OBG - ECOLI - GREMLIN Contacts

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OBG - GTPase ObgE/CgtA

UniProt:	P42641	Sequences: MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRELLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGTDPVENARIIISELEKYSQDLATKPRWLVFNKIDLLDKVEAEEKAKAIAEALGWEDKYYLISAASGLGVKDLCWDVMTFIIENPVVQAEEAKQPEKVEFMWDDYHRQQLEEIAEEDDEDWDDDWDEDDEEGVEFIYKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12795
Length:	390 (333)
Sequences:	3636 (1880)
Seq/√Len:	103.0

ECOLI - OBG
BACSU - OBG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
48_E	114_R	4.486	1.00
46_W	116_L	4.114	1.00
263_I	278_R	3.650	1.00
49_A	108_M	3.633	1.00
22_S	35_D	3.387	1.00
179_V	211_V	3.332	1.00
177_R	186_V	3.098	1.00
106_G	115_L	3.059	1.00
38_D	129_R	2.848	1.00
49_A	92_V	2.825	1.00
51_E	111_H	2.783	1.00
98_D	150_R	2.759	1.00
125_L	142_T	2.737	1.00
50_D	89_K	2.682	1.00
242_L	328_V	2.649	1.00
97_I	153_L	2.583	1.00
15_D	69_R	2.565	1.00
48_E	89_K	2.539	1.00
178_A	318_G	2.518	1.00
59_Y	88_I	2.506	1.00
97_I	104_T	2.499	1.00
311_Y	327_D	2.488	1.00
48_E	87_T	2.468	1.00
309_K	327_D	2.460	1.00
74_A	78_C	2.393	1.00
283_N	315_A	2.387	1.00
12_V	149_K	2.280	1.00
47_M	96_V	2.270	1.00
68_E	84_K	2.219	1.00
175_F	179_V	2.214	1.00
122_W	145_T	2.197	1.00
41_D	44_D	2.152	1.00
71_Q	74_A	2.134	1.00
264_S	267_E	2.096	1.00
10_L	151_E	2.088	1.00
109_T	113_Q	2.061	1.00
21_V	141_K	2.051	1.00
77_D	128_T	2.050	1.00
243_H	262_I	1.963	1.00
217_L	229_I	1.923	1.00
68_E	83_G	1.897	1.00
95_R	104_T	1.891	1.00
207_K	333_I	1.872	1.00
69_R	72_N	1.861	1.00
285_I	312_L	1.859	1.00
87_T	114_R	1.837	1.00
289_D	292_E	1.801	1.00
46_W	114_R	1.794	1.00
100_G	151_E	1.787	1.00
11_V	152_L	1.778	1.00
41_D	82_R	1.776	1.00
245_I	259_A	1.768	1.00
11_V	45_V	1.760	1.00
175_F	244_L	1.733	1.00
12_V	15_D	1.733	1.00
15_D	18_N	1.731	1.00
201_V	209_F	1.726	1.00
244_L	283_N	1.707	1.00
264_S	268_K	1.692	1.00
157_M	236_E	1.688	1.00
24_R	29_I	1.679	1.00
44_D	85_D	1.657	1.00
175_F	324_L	1.656	1.00
222_A	268_K	1.626	1.00
135_N	140_Q	1.618	1.00
110_K	113_Q	1.575	1.00
313_I	324_L	1.571	1.00
253_T	258_N	1.555	1.00
298_K	302_E	1.539	1.00
270_S	274_A	1.532	1.00
175_F	211_V	1.532	1.00
281_V	324_L	1.522	1.00
179_V	325_C	1.510	1.00
8_S	151_E	1.509	1.00
12_V	66_R	1.500	1.00
327_D	330_T	1.491	1.00
47_M	117_V	1.485	1.00
98_D	101_T	1.460	1.00
68_E	81_K	1.437	1.00
20_C	75_S	1.425	1.00
165_L	241_L	1.422	1.00
259_A	308_D	1.415	1.00
239_R	336_P	1.413	1.00
252_G	258_N	1.404	1.00
99_Q	153_L	1.403	1.00
13_A	118_A	1.400	1.00
257_E	261_I	1.395	1.00
240_V	328_V	1.394	1.00
10_L	149_K	1.379	1.00
167_M	261_I	1.365	0.99
271_Q	274_A	1.360	0.99
162_V	240_V	1.354	0.99
46_W	87_T	1.343	0.99
59_Y	65_F	1.339	0.99
247_I	282_F	1.334	0.99
254_D	257_E	1.333	0.99
20_C	74_A	1.321	0.99
259_A	263_I	1.310	0.99
256_V	260_R	1.305	0.99
18_N	72_N	1.304	0.99
10_L	64_S	1.300	0.99
164_M	211_V	1.298	0.99
47_M	88_I	1.285	0.99
6_E	153_L	1.280	0.99
44_D	116_L	1.276	0.99
329_M	333_I	1.271	0.99
301_A	305_G	1.265	0.99
13_A	148_D	1.258	0.99
125_L	129_R	1.256	0.99
330_T	334_E	1.255	0.99
128_T	131_K	1.251	0.99
279_W	328_V	1.241	0.99
287_L	316_A	1.228	0.99
267_E	274_A	1.219	0.99
174_T	315_A	1.218	0.99
236_E	270_S	1.209	0.99
44_D	119_K	1.202	0.99
260_R	304_L	1.202	0.99
15_D	146_P	1.198	0.99
240_V	331_F	1.184	0.99
246_D	283_N	1.184	0.99
170_A	190_P	1.175	0.98
311_Y	320_G	1.169	0.98
169_N	188_D	1.167	0.98
6_E	230_R	1.161	0.98
85_D	114_R	1.151	0.98
98_D	103_E	1.151	0.98
323_D	327_D	1.139	0.98
247_I	285_I	1.136	0.98
294_E	300_I	1.129	0.98
322_K	326_W	1.128	0.98
296_K	299_A	1.127	0.98
280_L	310_Y	1.116	0.98
259_A	278_R	1.114	0.98
79_T	82_R	1.112	0.98
155_E	233_K	1.100	0.98
13_A	45_V	1.091	0.98
300_I	304_L	1.086	0.97
320_G	323_D	1.085	0.97
219_E	261_I	1.082	0.97
77_D	129_R	1.072	0.97
288_L	293_A	1.069	0.97
325_C	328_V	1.066	0.97
26_E	29_I	1.065	0.97
248_D	287_L	1.065	0.97
297_A	300_I	1.062	0.97
331_F	334_E	1.058	0.97
8_S	99_Q	1.048	0.97
175_F	321_V	1.047	0.97
301_A	304_L	1.043	0.97
180_S	211_V	1.042	0.97
204_D	326_W	1.041	0.97
65_F	86_V	1.040	0.97
202_R	208_S	1.034	0.97
293_A	319_L	1.028	0.96
165_L	235_L	1.027	0.96
6_E	233_K	1.015	0.96
281_V	313_I	1.015	0.96
97_I	102_G	1.015	0.96
79_T	129_R	1.013	0.96
122_W	142_T	1.008	0.96
142_T	145_T	1.007	0.96
243_H	278_R	1.005	0.96
9_I	65_F	1.002	0.96
239_R	332_I	1.000	0.96
59_Y	154_L	0.998	0.96
119_K	148_D	0.988	0.96
272_D	275_T	0.984	0.95
290_K	293_A	0.982	0.95
167_M	253_T	0.980	0.95
330_T	333_I	0.979	0.95
174_T	177_R	0.978	0.95
282_F	312_L	0.973	0.95
245_I	280_L	0.970	0.95
256_V	300_I	0.967	0.95
43_G	67_A	0.959	0.95
296_K	300_I	0.957	0.95
242_L	281_V	0.956	0.95
105_M	152_L	0.955	0.95
131_K	136_R	0.952	0.95
174_T	287_L	0.948	0.94
47_M	115_L	0.948	0.94
177_R	184_P	0.943	0.94
240_V	335_N	0.939	0.94
299_A	303_A	0.939	0.94
62_E	65_F	0.935	0.94
282_F	297_A	0.935	0.94
47_M	90_V	0.934	0.94
207_K	329_M	0.934	0.94
162_V	332_I	0.929	0.94
203_M	326_W	0.927	0.94
71_Q	78_C	0.926	0.94
279_W	327_D	0.924	0.94
41_D	123_H	0.921	0.94
18_N	142_T	0.920	0.93
257_E	260_R	0.908	0.93
302_E	305_G	0.908	0.93
35_D	77_D	0.906	0.93
95_R	157_M	0.906	0.93
259_A	280_L	0.899	0.93
71_Q	81_K	0.898	0.93
203_M	329_M	0.897	0.93
294_E	301_A	0.895	0.93
230_R	233_K	0.895	0.93
23_F	35_D	0.890	0.92
116_L	119_K	0.883	0.92
204_D	207_K	0.878	0.92
58_D	61_F	0.876	0.92
117_V	152_L	0.873	0.92
11_V	118_A	0.870	0.91
244_L	313_I	0.868	0.91
15_D	147_G	0.866	0.91
11_V	150_R	0.866	0.91
251_D	258_N	0.862	0.91
50_D	111_H	0.862	0.91
285_I	293_A	0.861	0.91
291_V	319_L	0.859	0.91
170_A	188_D	0.859	0.91
98_D	105_M	0.859	0.91
99_Q	151_E	0.857	0.91
285_I	319_L	0.856	0.91
200_V	210_V	0.856	0.91
25_R	30_P	0.848	0.90
283_N	316_A	0.848	0.90
162_V	328_V	0.847	0.90
97_I	155_E	0.846	0.90
167_M	258_N	0.846	0.90
106_G	117_V	0.846	0.90
261_I	264_S	0.845	0.90
8_S	153_L	0.843	0.90
298_K	301_A	0.842	0.90
170_A	258_N	0.841	0.90
49_A	112_G	0.841	0.90
297_A	301_A	0.838	0.90
327_D	331_F	0.837	0.90
335_N	338_V	0.835	0.90
328_V	332_I	0.835	0.90
12_V	64_S	0.831	0.89
209_F	332_I	0.824	0.89
214_I	241_L	0.820	0.89
211_V	328_V	0.816	0.89
72_N	75_S	0.814	0.88
300_I	303_A	0.813	0.88
288_L	291_V	0.813	0.88
163_G	241_L	0.810	0.88
198_L	224_G	0.807	0.88
247_I	300_I	0.805	0.88
53_L	58_D	0.801	0.88
267_E	271_Q	0.800	0.88
240_V	277_P	0.798	0.87
68_E	71_Q	0.797	0.87
130_F	142_T	0.796	0.87
30_P	238_C	0.796	0.87
65_F	88_I	0.795	0.87
18_N	143_N	0.791	0.87
41_D	122_W	0.784	0.87
13_A	147_G	0.782	0.86
294_E	297_A	0.782	0.86
285_I	290_K	0.782	0.86
326_W	330_T	0.769	0.85
223_E	268_K	0.767	0.85
122_W	125_L	0.766	0.85
106_G	113_Q	0.765	0.85
118_A	150_R	0.763	0.85
271_Q	275_T	0.762	0.85
9_I	154_L	0.758	0.85
322_K	325_C	0.750	0.84
11_V	117_V	0.749	0.84
92_V	108_M	0.749	0.84
244_L	315_A	0.748	0.84
133_S	136_R	0.742	0.83
292_E	296_K	0.740	0.83
280_L	304_L	0.739	0.83
214_I	235_L	0.737	0.83
175_F	325_C	0.736	0.83
176_I	180_S	0.735	0.83
24_R	30_P	0.734	0.83
229_I	233_K	0.734	0.83
49_A	111_H	0.727	0.82
314_S	317_S	0.722	0.82
279_W	311_Y	0.722	0.82
295_E	299_A	0.722	0.82
95_R	155_E	0.720	0.82
92_V	110_K	0.717	0.81
118_A	148_D	0.717	0.81
184_P	197_S	0.714	0.81
246_D	284_K	0.714	0.81
260_R	300_I	0.712	0.81
140_Q	145_T	0.710	0.81
176_I	197_S	0.708	0.80
190_P	251_D	0.708	0.80
47_M	152_L	0.708	0.80
280_L	308_D	0.705	0.80
253_T	257_E	0.705	0.80
245_I	283_N	0.704	0.80
298_K	312_L	0.704	0.80
299_A	302_E	0.703	0.80
262_I	278_R	0.700	0.80
204_D	322_K	0.699	0.80
165_L	278_R	0.697	0.79
180_S	201_V	0.697	0.79
311_Y	323_D	0.692	0.79
75_S	78_C	0.689	0.79
22_S	75_S	0.686	0.78
226_G	265_E	0.679	0.78
26_E	32_G	0.675	0.77
281_V	312_L	0.672	0.77
282_F	310_Y	0.671	0.77
243_H	263_I	0.670	0.77
220_G	223_E	0.669	0.77
7_A	65_F	0.665	0.76
282_F	294_E	0.665	0.76
24_R	77_D	0.662	0.76
301_A	308_D	0.661	0.76
45_V	67_A	0.661	0.76
107_D	237_R	0.661	0.76
293_A	297_A	0.661	0.76
108_M	115_L	0.660	0.76
11_V	47_M	0.659	0.75
54_N	57_I	0.658	0.75
41_D	145_T	0.658	0.75
294_E	298_K	0.657	0.75
218_I	225_A	0.656	0.75
332_I	336_P	0.653	0.75
73_G	126_G	0.650	0.74
68_E	86_V	0.650	0.74
240_V	332_I	0.648	0.74
26_E	33_G	0.646	0.74
260_R	264_S	0.646	0.74
20_C	35_D	0.645	0.74
263_I	280_L	0.644	0.74
175_F	313_I	0.643	0.74
217_L	243_H	0.641	0.73
130_F	138_P	0.640	0.73
15_D	72_N	0.639	0.73
228_G	265_E	0.635	0.73
125_L	130_F	0.633	0.73
203_M	206_E	0.633	0.73
235_L	262_I	0.631	0.72
176_I	195_V	0.631	0.72
9_I	88_I	0.630	0.72
169_N	214_I	0.625	0.72
4_V	57_I	0.624	0.71
57_I	61_F	0.624	0.71
305_G	308_D	0.614	0.70
167_M	262_I	0.613	0.70
167_M	219_E	0.612	0.70
64_S	151_E	0.612	0.70
23_F	137_T	0.612	0.70
178_A	316_A	0.611	0.70
25_R	32_G	0.610	0.70
207_K	330_T	0.609	0.70
178_A	186_V	0.609	0.70
13_A	146_P	0.608	0.70
82_R	85_D	0.607	0.69
205_N	329_M	0.605	0.69
255_P	258_N	0.603	0.69
277_P	331_F	0.602	0.69
107_D	157_M	0.601	0.69
174_T	186_V	0.601	0.69
35_D	76_R	0.601	0.69
247_I	293_A	0.600	0.68
179_V	321_V	0.599	0.68
198_L	210_V	0.599	0.68
269_Y	277_P	0.599	0.68
136_R	176_I	0.598	0.68
123_H	129_R	0.595	0.68
318_G	321_V	0.595	0.68
35_D	75_S	0.592	0.67
267_E	275_T	0.591	0.67
23_F	139_R	0.590	0.67
49_A	113_Q	0.589	0.67
180_S	321_V	0.589	0.67
297_A	312_L	0.589	0.67
90_V	117_V	0.589	0.67
163_G	174_T	0.588	0.67
62_E	86_V	0.587	0.67
118_A	152_L	0.587	0.67
332_I	335_N	0.586	0.67
122_W	140_Q	0.585	0.67
13_A	150_R	0.584	0.66
187_A	194_L	0.584	0.66
289_D	295_E	0.584	0.66
108_M	113_Q	0.584	0.66
4_V	7_A	0.583	0.66
288_L	292_E	0.581	0.66
165_L	211_V	0.581	0.66
7_A	241_L	0.580	0.66
328_V	331_F	0.579	0.66
45_V	118_A	0.578	0.66
47_M	154_L	0.577	0.66
18_N	141_K	0.576	0.65
185_K	197_S	0.575	0.65
217_L	235_L	0.575	0.65
33_G	138_P	0.575	0.65
323_D	330_T	0.575	0.65
165_L	268_K	0.573	0.65
331_F	335_N	0.572	0.65
127_N	138_P	0.571	0.65
289_D	293_A	0.570	0.65
11_V	194_L	0.570	0.65
18_N	69_R	0.569	0.64
185_K	314_S	0.569	0.64
229_I	270_S	0.568	0.64
24_R	33_G	0.567	0.64
27_K	55_T	0.566	0.64
71_Q	84_K	0.566	0.64
280_L	312_L	0.563	0.64
48_E	112_G	0.563	0.64
14_G	17_G	0.562	0.63
117_V	150_R	0.562	0.63
31_K	137_T	0.562	0.63
23_F	75_S	0.560	0.63
24_R	28_Y	0.559	0.63
94_T	154_L	0.559	0.63
87_T	116_L	0.559	0.63
248_D	251_D	0.559	0.63
191_F	231_F	0.556	0.63
158_L	195_V	0.556	0.63
49_A	107_D	0.555	0.63
297_A	302_E	0.555	0.63
295_E	298_K	0.555	0.63
115_L	118_A	0.552	0.62
122_W	129_R	0.552	0.62
252_G	255_P	0.551	0.62
177_R	187_A	0.550	0.62
222_A	229_I	0.550	0.62
89_K	114_R	0.547	0.61
36_G	126_G	0.547	0.61
198_L	243_H	0.546	0.61
207_K	326_W	0.546	0.61
203_M	209_F	0.545	0.61
36_G	127_N	0.543	0.61
222_A	264_S	0.543	0.61
178_A	315_A	0.542	0.61
247_I	290_K	0.542	0.61
282_F	293_A	0.541	0.61
77_D	82_R	0.540	0.60
41_D	129_R	0.540	0.60
31_K	95_R	0.538	0.60
258_N	262_I	0.537	0.60
248_D	259_A	0.534	0.60
33_G	137_T	0.534	0.60
95_R	233_K	0.533	0.59
177_R	197_S	0.532	0.59
53_L	89_K	0.531	0.59
289_D	296_K	0.531	0.59
63_K	151_E	0.531	0.59
43_G	85_D	0.530	0.59
30_P	35_D	0.530	0.59
258_N	282_F	0.530	0.59
92_V	109_T	0.530	0.59
247_I	310_Y	0.525	0.58
101_T	153_L	0.525	0.58
57_I	159_L	0.525	0.58
99_Q	103_E	0.525	0.58
131_K	134_V	0.524	0.58
3_F	195_V	0.522	0.58
45_V	62_E	0.522	0.58
100_G	153_L	0.522	0.58
25_R	29_I	0.520	0.58
285_I	294_E	0.519	0.57
35_D	74_A	0.519	0.57
176_I	183_K	0.519	0.57
121_G	124_G	0.518	0.57
233_K	269_Y	0.518	0.57
178_A	317_S	0.518	0.57
41_D	85_D	0.518	0.57
29_I	32_G	0.518	0.57
164_M	176_I	0.517	0.57
164_M	209_F	0.517	0.57
302_E	308_D	0.517	0.57
164_M	244_L	0.517	0.57
58_D	89_K	0.516	0.57
180_S	184_P	0.516	0.57
176_I	325_C	0.516	0.57
21_V	140_Q	0.514	0.57
9_I	152_L	0.513	0.57
177_R	316_A	0.513	0.57
7_A	158_L	0.511	0.56
292_E	295_E	0.511	0.56
194_L	227_L	0.511	0.56
24_R	32_G	0.511	0.56
39_G	42_G	0.511	0.56
136_R	316_A	0.510	0.56
20_C	141_K	0.509	0.56
163_G	192_T	0.509	0.56
7_A	59_Y	0.508	0.56
45_V	66_R	0.507	0.56
278_R	308_D	0.507	0.56
47_M	146_P	0.505	0.55
224_G	243_H	0.505	0.55
12_V	69_R	0.504	0.55
95_R	158_L	0.504	0.55
326_W	329_M	0.503	0.55
334_E	338_V	0.503	0.55
264_S	334_E	0.502	0.55
53_L	158_L	0.501	0.55
49_A	109_T	0.501	0.55
79_T	128_T	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4csu9	1	0.8538	100	0.29	Contact Map
1lnzA	1	0.8769	100	0.295	Contact Map
1udxA	1	0.9615	100	0.311	Contact Map
3gehA	2	0.8256	100	0.735	Contact Map
1wxqA	1	0.4615	100	0.742	Contact Map
3geeA	2	0.7949	100	0.745	Contact Map
2dbyA	1	0.5615	100	0.779	Contact Map
2ohfA	1	0.5051	100	0.789	Contact Map
1ni3A	1	0.5615	100	0.791	Contact Map
1jalA	1	0.4949	100	0.791	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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