GREMLIN Database
YRAK - Uncharacterized fimbrial-like protein YraK
UniProt: P43319 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12776
Length: 363 (321)
Sequences: 221 (183)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
307_E338_W4.7511.00
190_G207_L4.4350.99
343_V347_L3.8560.99
72_C148_C3.8530.98
276_R361_I3.5680.97
237_I352_F3.5240.97
279_G290_V3.2600.96
168_L216_L3.0830.94
246_N316_I3.0800.94
173_P214_G3.0300.93
232_V257_F2.8740.91
9_G15_T2.7180.89
110_L188_I2.6320.87
181_P214_G2.6250.87
174_F216_L2.6210.87
308_N312_G2.5980.86
70_C176_G2.5580.86
105_D171_T2.4860.84
104_L170_V2.2740.78
12_L15_T2.2390.77
220_Q298_N2.1920.75
341_N347_L2.1360.73
66_W161_G2.1120.72
161_G164_T2.1120.72
94_Q104_L2.0420.70
219_P237_I1.8730.63
97_Y207_L1.8360.61
161_G208_V1.8310.61
60_T164_T1.8250.60
241_K251_G1.8200.60
174_F220_Q1.7960.59
234_F252_F1.7830.59
15_T19_Y1.7780.58
291_A304_I1.7490.57
306_I312_G1.7490.57
228_D354_G1.7490.57
96_G107_K1.7410.57
173_P321_G1.7390.57
219_P352_F1.7280.56
174_F191_A1.7100.55
109_T165_T1.7010.55
314_A319_Q1.6950.55
232_V354_G1.6820.54
135_N161_G1.6800.54
220_Q341_N1.6770.54
215_N221_S1.6760.54
230_I331_G1.6680.53
207_L229_V1.6500.53
176_G302_V1.6380.52
70_C302_V1.6030.50
223_K228_D1.5930.50
101_N206_D1.5700.49
304_I342_L1.5630.49
298_N347_L1.5590.48
302_V349_T1.5510.48
218_A273_L1.5460.48
99_K171_T1.5410.47
222_C263_C1.5280.47
227_G230_I1.5040.46
331_G357_T1.4660.44
252_F304_I1.4600.44
183_T214_G1.4480.43
97_Y179_T1.4190.42
68_Y306_I1.4140.42
227_G303_G1.4100.42
63_S85_S1.4030.41
282_G342_L1.4010.41
128_T208_V1.3980.41
180_I298_N1.3970.41
291_A296_S1.3930.41
164_T210_L1.3900.41
180_I301_D1.3870.40
234_F352_F1.3850.40
222_C339_P1.3790.40
58_S102_D1.3730.40
266_T329_G1.3670.40
29_S300_P1.3590.39
308_N343_V1.3580.39
110_L168_L1.3570.39
135_N190_G1.3530.39
220_Q344_G1.3520.39
245_R252_F1.3470.39
321_G329_G1.3470.39
218_A301_D1.3440.39
23_G164_T1.3350.38
8_T18_A1.3260.38
191_A347_L1.3200.38
32_G81_V1.3190.37
289_L304_I1.3180.37
40_V183_T1.3170.37
130_F164_T1.3150.37
176_G214_G1.2940.36
135_N160_I1.2900.36
40_V185_I1.2840.36
14_S185_I1.2800.36
175_L304_I1.2630.35
103_S261_Y1.2620.35
11_L64_T1.2610.35
97_Y324_P1.2590.35
225_N230_I1.2570.35
216_L266_T1.2560.35
244_T341_N1.2550.35
241_K266_T1.2520.35
96_G105_D1.2410.34
9_G12_L1.2300.34
174_F181_P1.2290.34
234_F257_F1.2220.33
106_I186_A1.2220.33
108_T186_A1.2180.33
162_A301_D1.2090.33
266_T335_M1.2080.33
219_P228_D1.2050.33
242_F341_N1.2040.33
186_A208_V1.1860.32
286_Q312_G1.1810.32
263_C339_P1.1770.32
108_T212_I1.1770.32
304_I357_T1.1720.31
323_L357_T1.1690.31
38_S212_I1.1690.31
161_G188_I1.1620.31
101_N174_F1.1480.30
259_I302_V1.1440.30
274_Q334_N1.1440.30
318_F322_I1.1380.30
12_L310_G1.1370.30
78_V195_G1.1370.30
204_F236_F1.1340.30
258_D335_M1.1330.30
70_C98_Y1.1240.29
272_S349_T1.1140.29
331_G338_W1.1100.29
232_V346_E1.1090.29
213_Q275_M1.1030.29
103_S217_T1.0990.29
22_S71_S1.0940.28
8_T41_D1.0940.28
291_A342_L1.0890.28
97_Y169_Y1.0820.28
60_T279_G1.0780.28
175_L223_K1.0700.27
355_T358_I1.0680.27
100_L267_S1.0630.27
148_C176_G1.0610.27
38_S185_I1.0590.27
130_F135_N1.0580.27
279_G287_Y1.0530.27
303_G340_V1.0520.27
189_K207_L1.0510.27
261_Y268_K1.0480.27
319_Q335_M1.0420.26
187_V209_K1.0370.26
220_Q347_L1.0270.26
117_G219_P1.0220.26
19_Y59_A1.0200.26
209_K247_A1.0160.25
55_E79_K1.0120.25
69_A149_Q1.0070.25
191_A298_N0.9990.25
195_G267_S0.9970.25
27_A207_L0.9960.25
304_I347_L0.9930.25
67_Q211_S0.9830.24
247_A318_F0.9750.24
298_N343_V0.9740.24
236_F327_P0.9730.24
249_P352_F0.9730.24
81_V84_V0.9720.24
224_I307_E0.9710.24
331_G341_N0.9670.24
96_G361_I0.9650.24
271_N333_V0.9600.24
117_G275_M0.9590.24
48_T301_D0.9560.23
223_K262_D0.9560.23
8_T19_Y0.9540.23
276_R331_G0.9540.23
167_T186_A0.9540.23
252_F331_G0.9530.23
80_L188_I0.9530.23
23_G277_I0.9460.23
11_L39_V0.9450.23
168_L188_I0.9370.23
314_A331_G0.9360.23
74_A104_L0.9340.23
40_V57_T0.9320.23
147_V207_L0.9300.23
314_A317_P0.9150.22
180_I214_G0.9150.22
99_K337_A0.9140.22
273_L361_I0.9140.22
105_D216_L0.9140.22
254_P307_E0.9090.22
261_Y354_G0.9050.22
39_V212_I0.9050.22
93_H195_G0.9010.22
53_G356_A0.8990.22
222_C350_G0.8990.22
55_E130_F0.8950.21
305_R358_I0.8880.21
308_N347_L0.8880.21
314_A341_N0.8870.21
176_G347_L0.8870.21
296_S337_A0.8860.21
312_G327_P0.8800.21
232_V235_G0.8770.21
181_P347_L0.8740.21
83_M207_L0.8740.21
78_V185_I0.8700.21
341_N344_G0.8690.21
50_N72_C0.8660.21
276_R347_L0.8650.21
14_S20_A0.8620.20
211_S249_P0.8590.20
260_T335_M0.8550.20
225_N232_V0.8530.20
220_Q343_V0.8520.20
245_R338_W0.8510.20
48_T233_N0.8500.20
79_K148_C0.8480.20
106_I169_Y0.8440.20
185_I302_V0.8420.20
46_N49_D0.8390.20
238_N241_K0.8350.20
259_I307_E0.8350.20
128_T147_V0.8320.20
170_V341_N0.8290.19
99_K340_V0.8280.19
16_S277_I0.8270.19
245_R341_N0.8250.19
317_P341_N0.8220.19
174_F298_N0.8210.19
148_C251_G0.8200.19
232_V268_K0.8200.19
321_G361_I0.8170.19
53_G339_P0.8170.19
276_R323_L0.8170.19
75_G133_I0.8160.19
94_Q354_G0.8130.19
8_T13_I0.8130.19
135_N210_L0.8120.19
98_Y161_G0.8120.19
172_K333_V0.8110.19
9_G17_C0.8100.19
168_L265_D0.8100.19
99_K277_I0.8090.19
257_F335_M0.8040.19
277_I337_A0.8040.19
179_T215_N0.8040.19
132_Q207_L0.8030.19
135_N164_T0.8030.19
316_I349_T0.8010.19
298_N344_G0.8010.19
242_F333_V0.8010.19
110_L161_G0.8010.19
88_L235_G0.8000.19
100_L323_L0.7980.19
100_L105_D0.7980.19
266_T271_N0.7960.19
158_V207_L0.7910.18
70_C181_P0.7910.18
278_D338_W0.7870.18
8_T11_L0.7820.18
173_P267_S0.7790.18
68_Y255_V0.7770.18
48_T194_D0.7770.18
13_I18_A0.7740.18
69_A74_A0.7720.18
334_N356_A0.7710.18
262_D337_A0.7700.18
342_L347_L0.7700.18
227_G301_D0.7700.18
100_L230_I0.7690.18
247_A338_W0.7690.18
104_L174_F0.7660.18
185_I188_I0.7660.18
98_Y169_Y0.7610.18
220_Q301_D0.7590.18
108_T192_W0.7580.18
332_T356_A0.7570.17
34_T157_P0.7560.17
300_P314_A0.7560.17
174_F214_G0.7530.17
303_G344_G0.7500.17
271_N290_V0.7480.17
229_V334_N0.7480.17
15_T234_F0.7470.17
25_C242_F0.7460.17
240_Q259_I0.7450.17
32_G331_G0.7440.17
44_T177_S0.7430.17
94_Q228_D0.7430.17
275_M322_I0.7420.17
55_E69_A0.7410.17
232_V255_V0.7390.17
218_A356_A0.7360.17
115_I264_G0.7350.17
84_V130_F0.7320.17
99_K102_D0.7320.17
62_S190_G0.7300.17
305_R335_M0.7300.17
115_I194_D0.7270.17
305_R317_P0.7270.17
204_F251_G0.7230.17
23_G62_S0.7220.17
11_L19_Y0.7190.16
333_V360_V0.7180.16
80_L89_T0.7170.16
135_N207_L0.7160.16
71_S302_V0.7160.16
33_A179_T0.7160.16
296_S340_V0.7140.16
290_V303_G0.7130.16
304_I331_G0.7070.16
314_A338_W0.7060.16
66_W168_L0.7050.16
13_I231_K0.7050.16
254_P305_R0.7040.16
318_F355_T0.7030.16
16_S19_Y0.7030.16
219_P224_I0.7010.16
96_G331_G0.6990.16
27_A230_I0.6980.16
185_I273_L0.6960.16
355_T359_T0.6930.16
100_L162_A0.6900.16
21_S29_S0.6900.16
275_M360_V0.6870.16
187_V228_D0.6870.16
25_C174_F0.6870.16
99_K187_V0.6860.16
214_G220_Q0.6850.16
279_G346_E0.6840.16
36_Y192_W0.6840.16
91_T166_F0.6830.16
41_D118_L0.6810.16
263_C350_G0.6800.16
176_G264_G0.6760.15
128_T328_S0.6730.15
168_L338_W0.6700.15
223_K242_F0.6700.15
25_C28_D0.6690.15
72_C183_T0.6680.15
64_T354_G0.6660.15
97_Y189_K0.6660.15
237_I297_D0.6650.15
232_V261_Y0.6650.15
188_I352_F0.6650.15
308_N341_N0.6640.15
223_K257_F0.6630.15
108_T161_G0.6610.15
32_G62_S0.6600.15
107_K178_M0.6590.15
33_A277_I0.6580.15
233_N250_D0.6570.15
176_G349_T0.6560.15
115_I267_S0.6550.15
249_P340_V0.6540.15
333_V337_A0.6540.15
85_S234_F0.6510.15
10_L308_N0.6500.15
48_T170_V0.6500.15
132_Q135_N0.6490.15
329_G354_G0.6490.15
12_L102_D0.6480.15
15_T22_S0.6480.15
15_T18_A0.6470.15
23_G27_A0.6470.15
219_P225_N0.6450.15
82_Y190_G0.6450.15
195_G250_D0.6440.15
167_T297_D0.6430.15
105_D230_I0.6410.15
53_G101_N0.6400.15
10_L131_T0.6390.15
106_I271_N0.6390.15
27_A161_G0.6380.15
100_L259_I0.6380.15
89_T195_G0.6360.14
296_S304_I0.6320.14
72_C168_L0.6320.14
223_K344_G0.6310.14
289_L345_G0.6260.14
188_I211_S0.6250.14
25_C289_L0.6240.14
322_I326_D0.6230.14
32_G109_T0.6220.14
312_G340_V0.6210.14
42_D55_E0.6210.14
168_L337_A0.6180.14
37_S195_G0.6170.14
321_G326_D0.6170.14
20_A344_G0.6170.14
35_N209_K0.6160.14
220_Q266_T0.6160.14
41_D85_S0.6140.14
22_S207_L0.6130.14
300_P360_V0.6100.14
273_L296_S0.6080.14
247_A324_P0.6070.14
130_F160_I0.6060.14
348_E353_Q0.6060.14
290_V341_N0.6050.14
46_N172_K0.6040.14
39_V102_D0.6020.14
103_S106_I0.6000.14
9_G151_D0.5980.14
23_G308_N0.5970.14
244_T254_P0.5960.14
330_H358_I0.5950.14
27_A164_T0.5870.13
184_D211_S0.5850.13
222_C303_G0.5850.13
189_K237_I0.5830.13
216_L308_N0.5830.13
102_D216_L0.5810.13
220_Q265_D0.5800.13
256_D283_V0.5790.13
232_V287_Y0.5790.13
220_Q242_F0.5780.13
302_V359_T0.5780.13
157_P212_I0.5770.13
240_Q351_K0.5770.13
82_Y188_I0.5760.13
291_A329_G0.5750.13
282_G355_T0.5740.13
291_A354_G0.5710.13
68_Y207_L0.5710.13
104_L355_T0.5630.13
224_I304_I0.5620.13
103_S359_T0.5610.13
261_Y265_D0.5580.13
72_C353_Q0.5570.13
256_D360_V0.5560.13
62_S208_V0.5550.13
63_S148_C0.5510.13
252_F318_F0.5490.13
17_C223_K0.5480.13
37_S40_V0.5440.12
342_L359_T0.5440.12
18_A32_G0.5430.12
275_M342_L0.5390.12
103_S316_I0.5380.12
251_G285_D0.5370.12
84_V188_I0.5360.12
339_P350_G0.5340.12
212_I337_A0.5340.12
135_N208_V0.5340.12
74_A94_Q0.5330.12
49_D291_A0.5300.12
205_H315_N0.5300.12
229_V358_I0.5290.12
304_I355_T0.5290.12
25_C220_Q0.5250.12
234_F258_D0.5240.12
9_G16_S0.5240.12
291_A331_G0.5240.12
95_T109_T0.5230.12
128_T132_Q0.5210.12
248_M254_P0.5190.12
214_G352_F0.5190.12
179_T205_H0.5180.12
184_D187_V0.5170.12
183_T357_T0.5170.12
66_W81_V0.5170.12
276_R359_T0.5150.12
38_S166_F0.5150.12
37_S216_L0.5140.12
11_L18_A0.5130.12
98_Y110_L0.5090.12
266_T269_I0.5090.12
195_G312_G0.5080.12
18_A204_F0.5070.12
127_N183_T0.5070.12
250_D302_V0.5070.12
177_S215_N0.5070.12
97_Y107_K0.5060.12
301_D348_E0.5040.12
272_S342_L0.5030.12
66_W84_V0.5020.12
73_S296_S0.5010.12
11_L15_T0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5afoA 1 0.8595 100 0.519 Contact Map
1n12A 1 0.3554 99.8 0.813 Contact Map
2w07B 1 0.3251 99.7 0.818 Contact Map
1pdkB 1 0.3829 99.7 0.823 Contact Map
2xg5B 1 0.3829 99.7 0.824 Contact Map
2jmrA 1 0.4132 99.7 0.824 Contact Map
3jwnH 1 0.7383 99.7 0.825 Contact Map
2jtyA 1 0.4187 99.7 0.83 Contact Map
2uy6B 2 0.3994 99.6 0.834 Contact Map
3bwuF 1 0.3388 99.6 0.836 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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