GREMLIN Database
PITB - Probable low-affinity inorganic phosphate transporter 2
UniProt: P43676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12883
Length: 499 (468)
Sequences: 366 (175)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_E154_K6.3131.00
267_V371_L5.3111.00
118_A484_A5.3041.00
177_L181_W5.2341.00
48_M60_F4.9100.99
329_Y332_L4.5020.99
178_R461_D4.3180.98
329_Y333_S4.1700.98
164_I168_V3.6120.95
56_M219_A3.4230.94
348_S372_R3.1870.91
74_Y381_Y3.1080.90
417_G427_Q3.0330.88
193_I201_K2.9290.86
227_A438_S2.8750.85
129_I348_S2.7590.83
110_G116_L2.7170.82
192_R201_K2.6580.80
161_V165_V2.6230.79
354_L428_M2.4470.74
71_S441_G2.4420.74
220_G431_A2.4370.74
399_M403_R2.3960.73
330_E333_S2.3750.72
133_L141_S2.3710.72
134_T486_F2.2060.66
183_G189_R2.2020.66
88_M103_A2.1980.66
156_F224_S2.1620.64
113_F116_L2.1550.64
134_T493_W2.1300.63
484_A488_S2.1190.63
118_A488_S2.1030.62
193_I475_M2.0440.60
118_A136_A2.0330.59
354_L360_V2.0280.59
137_L489_G2.0240.59
123_T449_V1.9670.57
442_M453_A1.9650.57
167_L459_V1.9650.57
89_G124_L1.9520.56
60_F381_Y1.9050.54
87_N496_L1.8890.53
151_E242_V1.8860.53
106_I483_A1.8820.53
422_Q458_M1.8730.53
88_M356_K1.8640.52
157_S161_V1.8630.52
434_I481_L1.8570.52
60_F63_F1.8540.52
149_L453_A1.8480.52
106_I116_L1.8400.51
149_L152_V1.8300.51
57_A152_V1.8270.51
438_S449_V1.8250.51
48_M424_M1.7970.50
68_G382_A1.7900.49
75_A156_F1.7650.48
59_F62_F1.7600.48
382_A387_I1.7590.48
106_I202_G1.7480.48
63_F492_Y1.7380.47
74_Y473_I1.7300.47
191_H217_S1.7100.46
215_I311_T1.7010.46
22_F263_T1.6960.46
59_F425_A1.6920.45
201_K332_L1.6900.45
217_S427_Q1.6870.45
311_T314_A1.6800.45
203_K354_L1.6780.45
82_T379_I1.6760.45
177_L425_A1.6580.44
425_A428_M1.6510.44
165_V224_S1.6460.44
295_S299_T1.6460.44
50_P496_L1.6460.44
88_M93_G1.6320.43
70_L382_A1.6110.42
301_V313_D1.5940.41
242_V247_A1.5780.41
77_V428_M1.5770.41
220_G224_S1.5740.41
202_G205_K1.5720.41
425_A472_S1.5680.40
406_A460_V1.5670.40
242_V270_F1.5600.40
97_V297_D1.5470.40
92_H242_V1.5360.39
395_G465_L1.5360.39
375_M379_I1.5330.39
110_G114_F1.5190.38
294_A301_V1.5180.38
299_T302_T1.5080.38
297_D311_T1.4970.38
327_E403_R1.4890.37
273_Y367_L1.4870.37
189_R462_G1.4810.37
155_I412_K1.4780.37
138_L412_K1.4720.37
42_V223_F1.4710.37
463_G478_V1.4590.36
374_D495_A1.4290.35
319_K492_Y1.4270.35
20_L135_N1.4130.34
74_Y349_D1.3890.34
326_M329_Y1.3740.33
416_R468_K1.3730.33
361_S364_D1.3730.33
154_K347_I1.3710.33
328_S333_S1.3710.33
69_G382_A1.3620.33
220_G457_T1.3290.31
55_V138_L1.3270.31
20_L390_V1.3270.31
421_A425_A1.3240.31
172_G191_H1.3220.31
318_V326_M1.3200.31
89_G338_S1.3200.31
133_L442_M1.3180.31
113_F297_D1.3180.31
139_T496_L1.3160.31
136_A496_L1.3130.31
19_A47_A1.3100.31
86_L90_S1.3050.31
402_W420_Y1.3030.30
174_I384_V1.3010.30
127_A396_I1.2990.30
124_L152_V1.2980.30
24_L90_S1.2970.30
295_S302_T1.2950.30
133_L136_A1.2930.30
156_F164_I1.2850.30
49_Q253_M1.2840.30
74_Y332_L1.2710.29
147_L386_I1.2690.29
60_F136_A1.2680.29
164_I176_L1.2610.29
133_L139_T1.2600.29
105_I458_M1.2590.29
209_W212_I1.2540.29
388_M484_A1.2510.29
274_L312_F1.2470.29
486_F489_G1.2470.29
368_L435_G1.2450.28
318_V329_Y1.2450.28
164_I310_N1.2450.28
210_T453_A1.2340.28
70_L234_I1.2330.28
88_M242_V1.2290.28
75_A247_A1.2030.27
136_A141_S1.1980.27
155_I215_I1.1980.27
102_L392_L1.1980.27
116_L349_D1.1970.27
369_K372_R1.1950.27
114_F283_K1.1810.26
322_L325_N1.1770.26
344_M348_S1.1740.26
371_L392_L1.1670.26
350_T493_W1.1630.26
97_V118_A1.1620.26
23_V433_S1.1460.25
301_V304_F1.1460.25
147_L379_I1.1450.25
472_S479_F1.1440.25
340_L485_I1.1410.25
91_T171_G1.1340.25
83_D463_G1.1330.25
85_L234_I1.1320.25
177_L416_R1.1310.25
244_I459_V1.1290.25
315_I365_Q1.1270.25
440_I484_A1.1240.25
68_G387_I1.1200.24
255_A337_R1.1180.24
18_L201_K1.1150.24
106_I205_K1.1130.24
295_S298_G1.1100.24
70_L387_I1.1080.24
60_F412_K1.1030.24
29_I344_M1.1020.24
350_T467_R1.0990.24
477_W480_T1.0920.24
191_H347_I1.0900.24
315_I322_L1.0880.23
218_A427_Q1.0870.23
172_G176_L1.0820.23
378_T473_I1.0790.23
334_V486_F1.0780.23
436_L440_I1.0640.23
47_A78_H1.0630.23
77_V355_A1.0630.23
368_L421_A1.0620.23
56_M218_A1.0610.23
271_E275_Q1.0600.23
124_L209_W1.0580.23
277_H364_D1.0570.23
242_V279_E1.0570.23
113_F133_L1.0570.23
336_Q492_Y1.0530.22
66_L388_M1.0520.22
339_Q484_A1.0510.22
218_A417_G1.0460.22
294_A302_T1.0460.22
24_L393_A1.0440.22
327_E333_S1.0440.22
340_L371_L1.0420.22
21_A192_R1.0400.22
49_Q483_A1.0370.22
85_L144_M1.0360.22
212_I368_L1.0330.22
58_A79_M1.0230.22
115_G423_G1.0230.22
18_L267_V1.0180.21
245_A274_L1.0140.21
220_G454_V1.0110.21
22_F495_A1.0100.21
217_S417_G1.0080.21
177_L208_F1.0060.21
265_D269_N1.0020.21
59_F67_L1.0020.21
359_G369_K0.9960.21
60_F354_L0.9960.21
106_I484_A0.9960.21
92_H179_R0.9880.21
57_A453_A0.9880.21
25_F69_G0.9860.21
316_A336_Q0.9840.21
156_F449_V0.9820.20
445_S456_G0.9820.20
443_P456_G0.9820.20
270_F492_Y0.9810.20
129_I479_F0.9810.20
328_S432_V0.9800.20
490_G494_I0.9790.20
46_R116_L0.9780.20
28_A167_L0.9770.20
188_D192_R0.9770.20
88_M98_F0.9770.20
364_D367_L0.9770.20
437_A444_V0.9750.20
227_A449_V0.9750.20
47_A493_W0.9730.20
95_A415_K0.9720.20
278_P340_L0.9690.20
116_L358_P0.9680.20
177_L421_A0.9590.20
154_K474_L0.9590.20
295_S301_V0.9590.20
29_I427_Q0.9590.20
161_V492_Y0.9580.20
86_L136_A0.9560.20
97_V123_T0.9540.20
80_L476_A0.9540.20
76_I215_I0.9520.20
220_G422_Q0.9500.20
470_V474_L0.9470.20
157_S473_I0.9440.19
135_N390_V0.9430.19
400_I457_T0.9420.19
318_V375_M0.9400.19
326_M344_M0.9390.19
77_V215_I0.9390.19
250_V424_M0.9360.19
118_A123_T0.9340.19
142_S192_R0.9320.19
298_G304_F0.9310.19
133_L496_L0.9310.19
156_F313_D0.9290.19
114_F479_F0.9250.19
86_L314_A0.9240.19
116_L353_K0.9240.19
331_P369_K0.9240.19
67_L189_R0.9230.19
165_V441_G0.9220.19
145_D495_A0.9200.19
94_L234_I0.9190.19
264_R267_V0.9160.19
69_G387_I0.9150.19
205_K248_G0.9050.19
20_L396_I0.9050.19
47_A87_N0.9030.18
171_G459_V0.9030.18
234_I427_Q0.9030.18
240_V495_A0.8980.18
216_V484_A0.8960.18
136_A142_S0.8960.18
70_L210_T0.8920.18
263_T326_M0.8910.18
269_N367_L0.8910.18
178_R284_L0.8880.18
133_L332_L0.8840.18
223_F453_A0.8830.18
324_G327_E0.8820.18
77_V496_L0.8820.18
303_E472_S0.8810.18
261_T389_A0.8800.18
470_V484_A0.8800.18
242_V276_Q0.8740.18
337_R370_K0.8740.18
479_F485_I0.8710.18
146_A409_I0.8680.18
253_M256_S0.8670.18
105_I422_Q0.8670.18
133_L467_R0.8670.18
150_R192_R0.8640.18
152_V158_S0.8630.17
476_A481_L0.8620.17
174_I460_V0.8550.17
125_I425_A0.8520.17
100_M103_A0.8510.17
47_A149_L0.8500.17
102_L358_P0.8490.17
116_L179_R0.8490.17
468_K486_F0.8480.17
415_K472_S0.8470.17
85_L344_M0.8460.17
134_T364_D0.8460.17
386_I460_V0.8460.17
278_P317_R0.8440.17
189_R497_Q0.8410.17
118_A462_G0.8410.17
94_L249_F0.8410.17
154_K484_A0.8370.17
29_I234_I0.8360.17
140_G303_E0.8330.17
424_M453_A0.8320.17
158_S321_M0.8300.17
307_H354_L0.8300.17
103_A462_G0.8290.17
188_D435_G0.8270.17
82_T243_G0.8270.17
271_E320_T0.8260.17
247_A263_T0.8260.17
155_I353_K0.8260.17
431_A459_V0.8260.17
459_V467_R0.8250.17
56_M427_Q0.8240.17
63_F103_A0.8240.17
78_H349_D0.8230.17
316_A354_L0.8220.17
162_S422_Q0.8180.16
272_H320_T0.8170.16
138_L475_M0.8160.16
142_S355_A0.8140.16
352_A484_A0.8140.16
350_T354_L0.8130.16
435_G439_Y0.8130.16
123_T438_S0.8120.16
165_V169_I0.8110.16
48_M285_I0.8110.16
436_L449_V0.8100.16
40_A115_G0.8080.16
307_H311_T0.8070.16
310_N492_Y0.8050.16
282_Q388_M0.8010.16
68_G234_I0.7990.16
18_L366_N0.7970.16
49_Q60_F0.7970.16
146_A386_I0.7960.16
70_L438_S0.7940.16
50_P395_G0.7930.16
179_R277_H0.7920.16
113_F244_I0.7890.16
260_I304_F0.7890.16
34_D37_N0.7880.16
148_N337_R0.7870.16
245_A442_M0.7830.16
300_Q312_F0.7830.16
142_S317_R0.7830.16
233_G241_L0.7820.16
294_A305_H0.7810.16
327_E498_L0.7780.16
89_G473_I0.7770.16
151_E309_A0.7770.16
116_L331_P0.7770.16
21_A431_A0.7770.16
152_V168_V0.7740.15
16_L42_V0.7730.15
301_V306_C0.7710.15
165_V244_I0.7690.15
129_I409_I0.7640.15
312_F373_S0.7630.15
52_L329_Y0.7630.15
388_M494_I0.7610.15
139_T473_I0.7590.15
138_L331_P0.7590.15
50_P99_S0.7590.15
274_L354_L0.7590.15
205_K219_A0.7580.15
363_E448_H0.7570.15
155_I266_A0.7560.15
103_A263_T0.7540.15
14_L161_V0.7540.15
123_T227_A0.7530.15
125_I375_M0.7510.15
50_P374_D0.7500.15
299_T486_F0.7460.15
106_I212_I0.7440.15
242_V311_T0.7420.15
68_G345_L0.7420.15
141_S496_L0.7410.15
17_L158_S0.7400.15
165_V340_L0.7390.15
307_H363_E0.7380.15
94_L140_G0.7360.15
220_G389_A0.7360.15
433_S438_S0.7360.15
234_I382_A0.7340.15
204_R468_K0.7340.15
462_G498_L0.7310.15
113_F157_S0.7310.15
113_F399_M0.7290.15
256_S475_M0.7290.15
91_T486_F0.7270.14
432_V435_G0.7260.14
315_I344_M0.7250.14
88_M430_A0.7250.14
253_M261_T0.7240.14
28_A386_I0.7220.14
362_K373_S0.7220.14
137_L486_F0.7190.14
165_V367_L0.7190.14
430_A476_A0.7180.14
220_G388_M0.7170.14
47_A322_L0.7170.14
458_M463_G0.7160.14
151_E467_R0.7160.14
75_A349_D0.7160.14
129_I459_V0.7140.14
165_V475_M0.7140.14
224_S460_V0.7130.14
374_D473_I0.7130.14
279_E478_V0.7130.14
275_Q278_P0.7120.14
357_L360_V0.7120.14
108_N446_T0.7100.14
201_K204_R0.7090.14
106_I348_S0.7090.14
190_I205_K0.7080.14
253_M380_E0.7080.14
69_G151_E0.7050.14
158_S164_I0.7040.14
189_R201_K0.7040.14
54_V406_A0.7020.14
209_W451_S0.6990.14
345_L387_I0.6990.14
420_Y450_L0.6980.14
274_L277_H0.6970.14
145_D342_R0.6960.14
295_S313_D0.6950.14
250_V352_A0.6950.14
99_S259_E0.6930.14
345_L382_A0.6930.14
38_A481_L0.6930.14
129_I351_S0.6920.14
74_Y449_V0.6900.14
402_W414_G0.6890.14
405_V427_Q0.6890.14
14_L189_R0.6880.14
297_D400_I0.6870.14
155_I161_V0.6840.14
70_L441_G0.6810.14
113_F123_T0.6790.14
295_S347_I0.6790.14
180_Y442_M0.6780.14
60_F254_N0.6770.13
48_M67_L0.6740.13
188_D492_Y0.6740.13
421_A435_G0.6730.13
176_L359_G0.6710.13
136_A151_E0.6690.13
354_L362_K0.6680.13
274_L349_D0.6680.13
103_A336_Q0.6680.13
275_Q324_G0.6680.13
143_V487_L0.6680.13
315_I331_P0.6660.13
48_M275_Q0.6650.13
77_V488_S0.6640.13
26_Y50_P0.6620.13
104_A448_H0.6610.13
165_V364_D0.6610.13
366_N403_R0.6590.13
374_D498_L0.6590.13
362_K475_M0.6580.13
17_L484_A0.6570.13
179_R360_V0.6570.13
259_E276_Q0.6540.13
68_G381_Y0.6530.13
349_D364_D0.6520.13
233_G420_Y0.6500.13
338_S492_Y0.6470.13
105_I402_W0.6460.13
59_F259_E0.6450.13
270_F364_D0.6440.13
156_F369_K0.6430.13
67_L320_T0.6430.13
270_F273_Y0.6430.13
18_L338_S0.6420.13
69_G177_L0.6420.13
443_P480_T0.6410.13
456_G480_T0.6410.13
445_S480_T0.6410.13
456_G477_W0.6410.13
445_S477_W0.6410.13
443_P477_W0.6410.13
479_F483_A0.6410.13
174_I498_L0.6400.13
373_S498_L0.6400.13
67_L432_V0.6390.13
272_H416_R0.6390.13
282_Q494_I0.6380.13
204_R296_T0.6380.13
116_L479_F0.6350.13
116_L418_M0.6350.13
346_C427_Q0.6350.13
372_R400_I0.6350.13
169_I242_V0.6310.13
353_K470_V0.6310.13
189_R488_S0.6290.13
87_N244_I0.6280.13
60_F67_L0.6280.13
265_D403_R0.6260.13
84_L128_I0.6200.12
169_I172_G0.6190.12
19_A315_I0.6190.12
324_G392_L0.6180.12
422_Q457_T0.6160.12
77_V125_I0.6140.12
268_T462_G0.6120.12
100_M430_A0.6110.12
232_K235_G0.6080.12
307_H312_F0.6060.12
55_V436_L0.6060.12
114_F156_F0.6040.12
83_D462_G0.6040.12
260_I439_Y0.6030.12
150_R360_V0.6020.12
137_L365_Q0.6000.12
58_A151_E0.6000.12
244_I442_M0.5990.12
84_L491_L0.5990.12
97_V399_M0.5990.12
180_Y425_A0.5990.12
442_M460_V0.5980.12
45_T111_T0.5980.12
167_L240_V0.5980.12
270_F318_V0.5970.12
294_A378_T0.5970.12
127_A461_D0.5950.12
362_K366_N0.5950.12
438_S441_G0.5950.12
123_T294_A0.5940.12
214_L419_T0.5930.12
172_G310_N0.5920.12
25_F28_A0.5920.12
362_K432_V0.5910.12
218_A346_C0.5900.12
106_I315_I0.5900.12
269_N468_K0.5900.12
138_L317_R0.5900.12
84_L207_P0.5900.12
78_H382_A0.5890.12
259_E498_L0.5890.12
474_L489_G0.5880.12
106_I374_D0.5880.12
95_A221_V0.5860.12
294_A299_T0.5850.12
102_L492_Y0.5840.12
298_G436_L0.5840.12
51_Q85_L0.5840.12
106_I183_G0.5830.12
103_A489_G0.5830.12
329_Y492_Y0.5830.12
160_I354_L0.5830.12
209_W458_M0.5820.12
68_G380_E0.5800.12
416_R488_S0.5790.12
60_F496_L0.5790.12
55_V424_M0.5780.12
247_A320_T0.5770.12
25_F94_L0.5770.12
88_M393_A0.5770.12
51_Q91_T0.5770.12
267_V367_L0.5760.12
111_T121_S0.5760.12
264_R488_S0.5760.12
71_S224_S0.5750.12
457_T463_G0.5740.12
454_V457_T0.5740.12
87_N322_L0.5730.12
204_R347_I0.5730.12
344_M416_R0.5720.12
88_M271_E0.5720.12
157_S364_D0.5710.12
365_Q369_K0.5710.12
311_T318_V0.5710.12
298_G421_A0.5680.12
408_T447_T0.5670.12
87_N325_N0.5650.11
85_L251_V0.5640.11
295_S311_T0.5630.11
16_L40_A0.5630.11
332_L490_G0.5620.11
48_M219_A0.5600.11
133_L484_A0.5590.11
314_A344_M0.5590.11
247_A339_Q0.5590.11
131_I406_A0.5590.11
263_T344_M0.5570.11
103_A390_V0.5560.11
178_R271_E0.5550.11
146_A251_V0.5550.11
327_E377_S0.5550.11
18_L183_G0.5530.11
75_A451_S0.5530.11
178_R224_S0.5520.11
55_V168_V0.5520.11
302_T307_H0.5520.11
82_T409_I0.5510.11
17_L136_A0.5490.11
215_I351_S0.5480.11
77_V303_E0.5480.11
365_Q419_T0.5470.11
140_G282_Q0.5470.11
275_Q311_T0.5450.11
24_L86_L0.5440.11
457_T468_K0.5440.11
436_L442_M0.5430.11
26_Y149_L0.5420.11
56_M217_S0.5420.11
83_D478_V0.5420.11
368_L451_S0.5410.11
17_L339_Q0.5410.11
272_H276_Q0.5410.11
160_I371_L0.5410.11
233_G402_W0.5400.11
176_L247_A0.5390.11
352_A462_G0.5390.11
247_A270_F0.5370.11
209_W422_Q0.5360.11
132_G430_A0.5360.11
425_A474_L0.5360.11
188_D259_E0.5360.11
131_I455_A0.5360.11
116_L484_A0.5350.11
164_I282_Q0.5350.11
161_V361_S0.5350.11
116_L154_K0.5340.11
149_L156_F0.5330.11
95_A105_I0.5320.11
17_L388_M0.5320.11
310_N350_T0.5300.11
296_T340_L0.5300.11
224_S436_L0.5280.11
270_F367_L0.5260.11
180_Y188_D0.5260.11
296_T338_S0.5250.11
260_I378_T0.5250.11
269_N490_G0.5250.11
51_Q305_H0.5250.11
14_L17_L0.5250.11
152_V479_F0.5240.11
358_P492_Y0.5240.11
225_H232_K0.5240.11
176_L496_L0.5220.11
214_L341_R0.5220.11
113_F364_D0.5220.11
243_G399_M0.5210.11
420_Y469_T0.5190.11
87_N181_W0.5190.11
357_L416_R0.5160.11
142_S189_R0.5150.11
271_E368_L0.5150.11
15_L105_I0.5120.11
490_G497_Q0.5120.11
89_G174_I0.5120.11
457_T464_G0.5110.11
42_V123_T0.5110.11
78_H87_N0.5110.11
129_I133_L0.5100.11
202_G440_I0.5100.11
50_P405_V0.5080.11
253_M337_R0.5080.11
300_Q303_E0.5080.11
421_A429_T0.5080.11
330_E392_L0.5060.11
162_S458_M0.5050.11
116_L165_V0.5050.11
242_V496_L0.5050.11
183_G416_R0.5050.11
474_L488_S0.5040.10
46_R490_G0.5030.10
193_I472_S0.5020.10
48_M439_Y0.5020.10
46_R178_R0.5020.10
339_Q378_T0.5020.10
333_S403_R0.5010.10
148_N263_T0.5000.10
262_R370_K0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.3527 91 0.973 Contact Map
4m5bA 1 0.2305 31.1 0.984 Contact Map
3qe7A 2 0.3427 29.7 0.984 Contact Map
3zbhA 2 0.1944 29.4 0.984 Contact Map
4i0xB 1 0.1703 27.7 0.984 Contact Map
3ogiB 1 0.1784 25.5 0.984 Contact Map
3gwkC 2 0.1904 17.9 0.985 Contact Map
2wscI 1 0.0601 15.4 0.986 Contact Map
4oj2X 3 0.3788 13.4 0.986 Contact Map
4dx5A 3 0.3186 12 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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