GREMLIN Database
YRBG - Inner membrane protein YrbG
UniProt: P45394 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12802
Length: 325 (304)
Sequences: 5330 (3717)
Seq/√Len: 213.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_D128_D4.1361.00
79_I83_L4.0651.00
129_G260_A3.9241.00
79_I218_I3.4601.00
118_V128_D3.0531.00
141_L145_K3.0221.00
43_T46_S2.9321.00
202_N208_E2.8141.00
130_I134_F2.6591.00
65_Q208_E2.5421.00
115_A252_I2.4981.00
113_V117_S2.4841.00
279_M283_S2.4641.00
37_P236_E2.4131.00
89_A302_G2.4121.00
196_N199_V2.3971.00
191_R195_D2.3911.00
172_L176_F2.3511.00
176_F180_G2.3501.00
7_L196_N2.2331.00
133_L137_V2.2321.00
293_R301_V2.2091.00
206_I210_T2.1591.00
136_A254_I2.1571.00
173_P177_L2.1411.00
278_V282_V2.0951.00
90_L306_T2.0941.00
111_V253_V2.0861.00
197_A216_I2.0591.00
8_L196_N2.0401.00
67_D268_D2.0261.00
137_V141_L2.0051.00
188_V192_M1.9601.00
108_M112_S1.9481.00
89_A297_P1.9291.00
18_S185_I1.9201.00
92_R235_G1.9121.00
130_I261_L1.8951.00
17_Y21_R1.8891.00
7_L192_M1.8571.00
117_S121_D1.8501.00
174_V178_W1.8081.00
280_L284_I1.8081.00
117_S120_Y1.7651.00
90_L303_V1.7471.00
49_T224_E1.7431.00
83_L218_I1.7001.00
200_L204_F1.6831.00
82_L305_L1.6521.00
57_S72_T1.6491.00
294_S301_V1.6291.00
310_I314_A1.6241.00
6_A10_V1.6131.00
82_L282_V1.6051.00
298_G301_V1.6021.00
125_S128_D1.5901.00
114_V118_V1.5561.00
280_L283_S1.5411.00
281_L284_I1.5371.00
201_A211_M1.5301.00
5_T9_I1.5271.00
86_G302_G1.5211.00
278_V283_S1.5201.00
110_L114_V1.5051.00
25_A182_A1.4941.00
87_L229_I1.4751.00
147_A150_A1.4721.00
132_L136_A1.4701.00
18_S189_A1.4661.00
28_I175_A1.4511.00
177_L181_I1.4471.00
307_G311_V1.4421.00
25_A179_L1.4391.00
133_L261_L1.4281.00
17_Y20_D1.4261.00
42_M45_V1.4241.00
32_T172_L1.4101.00
8_L200_L1.4051.00
29_L179_L1.3931.00
21_R178_W1.3921.00
126_R261_L1.3911.00
80_N248_N1.3861.00
73_A256_L1.3811.00
307_G314_A1.3661.00
228_A243_N1.3661.00
77_N251_N1.3601.00
251_N255_V1.3511.00
50_S247_A1.3361.00
68_L212_G1.3271.00
47_I51_L1.3231.00
58_L62_L1.3221.00
200_L203_Y1.3121.00
278_V281_L1.3101.00
65_Q198_T1.3081.00
183_L187_P1.2851.00
47_I250_F1.2841.00
171_G174_V1.2791.00
277_S281_L1.2761.00
22_L186_M1.2761.00
11_G14_L1.2611.00
129_G257_G1.2591.00
275_D312_W1.2581.00
55_I190_T1.2501.00
21_R181_I1.2461.00
58_L262_I1.2411.00
59_A63_H1.2411.00
277_S280_L1.2181.00
277_S282_V1.2171.00
29_L175_A1.2141.00
285_I289_L1.2101.00
275_D278_V1.1941.00
300_G303_V1.1781.00
39_I144_V1.1771.00
127_S314_A1.1691.00
45_V239_I1.1641.00
217_A221_S1.1601.00
199_V203_Y1.1481.00
11_G189_A1.1451.00
279_M282_V1.1421.00
199_V202_N1.1391.00
210_T317_Y1.1351.00
14_L185_I1.1111.00
271_A275_D1.1051.00
26_A45_V1.1021.00
76_S80_N1.0991.00
115_A119_L1.0941.00
93_P299_R1.0931.00
126_R264_P1.0931.00
42_M48_G1.0891.00
145_K149_Q1.0891.00
181_I185_I1.0861.00
276_Y280_L1.0771.00
279_M284_I1.0711.00
107_L113_V1.0701.00
67_D71_G1.0691.00
25_A178_W1.0661.00
250_F254_I1.0591.00
206_I211_M1.0551.00
21_R185_I1.0541.00
90_L302_G1.0541.00
300_G304_L1.0481.00
126_R130_I1.0411.00
192_M196_N1.0351.00
20_D24_F1.0331.00
124_L128_D1.0321.00
140_L144_V1.0271.00
14_L192_M1.0271.00
214_T217_A1.0231.00
7_L195_D1.0131.00
73_A259_P1.0031.00
102_R106_P1.0001.00
7_L10_V0.9981.00
221_S225_L0.9971.00
198_T202_N0.9971.00
145_K148_R0.9931.00
54_V255_V0.9921.00
170_G175_A0.9891.00
54_V58_L0.9881.00
54_V73_A0.9871.00
148_R152_R0.9851.00
47_I136_A0.9851.00
166_L169_D0.9831.00
195_D199_V0.9821.00
112_S116_G0.9791.00
202_N211_M0.9741.00
142_F146_L0.9701.00
8_L193_V0.9681.00
290_C293_R0.9641.00
18_S182_A0.9611.00
21_R24_F0.9601.00
227_T231_G0.9591.00
53_E223_P0.9591.00
88_A232_V0.9551.00
114_V117_S0.9551.00
54_V80_N0.9541.00
27_S236_E0.9511.00
15_V23_V0.9511.00
80_N247_A0.9511.00
10_V13_L0.9441.00
53_E224_E0.9430.99
49_T223_P0.9350.99
55_I187_P0.9340.99
277_S283_S0.9310.99
114_V135_L0.9270.99
148_R151_E0.9260.99
273_S276_Y0.9240.99
11_G196_N0.9230.99
36_P147_A0.9200.99
116_G119_L0.9180.99
128_D131_F0.9140.99
88_A228_A0.9130.99
95_T296_Q0.9130.99
26_A40_I0.9110.99
31_R40_I0.9040.99
178_W182_A0.9040.99
301_V305_L0.9010.99
134_F138_L0.8970.99
53_E220_T0.8940.99
19_A27_S0.8870.99
85_L241_V0.8840.99
119_L267_I0.8840.99
107_L110_L0.8780.99
247_A250_F0.8740.99
101_L105_L0.8710.99
178_W181_I0.8700.99
32_T37_P0.8640.99
79_I82_L0.8630.99
76_S221_S0.8630.99
229_I233_R0.8540.99
271_A274_R0.8530.99
274_R282_V0.8520.99
81_I247_A0.8510.99
139_W249_I0.8480.99
174_V177_L0.8460.99
223_P248_N0.8420.99
188_V191_R0.8360.99
76_S248_N0.8360.99
129_G132_L0.8350.99
85_L297_P0.8350.99
60_A69_A0.8340.99
108_M111_V0.8290.99
275_D283_S0.8270.99
187_P191_R0.8260.99
150_A154_G0.8230.99
98_S102_R0.8200.99
107_L117_S0.8150.99
84_I225_L0.8140.99
164_A167_P0.8120.98
184_I187_P0.8090.98
220_T223_P0.8080.98
116_G276_Y0.8070.98
170_G174_V0.8070.98
61_S259_P0.8040.98
313_L317_Y0.8040.98
302_G306_T0.8020.98
109_L113_V0.8020.98
294_S300_G0.7950.98
38_L42_M0.7930.98
192_M195_D0.7910.98
42_M46_S0.7910.98
126_R133_L0.7860.98
185_I188_V0.7840.98
115_A256_L0.7840.98
79_I225_L0.7800.98
112_S279_M0.7800.98
101_L106_P0.7780.98
108_M245_I0.7760.98
96_V235_G0.7730.98
50_S77_N0.7690.98
232_V237_N0.7680.98
78_I312_W0.7680.98
133_L258_L0.7660.98
284_I289_L0.7640.98
110_L117_S0.7620.98
111_V249_I0.7610.98
242_G246_G0.7600.98
275_D280_L0.7570.98
49_T220_T0.7560.98
29_L176_F0.7560.98
55_I186_M0.7550.98
12_L16_V0.7520.98
228_A240_A0.7490.97
223_P243_N0.7470.97
147_A151_E0.7430.97
31_R37_P0.7410.97
135_L139_W0.7400.97
12_L218_I0.7380.97
26_A231_G0.7330.97
19_A48_G0.7310.97
80_N220_T0.7300.97
115_A118_V0.7290.97
111_V114_V0.7280.97
288_L292_R0.7260.97
100_V104_E0.7260.97
28_I32_T0.7260.97
79_I221_S0.7210.97
231_G239_I0.7210.97
108_M283_S0.7190.97
190_T254_I0.7180.97
50_S248_N0.7140.97
118_V131_F0.7140.97
271_A276_Y0.7060.96
133_L254_I0.7050.96
314_A317_Y0.7040.96
46_S49_T0.6980.96
171_G175_A0.6970.96
92_R95_T0.6970.96
50_S80_N0.6930.96
29_L33_F0.6890.96
302_G305_L0.6870.96
139_W142_F0.6870.96
129_G136_A0.6870.96
214_T313_L0.6860.96
69_A72_T0.6860.96
83_L306_T0.6860.96
209_L212_G0.6850.96
221_S251_N0.6820.96
282_V285_I0.6790.95
87_L225_L0.6770.95
178_W185_I0.6770.95
53_E80_N0.6720.95
167_P170_G0.6690.95
176_F181_I0.6690.95
48_G247_A0.6690.95
303_V307_G0.6690.95
224_E255_V0.6680.95
17_Y24_F0.6660.95
136_A139_W0.6630.95
108_M136_A0.6620.95
275_D279_M0.6610.95
46_S52_P0.6590.95
26_A30_C0.6560.95
195_D198_T0.6520.94
84_I241_V0.6520.94
74_L82_L0.6510.94
65_Q68_L0.6510.94
59_A191_R0.6500.94
14_L17_Y0.6490.94
36_P148_R0.6460.94
49_T52_P0.6450.94
77_N247_A0.6410.94
57_S61_S0.6400.94
205_A216_I0.6370.94
121_D125_S0.6350.94
118_V132_L0.6340.94
11_G19_A0.6340.94
208_E212_G0.6330.93
50_S221_S0.6310.93
299_R302_G0.6290.93
306_T310_I0.6280.93
260_A264_P0.6250.93
174_V181_I0.6250.93
197_A220_T0.6220.93
68_L216_I0.6210.93
201_A212_G0.6170.93
304_L308_G0.6160.93
51_L250_F0.6150.92
9_I13_L0.6140.92
138_L142_F0.6120.92
61_S263_T0.6120.92
11_G214_T0.6100.92
186_M226_A0.6100.92
80_N223_P0.6080.92
51_L55_I0.6060.92
163_L166_L0.6060.92
20_D230_A0.6050.92
230_A233_R0.6030.92
238_D247_A0.6030.92
24_F234_K0.6020.92
272_Y284_I0.6000.92
113_V118_V0.6000.92
296_Q300_G0.6000.92
87_L91_V0.5970.91
82_L283_S0.5940.91
286_F289_L0.5930.91
235_G240_A0.5920.91
289_L292_R0.5900.91
254_I258_L0.5870.91
269_P273_S0.5860.91
240_A256_L0.5860.91
53_E216_I0.5860.91
209_L259_P0.5810.90
46_S50_S0.5810.90
88_A227_T0.5800.90
16_V20_D0.5800.90
220_T243_N0.5800.90
135_L138_L0.5780.90
72_T220_T0.5760.90
87_L306_T0.5750.90
77_N252_I0.5740.90
144_V148_R0.5740.90
87_L90_L0.5730.90
57_S259_P0.5720.90
276_Y279_M0.5720.90
94_F135_L0.5710.89
212_G217_A0.5700.89
10_V14_L0.5680.89
74_L256_L0.5680.89
163_L168_R0.5670.89
289_L305_L0.5650.89
221_S248_N0.5640.89
124_L256_L0.5640.89
84_I221_S0.5640.89
86_G93_P0.5640.89
220_T248_N0.5630.89
49_T243_N0.5610.89
281_L285_I0.5600.89
43_T244_I0.5600.89
39_I143_I0.5590.88
82_L88_A0.5590.88
111_V117_S0.5580.88
48_G183_L0.5540.88
63_H191_R0.5530.88
22_L29_L0.5530.88
14_L189_A0.5510.88
113_V116_G0.5500.88
281_L288_L0.5500.88
11_G192_M0.5500.88
80_N251_N0.5480.87
287_A291_W0.5460.87
142_F152_R0.5450.87
185_I189_A0.5440.87
77_N80_N0.5430.87
44_V179_L0.5410.87
141_L149_Q0.5410.87
57_S248_N0.5380.87
36_P39_I0.5380.87
224_E247_A0.5380.87
284_I291_W0.5380.87
40_I43_T0.5370.86
86_G91_V0.5360.86
99_D103_R0.5340.86
16_V19_A0.5340.86
31_R165_E0.5340.86
138_L145_K0.5320.86
223_P246_G0.5320.86
193_V222_L0.5300.86
84_I219_G0.5290.86
211_M215_A0.5280.86
49_T251_N0.5260.85
303_V308_G0.5260.85
84_I220_T0.5250.85
218_I225_L0.5250.85
108_M115_A0.5230.85
82_L240_A0.5230.85
256_L259_P0.5220.85
82_L86_G0.5210.85
165_E169_D0.5200.85
165_E168_R0.5190.85
270_L274_R0.5190.85
105_L245_I0.5190.85
19_A24_F0.5190.85
15_V18_S0.5180.84
81_I85_L0.5170.84
198_T208_E0.5170.84
24_F59_A0.5160.84
29_L44_V0.5150.84
135_L253_V0.5140.84
132_L253_V0.5130.84
186_M254_I0.5120.84
244_I248_N0.5120.84
55_I59_A0.5110.84
208_E211_M0.5110.84
112_S117_S0.5110.84
97_H238_D0.5080.83
107_L121_D0.5070.83
30_C44_V0.5070.83
26_A44_V0.5040.83
23_V220_T0.5040.83
309_F312_W0.5030.83
57_S221_S0.5020.83
136_A140_L0.5010.82
45_V143_I0.5010.82
80_N243_N0.5010.82
101_L104_E0.5000.82
213_L275_D0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v5uA 1 0.9077 100 0.19 Contact Map
4k1cA 4 0.9785 100 0.208 Contact Map
4kjrA 3 0.8862 100 0.23 Contact Map
4kppA 1 0.96 100 0.263 Contact Map
3giaA 1 0.4523 35.9 0.947 Contact Map
4rp9A 2 0.4092 32.1 0.948 Contact Map
3o7qA 1 0.4615 30.8 0.949 Contact Map
3l1lA 2 0.4492 17.6 0.954 Contact Map
4pgrA 1 0.44 15.3 0.955 Contact Map
3qe7A 2 0.44 14.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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