
45_M242_I0.5340.49
236_N259_R0.5340.49
61_G210_M0.5330.49
278_T281_G0.5330.49
76_T198_L0.5320.49
44_K127_I0.5310.49
222_T287_G0.5300.49
105_N147_V0.5290.49
51_K79_F0.5290.49
62_H103_I0.5270.48
41_A145_L0.5260.48
63_I207_N0.5260.48
249_I283_R0.5240.48
133_P149_V0.5230.48
204_L207_N0.5220.48
248_M310_G0.5210.48
61_G85_E0.5210.48
233_T240_T0.5210.48
19_V23_E0.5190.47
185_T188_D0.5170.47
241_V252_I0.5150.47
55_M116_I0.5150.47
69_A82_H0.5150.47
183_G268_V0.5150.47
232_V240_T0.5140.47
57_M320_H0.5140.47
43_E279_P0.5140.47
212_T216_I0.5130.47
233_T236_N0.5130.47
144_H170_M0.5130.47
113_T200_R0.5130.47
229_L258_L0.5120.46
51_K291_V0.5110.46
209_I322_L0.5110.46
12_F16_G0.5100.46
236_N298_Q0.5090.46
71_F78_S0.5090.46
32_Q309_D0.5040.45
47_W224_S0.5040.45
266_V269_R0.5020.45
184_F189_F0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fxaA 4 0.5854 100 0.717 Contact Map
3etnA 4 0.5854 100 0.732 Contact Map
3c3jA 2 0.9085 100 0.74 Contact Map
3euaA 2 0.814 100 0.741 Contact Map
3fj1A 2 0.9116 100 0.743 Contact Map
1moqA 2 0.9207 100 0.748 Contact Map
2pocA 4 0.936 100 0.749 Contact Map
2xhzA 4 0.5305 100 0.75 Contact Map
3hbaA 2 0.8476 100 0.751 Contact Map
3fkjA 2 0.8445 100 0.753 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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