GREMLIN Database
FLGN - Flagella synthesis protein FlgN
UniProt: P43533 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12665
Length: 138 (127)
Sequences: 264 (191)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_L86_L2.9530.98
56_L111_L2.9060.98
9_D75_R2.7490.97
119_L122_A2.6590.97
93_N111_L2.5240.96
17_D22_M2.4520.95
18_L50_L2.4380.95
120_Y124_G2.2090.91
94_G111_L2.2050.91
117_P122_A2.0480.88
11_M64_P2.0230.87
11_M86_L1.9890.86
32_G107_A1.9380.85
11_M53_L1.8360.81
68_N78_E1.8200.81
79_I86_L1.7970.80
11_M79_I1.7940.80
29_L96_L1.7690.79
89_M104_N1.7220.77
34_I101_I1.7130.77
64_P97_L1.6870.75
85_Q106_Q1.6420.73
13_A133_G1.6350.73
81_V102_E1.5980.71
13_A81_V1.4670.64
88_Q114_H1.4640.64
15_L50_L1.4600.64
4_L72_I1.4540.64
25_E46_K1.4240.62
23_D85_Q1.3930.60
18_L99_G1.3890.60
95_W109_E1.3720.59
6_E27_Q1.3560.58
7_I109_E1.3470.58
90_N94_G1.3250.56
89_M103_R1.2670.53
28_H42_I1.2470.52
53_L100_Q1.2470.52
38_Q108_L1.2370.51
11_M97_L1.2360.51
79_I112_K1.2350.51
52_T55_Y1.2290.51
95_W98_E1.2200.50
107_A113_P1.2190.50
19_K53_L1.2170.50
5_A103_R1.2120.50
18_L97_L1.1970.49
25_E124_G1.1860.48
25_E120_Y1.1860.48
46_K124_G1.1860.48
46_K120_Y1.1860.48
16_N82_K1.1690.47
28_H82_K1.1470.46
11_M57_E1.1450.46
103_R125_Q1.1430.46
105_Q110_M1.1420.46
50_L64_P1.1230.44
63_E91_Q1.1070.43
11_M110_M1.1060.43
13_A23_D1.1010.43
18_L102_E1.0880.42
52_T97_L1.0830.42
11_M54_D1.0820.42
118_T126_T1.0710.41
19_K86_L1.0200.38
119_L133_G1.0130.38
63_E71_D1.0100.38
46_K60_R1.0030.37
25_E60_R1.0030.37
41_W127_S0.9860.37
92_H97_L0.9860.37
97_L111_L0.9770.36
54_D100_Q0.9720.36
104_N125_Q0.9620.35
99_G119_L0.9510.35
107_A111_L0.9390.34
43_T58_Q0.9320.34
8_L96_L0.9270.33
91_Q119_L0.9180.33
31_M43_T0.9090.32
93_N108_L0.9040.32
50_L79_I0.8970.32
70_V106_Q0.8940.32
80_T122_A0.8920.31
50_L57_E0.8860.31
18_L40_Q0.8820.31
3_R105_Q0.8810.31
26_Q129_T0.8780.31
38_Q83_T0.8770.31
96_L122_A0.8760.31
42_I59_L0.8730.31
55_Y97_L0.8660.30
72_I129_T0.8480.29
12_S21_V0.8340.29
94_G108_L0.8320.28
48_S116_E0.8250.28
30_S59_L0.8170.28
73_S81_V0.8090.27
17_D20_T0.8080.27
22_M87_R0.7970.27
63_E66_T0.7970.27
57_E64_P0.7950.27
51_A58_Q0.7940.27
41_W114_H0.7920.27
35_N89_M0.7810.26
46_K76_W0.7810.26
25_E76_W0.7810.26
46_K90_N0.7800.26
25_E90_N0.7800.26
35_N61_R0.7780.26
29_L104_N0.7780.26
13_A85_Q0.7730.26
35_N83_T0.7660.25
64_P110_M0.7620.25
42_I107_A0.7580.25
121_G125_Q0.7570.25
80_T123_N0.7560.25
8_L24_Q0.7550.25
95_W99_G0.7550.25
72_I115_Q0.7540.25
60_R120_Y0.7490.25
60_R124_G0.7490.25
14_V100_Q0.7470.25
62_K77_Q0.7380.24
65_N84_Q0.7360.24
83_T86_L0.7330.24
10_Q101_I0.7310.24
56_L107_A0.7280.24
45_Q78_E0.7150.23
7_I101_I0.7150.23
78_E85_Q0.7020.23
28_H79_I0.7000.23
32_G123_N0.6840.22
49_L69_S0.6820.22
24_Q100_Q0.6710.21
57_E112_K0.6710.21
73_S78_E0.6630.21
52_T74_Q0.6610.21
16_N45_Q0.6560.21
31_M106_Q0.6540.21
59_L82_K0.6400.20
88_Q105_Q0.6380.20
92_H113_P0.6370.20
12_S47_S0.6370.20
82_K133_G0.6310.20
59_L62_K0.6260.20
4_L57_E0.6240.20
9_D85_Q0.6180.19
56_L108_L0.6180.19
87_R111_L0.6180.19
14_V56_L0.6170.19
35_N70_V0.6060.19
18_L76_W0.6050.19
45_Q129_T0.6010.19
32_G94_G0.5900.18
92_H107_A0.5850.18
30_S119_L0.5830.18
34_I100_Q0.5810.18
100_Q106_Q0.5790.18
58_Q133_G0.5770.18
57_E85_Q0.5750.18
22_M60_R0.5680.17
44_E103_R0.5680.17
40_Q64_P0.5670.17
10_Q40_Q0.5630.17
84_Q107_A0.5500.17
22_M94_G0.5480.17
62_K78_E0.5480.17
20_T23_D0.5450.17
10_Q42_I0.5440.17
64_P117_P0.5430.17
75_R110_M0.5430.17
73_S77_Q0.5370.16
24_Q42_I0.5330.16
54_D79_I0.5320.16
24_Q45_Q0.5300.16
90_N124_G0.5270.16
90_N120_Y0.5270.16
24_Q77_Q0.5250.16
51_A77_Q0.5200.16
111_L119_L0.5170.16
65_N109_E0.5160.16
92_H99_G0.5150.16
29_L46_K0.5130.16
25_E29_L0.5130.16
13_A41_W0.5110.16
94_G107_A0.5020.15
76_W124_G0.5020.15
76_W120_Y0.5020.15
102_E125_Q0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3opcA 2 0.8116 99.9 0.42 Contact Map
2fupA 1 0.7826 99.9 0.447 Contact Map
2hh7A 3 0.5 7.8 0.937 Contact Map
4kblA 2 0.5072 6.2 0.94 Contact Map
2ycuA 1 0.4565 4.3 0.944 Contact Map
3t98A 4 0.2319 4.1 0.945 Contact Map
3itfA 2 0.6594 4.1 0.945 Contact Map
2v2fA 1 0.1087 4 0.945 Contact Map
4j3hA 4 0.2319 3.7 0.946 Contact Map
1qvrA 3 0.9783 3.6 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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