GREMLIN Database
PTPD - N-acetylgalactosamine permease IID component
UniProt: P42911 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12771
Length: 263 (255)
Sequences: 1316 (829)
Seq/√Len: 51.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_T103_A5.7041.00
42_L53_L4.3511.00
242_H245_L4.1511.00
9_D44_K3.7441.00
48_D52_G3.3041.00
6_S9_D3.2751.00
50_K54_S3.2491.00
248_G252_V3.2111.00
41_I79_I3.0641.00
231_L234_Y3.0451.00
227_A231_L2.8481.00
214_D217_D2.8051.00
213_Q217_D2.7681.00
5_I79_I2.7601.00
197_V212_Q2.7571.00
211_L214_D2.7411.00
253_L257_C2.5931.00
5_I41_I2.5591.00
122_C133_G2.5431.00
34_F78_L2.4431.00
232_M250_T2.4381.00
43_K53_L2.3891.00
7_K153_H2.2781.00
149_V153_H2.2601.00
74_L103_A2.0931.00
16_R36_W2.0841.00
64_I74_L1.9280.99
241_A249_V1.8850.99
10_I152_T1.8670.99
83_E156_Y1.8610.99
21_Q24_F1.8100.99
6_S44_K1.8070.99
11_T153_H1.7990.99
35_T57_M1.7890.99
60_N82_E1.7680.99
228_Y250_T1.7550.99
256_V260_F1.7450.99
154_V157_S1.7420.99
220_F223_I1.7380.99
41_I45_I1.7300.99
38_M42_L1.7200.99
119_A137_F1.7170.99
66_T74_L1.6590.98
47_K52_G1.6400.98
225_P229_T1.5890.98
17_S71_V1.5680.98
197_V224_L1.5650.98
81_M90_T1.5110.97
241_A245_L1.5010.97
200_S209_V1.4830.97
85_G91_I1.4460.96
131_L134_P1.4340.96
23_S32_G1.4320.96
60_N95_K1.4290.96
52_G55_A1.3940.95
37_A75_M1.3910.95
256_V259_A1.3820.95
64_I71_V1.3790.95
62_E92_K1.3770.95
133_G136_L1.3660.95
74_L102_I1.3620.95
199_T212_Q1.3550.95
50_K53_L1.3340.94
5_I9_D1.3170.94
232_M246_L1.2940.93
48_D51_P1.2870.93
202_A209_V1.2850.93
118_M140_V1.2830.93
233_Y237_R1.2770.93
252_V256_V1.2680.92
136_L140_V1.2670.92
58_K61_L1.2570.92
53_L57_M1.2530.92
135_I139_A1.2480.92
10_I153_H1.2460.92
235_F241_A1.2380.91
153_H157_S1.2360.91
46_Y56_A1.2320.91
30_Q103_A1.2270.91
51_P55_A1.2260.91
13_L41_I1.2120.90
20_L30_Q1.2100.90
123_S127_S1.2090.90
42_L56_A1.2070.90
5_I10_I1.2070.90
92_K96_V1.2050.90
39_L57_M1.1870.90
139_A143_L1.1790.89
14_G149_V1.1700.89
223_I227_A1.1610.88
189_I229_T1.1600.88
235_F249_V1.1560.88
246_L250_T1.1560.88
244_V248_G1.1440.88
72_G152_T1.1400.88
158_V165_K1.1280.87
47_K50_K1.1180.87
35_T39_L1.1140.86
54_S58_K1.1060.86
134_P137_F1.1010.86
25_N28_R1.0970.85
8_K12_R1.0950.85
24_F31_A1.0940.85
226_M230_L1.0810.85
245_L249_V1.0800.85
195_I224_L1.0780.84
30_Q66_T1.0760.84
64_I75_M1.0650.84
33_G156_Y1.0630.84
56_A59_D1.0580.83
158_V161_K1.0500.83
28_R31_A1.0490.83
13_L152_T1.0300.82
59_D95_K1.0300.82
68_P184_V1.0290.82
7_K11_T1.0260.81
257_C262_I1.0240.81
38_M45_I1.0220.81
115_L137_F1.0050.80
257_C260_F1.0050.80
214_D260_F1.0040.80
228_Y251_F1.0030.80
146_F150_G1.0000.80
21_Q29_M0.9980.80
116_P188_L0.9880.79
105_I145_F0.9880.79
147_L151_W0.9840.79
43_K50_K0.9740.78
34_F38_M0.9730.78
52_G56_A0.9730.78
14_G148_R0.9630.77
11_T149_V0.9620.77
42_L45_I0.9590.77
136_L139_A0.9560.77
255_I259_A0.9510.76
51_P54_S0.9510.76
196_N257_C0.9500.76
29_M110_F0.9410.75
70_L102_I0.9360.75
79_I152_T0.9330.75
12_R44_K0.9310.75
34_F60_N0.9230.74
214_D218_K0.9210.74
9_D12_R0.9200.74
85_G88_R0.9180.74
195_I228_Y0.9160.73
118_M144_I0.9150.73
133_G138_F0.9140.73
45_I87_N0.9060.73
195_I198_V0.9060.73
60_N78_L0.9050.72
125_F128_Q0.9020.72
167_R170_S0.9010.72
64_I99_F0.8930.71
213_Q216_F0.8760.70
28_R61_L0.8730.70
250_T254_S0.8700.69
45_I52_G0.8680.69
228_Y232_M0.8670.69
125_F176_S0.8630.69
20_L71_V0.8590.68
132_L135_I0.8590.68
35_T38_M0.8550.68
13_L79_I0.8400.67
194_H222_N0.8390.67
195_I225_P0.8350.66
11_T15_F0.8320.66
4_E47_K0.8310.66
161_K164_D0.8280.66
228_Y253_L0.8220.65
116_P144_I0.8200.65
18_S145_F0.8190.65
12_R16_R0.8120.64
205_N209_V0.8090.64
52_G60_N0.8080.64
210_A215_F0.8070.64
90_T93_G0.8040.63
9_D83_E0.8030.63
117_I133_G0.8020.63
73_F151_W0.8010.63
51_P205_N0.8000.63
13_L36_W0.7970.63
35_T43_K0.7940.62
46_Y103_A0.7840.61
102_I146_F0.7840.61
249_V253_L0.7840.61
25_N229_T0.7830.61
119_A123_S0.7790.61
17_S20_L0.7750.60
114_L144_I0.7740.60
4_E87_N0.7670.60
38_M92_K0.7650.59
43_K57_M0.7630.59
84_K88_R0.7630.59
200_S205_N0.7620.59
67_H110_F0.7620.59
254_S258_S0.7620.59
18_S72_G0.7610.59
73_F163_I0.7590.59
118_M139_A0.7550.58
176_S180_L0.7510.58
45_I74_L0.7460.58
61_L138_F0.7430.57
90_T94_L0.7430.57
249_V252_V0.7430.57
144_I188_L0.7420.57
44_K156_Y0.7400.57
225_P230_L0.7380.57
17_S112_F0.7370.57
109_I161_K0.7330.56
45_I83_E0.7320.56
230_L233_Y0.7310.56
188_L192_Y0.7290.56
57_M239_K0.7260.55
10_I37_A0.7230.55
17_S119_A0.7200.55
215_F218_K0.7190.55
138_F142_L0.7160.54
117_I121_I0.7140.54
248_G262_I0.7130.54
162_A167_R0.7130.54
15_F143_L0.7100.54
52_G223_I0.7090.54
45_I86_E0.7060.53
59_D86_E0.7040.53
21_Q30_Q0.7040.53
25_N68_P0.7040.53
86_E112_F0.6970.52
97_A147_L0.6970.52
33_G40_P0.6960.52
32_G61_L0.6950.52
23_S216_F0.6940.52
34_F95_K0.6860.51
231_L249_V0.6780.50
199_T224_L0.6780.50
62_E89_D0.6770.50
219_V240_K0.6740.50
81_M154_V0.6670.49
252_V261_G0.6670.49
104_G112_F0.6660.49
28_R50_K0.6650.49
118_M135_I0.6620.49
54_S93_G0.6610.49
249_V257_C0.6590.49
199_T262_I0.6580.48
173_I180_L0.6580.48
200_S211_L0.6550.48
46_Y98_L0.6550.48
196_N258_S0.6520.48
164_D168_E0.6510.48
31_A61_L0.6480.47
112_F115_L0.6450.47
236_L240_K0.6420.47
17_S148_R0.6420.47
130_N133_G0.6400.47
50_K63_F0.6400.47
105_I108_A0.6390.46
47_K53_L0.6380.46
127_S200_S0.6370.46
121_I166_V0.6320.46
89_D171_Q0.6320.46
151_W229_T0.6290.45
78_L82_E0.6280.45
82_E186_G0.6280.45
4_E83_E0.6270.45
81_M222_N0.6250.45
94_L163_I0.6240.45
117_I186_G0.6190.44
178_T182_I0.6190.44
58_K132_L0.6170.44
197_V216_F0.6160.44
94_L180_L0.6150.44
243_P247_I0.6150.44
259_A262_I0.6140.44
26_Y31_A0.6090.43
195_I253_L0.6070.43
126_A188_L0.6070.43
76_G186_G0.6060.43
8_K15_F0.6060.43
132_L217_D0.6060.43
193_V225_P0.6050.43
79_I83_E0.6030.43
93_G96_V0.6030.43
33_G119_A0.6030.43
81_M168_E0.6020.43
104_G120_G0.6020.43
104_G155_G0.6020.43
21_Q26_Y0.6020.43
167_R174_A0.6000.42
23_S36_W0.5990.42
176_S187_G0.5990.42
24_F180_L0.5980.42
114_L204_D0.5980.42
184_V222_N0.5940.42
150_G154_V0.5930.42
91_I120_G0.5920.42
9_D13_L0.5890.41
250_T257_C0.5890.41
39_L53_L0.5890.41
108_A192_Y0.5890.41
169_N247_I0.5870.41
72_G151_W0.5860.41
198_V211_L0.5850.41
224_L261_G0.5850.41
48_D53_L0.5830.41
67_H116_P0.5820.41
97_A103_A0.5820.41
145_F183_T0.5820.41
50_K72_G0.5800.40
9_D41_I0.5790.40
74_L78_L0.5770.40
122_C140_V0.5750.40
229_T237_R0.5740.40
193_V229_T0.5730.40
118_M141_Y0.5720.40
230_L246_L0.5710.39
40_P260_F0.5690.39
29_M67_H0.5690.39
65_N181_G0.5680.39
25_N31_A0.5670.39
63_F104_G0.5670.39
7_K173_I0.5670.39
55_A89_D0.5660.39
203_I210_A0.5660.39
108_A218_K0.5650.39
211_L262_I0.5630.39
191_S222_N0.5610.38
91_I112_F0.5610.38
130_N190_A0.5580.38
84_K160_V0.5580.38
110_F147_L0.5550.38
177_A243_P0.5540.38
135_I259_A0.5520.38
83_E87_N0.5510.37
235_F240_K0.5510.37
86_E113_T0.5480.37
55_A154_V0.5460.37
201_F215_F0.5460.37
5_I45_I0.5440.37
24_F210_A0.5430.37
70_L150_G0.5420.37
161_K253_L0.5380.36
81_M117_I0.5380.36
172_M254_S0.5340.36
76_G82_E0.5340.36
143_L252_V0.5320.36
214_D256_V0.5320.36
15_F18_S0.5320.36
124_S137_F0.5300.35
60_N97_A0.5300.35
120_G203_I0.5280.35
23_S103_A0.5270.35
67_H103_A0.5270.35
122_C132_L0.5260.35
27_E61_L0.5250.35
135_I154_V0.5250.35
241_A244_V0.5240.35
126_A130_N0.5220.35
180_L188_L0.5190.34
54_S57_M0.5170.34
211_L217_D0.5170.34
236_L243_P0.5160.34
97_A194_H0.5160.34
71_V185_I0.5150.34
224_L227_A0.5150.34
184_V214_D0.5150.34
13_L17_S0.5150.34
98_L103_A0.5140.34
172_M179_I0.5140.34
41_I247_I0.5110.34
14_G18_S0.5100.34
13_L16_R0.5090.33
87_N217_D0.5070.33
121_I137_F0.5060.33
160_V217_D0.5060.33
117_I147_L0.5050.33
132_L136_L0.5030.33
48_D54_S0.5020.33
109_I136_L0.5020.33
24_F69_N0.5010.33
161_K262_I0.5000.33
117_I223_I0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hygA 3 0.327 16.5 0.972 Contact Map
4afiA 2 0.251 10.8 0.974 Contact Map
2jttC 1 0.1179 10.5 0.974 Contact Map
4huqS 1 0.5741 9.6 0.975 Contact Map
1oahA 2 0.327 6.7 0.976 Contact Map
1k1fA 4 0.0875 6.5 0.977 Contact Map
3owqA 1 0.2395 6.4 0.977 Contact Map
3nddA 1 0.3422 5.9 0.977 Contact Map
4r43A 1 0.327 5.6 0.977 Contact Map
3g5sA 1 0.2738 5.3 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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