GREMLIN Database
OBG - GTPase ObgE/CgtA
UniProt: P42641 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12795
Length: 390 (333)
Sequences: 3636 (1880)
Seq/√Len: 103.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_E114_R4.4861.00
46_W116_L4.1141.00
263_I278_R3.6501.00
49_A108_M3.6331.00
22_S35_D3.3871.00
179_V211_V3.3321.00
177_R186_V3.0981.00
106_G115_L3.0591.00
38_D129_R2.8481.00
49_A92_V2.8251.00
51_E111_H2.7831.00
98_D150_R2.7591.00
125_L142_T2.7371.00
50_D89_K2.6821.00
242_L328_V2.6491.00
97_I153_L2.5831.00
15_D69_R2.5651.00
48_E89_K2.5391.00
178_A318_G2.5181.00
59_Y88_I2.5061.00
97_I104_T2.4991.00
311_Y327_D2.4881.00
48_E87_T2.4681.00
309_K327_D2.4601.00
74_A78_C2.3931.00
283_N315_A2.3871.00
12_V149_K2.2801.00
47_M96_V2.2701.00
68_E84_K2.2191.00
175_F179_V2.2141.00
122_W145_T2.1971.00
41_D44_D2.1521.00
71_Q74_A2.1341.00
264_S267_E2.0961.00
10_L151_E2.0881.00
109_T113_Q2.0611.00
21_V141_K2.0511.00
77_D128_T2.0501.00
243_H262_I1.9631.00
217_L229_I1.9231.00
68_E83_G1.8971.00
95_R104_T1.8911.00
207_K333_I1.8721.00
69_R72_N1.8611.00
285_I312_L1.8591.00
87_T114_R1.8371.00
289_D292_E1.8011.00
46_W114_R1.7941.00
100_G151_E1.7871.00
11_V152_L1.7781.00
41_D82_R1.7761.00
245_I259_A1.7681.00
11_V45_V1.7601.00
175_F244_L1.7331.00
12_V15_D1.7331.00
15_D18_N1.7311.00
201_V209_F1.7261.00
244_L283_N1.7071.00
264_S268_K1.6921.00
157_M236_E1.6881.00
24_R29_I1.6791.00
44_D85_D1.6571.00
175_F324_L1.6561.00
222_A268_K1.6261.00
135_N140_Q1.6181.00
110_K113_Q1.5751.00
313_I324_L1.5711.00
253_T258_N1.5551.00
298_K302_E1.5391.00
270_S274_A1.5321.00
175_F211_V1.5321.00
281_V324_L1.5221.00
179_V325_C1.5101.00
8_S151_E1.5091.00
12_V66_R1.5001.00
327_D330_T1.4911.00
47_M117_V1.4851.00
98_D101_T1.4601.00
68_E81_K1.4371.00
20_C75_S1.4251.00
165_L241_L1.4221.00
259_A308_D1.4151.00
239_R336_P1.4131.00
252_G258_N1.4041.00
99_Q153_L1.4031.00
13_A118_A1.4001.00
257_E261_I1.3951.00
240_V328_V1.3941.00
10_L149_K1.3791.00
167_M261_I1.3650.99
271_Q274_A1.3600.99
162_V240_V1.3540.99
46_W87_T1.3430.99
59_Y65_F1.3390.99
247_I282_F1.3340.99
254_D257_E1.3330.99
20_C74_A1.3210.99
259_A263_I1.3100.99
256_V260_R1.3050.99
18_N72_N1.3040.99
10_L64_S1.3000.99
164_M211_V1.2980.99
47_M88_I1.2850.99
6_E153_L1.2800.99
44_D116_L1.2760.99
329_M333_I1.2710.99
301_A305_G1.2650.99
13_A148_D1.2580.99
125_L129_R1.2560.99
330_T334_E1.2550.99
128_T131_K1.2510.99
279_W328_V1.2410.99
287_L316_A1.2280.99
267_E274_A1.2190.99
174_T315_A1.2180.99
236_E270_S1.2090.99
44_D119_K1.2020.99
260_R304_L1.2020.99
15_D146_P1.1980.99
240_V331_F1.1840.99
246_D283_N1.1840.99
170_A190_P1.1750.98
311_Y320_G1.1690.98
169_N188_D1.1670.98
6_E230_R1.1610.98
85_D114_R1.1510.98
98_D103_E1.1510.98
323_D327_D1.1390.98
247_I285_I1.1360.98
294_E300_I1.1290.98
322_K326_W1.1280.98
296_K299_A1.1270.98
280_L310_Y1.1160.98
259_A278_R1.1140.98
79_T82_R1.1120.98
155_E233_K1.1000.98
13_A45_V1.0910.98
300_I304_L1.0860.97
320_G323_D1.0850.97
219_E261_I1.0820.97
77_D129_R1.0720.97
288_L293_A1.0690.97
325_C328_V1.0660.97
26_E29_I1.0650.97
248_D287_L1.0650.97
297_A300_I1.0620.97
331_F334_E1.0580.97
8_S99_Q1.0480.97
175_F321_V1.0470.97
301_A304_L1.0430.97
180_S211_V1.0420.97
204_D326_W1.0410.97
65_F86_V1.0400.97
202_R208_S1.0340.97
293_A319_L1.0280.96
165_L235_L1.0270.96
6_E233_K1.0150.96
281_V313_I1.0150.96
97_I102_G1.0150.96
79_T129_R1.0130.96
122_W142_T1.0080.96
142_T145_T1.0070.96
243_H278_R1.0050.96
9_I65_F1.0020.96
239_R332_I1.0000.96
59_Y154_L0.9980.96
119_K148_D0.9880.96
272_D275_T0.9840.95
290_K293_A0.9820.95
167_M253_T0.9800.95
330_T333_I0.9790.95
174_T177_R0.9780.95
282_F312_L0.9730.95
245_I280_L0.9700.95
256_V300_I0.9670.95
43_G67_A0.9590.95
296_K300_I0.9570.95
242_L281_V0.9560.95
105_M152_L0.9550.95
131_K136_R0.9520.95
174_T287_L0.9480.94
47_M115_L0.9480.94
177_R184_P0.9430.94
240_V335_N0.9390.94
299_A303_A0.9390.94
62_E65_F0.9350.94
282_F297_A0.9350.94
47_M90_V0.9340.94
207_K329_M0.9340.94
162_V332_I0.9290.94
203_M326_W0.9270.94
71_Q78_C0.9260.94
279_W327_D0.9240.94
41_D123_H0.9210.94
18_N142_T0.9200.93
257_E260_R0.9080.93
302_E305_G0.9080.93
35_D77_D0.9060.93
95_R157_M0.9060.93
259_A280_L0.8990.93
71_Q81_K0.8980.93
203_M329_M0.8970.93
294_E301_A0.8950.93
230_R233_K0.8950.93
23_F35_D0.8900.92
116_L119_K0.8830.92
204_D207_K0.8780.92
58_D61_F0.8760.92
117_V152_L0.8730.92
11_V118_A0.8700.91
244_L313_I0.8680.91
15_D147_G0.8660.91
11_V150_R0.8660.91
251_D258_N0.8620.91
50_D111_H0.8620.91
285_I293_A0.8610.91
291_V319_L0.8590.91
170_A188_D0.8590.91
98_D105_M0.8590.91
99_Q151_E0.8570.91
285_I319_L0.8560.91
200_V210_V0.8560.91
25_R30_P0.8480.90
283_N316_A0.8480.90
162_V328_V0.8470.90
97_I155_E0.8460.90
167_M258_N0.8460.90
106_G117_V0.8460.90
261_I264_S0.8450.90
8_S153_L0.8430.90
298_K301_A0.8420.90
170_A258_N0.8410.90
49_A112_G0.8410.90
297_A301_A0.8380.90
327_D331_F0.8370.90
335_N338_V0.8350.90
328_V332_I0.8350.90
12_V64_S0.8310.89
209_F332_I0.8240.89
214_I241_L0.8200.89
211_V328_V0.8160.89
72_N75_S0.8140.88
300_I303_A0.8130.88
288_L291_V0.8130.88
163_G241_L0.8100.88
198_L224_G0.8070.88
247_I300_I0.8050.88
53_L58_D0.8010.88
267_E271_Q0.8000.88
240_V277_P0.7980.87
68_E71_Q0.7970.87
130_F142_T0.7960.87
30_P238_C0.7960.87
65_F88_I0.7950.87
18_N143_N0.7910.87
41_D122_W0.7840.87
13_A147_G0.7820.86
294_E297_A0.7820.86
285_I290_K0.7820.86
326_W330_T0.7690.85
223_E268_K0.7670.85
122_W125_L0.7660.85
106_G113_Q0.7650.85
118_A150_R0.7630.85
271_Q275_T0.7620.85
9_I154_L0.7580.85
322_K325_C0.7500.84
11_V117_V0.7490.84
92_V108_M0.7490.84
244_L315_A0.7480.84
133_S136_R0.7420.83
292_E296_K0.7400.83
280_L304_L0.7390.83
214_I235_L0.7370.83
175_F325_C0.7360.83
176_I180_S0.7350.83
24_R30_P0.7340.83
229_I233_K0.7340.83
49_A111_H0.7270.82
314_S317_S0.7220.82
279_W311_Y0.7220.82
295_E299_A0.7220.82
95_R155_E0.7200.82
92_V110_K0.7170.81
118_A148_D0.7170.81
184_P197_S0.7140.81
246_D284_K0.7140.81
260_R300_I0.7120.81
140_Q145_T0.7100.81
176_I197_S0.7080.80
190_P251_D0.7080.80
47_M152_L0.7080.80
280_L308_D0.7050.80
253_T257_E0.7050.80
245_I283_N0.7040.80
298_K312_L0.7040.80
299_A302_E0.7030.80
262_I278_R0.7000.80
204_D322_K0.6990.80
165_L278_R0.6970.79
180_S201_V0.6970.79
311_Y323_D0.6920.79
75_S78_C0.6890.79
22_S75_S0.6860.78
226_G265_E0.6790.78
26_E32_G0.6750.77
281_V312_L0.6720.77
282_F310_Y0.6710.77
243_H263_I0.6700.77
220_G223_E0.6690.77
7_A65_F0.6650.76
282_F294_E0.6650.76
24_R77_D0.6620.76
301_A308_D0.6610.76
45_V67_A0.6610.76
107_D237_R0.6610.76
293_A297_A0.6610.76
108_M115_L0.6600.76
11_V47_M0.6590.75
54_N57_I0.6580.75
41_D145_T0.6580.75
294_E298_K0.6570.75
218_I225_A0.6560.75
332_I336_P0.6530.75
73_G126_G0.6500.74
68_E86_V0.6500.74
240_V332_I0.6480.74
26_E33_G0.6460.74
260_R264_S0.6460.74
20_C35_D0.6450.74
263_I280_L0.6440.74
175_F313_I0.6430.74
217_L243_H0.6410.73
130_F138_P0.6400.73
15_D72_N0.6390.73
228_G265_E0.6350.73
125_L130_F0.6330.73
203_M206_E0.6330.73
235_L262_I0.6310.72
176_I195_V0.6310.72
9_I88_I0.6300.72
169_N214_I0.6250.72
4_V57_I0.6240.71
57_I61_F0.6240.71
305_G308_D0.6140.70
167_M262_I0.6130.70
167_M219_E0.6120.70
64_S151_E0.6120.70
23_F137_T0.6120.70
178_A316_A0.6110.70
25_R32_G0.6100.70
207_K330_T0.6090.70
178_A186_V0.6090.70
13_A146_P0.6080.70
82_R85_D0.6070.69
205_N329_M0.6050.69
255_P258_N0.6030.69
277_P331_F0.6020.69
107_D157_M0.6010.69
174_T186_V0.6010.69
35_D76_R0.6010.69
247_I293_A0.6000.68
179_V321_V0.5990.68
198_L210_V0.5990.68
269_Y277_P0.5990.68
136_R176_I0.5980.68
123_H129_R0.5950.68
318_G321_V0.5950.68
35_D75_S0.5920.67
267_E275_T0.5910.67
23_F139_R0.5900.67
49_A113_Q0.5890.67
180_S321_V0.5890.67
297_A312_L0.5890.67
90_V117_V0.5890.67
163_G174_T0.5880.67
62_E86_V0.5870.67
118_A152_L0.5870.67
332_I335_N0.5860.67
122_W140_Q0.5850.67
13_A150_R0.5840.66
187_A194_L0.5840.66
289_D295_E0.5840.66
108_M113_Q0.5840.66
4_V7_A0.5830.66
288_L292_E0.5810.66
165_L211_V0.5810.66
7_A241_L0.5800.66
328_V331_F0.5790.66
45_V118_A0.5780.66
47_M154_L0.5770.66
18_N141_K0.5760.65
185_K197_S0.5750.65
217_L235_L0.5750.65
33_G138_P0.5750.65
323_D330_T0.5750.65
165_L268_K0.5730.65
331_F335_N0.5720.65
127_N138_P0.5710.65
289_D293_A0.5700.65
11_V194_L0.5700.65
18_N69_R0.5690.64
185_K314_S0.5690.64
229_I270_S0.5680.64
24_R33_G0.5670.64
27_K55_T0.5660.64
71_Q84_K0.5660.64
280_L312_L0.5630.64
48_E112_G0.5630.64
14_G17_G0.5620.63
117_V150_R0.5620.63
31_K137_T0.5620.63
23_F75_S0.5600.63
24_R28_Y0.5590.63
94_T154_L0.5590.63
87_T116_L0.5590.63
248_D251_D0.5590.63
191_F231_F0.5560.63
158_L195_V0.5560.63
49_A107_D0.5550.63
297_A302_E0.5550.63
295_E298_K0.5550.63
115_L118_A0.5520.62
122_W129_R0.5520.62
252_G255_P0.5510.62
177_R187_A0.5500.62
222_A229_I0.5500.62
89_K114_R0.5470.61
36_G126_G0.5470.61
198_L243_H0.5460.61
207_K326_W0.5460.61
203_M209_F0.5450.61
36_G127_N0.5430.61
222_A264_S0.5430.61
178_A315_A0.5420.61
247_I290_K0.5420.61
282_F293_A0.5410.61
77_D82_R0.5400.60
41_D129_R0.5400.60
31_K95_R0.5380.60
258_N262_I0.5370.60
248_D259_A0.5340.60
33_G137_T0.5340.60
95_R233_K0.5330.59
177_R197_S0.5320.59
53_L89_K0.5310.59
289_D296_K0.5310.59
63_K151_E0.5310.59
43_G85_D0.5300.59
30_P35_D0.5300.59
258_N282_F0.5300.59
92_V109_T0.5300.59
247_I310_Y0.5250.58
101_T153_L0.5250.58
57_I159_L0.5250.58
99_Q103_E0.5250.58
131_K134_V0.5240.58
3_F195_V0.5220.58
45_V62_E0.5220.58
100_G153_L0.5220.58
25_R29_I0.5200.58
285_I294_E0.5190.57
35_D74_A0.5190.57
176_I183_K0.5190.57
121_G124_G0.5180.57
233_K269_Y0.5180.57
178_A317_S0.5180.57
41_D85_D0.5180.57
29_I32_G0.5180.57
164_M176_I0.5170.57
164_M209_F0.5170.57
302_E308_D0.5170.57
164_M244_L0.5170.57
58_D89_K0.5160.57
180_S184_P0.5160.57
176_I325_C0.5160.57
21_V140_Q0.5140.57
9_I152_L0.5130.57
177_R316_A0.5130.57
7_A158_L0.5110.56
292_E295_E0.5110.56
194_L227_L0.5110.56
24_R32_G0.5110.56
39_G42_G0.5110.56
136_R316_A0.5100.56
20_C141_K0.5090.56
163_G192_T0.5090.56
7_A59_Y0.5080.56
45_V66_R0.5070.56
278_R308_D0.5070.56
47_M146_P0.5050.55
224_G243_H0.5050.55
12_V69_R0.5040.55
95_R158_L0.5040.55
326_W329_M0.5030.55
334_E338_V0.5030.55
264_S334_E0.5020.55
53_L158_L0.5010.55
49_A109_T0.5010.55
79_T128_T0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4csu9 1 0.8538 100 0.29 Contact Map
1lnzA 1 0.8769 100 0.295 Contact Map
1udxA 1 0.9615 100 0.311 Contact Map
3gehA 2 0.8256 100 0.735 Contact Map
1wxqA 1 0.4615 100 0.742 Contact Map
3geeA 2 0.7949 100 0.745 Contact Map
2dbyA 1 0.5615 100 0.779 Contact Map
2ohfA 1 0.5051 100 0.789 Contact Map
1ni3A 1 0.5615 100 0.791 Contact Map
1jalA 1 0.4949 100 0.791 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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