GREMLIN Database
AGAS - Putative tagatose-6-phosphate ketose/aldose isomerase
UniProt: P42907 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12767
Length: 384 (341)
Sequences: 5350 (3144)
Seq/√Len: 170.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_L104_P5.0041.00
137_P150_A4.0121.00
124_E149_N3.6291.00
25_R29_R3.4981.00
27_W204_C3.3891.00
58_L68_G3.1871.00
172_M175_S3.0511.00
205_Q209_T3.0221.00
27_W181_A2.7861.00
127_N151_I2.7441.00
110_F183_C2.6791.00
204_C344_M2.6171.00
28_I205_Q2.6021.00
310_A323_P2.5361.00
109_S123_V2.5281.00
68_G110_F2.5001.00
55_R84_S2.4061.00
242_S346_A2.3881.00
176_I238_A2.3661.00
125_L128_Q2.3541.00
54_L100_N2.2791.00
280_V296_L2.2021.00
219_F356_H2.1761.00
243_A254_L2.1541.00
211_L352_M2.0991.00
71_I183_C2.0951.00
355_L361_P2.0431.00
53_N106_L2.0321.00
220_G325_I2.0241.00
196_T334_I1.9921.00
315_S328_P1.9571.00
300_R324_H1.9391.00
26_A178_T1.8981.00
65_A69_D1.8831.00
285_H335_D1.8601.00
206_A209_T1.8351.00
123_V146_L1.8321.00
106_L136_L1.8251.00
111_G146_L1.8101.00
222_A356_H1.8101.00
210_S213_D1.7821.00
17_E21_R1.7811.00
220_G307_R1.7641.00
72_A76_A1.7641.00
199_D203_R1.7611.00
107_L133_C1.7461.00
87_P260_S1.7421.00
161_M178_T1.7191.00
75_L83_F1.7101.00
147_Y158_A1.6741.00
57_I105_L1.6741.00
261_P291_Y1.6701.00
46_E50_R1.6581.00
247_L255_A1.6531.00
30_S161_M1.6271.00
240_R256_A1.6271.00
139_T147_Y1.6181.00
176_I343_L1.6181.00
281_F346_A1.6091.00
25_R205_Q1.5801.00
142_E160_L1.5411.00
63_T172_M1.5361.00
55_R82_N1.5331.00
315_S332_H1.5241.00
203_R341_C1.5231.00
115_N145_A1.5191.00
125_L131_P1.5101.00
100_N103_H1.5071.00
56_I106_L1.5051.00
74_W184_L1.5001.00
21_R211_L1.4851.00
312_A328_P1.4791.00
352_M356_H1.4761.00
75_L187_F1.4751.00
30_S182_S1.4701.00
86_V94_N1.4571.00
135_H150_A1.4551.00
45_L51_K1.4501.00
72_A84_S1.4441.00
121_A124_E1.4401.00
312_A326_I1.4381.00
236_Q240_R1.4281.00
23_Q177_T1.4211.00
13_G355_L1.4111.00
196_T203_R1.4061.00
212_G215_S1.4011.00
330_S342_F1.3971.00
195_Q198_R1.3801.00
47_P51_K1.3731.00
100_N105_L1.3711.00
59_T91_L1.3671.00
202_D205_Q1.3661.00
77_S95_P1.3641.00
282_V296_L1.3631.00
225_K275_E1.3541.00
107_L126_A1.3381.00
56_I108_I1.3371.00
59_T107_L1.3341.00
57_I91_L1.3321.00
215_S352_M1.3311.00
14_T351_L1.3301.00
199_D202_D1.3301.00
200_V340_F1.3241.00
109_S135_H1.3151.00
225_K273_D1.3101.00
34_I39_S1.3091.00
58_L83_F1.3041.00
320_A328_P1.2941.00
207_I210_S1.2801.00
180_M340_F1.2761.00
134_Y157_F1.2721.00
217_G309_I1.2701.00
100_N104_P1.2691.00
33_N36_A1.2561.00
80_G98_Y1.2451.00
52_E104_P1.2431.00
12_T21_R1.2391.00
55_R105_L1.2351.00
242_S281_F1.2311.00
138_I183_C1.2281.00
221_Y349_F1.2111.00
47_P50_R1.2071.00
215_S219_F1.2031.00
45_L48_L1.2031.00
17_E351_L1.1931.00
241_E245_K1.1831.00
286_P335_D1.1821.00
207_I341_C1.1801.00
117_P121_A1.1791.00
45_L50_R1.1761.00
48_L51_K1.1751.00
35_D39_S1.1751.00
99_L133_C1.1731.00
80_G95_P1.1711.00
55_R100_N1.1681.00
46_E51_K1.1621.00
272_V278_V1.1511.00
195_Q199_D1.1441.00
283_S342_F1.1381.00
221_Y325_I1.1361.00
213_D216_E1.1281.00
206_A314_E1.1241.00
238_A343_L1.1241.00
29_R32_T1.1241.00
279_V349_F1.1231.00
278_V299_L1.1201.00
78_H336_V1.1161.00
303_N306_M1.1121.00
203_R333_F1.1121.00
58_L108_I1.1121.00
137_P158_A1.1111.00
299_L306_M1.1101.00
51_K134_Y1.1071.00
203_R206_A1.1061.00
282_V288_T1.1031.00
348_T352_M1.0921.00
13_G17_E1.0911.00
69_D240_R1.0901.00
137_P146_L1.0901.00
265_R298_E1.0891.00
26_A30_S1.0781.00
230_L264_F1.0771.00
46_E49_L1.0761.00
354_S359_N1.0641.00
216_E219_F1.0611.00
109_S119_S1.0601.00
225_K357_M1.0591.00
28_I202_D1.0540.99
360_T363_T1.0510.99
126_A133_C1.0460.99
21_R208_L1.0450.99
368_G372_R1.0430.99
349_F353_Q1.0410.99
159_L186_V1.0400.99
181_A340_F1.0370.99
313_A332_H1.0370.99
226_R253_K1.0330.99
325_I328_P1.0270.99
143_A147_Y1.0240.99
124_E128_Q1.0210.99
235_L338_Q1.0180.99
317_D320_A1.0170.99
105_L133_C1.0160.99
200_V341_C1.0160.99
127_N149_N1.0160.99
69_D85_A1.0140.99
297_A300_R0.9930.99
233_G287_Y0.9900.99
224_W307_R0.9890.99
159_L182_S0.9860.99
161_M179_M0.9840.99
278_V306_M0.9830.99
165_T174_S0.9820.99
196_T199_D0.9780.99
9_A363_T0.9700.99
229_Y246_V0.9700.99
14_T17_E0.9610.99
16_T169_G0.9560.99
230_L280_V0.9530.99
127_N135_H0.9520.99
296_L308_V0.9520.99
227_I246_V0.9510.99
251_A365_S0.9490.99
134_Y151_I0.9460.99
314_E328_P0.9460.99
54_L105_L0.9450.99
123_V150_A0.9440.99
206_A210_S0.9380.99
177_T340_F0.9270.99
92_V121_A0.9250.99
230_L299_L0.9250.99
79_T187_F0.9200.99
61_A116_S0.9190.99
109_S126_A0.9190.99
351_L355_L0.9180.99
16_T249_L0.9150.99
176_I237_G0.9120.99
35_D38_R0.9110.98
142_E163_A0.9070.98
120_V124_E0.9040.98
273_D365_S0.9030.98
314_E332_H0.9020.98
22_H174_S0.8970.98
288_T316_S0.8970.98
239_A281_F0.8950.98
78_H187_F0.8940.98
28_I32_T0.8880.98
43_N46_E0.8830.98
218_V349_F0.8820.98
298_E302_D0.8780.98
171_A249_L0.8750.98
14_T355_L0.8750.98
76_A94_N0.8710.98
229_Y279_V0.8650.98
228_V276_T0.8640.98
312_A315_S0.8640.98
235_L342_F0.8610.98
235_L281_F0.8600.98
53_N134_Y0.8590.98
311_I345_Y0.8580.98
33_N37_L0.8580.98
15_W18_E0.8560.98
242_S343_L0.8550.98
297_A322_G0.8510.98
167_D173_T0.8500.98
142_E158_A0.8470.98
227_I252_G0.8460.98
58_L85_A0.8430.98
17_E348_T0.8420.97
135_H151_I0.8340.97
53_N105_L0.8330.97
281_F342_F0.8310.97
264_F269_K0.8280.97
65_A87_P0.8280.97
264_F299_L0.8210.97
71_I187_F0.8120.97
323_P326_I0.8090.97
37_L41_L0.8090.97
91_L99_L0.8090.97
35_D41_L0.8080.97
74_W187_F0.8050.97
39_S42_N0.8050.97
12_T17_E0.8040.97
284_S313_A0.8010.97
108_I136_L0.8010.97
28_I198_R0.7940.96
211_L215_S0.7940.96
37_L40_A0.7940.96
56_I81_K0.7930.96
61_A88_T0.7910.96
307_R324_H0.7900.96
61_A263_G0.7890.96
60_G64_S0.7890.96
66_F240_R0.7860.96
138_I182_S0.7800.96
123_V135_H0.7790.96
196_T337_E0.7790.96
296_L310_A0.7770.96
63_T241_E0.7730.96
272_V306_M0.7730.96
160_L163_A0.7700.96
66_F69_D0.7700.96
120_V145_A0.7630.96
34_I41_L0.7620.95
112_R140_C0.7620.95
217_G221_Y0.7580.95
108_I186_V0.7560.95
58_L183_C0.7550.95
172_M270_S0.7540.95
95_P131_P0.7480.95
56_I83_F0.7480.95
210_S327_L0.7460.95
288_T293_L0.7450.95
145_A149_N0.7450.95
59_T109_S0.7370.95
226_R276_T0.7370.95
299_L308_V0.7330.94
52_E134_Y0.7290.94
28_I201_A0.7260.94
23_Q347_Q0.7250.94
67_I183_C0.7230.94
95_P125_L0.7230.94
47_P157_F0.7210.94
70_I238_A0.7210.94
167_D174_S0.7200.94
31_L181_A0.7180.94
60_G85_A0.7180.94
257_F268_P0.7160.94
44_F136_L0.7130.94
214_F349_F0.7130.94
311_I330_S0.7070.93
112_R167_D0.7050.93
333_F341_C0.7030.93
207_I211_L0.7030.93
241_E347_Q0.7030.93
251_A270_S0.7010.93
334_I337_E0.7000.93
353_Q357_M0.7000.93
26_A29_R0.6980.93
43_N47_P0.6960.93
143_A148_Q0.6920.93
30_S178_T0.6900.92
224_W277_L0.6890.92
34_I37_L0.6870.92
27_W161_M0.6850.92
252_G357_M0.6820.92
307_R325_I0.6810.92
203_R207_I0.6790.92
250_T359_N0.6790.92
147_Y160_L0.6760.92
75_L186_V0.6750.92
227_I279_V0.6710.91
179_M183_C0.6690.91
312_A317_D0.6690.91
311_I342_F0.6670.91
213_D325_I0.6660.91
265_R269_K0.6660.91
33_N39_S0.6660.91
245_K270_S0.6630.91
215_S356_H0.6620.91
64_S139_T0.6620.91
164_E178_T0.6620.91
36_A39_S0.6600.91
178_T182_S0.6600.91
314_E317_D0.6590.91
23_Q344_M0.6580.91
333_F337_E0.6580.91
17_E211_L0.6570.91
87_P262_T0.6550.90
45_L49_L0.6520.90
274_D303_N0.6510.90
221_Y227_I0.6500.90
36_A40_A0.6470.90
280_V291_Y0.6470.90
72_A85_A0.6460.90
63_T245_K0.6460.90
58_L75_L0.6430.90
341_C344_M0.6430.90
147_Y150_A0.6430.90
335_D338_Q0.6350.89
41_L45_L0.6330.89
121_A125_L0.6320.89
128_Q131_P0.6310.89
65_A85_A0.6300.89
118_E262_T0.6280.88
229_Y242_S0.6280.88
71_I75_L0.6250.88
25_R28_I0.6250.88
177_T344_M0.6220.88
40_A43_N0.6210.88
57_I84_S0.6200.88
210_S214_F0.6200.88
20_I23_Q0.6200.88
69_D237_G0.6190.88
282_V293_L0.6190.88
312_A316_S0.6180.88
143_A158_A0.6170.88
241_E244_L0.6160.88
202_D206_A0.6150.87
218_V356_H0.6150.87
282_V310_A0.6150.87
112_R172_M0.6150.87
33_N41_L0.6140.87
235_L283_S0.6130.87
89_T262_T0.6130.87
39_S43_N0.6130.87
42_N46_E0.6090.87
333_F338_Q0.6060.87
63_T268_P0.6060.87
242_S245_K0.6060.87
57_I107_L0.6030.86
109_S150_A0.6020.86
263_G366_A0.6010.86
142_E147_Y0.5990.86
54_L103_H0.5980.86
121_A294_D0.5970.86
177_T347_Q0.5970.86
173_T241_E0.5960.86
300_R308_V0.5960.86
112_R174_S0.5950.86
76_A82_N0.5950.86
243_A256_A0.5940.86
295_L298_E0.5940.86
80_G83_F0.5930.85
241_E362_D0.5930.85
324_H327_L0.5920.85
63_T176_I0.5910.85
33_N40_A0.5910.85
139_T181_A0.5890.85
74_W336_V0.5880.85
204_C340_F0.5870.85
24_P208_L0.5850.85
293_L297_A0.5840.85
176_I180_M0.5840.85
24_P205_Q0.5830.85
38_R198_R0.5830.85
77_S336_V0.5820.84
39_S44_F0.5820.84
298_E301_R0.5810.84
44_F47_P0.5800.84
140_C172_M0.5790.84
284_S288_T0.5760.84
89_T232_S0.5760.84
118_E265_R0.5750.84
163_A166_H0.5740.84
96_M125_L0.5730.84
219_F222_A0.5710.83
168_R363_T0.5710.83
72_A83_F0.5700.83
109_S146_L0.5700.83
313_A338_Q0.5690.83
70_I339_A0.5680.83
317_D328_P0.5670.83
124_E148_Q0.5650.83
34_I38_R0.5650.83
13_G363_T0.5630.82
214_F348_T0.5620.82
237_G268_P0.5620.82
63_T343_L0.5610.82
297_A301_R0.5600.82
64_S268_P0.5580.82
216_E220_G0.5580.82
63_T244_L0.5570.82
42_N159_L0.5540.81
214_F345_Y0.5530.81
80_G96_M0.5530.81
196_T333_F0.5520.81
112_R165_T0.5520.81
214_F327_L0.5510.81
208_L344_M0.5500.81
353_Q356_H0.5480.81
279_V309_I0.5480.81
70_I237_G0.5470.81
146_L150_A0.5460.80
144_G147_Y0.5460.80
368_G373_V0.5450.80
116_S251_A0.5430.80
173_T347_Q0.5430.80
221_Y353_Q0.5420.80
300_R322_G0.5420.80
22_H26_A0.5380.80
59_T126_A0.5370.79
221_Y224_W0.5370.79
313_A330_S0.5340.79
180_M184_L0.5340.79
365_S369_T0.5330.79
56_I75_L0.5310.79
232_S261_P0.5300.79
238_A281_F0.5300.79
220_G309_I0.5260.78
169_G175_S0.5250.78
293_L300_R0.5250.78
216_E325_I0.5250.78
65_A88_T0.5240.78
70_I180_M0.5230.78
44_F157_F0.5220.77
39_S128_Q0.5220.77
66_F241_E0.5210.77
354_S361_P0.5200.77
95_P286_P0.5180.77
32_T198_R0.5180.77
119_S122_A0.5170.77
265_R368_G0.5160.77
64_S110_F0.5160.77
67_I180_M0.5150.77
290_Q294_D0.5150.77
113_S140_C0.5140.76
67_I172_M0.5140.76
35_D40_A0.5140.76
35_D42_N0.5140.76
255_A271_L0.5130.76
252_G353_Q0.5130.76
124_E145_A0.5130.76
322_G325_I0.5120.76
88_T299_L0.5120.76
143_A160_L0.5110.76
23_Q204_C0.5110.76
269_K302_D0.5100.76
341_C345_Y0.5090.76
179_M269_K0.5090.76
222_A353_Q0.5070.75
330_S333_F0.5070.75
294_D298_E0.5070.75
285_H338_Q0.5060.75
247_L271_L0.5060.75
264_F272_V0.5050.75
175_S370_V0.5040.75
40_A52_E0.5040.75
181_A200_V0.5030.75
200_V337_E0.5030.75
82_N98_Y0.5010.75
265_R270_S0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3odpA 2 0.974 100 0.23 Contact Map
3c3jA 2 0.9297 100 0.231 Contact Map
3i0zA 2 0.9714 100 0.246 Contact Map
2zj3A 2 0.9036 100 0.253 Contact Map
1moqA 2 0.9089 100 0.258 Contact Map
2pocA 4 0.8698 100 0.259 Contact Map
3tbfA 2 0.8854 100 0.261 Contact Map
4s1wA 2 0.8646 100 0.269 Contact Map
4amvA 2 0.9245 100 0.274 Contact Map
3fj1A 2 0.8568 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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