KDSD - ECOLI - GREMLIN Contacts

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KDSD - Arabinose 5-phosphate isomerase KdsD

UniProt:	P45395	Sequences: MSHVELQPGFDFQQAGKEVLAIERECLAELDQYINQNFTLACEKMFWCKGKVVVMGMGKSGHIGRKMAATFASTGTPSFFVHPGEAAHGDLGMVTPQDVVIAISNSGESSEITALIPVLKRLHVPLICITGRPESSMARAADVHLCVKVAKEACPLGLAPTSSTTATLVMGDALAVALLKARGFTAEDFALSHPGGALGRKLLLRVNDIMHTGDEIPHVKKTASLRDALLEVTRKNLGMTVICDDNMMIEGIFTDGDLRRVFDMGVDVRQLSIADVMTPGGIRVRPGILAVEALNLMQSRHITSVMVADGDHLLGVLHMHDLLRAGVV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12803
Length:	328 (314)
Sequences:	2110 (1396)
Seq/√Len:	78.8

ECOLI - KDSD GUTQ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_I	168_L	4.113	1.00
108_E	136_S	3.684	1.00
128_C	141_A	3.434	1.00
282_I	300_R	3.271	1.00
18_E	180_K	3.140	1.00
57_M	84_G	3.054	1.00
253_F	273_I	3.026	1.00
241_V	306_M	2.886	1.00
228_A	273_I	2.835	1.00
20_L	169_V	2.792	1.00
231_E	235_K	2.680	1.00
54_V	64_G	2.659	1.00
52_V	76_T	2.652	1.00
33_Y	146_C	2.631	1.00
222_T	274_A	2.622	1.00
147_V	170_M	2.596	1.00
221_K	250_E	2.576	1.00
70_T	175_A	2.572	1.00
244_D	248_M	2.454	1.00
21_A	31_D	2.452	1.00
147_V	167_T	2.441	1.00
49_K	97_Q	2.430	1.00
24_R	28_A	2.393	1.00
284_V	288_I	2.392	1.00
48_C	99_V	2.369	1.00
67_M	71_F	2.360	1.00
52_V	101_I	2.345	1.00
272_S	275_D	2.339	1.00
55_M	102_A	2.331	1.00
103_I	167_T	2.316	1.00
306_M	313_L	2.299	1.00
24_R	27_L	2.293	1.00
57_M	83_P	2.254	1.00
44_K	143_V	2.231	1.00
41_A	127_I	2.213	1.00
51_K	95_T	2.190	1.00
207_N	287_G	2.157	1.00
41_A	143_V	2.140	1.00
13_Q	34_I	2.083	1.00
24_R	31_D	1.989	1.00
68_A	78_S	1.976	1.00
249_I	313_L	1.966	1.00
100_V	119_L	1.950	1.00
309_D	312_H	1.907	1.00
295_N	299_S	1.895	1.00
46_F	181_A	1.871	1.00
81_V	94_V	1.826	1.00
16_G	38_F	1.824	1.00
303_T	318_H	1.812	1.00
25_E	28_A	1.810	1.00
24_R	169_V	1.803	1.00
21_A	25_E	1.781	1.00
44_K	125_P	1.766	1.00
228_A	240_T	1.755	1.00
45_M	52_V	1.736	1.00
55_M	100_V	1.728	1.00
26_C	162_S	1.682	1.00
130_T	144_H	1.666	1.00
54_V	101_I	1.642	1.00
284_V	305_V	1.598	1.00
22_I	162_S	1.591	1.00
131_G	146_C	1.577	1.00
237_L	316_V	1.565	0.99
13_Q	39_T	1.563	0.99
46_F	182_R	1.556	0.99
120_K	142_D	1.546	0.99
12_F	181_A	1.537	0.99
219_V	242_I	1.536	0.99
138_A	144_H	1.533	0.99
218_H	241_V	1.521	0.99
72_A	93_M	1.519	0.99
29_E	150_A	1.516	0.99
15_A	19_V	1.510	0.99
15_A	180_K	1.498	0.99
45_M	99_V	1.496	0.99
286_P	314_L	1.494	0.99
255_D	259_R	1.494	0.99
288_I	292_E	1.490	0.99
110_S	114_A	1.484	0.99
211_H	321_D	1.456	0.99
249_I	306_M	1.443	0.99
125_P	142_D	1.415	0.99
64_G	103_I	1.407	0.99
43_E	47_W	1.399	0.99
82_H	85_E	1.396	0.99
12_F	39_T	1.394	0.99
161_T	176_V	1.381	0.99
239_M	316_V	1.375	0.99
267_D	270_Q	1.361	0.99
133_P	146_C	1.359	0.99
221_K	274_A	1.322	0.98
33_Y	148_K	1.321	0.98
209_I	317_L	1.309	0.98
207_N	286_P	1.301	0.98
129_I	170_M	1.290	0.98
206_V	293_A	1.284	0.98
221_K	279_P	1.276	0.98
248_M	312_H	1.276	0.98
261_V	276_V	1.273	0.98
220_K	245_D	1.250	0.97
286_P	309_D	1.247	0.97
282_I	302_I	1.243	0.97
211_H	237_L	1.242	0.97
247_M	313_L	1.226	0.97
68_A	72_A	1.212	0.97
271_L	275_D	1.201	0.97
145_L	170_M	1.194	0.97
19_V	177_A	1.189	0.97
13_Q	17_K	1.185	0.97
67_M	101_I	1.179	0.96
79_F	93_M	1.157	0.96
101_I	129_I	1.151	0.96
241_V	313_L	1.150	0.96
30_L	166_A	1.148	0.96
103_I	129_I	1.141	0.96
231_E	234_R	1.138	0.96
67_M	103_I	1.137	0.96
284_V	293_A	1.135	0.96
285_R	309_D	1.126	0.95
130_T	138_A	1.124	0.95
221_K	244_D	1.121	0.95
64_G	80_F	1.117	0.95
209_I	290_A	1.116	0.95
44_K	99_V	1.113	0.95
12_F	43_E	1.112	0.95
87_A	195_G	1.109	0.95
128_C	137_M	1.107	0.95
284_V	307_V	1.106	0.95
122_L	192_S	1.086	0.94
253_F	258_L	1.083	0.94
51_K	93_M	1.079	0.94
248_M	311_D	1.076	0.94
37_N	40_L	1.076	0.94
213_G	235_K	1.076	0.94
133_P	144_H	1.073	0.94
94_V	100_V	1.071	0.94
45_M	71_F	1.067	0.94
241_V	249_I	1.056	0.93
134_E	139_R	1.055	0.93
219_V	223_A	1.045	0.93
28_A	32_Q	1.041	0.93
53_V	79_F	1.041	0.93
231_E	240_T	1.035	0.93
223_A	227_D	1.034	0.93
18_E	151_K	1.031	0.93
131_G	170_M	1.027	0.92
128_C	144_H	1.026	0.92
74_T	178_L	1.022	0.92
15_A	18_E	1.021	0.92
239_M	304_S	1.004	0.92
52_V	71_F	1.003	0.92
239_M	252_I	1.002	0.92
129_I	147_V	0.999	0.91
21_A	28_A	0.997	0.91
21_A	24_R	0.996	0.91
45_M	76_T	0.995	0.91
292_E	295_N	0.988	0.91
72_A	79_F	0.988	0.91
53_V	94_V	0.985	0.91
133_P	138_A	0.979	0.91
244_D	250_E	0.979	0.91
20_L	30_L	0.967	0.90
304_S	318_H	0.966	0.90
18_E	22_I	0.964	0.90
22_I	151_K	0.956	0.90
293_A	305_V	0.954	0.89
283_R	308_A	0.952	0.89
225_L	228_A	0.949	0.89
64_G	167_T	0.947	0.89
40_L	43_E	0.941	0.89
228_A	253_F	0.941	0.89
112_I	137_M	0.938	0.89
219_V	240_T	0.930	0.88
233_T	259_R	0.929	0.88
285_R	311_D	0.929	0.88
36_Q	40_L	0.929	0.88
253_F	276_V	0.926	0.88
246_N	312_H	0.926	0.88
42_C	174_L	0.926	0.88
218_H	247_M	0.917	0.87
190_A	200_R	0.917	0.87
221_K	245_D	0.908	0.87
216_I	313_L	0.900	0.86
26_C	29_E	0.891	0.86
229_L	262_F	0.891	0.86
131_G	147_V	0.891	0.86
131_G	149_V	0.890	0.86
99_V	125_P	0.890	0.86
12_F	42_C	0.888	0.86
155_P	179_L	0.882	0.85
62_H	86_A	0.877	0.85
40_L	44_K	0.872	0.85
29_E	33_Y	0.866	0.84
17_K	21_A	0.861	0.84
206_V	284_V	0.859	0.84
285_R	310_G	0.859	0.84
226_R	263_D	0.853	0.83
16_G	39_T	0.853	0.83
218_H	313_L	0.852	0.83
247_M	250_E	0.852	0.83
17_K	31_D	0.846	0.83
113_T	136_S	0.844	0.83
243_C	250_E	0.842	0.83
28_A	31_D	0.837	0.82
251_G	277_M	0.835	0.82
321_D	324_R	0.833	0.82
68_A	79_F	0.833	0.82
121_R	289_L	0.832	0.82
109_S	112_I	0.830	0.82
285_R	288_I	0.829	0.82
33_Y	131_G	0.828	0.82
39_T	43_E	0.820	0.81
45_M	48_C	0.819	0.81
296_L	300_R	0.819	0.81
87_A	114_A	0.819	0.81
51_K	77_P	0.816	0.81
222_T	273_I	0.815	0.80
74_T	179_L	0.814	0.80
77_P	95_T	0.811	0.80
127_I	143_V	0.809	0.80
19_V	167_T	0.808	0.80
303_T	319_M	0.801	0.79
23_E	153_A	0.798	0.79
26_C	150_A	0.796	0.79
25_E	150_A	0.793	0.79
253_F	261_V	0.792	0.79
102_A	126_L	0.785	0.78
225_L	253_F	0.785	0.78
189_F	198_L	0.781	0.78
29_E	32_Q	0.781	0.78
85_E	93_M	0.779	0.77
15_A	177_A	0.773	0.77
42_C	177_A	0.772	0.77
61_G	83_P	0.772	0.77
221_K	243_C	0.772	0.77
67_M	171_G	0.770	0.77
234_R	263_D	0.766	0.76
220_K	223_A	0.764	0.76
40_L	125_P	0.757	0.75
145_L	174_L	0.752	0.75
43_E	181_A	0.751	0.75
162_S	166_A	0.750	0.75
219_V	231_E	0.749	0.75
200_R	325_A	0.749	0.75
45_M	101_I	0.747	0.74
149_V	162_S	0.745	0.74
57_M	85_E	0.741	0.74
36_Q	39_T	0.741	0.74
155_P	158_L	0.739	0.74
241_V	316_V	0.732	0.73
118_V	122_L	0.731	0.73
132_R	149_V	0.731	0.73
54_V	103_I	0.728	0.73
61_G	72_A	0.727	0.72
112_I	115_L	0.726	0.72
290_A	322_L	0.724	0.72
20_L	31_D	0.720	0.72
37_N	143_V	0.719	0.72
303_T	323_L	0.719	0.72
224_S	227_D	0.718	0.71
216_I	241_V	0.716	0.71
108_E	197_A	0.715	0.71
149_V	166_A	0.714	0.71
293_A	317_L	0.712	0.71
256_G	260_R	0.712	0.71
204_L	294_L	0.709	0.71
94_V	119_L	0.709	0.71
118_V	191_L	0.708	0.70
209_I	325_A	0.706	0.70
73_S	189_F	0.704	0.70
282_I	296_L	0.704	0.70
146_C	149_V	0.702	0.70
121_R	298_Q	0.697	0.69
49_K	312_H	0.697	0.69
61_G	68_A	0.694	0.69
99_V	127_I	0.693	0.69
218_H	243_C	0.693	0.69
266_V	271_L	0.687	0.68
122_L	191_L	0.687	0.68
151_K	157_G	0.684	0.68
156_L	179_L	0.682	0.68
25_E	29_E	0.679	0.67
230_L	233_T	0.679	0.67
62_H	65_R	0.679	0.67
81_V	86_A	0.677	0.67
247_M	312_H	0.677	0.67
222_T	272_S	0.677	0.67
54_V	69_A	0.675	0.67
125_P	143_V	0.674	0.67
62_H	271_L	0.673	0.67
158_L	202_L	0.671	0.66
301_H	324_R	0.670	0.66
23_E	165_T	0.669	0.66
266_V	270_Q	0.665	0.66
178_L	184_F	0.663	0.65
40_L	143_V	0.662	0.65
105_N	297_M	0.661	0.65
105_N	148_K	0.659	0.65
105_N	157_G	0.658	0.65
20_L	24_R	0.656	0.65
205_R	252_I	0.656	0.65
27_L	30_L	0.655	0.64
190_A	203_L	0.654	0.64
154_C	159_A	0.654	0.64
256_G	259_R	0.653	0.64
162_S	169_V	0.653	0.64
274_A	279_P	0.653	0.64
16_G	19_V	0.651	0.64
108_E	139_R	0.650	0.64
192_S	253_F	0.647	0.63
224_S	273_I	0.647	0.63
298_Q	320_H	0.646	0.63
250_E	279_P	0.646	0.63
14_Q	17_K	0.646	0.63
39_T	42_C	0.644	0.63
54_V	141_A	0.643	0.63
117_P	190_A	0.641	0.63
20_L	162_S	0.640	0.63
229_L	233_T	0.638	0.62
19_V	176_V	0.637	0.62
42_C	181_A	0.637	0.62
103_I	147_V	0.633	0.62
131_G	148_K	0.630	0.61
217_P	318_H	0.630	0.61
210_M	315_G	0.628	0.61
205_R	208_D	0.627	0.61
250_E	313_L	0.626	0.61
303_T	320_H	0.626	0.61
55_M	81_V	0.624	0.61
155_P	159_A	0.624	0.61
211_H	324_R	0.624	0.61
30_L	170_M	0.623	0.61
62_H	85_E	0.623	0.61
260_R	263_D	0.622	0.60
67_M	233_T	0.622	0.60
105_N	131_G	0.613	0.59
265_G	269_R	0.612	0.59
143_V	167_T	0.608	0.59
200_R	204_L	0.604	0.58
116_I	140_A	0.603	0.58
41_A	99_V	0.603	0.58
17_K	35_N	0.602	0.58
206_V	288_I	0.601	0.58
242_I	250_E	0.601	0.58
242_I	273_I	0.600	0.58
37_N	133_P	0.599	0.58
225_L	273_I	0.599	0.58
233_T	304_S	0.597	0.57
74_T	154_C	0.596	0.57
218_H	240_T	0.594	0.57
110_S	195_G	0.593	0.57
249_I	278_T	0.592	0.57
23_E	173_A	0.592	0.57
153_A	161_T	0.591	0.57
222_T	227_D	0.591	0.57
156_L	186_A	0.591	0.57
74_T	184_F	0.590	0.56
42_C	192_S	0.588	0.56
207_N	317_L	0.587	0.56
14_Q	18_E	0.586	0.56
245_D	270_Q	0.586	0.56
81_V	87_A	0.585	0.56
207_N	285_R	0.585	0.56
17_K	34_I	0.583	0.56
222_T	245_D	0.583	0.56
27_L	150_A	0.582	0.55
166_A	170_M	0.581	0.55
242_I	277_M	0.580	0.55
244_D	312_H	0.579	0.55
207_N	311_D	0.579	0.55
154_C	198_L	0.578	0.55
226_R	230_L	0.577	0.55
149_V	298_Q	0.576	0.55
154_C	176_V	0.576	0.55
105_N	156_L	0.574	0.54
283_R	306_M	0.573	0.54
223_A	228_A	0.573	0.54
225_L	269_R	0.573	0.54
225_L	271_L	0.573	0.54
62_H	81_V	0.572	0.54
12_F	177_A	0.571	0.54
71_F	178_L	0.571	0.54
211_H	323_L	0.571	0.54
38_F	166_A	0.570	0.54
38_F	42_C	0.569	0.54
14_Q	222_T	0.569	0.54
216_I	240_T	0.569	0.54
307_V	314_L	0.569	0.54
236_N	255_D	0.569	0.54
141_A	144_H	0.568	0.54
109_S	201_K	0.568	0.54
217_P	255_D	0.567	0.54
67_M	320_H	0.565	0.53
14_Q	310_G	0.565	0.53
94_V	124_V	0.565	0.53
223_A	274_A	0.564	0.53
215_E	235_K	0.564	0.53
261_V	264_M	0.563	0.53
138_A	146_C	0.563	0.53
115_L	124_V	0.561	0.53
128_C	138_A	0.560	0.53
55_M	112_I	0.559	0.52
226_R	266_V	0.559	0.52
63_I	67_M	0.558	0.52
156_L	198_L	0.555	0.52
177_A	181_A	0.553	0.52
63_I	133_P	0.553	0.52
112_I	197_A	0.551	0.51
99_V	143_V	0.551	0.51
119_L	124_V	0.551	0.51
85_E	203_L	0.549	0.51
197_A	201_K	0.548	0.51
237_L	303_T	0.547	0.51
63_I	212_T	0.546	0.51
74_T	159_A	0.546	0.51
104_S	128_C	0.545	0.51
114_A	192_S	0.545	0.51
224_S	272_S	0.545	0.51
16_G	170_M	0.543	0.50
252_I	279_P	0.542	0.50
110_S	200_R	0.542	0.50
72_A	203_L	0.540	0.50
271_L	276_V	0.539	0.50
24_R	162_S	0.538	0.50
42_C	281_G	0.537	0.50
303_T	316_V	0.537	0.50
26_C	177_A	0.537	0.50
76_T	178_L	0.536	0.50
288_I	296_L	0.536	0.50
47_W	310_G	0.535	0.49
45_M	242_I	0.534	0.49
236_N	259_R	0.534	0.49
61_G	210_M	0.533	0.49
278_T	281_G	0.533	0.49
76_T	198_L	0.532	0.49
44_K	127_I	0.531	0.49
222_T	287_G	0.530	0.49
105_N	147_V	0.529	0.49
51_K	79_F	0.529	0.49
62_H	103_I	0.527	0.48
41_A	145_L	0.526	0.48
63_I	207_N	0.526	0.48
249_I	283_R	0.524	0.48
133_P	149_V	0.523	0.48
204_L	207_N	0.522	0.48
248_M	310_G	0.521	0.48
61_G	85_E	0.521	0.48
233_T	240_T	0.521	0.48
19_V	23_E	0.519	0.47
185_T	188_D	0.517	0.47
241_V	252_I	0.515	0.47
55_M	116_I	0.515	0.47
69_A	82_H	0.515	0.47
183_G	268_V	0.515	0.47
232_V	240_T	0.514	0.47
57_M	320_H	0.514	0.47
43_E	279_P	0.514	0.47
212_T	216_I	0.513	0.47
233_T	236_N	0.513	0.47
144_H	170_M	0.513	0.47
113_T	200_R	0.513	0.47
229_L	258_L	0.512	0.46
51_K	291_V	0.511	0.46
209_I	322_L	0.511	0.46
12_F	16_G	0.510	0.46
236_N	298_Q	0.509	0.46
71_F	78_S	0.509	0.46
32_Q	309_D	0.504	0.45
47_W	224_S	0.504	0.45
266_V	269_R	0.502	0.45
184_F	189_F	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fxaA	4	0.5854	100	0.717	Contact Map
3etnA	4	0.5854	100	0.732	Contact Map
3c3jA	2	0.9085	100	0.74	Contact Map
3euaA	2	0.814	100	0.741	Contact Map
3fj1A	2	0.9116	100	0.743	Contact Map
1moqA	2	0.9207	100	0.748	Contact Map
2pocA	4	0.936	100	0.749	Contact Map
2xhzA	4	0.5305	100	0.75	Contact Map
3hbaA	2	0.8476	100	0.751	Contact Map
3fkjA	2	0.8445	100	0.753	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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