GREMLIN Database
AGAI - Putative galactosamine-6-phosphate isomerase
UniProt: P42912 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12772
Length: 251 (220)
Sequences: 5198 (3804)
Seq/√Len: 256.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_T105_Q3.7221.00
130_E133_R2.7461.00
153_K217_G2.7331.00
208_E244_N2.7111.00
65_Y68_E2.6061.00
27_N30_A2.5131.00
222_T249_I2.5071.00
104_Q109_Q2.3871.00
121_F196_I2.3681.00
136_N140_R2.3201.00
42_V49_A2.2461.00
76_D112_G2.1791.00
220_D224_R2.1771.00
25_V34_R2.1461.00
32_S61_L2.1381.00
93_L100_E2.0561.00
39_L62_T2.0041.00
31_L214_T1.9981.00
105_Q109_Q1.9541.00
145_D207_R1.9511.00
147_C206_A1.9451.00
174_Q194_R1.9131.00
33_E65_Y1.8791.00
187_T190_R1.8781.00
60_L106_H1.8431.00
82_F108_V1.8401.00
204_L238_F1.8311.00
81_T119_I1.8281.00
100_E104_Q1.8221.00
223_D227_T1.7981.00
126_I129_T1.7381.00
224_R234_I1.7361.00
48_N81_T1.7291.00
119_I137_L1.7271.00
83_V141_K1.7191.00
28_Y32_S1.7151.00
42_V208_E1.6901.00
58_T212_L1.6631.00
40_L75_V1.6531.00
104_Q115_E1.6221.00
151_L213_V1.6111.00
89_V127_N1.6031.00
67_V110_P1.5731.00
62_T148_V1.5591.00
177_A181_Q1.5541.00
132_E136_N1.5461.00
129_T133_R1.5381.00
39_L51_I1.5281.00
213_V222_T1.4921.00
64_H106_H1.4891.00
100_E120_S1.4471.00
133_R137_L1.4291.00
153_K182_H1.4271.00
78_S112_G1.4241.00
52_C147_C1.4241.00
151_L225_F1.4221.00
54_A85_L1.4121.00
26_E30_A1.4101.00
81_T117_Q1.4081.00
221_A234_I1.3841.00
94_T101_T1.3831.00
155_G234_I1.3541.00
43_I80_L1.3341.00
38_Y248_L1.3321.00
146_L210_L1.3181.00
198_L202_D1.3071.00
225_F236_A1.2991.00
25_V248_L1.2941.00
68_E72_Q1.2911.00
35_A62_T1.2851.00
52_C85_L1.2811.00
114_R117_Q1.2681.00
40_L44_R1.2591.00
208_E246_I1.2391.00
135_T202_D1.2301.00
133_R136_N1.2291.00
136_N139_A1.2221.00
28_Y61_L1.2161.00
50_V83_V1.2091.00
151_L236_A1.2051.00
29_T61_L1.2001.00
62_T212_L1.1971.00
113_L117_Q1.1971.00
50_V81_T1.1971.00
225_F247_C1.1941.00
39_L146_L1.1931.00
219_Q223_D1.1891.00
84_K103_L1.1881.00
35_A210_L1.1861.00
96_P101_T1.1841.00
139_A205_N1.1811.00
61_L64_H1.1761.00
35_A248_L1.1741.00
158_G203_I1.1631.00
241_L245_F1.1611.00
25_V30_A1.1601.00
34_R37_E1.1551.00
25_V31_L1.1541.00
77_V80_L1.1421.00
38_Y208_E1.1391.00
137_L140_R1.1391.00
178_R182_H1.1371.00
98_T101_T1.1321.00
46_K145_D1.0981.00
60_L64_H1.0911.00
47_P79_Q1.0821.00
60_L102_F1.0731.00
49_A80_L1.0711.00
38_Y210_L1.0561.00
201_K205_N1.0511.00
31_L248_L1.0501.00
131_C135_T1.0461.00
137_L141_K1.0441.00
24_Q249_I1.0421.00
46_K207_R1.0391.00
102_F106_H1.0381.00
81_T141_K1.0181.00
64_H110_P1.0161.00
23_Q34_R1.0141.00
200_L238_F1.0041.00
221_A224_R0.9951.00
92_P124_E0.9951.00
23_Q246_I0.9881.00
128_E132_E0.9851.00
28_Y214_T0.9761.00
76_D79_Q0.9721.00
52_C144_L0.9681.00
32_S62_T0.9641.00
49_A146_L0.9621.00
37_E41_A0.9581.00
53_L82_F0.9581.00
188_A191_P0.9511.00
30_A33_E0.9491.00
138_I144_L0.9461.00
81_T114_R0.9321.00
108_V118_L0.9261.00
222_T225_F0.9191.00
206_A209_V0.9171.00
122_R130_E0.9141.00
39_L148_V0.9111.00
188_A193_T0.8991.00
54_A147_C0.8951.00
44_R74_Q0.8911.00
43_I49_A0.8911.00
78_S114_R0.8911.00
144_L147_C0.8911.00
23_Q248_L0.8871.00
129_T132_E0.8861.00
234_I237_S0.8811.00
151_L222_T0.8801.00
104_Q118_L0.8721.00
186_K190_R0.8691.00
127_N196_I0.8651.00
104_Q120_S0.8651.00
211_L236_A0.8621.00
35_A212_L0.8621.00
75_V80_L0.8611.00
130_E196_I0.8601.00
224_R228_A0.8591.00
29_T65_Y0.8500.99
77_V111_L0.8500.99
57_A184_M0.8490.99
224_R233_A0.8490.99
225_F234_I0.8440.99
61_L65_Y0.8430.99
53_L63_Y0.8400.99
229_K237_S0.8400.99
58_T214_T0.8340.99
88_W99_C0.8330.99
222_T247_C0.8320.99
185_L190_R0.8270.99
88_W195_G0.8270.99
86_D156_H0.8260.99
83_V119_I0.8250.99
83_V137_L0.8240.99
209_V245_F0.8230.99
163_G232_T0.8220.99
46_K49_A0.8200.99
204_L242_H0.8150.99
92_P95_M0.8140.99
37_E74_Q0.8030.99
54_A157_L0.7960.99
179_T182_H0.7900.99
85_L203_I0.7890.99
93_L104_Q0.7880.99
64_H68_E0.7820.99
189_G193_T0.7680.99
103_L108_V0.7620.99
122_R133_R0.7610.99
135_T139_A0.7560.99
29_T33_E0.7530.99
203_I209_V0.7530.99
230_V241_L0.7510.99
127_N194_R0.7510.99
204_L239_L0.7480.99
204_L241_L0.7450.99
148_V212_L0.7410.99
59_P63_Y0.7380.98
149_L203_I0.7310.98
33_E37_E0.7300.98
38_Y42_V0.7290.98
51_I82_F0.7260.98
99_C195_G0.7230.98
185_L188_A0.7200.98
85_L198_L0.7180.98
177_A180_Q0.7150.98
220_D223_D0.7110.98
28_Y31_L0.7110.98
40_L74_Q0.7090.98
157_L211_L0.7080.98
88_W159_L0.7070.98
36_S66_L0.7050.98
173_S195_G0.7050.98
34_R38_Y0.7020.98
41_A44_R0.7010.98
153_K221_A0.7000.98
57_A102_F0.6990.98
123_S130_E0.6930.98
30_A34_R0.6910.98
114_R118_L0.6910.98
231_S237_S0.6830.97
48_N79_Q0.6820.97
35_A39_L0.6820.97
55_T99_C0.6810.97
155_G221_A0.6810.97
29_T64_H0.6780.97
225_F240_W0.6780.97
115_E118_L0.6780.97
97_G193_T0.6690.97
36_S65_Y0.6670.97
40_L66_L0.6630.97
21_T246_I0.6630.97
67_V106_H0.6610.97
185_L189_G0.6610.97
138_I142_G0.6590.97
175_L183_E0.6570.97
91_L101_T0.6560.97
98_T123_S0.6540.97
135_T180_Q0.6520.97
151_L221_A0.6490.97
164_E233_A0.6470.97
44_R75_V0.6470.97
66_L77_V0.6460.97
42_V146_L0.6420.96
34_R248_L0.6380.96
93_L124_E0.6300.96
238_F241_L0.6280.96
84_K120_S0.6280.96
93_L120_S0.6270.96
120_S123_S0.6260.96
22_L226_L0.6250.96
73_Q77_V0.6250.96
91_L95_M0.6250.96
88_W161_E0.6240.96
91_L98_T0.6230.96
179_T183_E0.6190.96
200_L235_P0.6150.95
183_E197_T0.6130.95
147_C203_I0.6130.95
120_S124_E0.6090.95
84_K100_E0.6060.95
82_F103_L0.6060.95
126_I194_R0.6050.95
161_E195_G0.6030.95
54_A63_Y0.6000.95
36_S40_L0.5990.95
32_S65_Y0.5980.95
83_V144_L0.5980.95
222_T226_L0.5950.95
221_A225_F0.5950.95
21_T244_N0.5880.94
158_G197_T0.5880.94
39_L66_L0.5860.94
125_E130_E0.5840.94
159_L195_G0.5830.94
83_V138_I0.5780.94
226_L247_C0.5770.94
40_L73_Q0.5750.93
38_Y246_I0.5690.93
50_V142_G0.5690.93
211_L247_C0.5660.93
85_L158_G0.5660.93
209_V239_L0.5650.93
228_A231_S0.5650.93
121_F134_V0.5640.93
57_A60_L0.5630.93
31_L35_A0.5620.93
131_C196_I0.5600.93
97_G190_R0.5560.92
181_Q188_A0.5560.92
99_C159_L0.5530.92
22_L249_I0.5510.92
107_I111_L0.5510.92
99_C161_E0.5500.92
104_Q108_V0.5490.92
147_C158_G0.5490.92
202_D205_N0.5480.92
197_T201_K0.5470.92
174_Q183_E0.5440.91
210_L248_L0.5430.91
63_Y148_V0.5430.91
209_V241_L0.5420.91
57_A153_K0.5390.91
85_L147_C0.5340.91
91_L94_T0.5320.91
150_G218_K0.5300.90
116_D120_S0.5290.90
207_R243_S0.5240.90
100_E118_L0.5230.90
55_T161_E0.5230.90
53_L103_L0.5210.90
173_S197_T0.5180.89
58_T102_F0.5180.89
35_A38_Y0.5170.89
74_Q111_L0.5160.89
200_L239_L0.5150.89
86_D218_K0.5130.89
176_D181_Q0.5130.89
55_T88_W0.5120.89
157_L239_L0.5100.89
121_F130_E0.5100.89
127_N131_C0.5070.88
131_C134_V0.5050.88
131_C197_T0.5050.88
46_K79_Q0.5040.88
186_K194_R0.5030.88
187_T193_T0.5030.88
138_I143_G0.5020.88
184_M191_P0.5010.88
190_R193_T0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx2A 1 0.8924 100 0.142 Contact Map
3icoA 1 0.8884 100 0.144 Contact Map
4tm7A 1 0.8884 100 0.146 Contact Map
3eb9A 1 0.8884 100 0.167 Contact Map
1vl1A 1 0.8486 100 0.186 Contact Map
3cssA 1 0.8845 100 0.205 Contact Map
3e15A 2 0.9681 100 0.206 Contact Map
3lwdA 2 0.8526 100 0.21 Contact Map
3lhiA 1 0.8645 100 0.225 Contact Map
1y89A 2 0.8845 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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