GREMLIN Database
NUDL - Uncharacterized Nudix hydrolase NudL
UniProt: P43337 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12693
Length: 192 (167)
Sequences: 3101 (2295)
Seq/√Len: 177.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_V79_A5.2271.00
48_L181_I3.5701.00
77_I115_V2.9141.00
85_E92_P2.7241.00
95_V117_G2.6771.00
74_A78_A2.6721.00
35_L84_A2.5461.00
43_Q141_A2.4451.00
49_T63_A2.3501.00
69_V76_A2.3101.00
134_A171_Y2.2751.00
127_A135_V2.2671.00
75_S78_A2.2221.00
45_G137_E2.1551.00
35_L117_G2.1281.00
96_E120_P1.9961.00
36_I180_I1.9591.00
41_R45_G1.9181.00
38_I44_P1.9061.00
77_I100_V1.8721.00
84_A95_V1.8711.00
78_A92_P1.8471.00
176_M180_I1.8141.00
84_A90_I1.8061.00
77_I97_V1.7721.00
36_I184_L1.7251.00
53_I133_S1.7221.00
76_A115_V1.6841.00
112_V176_M1.6631.00
50_Q53_I1.6451.00
46_L181_I1.6191.00
182_R186_L1.5851.00
70_D128_S1.5631.00
76_A79_A1.5481.00
97_V117_G1.5461.00
37_P119_I1.5041.00
62_V171_Y1.5041.00
165_L172_F1.4951.00
102_P183_E1.4881.00
41_R137_E1.4821.00
68_A110_Y1.4501.00
173_V181_I1.4491.00
73_D78_A1.4491.00
50_Q133_S1.4411.00
31_Q69_V1.4291.00
47_L88_V1.4161.00
62_V136_F1.3991.00
50_Q134_A1.3991.00
48_L177_T1.3831.00
50_Q171_Y1.3501.00
91_P94_A1.3481.00
58_H61_Q1.3251.00
89_A127_A1.3141.00
168_Y173_V1.3101.00
54_H130_D1.2811.00
100_V115_V1.2791.00
106_S176_M1.2711.00
151_P162_R1.2541.00
49_T55_L1.2471.00
144_L185_A1.2451.00
39_V137_E1.2401.00
136_F171_Y1.2161.00
155_Y160_S1.2031.00
81_L85_E1.2031.00
153_D160_S1.1871.00
143_A185_A1.1841.00
112_V180_I1.1701.00
40_R44_P1.1611.00
55_L59_A1.1421.00
30_R68_A1.1411.00
85_E91_P1.1341.00
139_P142_Q1.1291.00
37_P117_G1.1021.00
103_P113_T1.0791.00
103_P111_Q1.0781.00
31_Q111_Q1.0591.00
104_V179_G1.0531.00
116_V184_L1.0511.00
149_Y182_R1.0300.99
52_S55_L1.0230.99
62_V173_V1.0220.99
49_T132_V1.0120.99
64_F180_I1.0040.99
108_T176_M0.9880.99
40_R118_I0.9780.99
167_W170_Q0.9740.99
49_T58_H0.9520.99
84_A115_V0.9510.99
32_A110_Y0.9480.99
39_V45_G0.9460.99
34_V180_I0.9360.99
145_H148_R0.9310.99
125_Y135_V0.9310.99
36_I46_L0.9290.99
72_T78_A0.9240.99
73_D79_A0.9150.99
55_L58_H0.9140.99
143_A181_I0.9130.99
138_M173_V0.9120.99
164_W182_R0.9050.99
48_L62_V0.8970.99
92_P95_V0.8920.98
47_L119_I0.8880.98
76_A113_T0.8850.98
53_I59_A0.8820.98
48_L64_F0.8770.98
81_L97_V0.8720.98
149_Y166_S0.8710.98
142_Q168_Y0.8700.98
61_Q110_Y0.8640.98
101_L116_V0.8600.98
30_R110_Y0.8590.98
94_A123_L0.8590.98
156_R159_D0.8520.98
33_A76_A0.8360.98
52_S59_A0.8250.98
153_D162_R0.8190.97
44_P118_I0.8110.97
149_Y185_A0.8050.97
106_S110_Y0.7980.97
142_Q148_R0.7980.97
29_H105_D0.7940.97
94_A120_P0.7940.97
35_L97_V0.7920.97
26_T29_H0.7880.97
49_T57_K0.7850.97
85_E93_S0.7810.97
84_A88_V0.7780.96
140_L144_L0.7770.96
120_P123_L0.7770.96
48_L185_A0.7710.96
155_Y159_D0.7700.96
110_Y176_M0.7680.96
141_A145_H0.7670.96
31_Q103_P0.7580.96
53_I60_G0.7560.96
105_D111_Q0.7540.96
81_L95_V0.7490.96
36_I64_F0.7490.96
85_E126_R0.7470.96
142_Q169_E0.7470.96
155_Y158_G0.7460.95
97_V115_V0.7430.95
96_E118_I0.7340.95
35_L80_A0.7310.95
56_R59_A0.7250.95
152_L165_L0.7250.95
167_W172_F0.7220.95
61_Q107_V0.7220.95
142_Q173_V0.7190.95
168_Y171_Y0.7160.94
75_S79_A0.7120.94
101_L114_P0.7120.94
35_L95_V0.7080.94
38_I140_L0.7070.94
33_A114_P0.6990.94
37_P64_F0.6960.94
150_H167_W0.6880.93
57_K108_T0.6770.93
57_K110_Y0.6760.93
98_I118_I0.6730.92
153_D156_R0.6720.92
37_P65_P0.6680.92
88_V127_A0.6680.92
144_L188_I0.6670.92
49_T88_V0.6660.92
88_V132_V0.6630.92
179_G183_E0.6580.91
48_L136_F0.6480.91
88_V135_V0.6480.91
100_V113_T0.6420.90
164_W179_G0.6370.90
148_R166_S0.6350.90
77_I81_L0.6310.90
88_V125_Y0.6290.90
38_I116_V0.6210.89
22_I25_E0.6210.89
46_L140_L0.6190.89
47_L64_F0.6170.89
143_A166_S0.6160.89
156_R162_R0.6130.88
51_R132_V0.6090.88
63_A84_A0.6070.88
166_S185_A0.6060.88
80_A84_A0.6050.88
173_V178_A0.6040.88
31_Q76_A0.6010.87
83_E131_E0.6000.87
62_V168_Y0.5990.87
154_I165_L0.5980.87
55_L130_D0.5950.87
64_F104_V0.5950.87
139_P168_Y0.5930.87
81_L117_G0.5900.86
89_A128_S0.5900.86
95_V119_I0.5900.86
61_Q108_T0.5890.86
55_L63_A0.5890.86
92_P117_G0.5880.86
38_I45_G0.5860.86
94_A121_P0.5760.85
81_L92_P0.5760.85
106_S109_G0.5750.85
46_L143_A0.5720.85
38_I184_L0.5700.84
64_F185_A0.5610.84
64_F181_I0.5600.83
149_Y164_W0.5600.83
93_S124_P0.5590.83
41_R122_D0.5570.83
176_M183_E0.5560.83
100_V103_P0.5560.83
104_V183_E0.5530.83
37_P48_L0.5530.83
24_R28_N0.5500.82
114_P180_I0.5500.82
38_I46_L0.5460.82
107_V110_Y0.5460.82
84_A89_A0.5400.81
183_E187_Q0.5390.81
49_T52_S0.5360.81
58_H178_A0.5330.80
37_P40_R0.5330.80
124_P127_A0.5300.80
46_L185_A0.5280.80
37_P47_L0.5280.80
43_Q139_P0.5270.80
22_I27_L0.5260.79
148_R153_D0.5240.79
146_L149_Y0.5230.79
49_T61_Q0.5190.79
127_A132_V0.5190.79
62_V174_W0.5190.79
57_K107_V0.5180.78
102_P114_P0.5150.78
133_S171_Y0.5150.78
106_S179_G0.5150.78
55_L178_A0.5140.78
109_G176_M0.5130.78
58_H108_T0.5090.77
29_H111_Q0.5080.77
43_Q159_D0.5080.77
166_S182_R0.5070.77
97_V118_I0.5050.77
35_L64_F0.5050.77
127_A130_D0.5050.77
32_A134_A0.5050.77
138_M168_Y0.5050.77
154_I157_R0.5030.76
68_A136_F0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nqzA 1 0.849 100 0.515 Contact Map
3h95A 2 0.7708 99.8 0.635 Contact Map
4c9xA 2 0.7708 99.8 0.669 Contact Map
4nfwA 6 0.7604 99.7 0.68 Contact Map
5bonA 4 0.7812 99.7 0.681 Contact Map
3kvhA 2 0.7812 99.7 0.686 Contact Map
2w4eA 2 0.7031 99.7 0.688 Contact Map
3qsjA 1 0.776 99.7 0.691 Contact Map
3fjyA 2 0.7708 99.7 0.697 Contact Map
1u20A 2 0.849 99.7 0.698 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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