GREMLIN Database
AGAA - Putative N-acetylgalactosamine-6-phosphate deacetylase
UniProt: P42906 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12766
Length: 167 (161)
Sequences: 2959 (1999)
Seq/√Len: 157.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_L143_R3.4791.00
97_L102_A3.2321.00
150_D154_H3.0561.00
137_S142_K3.0381.00
3_C46_C2.4811.00
70_R77_E2.3641.00
103_V121_A2.2571.00
33_A43_M2.2531.00
138_L146_V2.2301.00
10_L19_G2.2121.00
58_T99_V2.0621.00
131_V135_L2.0451.00
79_Q88_A1.9171.00
98_S101_A1.7741.00
139_K142_K1.7521.00
8_T14_E1.7241.00
143_R161_Q1.6911.00
123_L132_D1.6751.00
72_T77_E1.6671.00
72_T75_G1.6491.00
8_T17_M1.6041.00
55_V124_H1.5951.00
77_E88_A1.5911.00
105_N109_L1.5861.00
56_L121_A1.5851.00
100_D104_R1.5661.00
150_D156_Q1.5631.00
6_G91_G1.5581.00
118_I122_S1.5561.00
47_C120_M1.5501.00
55_V128_M1.5441.00
80_M85_V1.5411.00
4_Y46_C1.5311.00
10_L42_A1.5171.00
107_V117_A1.4931.00
113_T116_E1.4911.00
149_L153_L1.4771.00
70_R79_Q1.4701.00
23_T44_S1.4461.00
35_G109_L1.4341.00
52_E119_H1.4311.00
114_P153_L1.4231.00
123_L127_R1.4041.00
147_V155_V1.3801.00
119_H123_L1.3691.00
107_V114_P1.3691.00
4_Y42_A1.3671.00
61_M85_V1.3401.00
84_V92_L1.3361.00
23_T45_L1.3291.00
33_A106_M1.3171.00
127_R132_D1.3091.00
51_K116_E1.3031.00
47_C54_I1.3001.00
66_M69_G1.2961.00
31_L43_M1.2631.00
56_L106_M1.2551.00
63_A80_M1.2511.00
31_L54_I1.2501.00
15_P39_H1.2471.00
100_D155_V1.2351.00
106_M110_T1.2241.00
3_C21_G1.2131.00
25_K48_C1.2121.00
38_V42_A1.2101.00
12_H42_A1.2061.00
28_W55_V1.2051.00
60_A64_A1.1991.00
50_A53_R1.1931.00
33_A56_L1.1751.00
99_V121_A1.1741.00
104_R154_H1.1731.00
30_E57_I1.1721.00
21_G29_L1.1591.00
28_W128_M1.1511.00
135_L145_S1.1321.00
63_A74_C1.1241.00
145_S161_Q1.1221.00
40_P109_L1.1161.00
127_R137_S1.1151.00
85_V96_T1.1081.00
44_S48_C1.1051.00
146_V159_W1.0830.99
58_T97_L1.0800.99
121_A125_P1.0780.99
148_A159_W1.0690.99
107_V153_L1.0660.99
42_A46_C1.0480.99
3_C29_L1.0440.99
119_H124_H1.0400.99
112_V117_A1.0340.99
28_W53_R1.0280.99
76_E87_T1.0150.99
45_L49_C1.0130.99
61_M73_L1.0090.99
52_E127_R1.0010.99
132_D137_S0.9960.99
112_V120_M0.9810.99
43_M109_L0.9770.99
80_M96_T0.9610.99
40_P105_N0.9550.99
50_A124_H0.9540.99
102_A106_M0.9530.99
36_H84_V0.9460.98
104_R108_E0.9450.98
23_T49_C0.9270.98
29_L54_I0.8840.98
120_M124_H0.8790.98
19_G45_L0.8740.97
11_H14_E0.8710.97
97_L101_A0.8710.97
148_A157_Q0.8690.97
101_A104_R0.8640.97
22_L49_C0.8590.97
106_M112_V0.8590.97
70_R88_A0.8570.97
61_M78_V0.8530.97
149_L155_V0.8500.97
63_A73_L0.8420.97
24_D27_A0.8410.97
10_L45_L0.8380.97
23_T41_A0.8310.97
50_A120_M0.8310.97
4_Y18_V0.8270.96
117_A121_A0.8110.96
68_D96_T0.8090.96
68_D80_M0.8030.96
126_A136_G0.8010.96
9_G16_G0.7990.96
63_A85_V0.7890.95
76_E91_G0.7890.95
106_M120_M0.7880.95
44_S111_G0.7880.95
155_V158_I0.7870.95
101_A105_N0.7870.95
19_G42_A0.7830.95
28_W124_H0.7810.95
116_E124_H0.7800.95
63_A96_T0.7690.95
14_E19_G0.7630.94
100_D147_V0.7520.94
86_R90_G0.7500.94
107_V113_T0.7480.94
42_A45_L0.7430.94
56_L102_A0.7370.93
62_Q71_Y0.7370.93
135_L161_Q0.7340.93
95_S102_A0.7340.93
4_Y15_P0.7260.93
31_L38_V0.7250.93
64_A98_S0.7180.92
68_D81_H0.7130.92
87_T93_A0.7100.92
63_A69_G0.7080.92
58_T100_D0.7020.92
132_D142_K0.7010.92
10_L18_V0.6980.91
63_A78_V0.6970.91
147_V158_I0.6970.91
67_P71_Y0.6960.91
47_C106_M0.6940.91
107_V111_G0.6900.91
62_Q76_E0.6860.91
21_G27_A0.6810.90
116_E119_H0.6800.90
55_V125_P0.6780.90
73_L76_E0.6770.90
9_G12_H0.6630.89
29_L50_A0.6600.89
51_K119_H0.6590.89
123_L137_S0.6570.89
51_K124_H0.6570.89
29_L46_C0.6510.88
107_V110_T0.6490.88
13_R16_G0.6490.88
47_C112_V0.6460.88
145_S162_G0.6320.87
35_G105_N0.6290.87
4_Y38_V0.6270.86
98_S102_A0.6220.86
103_V118_I0.6190.86
68_D71_Y0.6170.85
66_M71_Y0.6150.85
35_G43_M0.6140.85
52_E116_E0.6140.85
34_D37_H0.6130.85
78_V93_A0.6120.85
7_M17_M0.6110.85
20_A23_T0.6050.84
47_C51_K0.6040.84
87_T91_G0.5980.84
50_A54_I0.5970.84
58_T98_S0.5950.83
73_L78_V0.5950.83
108_E152_G0.5940.83
46_C54_I0.5880.83
23_T48_C0.5860.82
47_C50_A0.5860.82
31_L46_C0.5850.82
18_V22_L0.5820.82
103_V122_S0.5790.82
5_N92_L0.5790.82
112_V116_E0.5780.82
58_T126_A0.5780.82
145_S148_A0.5760.81
62_Q72_T0.5740.81
32_I37_H0.5740.81
151_S156_Q0.5720.81
17_M21_G0.5720.81
68_D82_G0.5720.81
147_V157_Q0.5670.80
117_A125_P0.5660.80
33_A105_N0.5610.80
136_G144_A0.5590.79
22_L46_C0.5540.79
141_G144_A0.5490.78
128_M131_V0.5470.78
44_S119_H0.5450.78
8_T18_V0.5410.77
43_M110_T0.5400.77
73_L87_T0.5390.77
74_C78_V0.5340.76
104_R153_L0.5310.76
103_V114_P0.5250.75
154_H157_Q0.5220.75
69_G74_C0.5220.75
63_A71_Y0.5220.75
81_H86_R0.5210.74
10_L38_V0.5180.74
30_E64_A0.5140.74
133_G143_R0.5130.73
127_R142_K0.5130.73
71_Y78_V0.5100.73
130_G133_G0.5100.73
68_D83_G0.5100.73
7_M15_P0.5070.73
83_G96_T0.5060.72
43_M106_M0.5050.72
20_A24_D0.5030.72
47_C110_T0.5020.72
25_K53_R0.5020.72
146_V157_Q0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iv8A 2 1 100 0.417 Contact Map
1yrrA 3 1 100 0.426 Contact Map
2vhlA 1 1 100 0.436 Contact Map
1o12A 2 0.994 100 0.481 Contact Map
2vunA 3 0.8024 99.9 0.613 Contact Map
3gipA 1 0.9701 99.9 0.621 Contact Map
1onwA 5 0.8503 99.9 0.64 Contact Map
2ftwA 3 0.9461 99.9 0.64 Contact Map
2icsA 1 0.8323 99.8 0.652 Contact Map
2vm8A 3 0.9701 99.8 0.654 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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