AGAS - ECOLI - GREMLIN Contacts

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AGAS - Putative tagatose-6-phosphate ketose/aldose isomerase

UniProt:	P42907	Sequences: MPENYTPAAAATGTWTEEEIRHQPRAWIRSLTNIDALRSALNNFLEPLLRKENLRIILTGAGTSAFIGDIIAPWLASHTGKNFSAVPTTDLVTNPMDYLNPAHPLLLISFGRSGNSPESVAAVELANQFVPECYHLPITCNEAGALYQNAINSDNAFALLMPAETHDRGFAMTSSITTMMASCLAVFAPETINSQTFRDVADRCQAILTSLGDFSEGVFGYAPWKRIVYLGSGGLQGAARESALKVLELTAGKLAAFYDSPTGFRHGPKSLVDDETLVVVFVSSHPYTRQYDLDLLAELRRDNQAMRVIAIAAESSDIVAAGPHIILPPSRHFIDVEQAFCFLMYAQTFALMQSLHMGNTPDTPSASGTVNRVVQGVIIHPWQA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12767
Length:	384 (341)
Sequences:	5350 (3144)
Seq/√Len:	170.2

ECOLI - AGAS GLMS FRLB
BACSU - GLMS FRLB
HALSA - GLMS
SULSO - Q980D3 Q97YQ6 Q97W10 PGMI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
54_L	104_P	5.004	1.00
137_P	150_A	4.012	1.00
124_E	149_N	3.629	1.00
25_R	29_R	3.498	1.00
27_W	204_C	3.389	1.00
58_L	68_G	3.187	1.00
172_M	175_S	3.051	1.00
205_Q	209_T	3.022	1.00
27_W	181_A	2.786	1.00
127_N	151_I	2.744	1.00
110_F	183_C	2.679	1.00
204_C	344_M	2.617	1.00
28_I	205_Q	2.602	1.00
310_A	323_P	2.536	1.00
109_S	123_V	2.528	1.00
68_G	110_F	2.500	1.00
55_R	84_S	2.406	1.00
242_S	346_A	2.388	1.00
176_I	238_A	2.366	1.00
125_L	128_Q	2.354	1.00
54_L	100_N	2.279	1.00
280_V	296_L	2.202	1.00
219_F	356_H	2.176	1.00
243_A	254_L	2.154	1.00
211_L	352_M	2.099	1.00
71_I	183_C	2.095	1.00
355_L	361_P	2.043	1.00
53_N	106_L	2.032	1.00
220_G	325_I	2.024	1.00
196_T	334_I	1.992	1.00
315_S	328_P	1.957	1.00
300_R	324_H	1.939	1.00
26_A	178_T	1.898	1.00
65_A	69_D	1.883	1.00
285_H	335_D	1.860	1.00
206_A	209_T	1.835	1.00
123_V	146_L	1.832	1.00
106_L	136_L	1.825	1.00
111_G	146_L	1.810	1.00
222_A	356_H	1.810	1.00
210_S	213_D	1.782	1.00
17_E	21_R	1.781	1.00
220_G	307_R	1.764	1.00
72_A	76_A	1.764	1.00
199_D	203_R	1.761	1.00
107_L	133_C	1.746	1.00
87_P	260_S	1.742	1.00
161_M	178_T	1.719	1.00
75_L	83_F	1.710	1.00
147_Y	158_A	1.674	1.00
57_I	105_L	1.674	1.00
261_P	291_Y	1.670	1.00
46_E	50_R	1.658	1.00
247_L	255_A	1.653	1.00
30_S	161_M	1.627	1.00
240_R	256_A	1.627	1.00
139_T	147_Y	1.618	1.00
176_I	343_L	1.618	1.00
281_F	346_A	1.609	1.00
25_R	205_Q	1.580	1.00
142_E	160_L	1.541	1.00
63_T	172_M	1.536	1.00
55_R	82_N	1.533	1.00
315_S	332_H	1.524	1.00
203_R	341_C	1.523	1.00
115_N	145_A	1.519	1.00
125_L	131_P	1.510	1.00
100_N	103_H	1.507	1.00
56_I	106_L	1.505	1.00
74_W	184_L	1.500	1.00
21_R	211_L	1.485	1.00
312_A	328_P	1.479	1.00
352_M	356_H	1.476	1.00
75_L	187_F	1.475	1.00
30_S	182_S	1.470	1.00
86_V	94_N	1.457	1.00
135_H	150_A	1.455	1.00
45_L	51_K	1.450	1.00
72_A	84_S	1.444	1.00
121_A	124_E	1.440	1.00
312_A	326_I	1.438	1.00
236_Q	240_R	1.428	1.00
23_Q	177_T	1.421	1.00
13_G	355_L	1.411	1.00
196_T	203_R	1.406	1.00
212_G	215_S	1.401	1.00
330_S	342_F	1.397	1.00
195_Q	198_R	1.380	1.00
47_P	51_K	1.373	1.00
100_N	105_L	1.371	1.00
59_T	91_L	1.367	1.00
202_D	205_Q	1.366	1.00
77_S	95_P	1.364	1.00
282_V	296_L	1.363	1.00
225_K	275_E	1.354	1.00
107_L	126_A	1.338	1.00
56_I	108_I	1.337	1.00
59_T	107_L	1.334	1.00
57_I	91_L	1.332	1.00
215_S	352_M	1.331	1.00
14_T	351_L	1.330	1.00
199_D	202_D	1.330	1.00
200_V	340_F	1.324	1.00
109_S	135_H	1.315	1.00
225_K	273_D	1.310	1.00
34_I	39_S	1.309	1.00
58_L	83_F	1.304	1.00
320_A	328_P	1.294	1.00
207_I	210_S	1.280	1.00
180_M	340_F	1.276	1.00
134_Y	157_F	1.272	1.00
217_G	309_I	1.270	1.00
100_N	104_P	1.269	1.00
33_N	36_A	1.256	1.00
80_G	98_Y	1.245	1.00
52_E	104_P	1.243	1.00
12_T	21_R	1.239	1.00
55_R	105_L	1.235	1.00
242_S	281_F	1.231	1.00
138_I	183_C	1.228	1.00
221_Y	349_F	1.211	1.00
47_P	50_R	1.207	1.00
215_S	219_F	1.203	1.00
45_L	48_L	1.203	1.00
17_E	351_L	1.193	1.00
241_E	245_K	1.183	1.00
286_P	335_D	1.182	1.00
207_I	341_C	1.180	1.00
117_P	121_A	1.179	1.00
45_L	50_R	1.176	1.00
48_L	51_K	1.175	1.00
35_D	39_S	1.175	1.00
99_L	133_C	1.173	1.00
80_G	95_P	1.171	1.00
55_R	100_N	1.168	1.00
46_E	51_K	1.162	1.00
272_V	278_V	1.151	1.00
195_Q	199_D	1.144	1.00
283_S	342_F	1.138	1.00
221_Y	325_I	1.136	1.00
213_D	216_E	1.128	1.00
206_A	314_E	1.124	1.00
238_A	343_L	1.124	1.00
29_R	32_T	1.124	1.00
279_V	349_F	1.123	1.00
278_V	299_L	1.120	1.00
78_H	336_V	1.116	1.00
303_N	306_M	1.112	1.00
203_R	333_F	1.112	1.00
58_L	108_I	1.112	1.00
137_P	158_A	1.111	1.00
299_L	306_M	1.110	1.00
51_K	134_Y	1.107	1.00
203_R	206_A	1.106	1.00
282_V	288_T	1.103	1.00
348_T	352_M	1.092	1.00
13_G	17_E	1.091	1.00
69_D	240_R	1.090	1.00
137_P	146_L	1.090	1.00
265_R	298_E	1.089	1.00
26_A	30_S	1.078	1.00
230_L	264_F	1.077	1.00
46_E	49_L	1.076	1.00
354_S	359_N	1.064	1.00
216_E	219_F	1.061	1.00
109_S	119_S	1.060	1.00
225_K	357_M	1.059	1.00
28_I	202_D	1.054	0.99
360_T	363_T	1.051	0.99
126_A	133_C	1.046	0.99
21_R	208_L	1.045	0.99
368_G	372_R	1.043	0.99
349_F	353_Q	1.041	0.99
159_L	186_V	1.040	0.99
181_A	340_F	1.037	0.99
313_A	332_H	1.037	0.99
226_R	253_K	1.033	0.99
325_I	328_P	1.027	0.99
143_A	147_Y	1.024	0.99
124_E	128_Q	1.021	0.99
235_L	338_Q	1.018	0.99
317_D	320_A	1.017	0.99
105_L	133_C	1.016	0.99
200_V	341_C	1.016	0.99
127_N	149_N	1.016	0.99
69_D	85_A	1.014	0.99
297_A	300_R	0.993	0.99
233_G	287_Y	0.990	0.99
224_W	307_R	0.989	0.99
159_L	182_S	0.986	0.99
161_M	179_M	0.984	0.99
278_V	306_M	0.983	0.99
165_T	174_S	0.982	0.99
196_T	199_D	0.978	0.99
9_A	363_T	0.970	0.99
229_Y	246_V	0.970	0.99
14_T	17_E	0.961	0.99
16_T	169_G	0.956	0.99
230_L	280_V	0.953	0.99
127_N	135_H	0.952	0.99
296_L	308_V	0.952	0.99
227_I	246_V	0.951	0.99
251_A	365_S	0.949	0.99
134_Y	151_I	0.946	0.99
314_E	328_P	0.946	0.99
54_L	105_L	0.945	0.99
123_V	150_A	0.944	0.99
206_A	210_S	0.938	0.99
177_T	340_F	0.927	0.99
92_V	121_A	0.925	0.99
230_L	299_L	0.925	0.99
79_T	187_F	0.920	0.99
61_A	116_S	0.919	0.99
109_S	126_A	0.919	0.99
351_L	355_L	0.918	0.99
16_T	249_L	0.915	0.99
176_I	237_G	0.912	0.99
35_D	38_R	0.911	0.98
142_E	163_A	0.907	0.98
120_V	124_E	0.904	0.98
273_D	365_S	0.903	0.98
314_E	332_H	0.902	0.98
22_H	174_S	0.897	0.98
288_T	316_S	0.897	0.98
239_A	281_F	0.895	0.98
78_H	187_F	0.894	0.98
28_I	32_T	0.888	0.98
43_N	46_E	0.883	0.98
218_V	349_F	0.882	0.98
298_E	302_D	0.878	0.98
171_A	249_L	0.875	0.98
14_T	355_L	0.875	0.98
76_A	94_N	0.871	0.98
229_Y	279_V	0.865	0.98
228_V	276_T	0.864	0.98
312_A	315_S	0.864	0.98
235_L	342_F	0.861	0.98
235_L	281_F	0.860	0.98
53_N	134_Y	0.859	0.98
311_I	345_Y	0.858	0.98
33_N	37_L	0.858	0.98
15_W	18_E	0.856	0.98
242_S	343_L	0.855	0.98
297_A	322_G	0.851	0.98
167_D	173_T	0.850	0.98
142_E	158_A	0.847	0.98
227_I	252_G	0.846	0.98
58_L	85_A	0.843	0.98
17_E	348_T	0.842	0.97
135_H	151_I	0.834	0.97
53_N	105_L	0.833	0.97
281_F	342_F	0.831	0.97
264_F	269_K	0.828	0.97
65_A	87_P	0.828	0.97
264_F	299_L	0.821	0.97
71_I	187_F	0.812	0.97
323_P	326_I	0.809	0.97
37_L	41_L	0.809	0.97
91_L	99_L	0.809	0.97
35_D	41_L	0.808	0.97
74_W	187_F	0.805	0.97
39_S	42_N	0.805	0.97
12_T	17_E	0.804	0.97
284_S	313_A	0.801	0.97
108_I	136_L	0.801	0.97
28_I	198_R	0.794	0.96
211_L	215_S	0.794	0.96
37_L	40_A	0.794	0.96
56_I	81_K	0.793	0.96
61_A	88_T	0.791	0.96
307_R	324_H	0.790	0.96
61_A	263_G	0.789	0.96
60_G	64_S	0.789	0.96
66_F	240_R	0.786	0.96
138_I	182_S	0.780	0.96
123_V	135_H	0.779	0.96
196_T	337_E	0.779	0.96
296_L	310_A	0.777	0.96
63_T	241_E	0.773	0.96
272_V	306_M	0.773	0.96
160_L	163_A	0.770	0.96
66_F	69_D	0.770	0.96
120_V	145_A	0.763	0.96
34_I	41_L	0.762	0.95
112_R	140_C	0.762	0.95
217_G	221_Y	0.758	0.95
108_I	186_V	0.756	0.95
58_L	183_C	0.755	0.95
172_M	270_S	0.754	0.95
95_P	131_P	0.748	0.95
56_I	83_F	0.748	0.95
210_S	327_L	0.746	0.95
288_T	293_L	0.745	0.95
145_A	149_N	0.745	0.95
59_T	109_S	0.737	0.95
226_R	276_T	0.737	0.95
299_L	308_V	0.733	0.94
52_E	134_Y	0.729	0.94
28_I	201_A	0.726	0.94
23_Q	347_Q	0.725	0.94
67_I	183_C	0.723	0.94
95_P	125_L	0.723	0.94
47_P	157_F	0.721	0.94
70_I	238_A	0.721	0.94
167_D	174_S	0.720	0.94
31_L	181_A	0.718	0.94
60_G	85_A	0.718	0.94
257_F	268_P	0.716	0.94
44_F	136_L	0.713	0.94
214_F	349_F	0.713	0.94
311_I	330_S	0.707	0.93
112_R	167_D	0.705	0.93
333_F	341_C	0.703	0.93
207_I	211_L	0.703	0.93
241_E	347_Q	0.703	0.93
251_A	270_S	0.701	0.93
334_I	337_E	0.700	0.93
353_Q	357_M	0.700	0.93
26_A	29_R	0.698	0.93
43_N	47_P	0.696	0.93
143_A	148_Q	0.692	0.93
30_S	178_T	0.690	0.92
224_W	277_L	0.689	0.92
34_I	37_L	0.687	0.92
27_W	161_M	0.685	0.92
252_G	357_M	0.682	0.92
307_R	325_I	0.681	0.92
203_R	207_I	0.679	0.92
250_T	359_N	0.679	0.92
147_Y	160_L	0.676	0.92
75_L	186_V	0.675	0.92
227_I	279_V	0.671	0.91
179_M	183_C	0.669	0.91
312_A	317_D	0.669	0.91
311_I	342_F	0.667	0.91
213_D	325_I	0.666	0.91
265_R	269_K	0.666	0.91
33_N	39_S	0.666	0.91
245_K	270_S	0.663	0.91
215_S	356_H	0.662	0.91
64_S	139_T	0.662	0.91
164_E	178_T	0.662	0.91
36_A	39_S	0.660	0.91
178_T	182_S	0.660	0.91
314_E	317_D	0.659	0.91
23_Q	344_M	0.658	0.91
333_F	337_E	0.658	0.91
17_E	211_L	0.657	0.91
87_P	262_T	0.655	0.90
45_L	49_L	0.652	0.90
274_D	303_N	0.651	0.90
221_Y	227_I	0.650	0.90
36_A	40_A	0.647	0.90
280_V	291_Y	0.647	0.90
72_A	85_A	0.646	0.90
63_T	245_K	0.646	0.90
58_L	75_L	0.643	0.90
341_C	344_M	0.643	0.90
147_Y	150_A	0.643	0.90
335_D	338_Q	0.635	0.89
41_L	45_L	0.633	0.89
121_A	125_L	0.632	0.89
128_Q	131_P	0.631	0.89
65_A	85_A	0.630	0.89
118_E	262_T	0.628	0.88
229_Y	242_S	0.628	0.88
71_I	75_L	0.625	0.88
25_R	28_I	0.625	0.88
177_T	344_M	0.622	0.88
40_A	43_N	0.621	0.88
57_I	84_S	0.620	0.88
210_S	214_F	0.620	0.88
20_I	23_Q	0.620	0.88
69_D	237_G	0.619	0.88
282_V	293_L	0.619	0.88
312_A	316_S	0.618	0.88
143_A	158_A	0.617	0.88
241_E	244_L	0.616	0.88
202_D	206_A	0.615	0.87
218_V	356_H	0.615	0.87
282_V	310_A	0.615	0.87
112_R	172_M	0.615	0.87
33_N	41_L	0.614	0.87
235_L	283_S	0.613	0.87
89_T	262_T	0.613	0.87
39_S	43_N	0.613	0.87
42_N	46_E	0.609	0.87
333_F	338_Q	0.606	0.87
63_T	268_P	0.606	0.87
242_S	245_K	0.606	0.87
57_I	107_L	0.603	0.86
109_S	150_A	0.602	0.86
263_G	366_A	0.601	0.86
142_E	147_Y	0.599	0.86
54_L	103_H	0.598	0.86
121_A	294_D	0.597	0.86
177_T	347_Q	0.597	0.86
173_T	241_E	0.596	0.86
300_R	308_V	0.596	0.86
112_R	174_S	0.595	0.86
76_A	82_N	0.595	0.86
243_A	256_A	0.594	0.86
295_L	298_E	0.594	0.86
80_G	83_F	0.593	0.85
241_E	362_D	0.593	0.85
324_H	327_L	0.592	0.85
63_T	176_I	0.591	0.85
33_N	40_A	0.591	0.85
139_T	181_A	0.589	0.85
74_W	336_V	0.588	0.85
204_C	340_F	0.587	0.85
24_P	208_L	0.585	0.85
293_L	297_A	0.584	0.85
176_I	180_M	0.584	0.85
24_P	205_Q	0.583	0.85
38_R	198_R	0.583	0.85
77_S	336_V	0.582	0.84
39_S	44_F	0.582	0.84
298_E	301_R	0.581	0.84
44_F	47_P	0.580	0.84
140_C	172_M	0.579	0.84
284_S	288_T	0.576	0.84
89_T	232_S	0.576	0.84
118_E	265_R	0.575	0.84
163_A	166_H	0.574	0.84
96_M	125_L	0.573	0.84
219_F	222_A	0.571	0.83
168_R	363_T	0.571	0.83
72_A	83_F	0.570	0.83
109_S	146_L	0.570	0.83
313_A	338_Q	0.569	0.83
70_I	339_A	0.568	0.83
317_D	328_P	0.567	0.83
124_E	148_Q	0.565	0.83
34_I	38_R	0.565	0.83
13_G	363_T	0.563	0.82
214_F	348_T	0.562	0.82
237_G	268_P	0.562	0.82
63_T	343_L	0.561	0.82
297_A	301_R	0.560	0.82
64_S	268_P	0.558	0.82
216_E	220_G	0.558	0.82
63_T	244_L	0.557	0.82
42_N	159_L	0.554	0.81
214_F	345_Y	0.553	0.81
80_G	96_M	0.553	0.81
196_T	333_F	0.552	0.81
112_R	165_T	0.552	0.81
214_F	327_L	0.551	0.81
208_L	344_M	0.550	0.81
353_Q	356_H	0.548	0.81
279_V	309_I	0.548	0.81
70_I	237_G	0.547	0.81
146_L	150_A	0.546	0.80
144_G	147_Y	0.546	0.80
368_G	373_V	0.545	0.80
116_S	251_A	0.543	0.80
173_T	347_Q	0.543	0.80
221_Y	353_Q	0.542	0.80
300_R	322_G	0.542	0.80
22_H	26_A	0.538	0.80
59_T	126_A	0.537	0.79
221_Y	224_W	0.537	0.79
313_A	330_S	0.534	0.79
180_M	184_L	0.534	0.79
365_S	369_T	0.533	0.79
56_I	75_L	0.531	0.79
232_S	261_P	0.530	0.79
238_A	281_F	0.530	0.79
220_G	309_I	0.526	0.78
169_G	175_S	0.525	0.78
293_L	300_R	0.525	0.78
216_E	325_I	0.525	0.78
65_A	88_T	0.524	0.78
70_I	180_M	0.523	0.78
44_F	157_F	0.522	0.77
39_S	128_Q	0.522	0.77
66_F	241_E	0.521	0.77
354_S	361_P	0.520	0.77
95_P	286_P	0.518	0.77
32_T	198_R	0.518	0.77
119_S	122_A	0.517	0.77
265_R	368_G	0.516	0.77
64_S	110_F	0.516	0.77
67_I	180_M	0.515	0.77
290_Q	294_D	0.515	0.77
113_S	140_C	0.514	0.76
67_I	172_M	0.514	0.76
35_D	40_A	0.514	0.76
35_D	42_N	0.514	0.76
255_A	271_L	0.513	0.76
252_G	353_Q	0.513	0.76
124_E	145_A	0.513	0.76
322_G	325_I	0.512	0.76
88_T	299_L	0.512	0.76
143_A	160_L	0.511	0.76
23_Q	204_C	0.511	0.76
269_K	302_D	0.510	0.76
341_C	345_Y	0.509	0.76
179_M	269_K	0.509	0.76
222_A	353_Q	0.507	0.75
330_S	333_F	0.507	0.75
294_D	298_E	0.507	0.75
285_H	338_Q	0.506	0.75
247_L	271_L	0.506	0.75
264_F	272_V	0.505	0.75
175_S	370_V	0.504	0.75
40_A	52_E	0.504	0.75
181_A	200_V	0.503	0.75
200_V	337_E	0.503	0.75
82_N	98_Y	0.501	0.75
265_R	270_S	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3odpA	2	0.974	100	0.23	Contact Map
3c3jA	2	0.9297	100	0.231	Contact Map
3i0zA	2	0.9714	100	0.246	Contact Map
2zj3A	2	0.9036	100	0.253	Contact Map
1moqA	2	0.9089	100	0.258	Contact Map
2pocA	4	0.8698	100	0.259	Contact Map
3tbfA	2	0.8854	100	0.261	Contact Map
4s1wA	2	0.8646	100	0.269	Contact Map
4amvA	2	0.9245	100	0.274	Contact Map
3fj1A	2	0.8568	100	0.296	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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