GREMLIN Database
PTPC1 - N-acetylgalactosamine permease IIC component 1
UniProt: P42910 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12770
Length: 267 (247)
Sequences: 1422 (900)
Seq/√Len: 57.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_D136_A5.2191.00
212_A234_G5.1041.00
46_D49_T5.0521.00
222_V227_P3.9861.00
15_L39_L3.6331.00
42_A47_I3.5671.00
32_R58_E3.4121.00
124_K127_K3.3891.00
17_F149_A3.3461.00
215_L231_L3.0651.00
176_A180_H2.9851.00
127_K131_E2.9551.00
15_L43_I2.8371.00
215_L230_V2.8101.00
128_C136_A2.7281.00
211_I230_V2.7151.00
123_T126_D2.5741.00
168_Q172_K2.4941.00
37_C50_G2.4941.00
9_G13_A2.4041.00
135_A139_R2.3001.00
39_L43_I2.2751.00
209_Y242_N2.2241.00
124_K128_C2.1581.00
17_F153_A2.1551.00
128_C133_D2.1501.00
6_L10_L2.1161.00
12_L40_T2.1001.00
44_L88_S1.9911.00
11_S43_I1.9351.00
13_A157_F1.9241.00
180_H184_V1.9211.00
38_T47_I1.9031.00
128_C140_L1.8951.00
136_A139_R1.8821.00
127_K130_K1.8771.00
207_I211_I1.8711.00
13_A153_A1.8531.00
217_V228_V1.8491.00
77_M107_M1.8320.99
49_T53_T1.7910.99
128_C131_E1.7870.99
209_Y239_E1.7410.99
48_Q52_I1.7250.99
223_S227_P1.7010.99
209_Y238_Y1.6290.99
133_D139_R1.6270.99
18_V30_L1.6140.99
16_V156_A1.6130.99
124_K140_L1.5930.99
56_L60_A1.5740.98
184_V187_G1.5530.98
86_A96_A1.5500.98
34_I38_T1.5370.98
165_G168_Q1.5330.98
180_H183_E1.5060.98
239_E242_N1.5050.98
170_L173_A1.5000.98
129_A132_A1.4590.97
49_T87_W1.4490.97
110_V155_I1.4020.97
6_L161_Y1.3900.96
10_L157_F1.3530.96
95_T98_G1.3510.96
129_A137_F1.3370.96
125_A141_N1.3040.95
78_A84_V1.2960.95
7_L11_S1.2780.94
219_Y226_L1.2780.94
149_A153_A1.2670.94
216_F220_I1.2640.94
106_L171_V1.2470.94
219_Y223_S1.2460.93
129_A136_A1.2410.93
177_W181_G1.2380.93
221_Q225_L1.2180.93
125_A129_A1.2010.92
35_I38_T1.1930.92
229_A232_G1.1710.91
32_R35_I1.1660.91
74_N77_M1.1550.91
166_A169_A1.1520.90
219_Y222_V1.1470.90
70_V115_Y1.1250.89
73_P104_S1.1170.89
50_G54_G1.1160.89
62_A105_L1.1110.89
174_M178_L1.1090.89
15_L36_V1.1060.89
69_G186_G1.1010.88
169_A172_K1.0980.88
153_A157_F1.0900.88
116_S119_S1.0640.87
78_A104_S1.0630.87
26_E32_R1.0610.86
249_A252_Q1.0530.86
225_L229_A1.0530.86
222_V228_V1.0520.86
111_I115_Y1.0480.86
114_F147_I1.0450.86
104_S145_M1.0430.85
99_L103_F1.0320.85
7_L10_L1.0290.85
44_L87_W1.0290.85
202_F210_L1.0260.85
248_Q251_P1.0190.84
220_I223_S1.0090.84
62_A76_I1.0070.83
12_L80_L0.9970.83
139_R143_T0.9920.82
215_L222_V0.9910.82
129_A133_D0.9880.82
49_T52_I0.9860.82
91_V95_T0.9840.82
181_G185_A0.9840.82
62_A79_G0.9780.82
158_L166_A0.9760.81
8_Q43_I0.9740.81
104_S194_F0.9660.81
243_A246_R0.9640.81
249_A253_P0.9490.80
12_L44_L0.9460.79
176_A179_T0.9290.78
48_Q51_L0.9290.78
9_G157_F0.9240.78
7_L241_F0.9140.77
86_A189_L0.9120.77
12_L43_I0.9100.77
135_A247_Q0.9070.76
52_I55_G0.9050.76
74_N152_Y0.9030.76
238_Y242_N0.9020.76
166_A170_L0.9010.76
125_A140_L0.8990.76
8_Q88_S0.8900.75
250_Q253_P0.8890.75
74_N111_I0.8870.75
52_I59_L0.8850.75
134_T138_S0.8790.74
41_G54_G0.8770.74
105_L109_Y0.8760.74
52_I85_I0.8670.73
136_A140_L0.8660.73
57_T79_G0.8630.73
233_A237_V0.8630.73
51_L54_G0.8580.72
94_K221_Q0.8580.72
66_P148_V0.8540.72
19_L36_V0.8470.71
22_D73_P0.8470.71
117_A147_I0.8440.71
205_Q245_S0.8420.71
102_P105_L0.8350.70
235_F238_Y0.8330.70
12_L156_A0.8290.70
126_D130_K0.8250.69
175_P181_G0.8240.69
135_A138_S0.8220.69
169_A173_A0.8100.68
36_V80_L0.8070.68
211_I234_G0.8070.68
208_P211_I0.8060.68
16_V197_L0.8040.67
247_Q252_Q0.7930.66
61_F78_A0.7870.66
58_E108_Q0.7860.66
34_I55_G0.7830.65
161_Y165_G0.7830.65
59_L142_W0.7830.65
81_M85_I0.7830.65
36_V79_G0.7820.65
37_C69_G0.7800.65
81_M103_F0.7770.65
59_L198_L0.7590.63
11_S14_A0.7560.63
219_Y227_P0.7550.62
10_L13_A0.7520.62
131_E136_A0.7500.62
40_T84_V0.7490.62
124_K139_R0.7470.62
196_L201_M0.7450.61
8_Q12_L0.7450.61
248_Q252_Q0.7420.61
121_F147_I0.7380.61
206_Y211_I0.7370.61
185_A189_L0.7350.60
58_E200_V0.7350.60
16_V80_L0.7330.60
15_L80_L0.7330.60
86_A92_D0.7320.60
223_S226_L0.7250.59
129_A134_T0.7250.59
82_T86_A0.7170.58
78_A85_I0.7120.58
109_Y112_L0.7120.58
10_L246_R0.7100.58
246_R250_Q0.7100.58
24_W71_Q0.7040.57
167_M189_L0.7030.57
244_K247_Q0.7030.57
105_L108_Q0.7020.57
79_G83_T0.6990.57
208_P237_V0.6970.56
81_M159_C0.6960.56
66_P152_Y0.6950.56
216_F231_L0.6950.56
165_G169_A0.6940.56
6_L9_G0.6930.56
8_Q44_L0.6890.55
19_L31_F0.6870.55
119_S122_M0.6830.55
248_Q253_P0.6820.55
26_E96_A0.6760.54
170_L211_I0.6760.54
150_S154_V0.6720.54
216_F235_F0.6720.54
15_L19_L0.6710.53
7_L251_P0.6700.53
90_G245_S0.6690.53
67_A71_Q0.6670.53
89_T100_G0.6650.53
37_C83_T0.6590.52
158_L231_L0.6590.52
78_A82_T0.6570.52
108_Q112_L0.6570.52
159_C167_M0.6560.52
237_V245_S0.6550.52
73_P108_Q0.6550.52
172_K176_A0.6540.52
234_G237_V0.6510.51
220_I228_V0.6500.51
235_F239_E0.6460.51
81_M84_V0.6440.51
62_A74_N0.6410.50
109_Y182_F0.6370.50
58_E159_C0.6370.50
38_T42_A0.6310.49
40_T87_W0.6300.49
63_G128_C0.6290.49
59_L103_F0.6270.49
175_P213_G0.6260.49
121_F124_K0.6240.48
124_K136_A0.6230.48
83_T87_W0.6230.48
157_F161_Y0.6220.48
8_Q11_S0.6210.48
125_A243_A0.6200.48
13_A161_Y0.6180.48
57_T78_A0.6180.48
241_F245_S0.6170.48
153_A171_V0.6140.47
202_F207_I0.6130.47
34_I37_C0.6080.47
130_K250_Q0.6070.46
62_A111_I0.6060.46
247_Q250_Q0.6050.46
29_F79_G0.6000.46
107_M148_V0.6000.46
20_G97_I0.5990.46
63_G102_P0.5990.46
87_W92_D0.5990.46
163_A197_L0.5970.45
126_D137_F0.5950.45
90_G117_A0.5920.45
158_L195_G0.5890.45
63_G181_G0.5880.44
57_T77_M0.5870.44
150_S155_I0.5870.44
18_V172_K0.5870.44
48_Q172_K0.5860.44
107_M151_A0.5860.44
192_V240_F0.5850.44
60_A82_T0.5850.44
56_L221_Q0.5850.44
54_G213_G0.5850.44
63_G101_L0.5850.44
33_P210_L0.5810.44
37_C44_L0.5800.44
160_T194_F0.5800.44
246_R252_Q0.5800.44
24_W115_Y0.5780.43
106_L180_H0.5770.43
107_M225_L0.5770.43
77_M152_Y0.5740.43
7_L131_E0.5740.43
125_A144_T0.5680.42
75_P82_T0.5680.42
15_L58_E0.5680.42
230_V233_A0.5680.42
85_I88_S0.5680.42
94_K183_E0.5660.42
33_P97_I0.5630.42
12_L15_L0.5600.41
212_A231_L0.5600.41
69_G199_R0.5590.41
179_T182_F0.5580.41
20_G171_V0.5570.41
19_L30_L0.5570.41
74_N108_Q0.5550.41
74_N101_L0.5550.41
55_G185_A0.5550.41
138_S142_W0.5550.41
40_T83_T0.5510.40
237_V244_K0.5500.40
25_L62_A0.5500.40
58_E219_Y0.5490.40
145_M186_G0.5480.40
55_G229_A0.5480.40
55_G75_P0.5470.40
108_Q111_I0.5460.40
50_G67_A0.5460.40
242_N245_S0.5440.40
22_D28_L0.5440.40
18_V21_I0.5440.40
22_D210_L0.5430.40
157_F162_L0.5420.40
7_L150_S0.5410.39
202_F208_P0.5390.39
245_S250_Q0.5390.39
176_A250_Q0.5380.39
184_V253_P0.5380.39
121_F231_L0.5380.39
180_H251_P0.5370.39
98_G101_L0.5350.39
95_T160_T0.5330.39
100_G105_L0.5320.38
94_K97_I0.5320.38
168_Q176_A0.5290.38
108_Q201_M0.5290.38
127_K245_S0.5270.38
26_E153_A0.5270.38
94_K187_G0.5270.38
71_Q75_P0.5260.38
42_A250_Q0.5260.38
61_F73_P0.5260.38
39_L50_G0.5250.38
88_S160_T0.5240.38
115_Y151_A0.5220.37
38_T51_L0.5220.37
245_S253_P0.5210.37
16_V20_G0.5200.37
77_M156_A0.5200.37
90_G158_L0.5200.37
15_L214_F0.5190.37
207_I237_V0.5190.37
154_V158_L0.5160.37
22_D197_L0.5160.37
132_A135_A0.5150.37
112_L115_Y0.5140.37
50_G84_V0.5140.37
10_L176_A0.5130.37
47_I51_L0.5120.36
59_L232_G0.5110.36
184_V232_G0.5100.36
85_I167_M0.5090.36
35_I211_I0.5070.36
80_L84_V0.5070.36
32_R85_I0.5060.36
210_L227_P0.5060.36
120_L140_L0.5060.36
127_K246_R0.5060.36
24_W195_G0.5050.36
162_L232_G0.5040.36
9_G37_C0.5030.35
84_V197_L0.5030.35
20_G64_L0.5030.35
75_P78_A0.5030.35
231_L246_R0.5010.35
216_F222_V0.5000.35
94_K244_K0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k1cA 4 0.633 48 0.956 Contact Map
4kjrA 3 0.4906 30.1 0.961 Contact Map
3giaA 1 0.9139 28 0.962 Contact Map
4cbcA 3 0.3184 27.9 0.962 Contact Map
3qnqA 2 0.8801 26.3 0.962 Contact Map
3qe7A 2 0.794 22.4 0.963 Contact Map
4ltoA 3 0.3933 16.5 0.965 Contact Map
3l1lA 2 0.8801 13.7 0.967 Contact Map
2xzeQ 1 0.0412 11.3 0.968 Contact Map
3vopA 3 0.0225 10.4 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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