GREMLIN Database
PTPB1 - N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1
UniProt: P42909 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12769
Length: 158 (149)
Sequences: 1621 (1106)
Seq/√Len: 90.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_D91_T4.2951.00
97_E135_F3.8931.00
70_I98_G2.9121.00
104_D142_N2.8471.00
93_R97_E2.6311.00
92_V105_V2.6251.00
127_D131_T2.5381.00
93_R135_F2.4651.00
97_E139_R2.4611.00
67_E71_N2.4251.00
86_C92_V2.3231.00
93_R132_D2.2201.00
117_K130_L2.1501.00
38_D94_K2.0631.00
142_N153_K2.0001.00
66_I94_K1.9971.00
96_V136_I1.9251.00
119_I125_V1.9171.00
67_E94_K1.8851.00
86_C95_L1.8421.00
30_A83_F1.8371.00
90_Q132_D1.7731.00
25_T59_F1.7331.00
117_K127_D1.7251.00
7_L81_K1.6871.00
54_A61_I1.6761.00
29_G81_K1.6671.00
46_Q87_R1.6661.00
131_T135_F1.6581.00
90_Q128_Q1.6361.00
11_I133_L1.5851.00
37_D87_R1.5791.00
41_A65_T1.5421.00
113_S116_K1.4681.00
118_Q124_Y1.4340.99
107_V133_L1.4260.99
135_F138_Q1.4180.99
104_D153_K1.4100.99
25_T33_L1.4050.99
96_V102_L1.3980.99
11_I107_V1.3940.99
13_N109_N1.3690.99
9_T92_V1.3460.99
44_D47_Q1.3420.99
89_P110_M1.3360.99
104_D144_F1.3180.99
11_I89_P1.3170.99
32_L62_R1.2950.99
7_L28_I1.2770.99
109_N122_K1.2620.99
89_P132_D1.2570.98
135_F139_R1.2180.98
64_F72_V1.1740.98
67_E98_G1.1680.98
142_N155_Q1.1670.98
137_K143_V1.1550.97
126_D129_D1.1520.97
43_D46_Q1.1430.97
134_R138_Q1.1400.97
146_Q149_P1.1370.97
13_N111_H1.1320.97
94_K98_G1.1240.97
23_T149_P1.1220.97
116_K126_D1.1200.97
94_K97_E1.0900.96
128_Q131_T1.0880.96
89_P133_L1.0830.96
133_L143_V1.0800.96
23_T150_G1.0800.96
36_V69_T1.0620.96
32_L80_Q1.0560.96
16_V61_I1.0400.95
68_K71_N1.0370.95
16_V50_M1.0330.95
66_I91_T0.9900.94
16_V35_V0.9880.94
107_V145_I0.9780.93
90_Q94_K0.9770.93
39_V43_D0.9760.93
93_R139_R0.9520.92
128_Q132_D0.9450.92
9_T102_L0.9400.92
110_M125_V0.9360.92
110_M133_L0.9350.92
38_D66_I0.9190.91
118_Q121_S0.9190.91
13_N16_V0.9180.91
72_V75_K0.9170.91
146_Q153_K0.9150.91
9_T86_C0.9120.91
7_L30_A0.9080.90
88_T91_T0.9020.90
31_N81_K0.8990.90
112_F115_G0.8990.90
42_N65_T0.8920.90
36_V91_T0.8880.89
70_I74_G0.8800.89
64_F75_K0.8790.89
120_S123_V0.8780.89
9_T84_L0.8630.88
122_K147_D0.8580.88
21_G25_T0.8410.87
110_M123_V0.8400.87
8_L83_F0.8370.86
65_T68_K0.8320.86
96_V139_R0.8310.86
71_N74_G0.8250.86
112_F124_Y0.8160.85
34_V72_V0.8100.85
40_V46_Q0.8050.84
91_T94_K0.8000.84
33_L54_A0.7910.83
48_K52_I0.7810.82
73_I101_D0.7780.82
46_Q50_M0.7780.82
83_F151_D0.7760.82
116_K129_D0.7540.80
111_H116_K0.7520.80
23_T27_T0.7510.80
47_Q63_F0.7460.79
38_D65_T0.7390.79
107_V143_V0.7340.78
26_S85_I0.7340.78
144_F153_K0.7310.78
26_S58_G0.7280.78
15_L85_I0.7260.78
71_N75_K0.7210.77
31_N80_Q0.7200.77
96_V105_V0.7140.76
8_L28_I0.7100.76
103_K142_N0.7090.76
38_D91_T0.7080.76
137_K155_Q0.7020.75
132_D135_F0.7000.75
73_I95_L0.6890.74
125_V133_L0.6860.74
45_I49_L0.6850.73
34_V86_C0.6820.73
32_L82_I0.6810.73
123_V145_I0.6790.73
121_S151_D0.6770.73
70_I94_K0.6750.72
64_F77_A0.6710.72
131_T134_R0.6690.72
47_Q51_G0.6690.72
72_V76_A0.6650.71
21_G53_T0.6640.71
101_D139_R0.6620.71
40_V106_N0.6600.71
74_G98_G0.6580.70
18_G108_G0.6570.70
62_R77_A0.6570.70
64_F68_K0.6540.70
62_R72_V0.6540.70
36_V95_L0.6420.69
40_V50_M0.6400.68
66_I98_G0.6390.68
81_K145_I0.6380.68
96_V141_V0.6260.67
85_I124_Y0.6260.67
39_V87_R0.6240.66
36_V66_I0.6210.66
42_N85_I0.6150.65
51_G61_I0.6140.65
84_L92_V0.6130.65
51_G63_F0.6120.65
33_L85_I0.6110.65
111_H122_K0.6090.64
68_K72_V0.5960.63
105_V141_V0.5940.63
7_L29_G0.5940.63
109_N147_D0.5920.62
65_T95_L0.5910.62
70_I102_L0.5880.62
115_G126_D0.5880.62
116_K124_Y0.5820.61
13_N87_R0.5820.61
67_E70_I0.5800.61
34_V76_A0.5780.60
20_V25_T0.5750.60
39_V44_D0.5740.60
19_Q109_N0.5740.60
73_I76_A0.5730.60
59_F83_F0.5680.59
35_V85_I0.5680.59
16_V30_A0.5670.59
146_Q151_D0.5610.58
53_T56_T0.5600.58
39_V46_Q0.5580.58
11_I32_L0.5570.58
125_V130_L0.5520.57
102_L133_L0.5510.57
69_T82_I0.5510.57
31_N98_G0.5480.56
131_T138_Q0.5470.56
27_T150_G0.5460.56
22_V124_Y0.5450.56
26_S30_A0.5430.56
32_L69_T0.5420.56
69_T73_I0.5410.55
26_S29_G0.5360.55
76_A82_I0.5340.55
95_L100_I0.5310.54
64_F76_A0.5280.54
16_V109_N0.5280.54
8_L22_V0.5260.53
120_S145_I0.5240.53
110_M124_Y0.5240.53
56_T85_I0.5220.53
34_V69_T0.5210.53
21_G50_M0.5200.53
13_N110_M0.5180.52
56_T59_F0.5150.52
85_I116_K0.5150.52
36_V70_I0.5130.52
130_L134_R0.5050.51
32_L64_F0.5050.51
72_V77_A0.5040.50
62_R80_Q0.5040.50
70_I100_I0.5030.50
16_V54_A0.5020.50
112_F118_Q0.5020.50
69_T72_V0.5010.50
89_P93_R0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eyeA 1 0.962 100 0.049 Contact Map
1bleA 3 0.9747 100 0.062 Contact Map
3lfjA 1 0.9937 100 0.063 Contact Map
1nrzA 2 0.9747 100 0.064 Contact Map
1vsqC 1 0.9937 100 0.07 Contact Map
3p3vA 1 0.9873 100 0.079 Contact Map
3co8A 2 0.8228 34.6 0.935 Contact Map
2wk1A 2 0.481 18.2 0.943 Contact Map
2yggA 1 0.2342 16.2 0.944 Contact Map
3hl4A 2 0.5063 14.8 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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