AGAI - ECOLI - GREMLIN Contacts

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AGAI - Putative galactosamine-6-phosphate isomerase

UniProt:	P42912	Sequences: MERGTASGGASLLKEFHPVQTLQQVENYTALSERASEYLLAVIRSKPNAVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEINETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLDARTQQHEMLKTAGRPVTRGITLGLKDILNAREVLLLVTGEGKQDATDRFLTAKVSTAIPASFLWLHSNFICLINT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12772
Length:	251 (220)
Sequences:	5198 (3804)
Seq/√Len:	256.4

ECOLI - AGAI NAGB YIEK
BACSU - NAGB GAMA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_T	105_Q	3.722	1.00
130_E	133_R	2.746	1.00
153_K	217_G	2.733	1.00
208_E	244_N	2.711	1.00
65_Y	68_E	2.606	1.00
27_N	30_A	2.513	1.00
222_T	249_I	2.507	1.00
104_Q	109_Q	2.387	1.00
121_F	196_I	2.368	1.00
136_N	140_R	2.320	1.00
42_V	49_A	2.246	1.00
76_D	112_G	2.179	1.00
220_D	224_R	2.177	1.00
25_V	34_R	2.146	1.00
32_S	61_L	2.138	1.00
93_L	100_E	2.056	1.00
39_L	62_T	2.004	1.00
31_L	214_T	1.998	1.00
105_Q	109_Q	1.954	1.00
145_D	207_R	1.951	1.00
147_C	206_A	1.945	1.00
174_Q	194_R	1.913	1.00
33_E	65_Y	1.879	1.00
187_T	190_R	1.878	1.00
60_L	106_H	1.843	1.00
82_F	108_V	1.840	1.00
204_L	238_F	1.831	1.00
81_T	119_I	1.828	1.00
100_E	104_Q	1.822	1.00
223_D	227_T	1.798	1.00
126_I	129_T	1.738	1.00
224_R	234_I	1.736	1.00
48_N	81_T	1.729	1.00
119_I	137_L	1.727	1.00
83_V	141_K	1.719	1.00
28_Y	32_S	1.715	1.00
42_V	208_E	1.690	1.00
58_T	212_L	1.663	1.00
40_L	75_V	1.653	1.00
104_Q	115_E	1.622	1.00
151_L	213_V	1.611	1.00
89_V	127_N	1.603	1.00
67_V	110_P	1.573	1.00
62_T	148_V	1.559	1.00
177_A	181_Q	1.554	1.00
132_E	136_N	1.546	1.00
129_T	133_R	1.538	1.00
39_L	51_I	1.528	1.00
213_V	222_T	1.492	1.00
64_H	106_H	1.489	1.00
100_E	120_S	1.447	1.00
133_R	137_L	1.429	1.00
153_K	182_H	1.427	1.00
78_S	112_G	1.424	1.00
52_C	147_C	1.424	1.00
151_L	225_F	1.422	1.00
54_A	85_L	1.412	1.00
26_E	30_A	1.410	1.00
81_T	117_Q	1.408	1.00
221_A	234_I	1.384	1.00
94_T	101_T	1.383	1.00
155_G	234_I	1.354	1.00
43_I	80_L	1.334	1.00
38_Y	248_L	1.332	1.00
146_L	210_L	1.318	1.00
198_L	202_D	1.307	1.00
225_F	236_A	1.299	1.00
25_V	248_L	1.294	1.00
68_E	72_Q	1.291	1.00
35_A	62_T	1.285	1.00
52_C	85_L	1.281	1.00
114_R	117_Q	1.268	1.00
40_L	44_R	1.259	1.00
208_E	246_I	1.239	1.00
135_T	202_D	1.230	1.00
133_R	136_N	1.229	1.00
136_N	139_A	1.222	1.00
28_Y	61_L	1.216	1.00
50_V	83_V	1.209	1.00
151_L	236_A	1.205	1.00
29_T	61_L	1.200	1.00
62_T	212_L	1.197	1.00
113_L	117_Q	1.197	1.00
50_V	81_T	1.197	1.00
225_F	247_C	1.194	1.00
39_L	146_L	1.193	1.00
219_Q	223_D	1.189	1.00
84_K	103_L	1.188	1.00
35_A	210_L	1.186	1.00
96_P	101_T	1.184	1.00
139_A	205_N	1.181	1.00
61_L	64_H	1.176	1.00
35_A	248_L	1.174	1.00
158_G	203_I	1.163	1.00
241_L	245_F	1.161	1.00
25_V	30_A	1.160	1.00
34_R	37_E	1.155	1.00
25_V	31_L	1.154	1.00
77_V	80_L	1.142	1.00
38_Y	208_E	1.139	1.00
137_L	140_R	1.139	1.00
178_R	182_H	1.137	1.00
98_T	101_T	1.132	1.00
46_K	145_D	1.098	1.00
60_L	64_H	1.091	1.00
47_P	79_Q	1.082	1.00
60_L	102_F	1.073	1.00
49_A	80_L	1.071	1.00
38_Y	210_L	1.056	1.00
201_K	205_N	1.051	1.00
31_L	248_L	1.050	1.00
131_C	135_T	1.046	1.00
137_L	141_K	1.044	1.00
24_Q	249_I	1.042	1.00
46_K	207_R	1.039	1.00
102_F	106_H	1.038	1.00
81_T	141_K	1.018	1.00
64_H	110_P	1.016	1.00
23_Q	34_R	1.014	1.00
200_L	238_F	1.004	1.00
221_A	224_R	0.995	1.00
92_P	124_E	0.995	1.00
23_Q	246_I	0.988	1.00
128_E	132_E	0.985	1.00
28_Y	214_T	0.976	1.00
76_D	79_Q	0.972	1.00
52_C	144_L	0.968	1.00
32_S	62_T	0.964	1.00
49_A	146_L	0.962	1.00
37_E	41_A	0.958	1.00
53_L	82_F	0.958	1.00
188_A	191_P	0.951	1.00
30_A	33_E	0.949	1.00
138_I	144_L	0.946	1.00
81_T	114_R	0.932	1.00
108_V	118_L	0.926	1.00
222_T	225_F	0.919	1.00
206_A	209_V	0.917	1.00
122_R	130_E	0.914	1.00
39_L	148_V	0.911	1.00
188_A	193_T	0.899	1.00
54_A	147_C	0.895	1.00
44_R	74_Q	0.891	1.00
43_I	49_A	0.891	1.00
78_S	114_R	0.891	1.00
144_L	147_C	0.891	1.00
23_Q	248_L	0.887	1.00
129_T	132_E	0.886	1.00
234_I	237_S	0.881	1.00
151_L	222_T	0.880	1.00
104_Q	118_L	0.872	1.00
186_K	190_R	0.869	1.00
127_N	196_I	0.865	1.00
104_Q	120_S	0.865	1.00
211_L	236_A	0.862	1.00
35_A	212_L	0.862	1.00
75_V	80_L	0.861	1.00
130_E	196_I	0.860	1.00
224_R	228_A	0.859	1.00
29_T	65_Y	0.850	0.99
77_V	111_L	0.850	0.99
57_A	184_M	0.849	0.99
224_R	233_A	0.849	0.99
225_F	234_I	0.844	0.99
61_L	65_Y	0.843	0.99
53_L	63_Y	0.840	0.99
229_K	237_S	0.840	0.99
58_T	214_T	0.834	0.99
88_W	99_C	0.833	0.99
222_T	247_C	0.832	0.99
185_L	190_R	0.827	0.99
88_W	195_G	0.827	0.99
86_D	156_H	0.826	0.99
83_V	119_I	0.825	0.99
83_V	137_L	0.824	0.99
209_V	245_F	0.823	0.99
163_G	232_T	0.822	0.99
46_K	49_A	0.820	0.99
204_L	242_H	0.815	0.99
92_P	95_M	0.814	0.99
37_E	74_Q	0.803	0.99
54_A	157_L	0.796	0.99
179_T	182_H	0.790	0.99
85_L	203_I	0.789	0.99
93_L	104_Q	0.788	0.99
64_H	68_E	0.782	0.99
189_G	193_T	0.768	0.99
103_L	108_V	0.762	0.99
122_R	133_R	0.761	0.99
135_T	139_A	0.756	0.99
29_T	33_E	0.753	0.99
203_I	209_V	0.753	0.99
230_V	241_L	0.751	0.99
127_N	194_R	0.751	0.99
204_L	239_L	0.748	0.99
204_L	241_L	0.745	0.99
148_V	212_L	0.741	0.99
59_P	63_Y	0.738	0.98
149_L	203_I	0.731	0.98
33_E	37_E	0.730	0.98
38_Y	42_V	0.729	0.98
51_I	82_F	0.726	0.98
99_C	195_G	0.723	0.98
185_L	188_A	0.720	0.98
85_L	198_L	0.718	0.98
177_A	180_Q	0.715	0.98
220_D	223_D	0.711	0.98
28_Y	31_L	0.711	0.98
40_L	74_Q	0.709	0.98
157_L	211_L	0.708	0.98
88_W	159_L	0.707	0.98
36_S	66_L	0.705	0.98
173_S	195_G	0.705	0.98
34_R	38_Y	0.702	0.98
41_A	44_R	0.701	0.98
153_K	221_A	0.700	0.98
57_A	102_F	0.699	0.98
123_S	130_E	0.693	0.98
30_A	34_R	0.691	0.98
114_R	118_L	0.691	0.98
231_S	237_S	0.683	0.97
48_N	79_Q	0.682	0.97
35_A	39_L	0.682	0.97
55_T	99_C	0.681	0.97
155_G	221_A	0.681	0.97
29_T	64_H	0.678	0.97
225_F	240_W	0.678	0.97
115_E	118_L	0.678	0.97
97_G	193_T	0.669	0.97
36_S	65_Y	0.667	0.97
40_L	66_L	0.663	0.97
21_T	246_I	0.663	0.97
67_V	106_H	0.661	0.97
185_L	189_G	0.661	0.97
138_I	142_G	0.659	0.97
175_L	183_E	0.657	0.97
91_L	101_T	0.656	0.97
98_T	123_S	0.654	0.97
135_T	180_Q	0.652	0.97
151_L	221_A	0.649	0.97
164_E	233_A	0.647	0.97
44_R	75_V	0.647	0.97
66_L	77_V	0.646	0.97
42_V	146_L	0.642	0.96
34_R	248_L	0.638	0.96
93_L	124_E	0.630	0.96
238_F	241_L	0.628	0.96
84_K	120_S	0.628	0.96
93_L	120_S	0.627	0.96
120_S	123_S	0.626	0.96
22_L	226_L	0.625	0.96
73_Q	77_V	0.625	0.96
91_L	95_M	0.625	0.96
88_W	161_E	0.624	0.96
91_L	98_T	0.623	0.96
179_T	183_E	0.619	0.96
200_L	235_P	0.615	0.95
183_E	197_T	0.613	0.95
147_C	203_I	0.613	0.95
120_S	124_E	0.609	0.95
84_K	100_E	0.606	0.95
82_F	103_L	0.606	0.95
126_I	194_R	0.605	0.95
161_E	195_G	0.603	0.95
54_A	63_Y	0.600	0.95
36_S	40_L	0.599	0.95
32_S	65_Y	0.598	0.95
83_V	144_L	0.598	0.95
222_T	226_L	0.595	0.95
221_A	225_F	0.595	0.95
21_T	244_N	0.588	0.94
158_G	197_T	0.588	0.94
39_L	66_L	0.586	0.94
125_E	130_E	0.584	0.94
159_L	195_G	0.583	0.94
83_V	138_I	0.578	0.94
226_L	247_C	0.577	0.94
40_L	73_Q	0.575	0.93
38_Y	246_I	0.569	0.93
50_V	142_G	0.569	0.93
211_L	247_C	0.566	0.93
85_L	158_G	0.566	0.93
209_V	239_L	0.565	0.93
228_A	231_S	0.565	0.93
121_F	134_V	0.564	0.93
57_A	60_L	0.563	0.93
31_L	35_A	0.562	0.93
131_C	196_I	0.560	0.93
97_G	190_R	0.556	0.92
181_Q	188_A	0.556	0.92
99_C	159_L	0.553	0.92
22_L	249_I	0.551	0.92
107_I	111_L	0.551	0.92
99_C	161_E	0.550	0.92
104_Q	108_V	0.549	0.92
147_C	158_G	0.549	0.92
202_D	205_N	0.548	0.92
197_T	201_K	0.547	0.92
174_Q	183_E	0.544	0.91
210_L	248_L	0.543	0.91
63_Y	148_V	0.543	0.91
209_V	241_L	0.542	0.91
57_A	153_K	0.539	0.91
85_L	147_C	0.534	0.91
91_L	94_T	0.532	0.91
150_G	218_K	0.530	0.90
116_D	120_S	0.529	0.90
207_R	243_S	0.524	0.90
100_E	118_L	0.523	0.90
55_T	161_E	0.523	0.90
53_L	103_L	0.521	0.90
173_S	197_T	0.518	0.89
58_T	102_F	0.518	0.89
35_A	38_Y	0.517	0.89
74_Q	111_L	0.516	0.89
200_L	239_L	0.515	0.89
86_D	218_K	0.513	0.89
176_D	181_Q	0.513	0.89
55_T	88_W	0.512	0.89
157_L	239_L	0.510	0.89
121_F	130_E	0.510	0.89
127_N	131_C	0.507	0.88
131_C	134_V	0.505	0.88
131_C	197_T	0.505	0.88
46_K	79_Q	0.504	0.88
186_K	194_R	0.503	0.88
187_T	193_T	0.503	0.88
138_I	143_G	0.502	0.88
184_M	191_P	0.501	0.88
190_R	193_T	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tx2A	1	0.8924	100	0.142	Contact Map
3icoA	1	0.8884	100	0.144	Contact Map
4tm7A	1	0.8884	100	0.146	Contact Map
3eb9A	1	0.8884	100	0.167	Contact Map
1vl1A	1	0.8486	100	0.186	Contact Map
3cssA	1	0.8845	100	0.205	Contact Map
3e15A	2	0.9681	100	0.206	Contact Map
3lwdA	2	0.8526	100	0.21	Contact Map
3lhiA	1	0.8645	100	0.225	Contact Map
1y89A	2	0.8845	100	0.242	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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