GREMLIN Database
PTPC2 - Putative N-acetylgalactosamine permease IIC component 2
UniProt: P42905 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12765
Length: 133 (128)
Sequences: 1200 (659)
Seq/√Len: 58.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_D48_T5.2061.00
14_I38_L3.6731.00
123_R126_L3.5901.00
31_R57_E3.5491.00
41_L46_L2.9751.00
36_G49_G2.8431.00
14_I42_V2.7221.00
126_L130_P2.7071.00
8_A12_G2.6671.00
122_S125_D2.4751.00
127_A132_R2.2131.00
123_R127_A2.2011.00
76_I106_V2.1501.00
38_L42_V2.1461.00
11_L39_V2.0431.00
126_L129_N2.0101.00
85_A95_A1.9951.00
47_H51_L1.9781.00
128_T131_R1.7780.99
37_P46_L1.7510.99
55_T59_V1.7060.99
48_T86_I1.6910.99
43_L87_T1.6620.99
5_L9_F1.6370.99
94_V97_G1.6300.99
127_A130_P1.6180.99
48_T52_T1.6130.99
6_L10_A1.6020.99
17_I29_M1.4940.98
33_V37_P1.4380.97
10_A42_V1.4180.97
128_T132_R1.4160.97
77_G103_A1.3550.96
6_L9_F1.3410.96
124_C128_T1.3100.95
21_D72_P1.2700.94
73_N76_I1.2580.94
77_G83_A1.2470.94
69_A114_F1.2440.94
7_Q87_T1.2330.93
43_L86_I1.2220.93
51_L54_G1.2120.93
98_V102_F1.1990.92
72_P103_A1.1860.92
125_D129_N1.1520.91
14_I35_L1.1440.91
110_I114_F1.1190.90
49_G53_G1.0800.88
50_I53_G1.0760.88
51_L84_F1.0690.87
48_T51_L1.0670.87
73_N110_I1.0530.86
39_V83_A1.0500.86
61_M104_V1.0380.86
11_L42_V1.0300.85
11_L79_I1.0240.85
120_V123_R1.0090.84
31_R34_V0.9990.83
25_G31_R0.9980.83
15_A79_I0.9960.83
35_L78_T0.9920.83
59_V81_G0.9900.83
104_V108_M0.9710.82
47_H50_I0.9660.81
18_A35_L0.9620.81
90_V94_V0.9610.81
104_V107_Q0.9540.81
80_V102_F0.9360.79
10_A13_I0.9290.79
107_Q111_T0.8980.76
36_G82_T0.8950.76
62_G127_A0.8820.75
129_N132_R0.8680.74
33_V36_G0.8660.74
60_W77_G0.8640.73
33_V54_G0.8570.73
85_A91_K0.8480.72
7_Q42_V0.8410.71
35_L79_I0.8380.71
62_G101_P0.8360.71
56_L77_G0.8300.70
40_G53_G0.8260.70
80_V84_F0.8210.70
28_H78_T0.8190.69
80_V83_A0.8170.69
34_V37_P0.8100.69
14_I79_I0.8090.68
7_Q10_A0.7790.66
101_P104_V0.7750.65
91_K94_V0.7650.64
118_S121_M0.7560.63
61_M78_T0.7480.62
36_G78_T0.7450.62
5_L8_A0.7420.62
99_A104_V0.7400.62
14_I18_A0.7390.61
74_V81_G0.7350.61
87_T93_D0.7290.60
61_M75_I0.7280.60
12_G118_S0.7280.60
17_I20_L0.7140.59
56_L78_T0.7120.59
36_G68_G0.7070.58
122_S126_L0.7050.58
23_F114_F0.7020.58
101_P105_A0.6950.57
119_G123_R0.6950.57
108_M111_T0.6870.56
19_G96_V0.6850.56
90_V122_S0.6840.56
78_T99_A0.6840.56
111_T115_S0.6830.55
108_M112_F0.6830.55
20_L73_N0.6820.55
31_R84_F0.6760.55
84_F87_T0.6750.55
66_L70_Q0.6750.55
77_G84_F0.6750.55
88_T130_P0.6740.54
97_G100_V0.6730.54
68_G72_P0.6720.54
70_Q74_V0.6700.54
51_L58_L0.6640.53
36_G43_L0.6630.53
107_Q110_I0.6620.53
77_G81_G0.6580.53
98_V104_V0.6560.52
61_M73_N0.6510.52
21_D100_V0.6510.52
62_G100_V0.6480.52
46_L50_I0.6380.50
82_T86_I0.6370.50
49_G83_A0.6260.49
58_L72_P0.6200.49
50_I55_T0.6200.49
18_A75_I0.6150.48
65_P70_Q0.6140.48
32_P96_V0.6120.48
49_G66_L0.6070.47
74_V77_G0.6060.47
89_G116_V0.6040.47
85_A92_P0.5980.46
55_T96_V0.5960.46
48_T78_T0.5950.46
81_G85_A0.5890.45
7_Q43_L0.5880.45
18_A30_H0.5840.45
7_Q11_L0.5750.44
11_L43_L0.5730.43
91_K130_P0.5700.43
64_A106_V0.5690.43
76_I94_V0.5670.43
25_G95_A0.5660.43
80_V104_V0.5630.42
78_T108_M0.5580.42
41_L128_T0.5550.41
106_V117_M0.5530.41
6_L126_L0.5510.41
37_P116_V0.5510.41
68_G85_A0.5480.41
60_W67_A0.5450.40
12_G83_A0.5440.40
88_T99_A0.5410.40
82_T120_V0.5400.40
9_F12_G0.5400.40
76_I99_A0.5390.40
63_L79_I0.5380.40
54_G74_V0.5370.39
30_H39_V0.5360.39
56_L76_I0.5360.39
58_L61_M0.5350.39
115_S118_S0.5350.39
79_I83_A0.5340.39
58_L102_F0.5300.39
9_F44_G0.5290.39
18_A96_V0.5280.39
116_V131_R0.5260.38
16_F98_V0.5230.38
73_N107_Q0.5230.38
92_P98_V0.5220.38
10_A92_P0.5210.38
38_L49_G0.5210.38
89_G93_D0.5190.38
86_I91_K0.5180.37
52_T82_T0.5140.37
39_V86_I0.5130.37
96_V109_G0.5100.37
15_A107_Q0.5080.36
74_V95_A0.5070.36
21_D59_V0.5060.36
9_F47_H0.5010.36
78_T82_T0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1orqC 4 0.7068 1.5 0.959 Contact Map
3qnqA 2 0.8346 1.5 0.959 Contact Map
4pevA 1 0.2556 1.1 0.963 Contact Map
1jb0M 1 0.2331 1.1 0.963 Contact Map
4lh9A 4 0.2331 1 0.964 Contact Map
4qoyE 1 0.1203 1 0.964 Contact Map
2eq8C 1 0.1128 1 0.964 Contact Map
2eq9C 1 0.1203 1 0.964 Contact Map
1ji6A 1 0.3759 0.9 0.966 Contact Map
4ru1A 2 0.2707 0.8 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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