GREMLIN Database
LPXH - UDP-2,3-diacylglucosamine hydrolase
UniProt: P43341 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12666
Length: 240 (228)
Sequences: 2166 (1444)
Seq/√Len: 95.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_I42_L4.6721.00
113_M191_L3.8541.00
201_V212_F3.5641.00
35_A72_P3.5301.00
121_D175_N3.2541.00
33_A36_L3.1491.00
72_P95_T3.1061.00
110_V190_W2.9281.00
39_L112_I2.8651.00
6_I9_L2.6791.00
108_R189_Q2.6491.00
128_F132_V2.6061.00
229_T232_D2.5591.00
137_L140_L2.5321.00
27_A62_A2.5091.00
75_F84_L2.4371.00
110_V192_I2.4291.00
38_I63_I2.4251.00
63_I73_C2.4191.00
23_L62_A2.4071.00
201_V214_V2.3341.00
229_T234_E2.2411.00
5_F37_Y2.2041.00
183_M191_L2.1871.00
139_T143_A2.1721.00
178_A181_S2.1381.00
35_A74_Y2.1101.00
24_R28_G2.1051.00
217_G224_S2.0281.00
76_I100_E1.9651.00
75_F94_M1.9501.00
203_E206_A1.8971.00
67_S73_C1.8951.00
104_E110_V1.8231.00
144_L148_V1.8091.00
66_V71_V1.7761.00
127_A131_K1.7561.00
228_V233_V1.7451.00
132_V141_F1.7341.00
179_V183_M1.7171.00
76_I112_I1.6961.00
64_K68_D1.6761.00
104_E109_R1.6721.00
6_I38_I1.6141.00
3_T35_A1.5891.00
4_L33_A1.5831.00
4_L31_R1.5381.00
203_E212_F1.5351.00
6_I36_L1.5301.00
6_I22_F1.5281.00
3_T106_Y1.4861.00
104_E107_G1.4851.00
134_K137_L1.4331.00
9_L22_F1.4311.00
199_P235_L1.4150.99
86_K90_R1.4010.99
67_S92_S1.4000.99
74_Y95_T1.3730.99
214_V226_V1.3570.99
28_G31_R1.3550.99
227_K236_I1.3380.99
34_D72_P1.3180.99
73_C94_M1.3160.99
178_A182_A1.3040.99
226_V233_V1.3000.99
177_N181_S1.2950.99
122_D125_Y1.2850.99
184_E206_A1.2760.99
4_L227_K1.2730.99
60_A92_S1.2530.99
181_S185_K1.2460.99
163_A167_K1.2410.99
22_F59_M1.2350.99
2_A227_K1.2260.99
88_F92_S1.2140.98
108_R190_W1.2140.98
113_M117_T1.2060.98
141_F152_I1.1890.98
61_A65_A1.1820.98
12_C44_E1.1810.98
61_A68_D1.1740.98
33_A66_V1.1650.98
89_A96_L1.1560.98
65_A68_D1.1510.98
164_N172_M1.1490.98
60_A88_F1.1460.98
123_A127_A1.1440.98
111_L191_L1.1340.98
183_M188_V1.1260.97
171_I174_V1.1260.97
206_A211_A1.1220.97
182_A185_K1.1200.97
109_R189_Q1.1010.97
167_K172_M1.0920.97
36_L73_C1.0920.97
47_I153_A1.0740.97
55_L59_M1.0570.96
99_E113_M1.0520.96
138_Q141_F1.0510.96
180_V204_L1.0420.96
176_Q204_L1.0400.96
167_K171_I1.0390.96
140_L148_V1.0250.95
153_A160_S1.0240.95
204_L211_A1.0040.95
3_T105_L1.0020.95
180_V184_E0.9970.95
140_L144_L0.9880.94
182_A186_H0.9820.94
133_H138_Q0.9820.94
104_E108_R0.9770.94
5_F39_L0.9770.94
105_L110_V0.9760.94
51_D146_L0.9740.94
74_Y97_L0.9660.94
214_V233_V0.9650.94
184_E205_I0.9590.94
216_L226_V0.9560.93
155_R159_N0.9440.93
143_A147_F0.9400.93
99_E186_H0.9350.93
120_T173_D0.9230.92
132_V138_Q0.9210.92
5_F228_V0.9200.92
60_A94_M0.9140.92
201_V235_L0.9030.91
9_L42_L0.8870.91
4_L32_K0.8840.90
45_A141_F0.8790.90
131_K136_W0.8740.90
228_V231_D0.8680.90
60_A91_E0.8680.90
131_K137_L0.8670.90
87_R91_E0.8640.89
76_I101_K0.8640.89
19_T59_M0.8610.89
45_A83_L0.8580.89
77_H96_L0.8570.89
101_K188_V0.8540.89
27_A65_A0.8410.88
157_R160_S0.8390.88
111_L182_A0.8370.88
199_P224_S0.8360.88
58_K61_A0.8330.88
46_W219_W0.8270.87
180_V183_M0.8240.87
62_A69_S0.8180.87
81_D194_G0.8180.87
62_A65_A0.8150.87
179_V182_A0.8030.86
136_W140_L0.8030.86
37_Y103_L0.7970.85
88_F91_E0.7970.85
49_D149_R0.7960.85
61_A64_K0.7950.85
180_V211_A0.7940.85
23_L58_K0.7870.85
137_L143_A0.7850.84
34_D106_Y0.7850.84
225_M236_I0.7840.84
36_L71_V0.7830.84
105_L228_V0.7810.84
100_E117_T0.7810.84
23_L59_M0.7790.84
49_D122_D0.7710.83
140_L147_F0.7650.83
122_D178_A0.7640.83
5_F103_L0.7610.83
168_S172_M0.7590.82
166_S169_L0.7580.82
58_K68_D0.7550.82
177_N180_V0.7530.82
137_L148_V0.7520.82
18_I21_G0.7470.81
98_P101_K0.7460.81
39_L216_L0.7450.81
122_D129_R0.7440.81
227_K234_E0.7430.81
183_M204_L0.7410.81
127_A140_L0.7400.81
5_F112_I0.7390.81
217_G221_T0.7380.81
77_H99_E0.7380.81
126_Q130_A0.7370.81
19_T55_L0.7360.80
217_G220_H0.7320.80
63_I94_M0.7320.80
112_I192_I0.7300.80
3_T37_Y0.7290.80
52_P56_H0.7250.79
33_A71_V0.7240.79
62_A66_V0.7240.79
53_N56_H0.7200.79
136_W139_T0.7190.79
11_L219_W0.7130.78
18_I220_H0.7100.78
178_A183_M0.7100.78
31_R66_V0.7060.78
15_E220_H0.7030.77
58_K62_A0.6960.77
5_F233_V0.6940.76
199_P215_V0.6940.76
109_R187_Q0.6940.76
193_H213_R0.6910.76
100_E186_H0.6900.76
124_G131_K0.6890.76
76_I99_E0.6890.76
148_V151_R0.6880.76
42_L59_M0.6870.76
48_G149_R0.6830.75
45_A153_A0.6800.75
53_N60_A0.6790.75
79_N114_H0.6780.75
119_C213_R0.6770.75
36_L66_V0.6770.75
51_D150_K0.6760.75
124_G127_A0.6690.74
65_A69_S0.6680.74
171_I198_R0.6660.73
142_L146_L0.6650.73
113_M118_L0.6650.73
6_I25_F0.6620.73
164_N167_K0.6600.73
52_P57_R0.6590.73
131_K139_T0.6580.73
47_I150_K0.6580.73
147_F151_R0.6540.72
100_E113_M0.6520.72
27_A58_K0.6520.72
7_A216_L0.6510.72
18_I222_E0.6480.71
152_I156_M0.6470.71
19_T56_H0.6470.71
189_Q211_A0.6390.70
19_T23_L0.6370.70
35_A95_T0.6360.70
135_P138_Q0.6340.70
220_H224_S0.6320.69
110_V214_V0.6310.69
98_P117_T0.6270.69
109_R190_W0.6250.69
18_I217_G0.6220.68
183_M211_A0.6220.68
12_C159_N0.6210.68
111_L188_V0.6200.68
46_W218_A0.6180.68
192_I226_V0.6170.68
190_W212_F0.6150.67
64_K93_G0.6090.67
110_V233_V0.6080.67
181_S184_E0.6060.66
119_C193_H0.6060.66
161_K164_N0.6050.66
48_G52_P0.6030.66
32_K66_V0.6010.66
142_L147_F0.6000.66
15_E19_T0.5980.65
205_I211_A0.5980.65
113_M182_A0.5970.65
15_E21_G0.5930.65
143_A148_V0.5930.65
126_Q129_R0.5910.64
132_V137_L0.5900.64
25_F225_M0.5900.64
67_S94_M0.5860.64
55_L58_K0.5840.63
110_V228_V0.5820.63
7_A12_C0.5820.63
171_I175_N0.5800.63
76_I117_T0.5790.63
174_V179_V0.5770.63
36_L86_K0.5760.62
48_G83_L0.5740.62
2_A34_D0.5700.62
48_G125_Y0.5680.61
26_L38_I0.5660.61
172_M175_N0.5640.61
212_F226_V0.5630.61
36_L74_Y0.5620.60
12_C132_V0.5610.60
12_C15_E0.5610.60
83_L138_Q0.5600.60
12_C19_T0.5600.60
189_Q206_A0.5600.60
118_L179_V0.5590.60
56_H60_A0.5590.60
83_L141_F0.5580.60
21_G223_G0.5570.60
119_C126_Q0.5550.60
65_A234_E0.5520.59
110_V212_F0.5510.59
102_V188_V0.5510.59
76_I97_L0.5490.59
179_V198_R0.5490.59
125_Y129_R0.5480.59
220_H223_G0.5470.58
134_K138_Q0.5450.58
43_F129_R0.5450.58
175_N178_A0.5440.58
64_K69_S0.5420.58
144_L151_R0.5420.58
82_F133_H0.5410.58
108_R232_D0.5410.58
180_V233_V0.5410.58
20_A230_A0.5400.57
230_A234_E0.5370.57
7_A215_V0.5340.57
82_F126_Q0.5340.57
184_E211_A0.5330.56
11_L160_S0.5320.56
11_L116_D0.5320.56
12_C26_L0.5320.56
121_D178_A0.5290.56
149_R196_T0.5290.56
65_A90_R0.5270.56
7_A10_H0.5270.56
127_A137_L0.5260.56
139_T142_L0.5260.56
149_R156_M0.5250.55
84_L94_M0.5240.55
61_A91_E0.5240.55
161_K223_G0.5220.55
133_H137_L0.5150.54
88_F94_M0.5150.54
127_A136_W0.5150.54
37_Y74_Y0.5130.54
24_R31_R0.5120.54
20_A23_L0.5120.54
130_A134_K0.5120.54
102_V111_L0.5120.54
74_Y101_K0.5110.53
106_Y109_R0.5110.53
97_L100_E0.5110.53
159_N162_E0.5070.53
80_R213_R0.5060.53
55_L60_A0.5050.53
217_G235_L0.5040.52
21_G24_R0.5020.52
28_G65_A0.5020.52
43_F122_D0.5010.52
146_L149_R0.5010.52
46_W82_F0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e0jA 1 0.8542 99.9 0.62 Contact Map
4y97A 1 0.8917 99.9 0.644 Contact Map
1su1A 3 0.6917 99.9 0.654 Contact Map
2a22A 1 0.6875 99.9 0.656 Contact Map
1z2wA 2 0.65 99.9 0.661 Contact Map
2kknA 1 0.6417 99.9 0.661 Contact Map
1s3lA 1 0.6417 99.9 0.666 Contact Map
1nnwA 2 0.75 99.9 0.672 Contact Map
2yvtA 1 0.9292 99.8 0.677 Contact Map
2z72A 1 0.8917 99.8 0.679 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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