GREMLIN Database
PTPB2 - N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2
UniProt: P42904 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12764
Length: 157 (151)
Sequences: 1625 (1097)
Seq/√Len: 89.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_N88_D4.4081.00
94_K132_D3.9031.00
67_I95_G2.9331.00
101_R139_E2.8321.00
89_F102_I2.6981.00
124_A128_A2.6111.00
90_L94_K2.6071.00
90_L132_D2.5041.00
64_Q68_D2.4881.00
94_K136_A2.3961.00
83_C89_F2.3531.00
90_L129_A2.2121.00
36_D91_T2.1441.00
114_Q127_I2.1091.00
63_L91_T2.0431.00
139_E150_A1.9831.00
116_I122_V1.9351.00
52_L58_V1.9091.00
93_V133_L1.8971.00
64_Q91_T1.8731.00
83_C92_L1.8681.00
28_A80_L1.8321.00
87_A129_A1.7921.00
5_V78_K1.7681.00
44_Q84_K1.7261.00
27_G78_K1.7101.00
23_V56_I1.6941.00
87_A125_G1.6881.00
114_Q124_A1.6591.00
128_A132_D1.6381.00
35_N84_K1.6121.00
39_A62_T1.5401.00
9_I130_F1.5351.00
132_D135_T1.4610.99
110_A113_K1.4600.99
115_Q121_S1.4390.99
101_R150_A1.4120.99
93_V99_V1.4050.99
42_P45_Q1.3830.99
23_V31_V1.3760.99
104_V130_F1.3730.99
11_E106_N1.3670.99
139_E152_D1.3530.99
9_I104_V1.3450.99
9_I86_P1.3410.99
101_R141_F1.3270.99
7_S89_F1.3190.99
86_P107_M1.3190.99
30_L59_R1.3090.99
106_N119_T1.2970.99
86_P129_A1.2570.98
134_K154_F1.2560.98
5_V26_A1.2420.98
132_D136_A1.2180.98
61_W69_N1.1880.98
123_D126_D1.1880.98
64_Q95_G1.1860.98
143_Q146_P1.1620.97
125_G128_A1.1620.97
11_E108_H1.1390.97
21_Q146_P1.1330.97
41_D44_Q1.1280.97
131_N135_T1.1080.96
134_K140_C1.1040.96
113_K123_D1.0950.96
91_T95_G1.0870.96
86_P130_F1.0680.96
30_L77_Q1.0670.96
143_Q150_A1.0570.95
130_F140_C1.0510.95
21_Q147_T1.0420.95
14_I58_V1.0370.95
91_T94_K1.0330.95
34_A66_V1.0300.95
14_I48_M1.0260.95
65_K68_D1.0220.94
87_A91_T0.9800.93
63_L88_D0.9780.93
104_V142_V0.9660.93
37_E41_D0.9650.93
14_I33_V0.9630.92
7_S99_V0.9440.92
11_E14_I0.9380.91
107_M122_V0.9330.91
90_L136_A0.9320.91
115_Q118_K0.9180.91
7_S83_C0.9170.91
34_A88_D0.9170.91
85_T88_D0.9130.90
69_N72_R0.9060.90
107_M130_F0.9020.90
5_V28_A0.8980.90
67_I71_H0.8930.89
29_N78_K0.8880.89
125_G129_A0.8860.89
61_W72_R0.8840.89
119_T144_G0.8770.88
36_D63_L0.8770.88
7_S81_L0.8730.88
40_E62_T0.8680.88
109_Y112_G0.8500.87
62_T65_K0.8490.87
117_A120_V0.8390.86
19_G23_V0.8330.86
107_M120_V0.8310.86
38_V44_Q0.8280.85
109_Y121_S0.8260.85
68_D71_H0.8120.84
6_L80_L0.8100.84
93_V136_A0.7940.83
46_N50_M0.7940.83
31_V52_L0.7870.82
88_D91_T0.7830.82
32_L69_N0.7810.82
14_I52_L0.7700.81
70_I98_P0.7630.80
108_H113_K0.7630.80
100_N139_E0.7630.80
21_Q25_F0.7520.79
45_Q60_F0.7500.79
36_D62_T0.7430.79
141_F150_A0.7360.78
44_Q48_M0.7360.78
104_V140_C0.7330.78
80_L148_E0.7310.78
24_G55_G0.7240.77
13_L82_V0.7220.77
134_K152_D0.7110.76
113_K126_D0.7110.76
68_D72_R0.7060.75
6_L26_A0.7060.75
130_F153_L0.7040.75
69_N73_A0.6990.74
129_A132_D0.6960.74
70_I92_L0.6940.74
38_V48_M0.6930.74
24_G82_V0.6920.74
29_N77_Q0.6900.73
32_L83_C0.6840.73
47_L52_L0.6730.72
30_L79_I0.6710.71
71_H95_G0.6690.71
43_V47_L0.6660.71
67_I91_T0.6640.71
19_G51_V0.6600.70
118_K148_E0.6590.70
59_R74_A0.6560.70
38_V103_N0.6550.69
36_D88_D0.6520.69
45_Q49_E0.6520.69
120_V142_V0.6510.69
31_V82_V0.6500.69
63_L95_G0.6490.69
61_W65_K0.6470.69
16_G105_G0.6440.68
128_A131_N0.6390.68
49_E58_V0.6380.67
122_V130_F0.6330.67
93_V102_I0.6320.67
59_R69_N0.6200.65
34_A63_L0.6190.65
34_A92_L0.6180.65
49_E60_F0.6170.65
82_V121_S0.6150.65
93_V138_V0.6140.65
64_Q67_I0.6090.64
37_E84_K0.6080.64
98_P136_A0.6070.64
78_K142_V0.6070.64
40_E82_V0.5950.62
102_I138_V0.5890.61
11_E84_K0.5890.61
65_K69_N0.5840.61
113_K121_S0.5830.61
106_N144_G0.5810.60
20_V121_S0.5790.60
122_V154_F0.5790.60
62_T92_L0.5780.60
108_H119_T0.5770.60
14_I28_A0.5760.60
56_I80_L0.5740.59
70_I73_A0.5720.59
24_G28_A0.5700.59
17_Q106_N0.5690.59
81_L89_F0.5660.58
5_V27_G0.5630.58
67_I99_V0.5620.58
37_E42_P0.5620.58
125_G154_F0.5600.57
142_V153_L0.5560.57
82_V153_L0.5550.57
122_V127_I0.5530.57
66_V70_I0.5510.56
18_V23_V0.5470.56
128_A135_T0.5440.55
52_L56_I0.5430.55
9_I30_L0.5420.55
37_E44_Q0.5410.55
19_G53_A0.5400.55
99_V130_F0.5400.55
11_E107_M0.5390.55
25_F147_T0.5370.54
73_A79_I0.5360.54
61_W74_A0.5330.54
24_G27_G0.5320.54
140_C154_F0.5320.54
92_L97_V0.5310.54
64_Q154_F0.5310.54
117_A142_V0.5300.53
30_L75_D0.5270.53
66_V79_I0.5250.53
69_N74_A0.5240.53
104_V153_L0.5210.52
112_G123_D0.5190.52
6_L20_V0.5190.52
143_Q148_E0.5170.52
32_L73_A0.5150.51
30_L66_V0.5130.51
14_I106_N0.5120.51
83_C86_P0.5050.50
33_V82_V0.5040.50
27_G87_A0.5040.50
14_I82_V0.5020.50
19_G48_M0.5020.50
33_V58_V0.5010.49
107_M121_S0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lfjA 1 1 100 0.035 Contact Map
1bleA 3 0.9936 100 0.042 Contact Map
1nrzA 2 0.9936 100 0.047 Contact Map
1vsqC 1 0.9936 100 0.048 Contact Map
3eyeA 1 0.9682 100 0.055 Contact Map
3p3vA 1 0.9936 100 0.061 Contact Map
3co8A 2 0.8344 40.3 0.932 Contact Map
3hl4A 2 0.4968 28.8 0.937 Contact Map
2wk1A 2 0.4713 25.1 0.939 Contact Map
4eclA 2 0.828 17.3 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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