GREMLIN Database
TDCG - L-serine dehydratase TdcG
UniProt: P42630 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12756
Length: 454 (449)
Sequences: 1766 (991)
Seq/√Len: 46.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_A313_A4.6271.00
189_S356_E4.1841.00
373_M424_V4.1321.00
264_I404_V3.9931.00
220_I298_A3.9321.00
197_L202_K3.7081.00
426_E430_E3.5871.00
265_N405_N3.5681.00
128_R142_T3.5131.00
71_A86_F3.2551.00
314_R356_E3.2371.00
180_M184_N3.1411.00
44_H112_N3.1101.00
197_L205_I3.0841.00
355_T360_G3.0231.00
300_Y311_S2.9941.00
182_D363_A2.9181.00
201_S204_E2.8851.00
355_T407_A2.8271.00
326_Y348_S2.8161.00
194_H197_L2.8121.00
180_M191_L2.7631.00
244_R248_V2.7101.00
122_R144_Y2.7101.00
337_V341_G2.7021.00
325_L425_I2.6791.00
193_M206_D2.6561.00
34_E102_A2.5521.00
67_I90_V2.5461.00
347_C372_A2.5401.00
91_T109_V2.5351.00
209_F316_F2.5291.00
94_G108_P2.5001.00
95_R104_I2.4531.00
241_V245_R2.4301.00
179_K183_Y2.4211.00
108_P111_K2.3431.00
326_Y345_V2.2451.00
210_A309_E2.2451.00
44_H132_W2.2171.00
206_D313_A2.1941.00
130_T140_S2.1931.00
189_S314_R2.1811.00
74_S77_D2.1801.00
71_A90_V2.1131.00
48_D116_H2.1111.00
10_I211_R2.1011.00
181_C362_P2.0941.00
4_A320_G2.0691.00
227_E245_R2.0581.00
202_K206_D2.0521.00
9_K24_N2.0190.99
4_A209_F2.0110.99
120_L126_G1.9960.99
67_I113_I1.9740.99
322_I352_A1.9200.99
229_V235_N1.9030.99
27_K31_D1.9030.99
233_P387_Q1.8850.99
89_L93_S1.8670.99
48_D130_T1.8660.99
133_K136_E1.8460.99
49_L66_I1.8390.99
130_T138_L1.8300.99
206_D210_A1.8260.99
309_E313_A1.8180.99
8_F319_A1.8070.99
28_S151_I1.8040.99
206_D309_E1.7880.99
356_E365_V1.7790.99
133_K137_E1.7650.98
419_V451_V1.7610.98
5_F208_G1.7470.98
334_G397_A1.7330.98
362_P365_V1.7310.98
169_Y194_H1.7290.98
347_C376_N1.7160.98
177_L191_L1.7160.98
326_Y373_M1.7120.98
203_A207_A1.7030.98
63_D115_F1.6980.98
45_I98_V1.6940.98
9_K76_Q1.6930.98
434_D439_Y1.6660.98
38_L41_A1.6630.98
186_L191_L1.6600.98
43_S133_K1.6480.98
360_G411_M1.6450.98
190_G194_H1.6340.97
307_V311_S1.6280.97
141_K153_E1.5970.97
43_S136_E1.5730.97
40_T103_H1.5690.97
172_H328_M1.5610.97
426_E429_Y1.5560.97
421_L425_I1.5410.96
361_S364_Q1.5400.96
345_V399_N1.5370.96
176_E179_K1.5320.96
217_H298_A1.5310.96
142_T154_E1.5290.96
81_D222_R1.5280.96
413_R417_P1.5280.96
267_Y303_F1.5220.96
5_F205_I1.5210.96
32_R141_K1.5110.96
192_M324_A1.5070.96
318_A356_E1.5070.96
367_N413_R1.4940.96
348_S373_M1.4840.96
237_P416_A1.4830.96
310_R314_R1.4800.95
308_N311_S1.4780.95
200_R204_E1.4610.95
181_C191_L1.4570.95
33_L131_A1.4530.95
67_I109_V1.4500.95
193_M202_K1.4470.95
256_D408_R1.4430.95
67_I71_A1.4410.95
430_E433_K1.4400.95
206_D310_R1.4400.95
172_H176_E1.4390.95
218_D222_R1.4330.95
429_Y433_K1.4210.94
169_Y184_N1.4200.94
217_H220_I1.4100.94
73_N86_F1.4090.94
331_S341_G1.4070.94
311_S357_L1.4060.94
201_S205_I1.4050.94
39_L103_H1.3930.94
27_K74_S1.3760.93
193_M205_I1.3760.93
97_P104_I1.3490.93
180_M183_Y1.3470.93
222_R274_E1.3410.92
88_E92_R1.3380.92
213_W312_I1.3370.92
200_R208_G1.3360.92
10_I215_V1.3290.92
390_I418_R1.3280.92
376_N379_L1.3220.92
367_N417_P1.3220.92
119_M124_E1.3170.92
43_S134_G1.3120.92
99_A102_A1.3100.91
366_C417_P1.3070.91
171_F192_M1.2970.91
187_S190_G1.2930.91
300_Y307_V1.2820.91
426_E450_K1.2810.91
398_I405_N1.2810.91
95_R106_D1.2780.90
26_G129_I1.2670.90
73_N82_E1.2640.90
211_R215_V1.2610.90
136_E139_L1.2600.90
46_V130_T1.2530.90
66_I127_M1.2500.89
122_R157_F1.2490.89
178_L362_P1.2460.89
108_P112_N1.2420.89
224_M266_M1.2380.89
401_V405_N1.2320.89
34_E99_A1.2290.89
322_I353_G1.2190.88
86_F90_V1.2100.88
292_I334_G1.2000.87
214_Q218_D1.1810.87
345_V348_S1.1800.86
367_N415_S1.1770.86
246_Q412_R1.1560.85
64_V84_P1.1530.85
170_D180_M1.1510.85
208_G212_I1.1410.85
265_N398_I1.1380.84
334_G343_I1.1280.84
310_R313_A1.1230.84
46_V114_I1.1210.84
58_K63_D1.1080.83
331_S337_V1.1080.83
184_N191_L1.1030.83
202_K205_I1.1000.82
186_L194_H1.0990.82
221_E225_N1.0960.82
245_R248_V1.0950.82
50_Y126_G1.0940.82
200_R205_I1.0850.81
261_I401_V1.0770.81
173_S176_E1.0750.81
82_E86_F1.0740.81
292_I379_L1.0700.81
197_L201_S1.0650.80
267_Y302_K1.0580.80
132_W138_L1.0530.79
262_D408_R1.0500.79
122_R154_E1.0490.79
217_H221_E1.0470.79
127_M451_V1.0460.79
28_S156_H1.0450.79
58_K115_F1.0450.79
437_D444_R1.0440.79
219_G281_V1.0410.79
96_L107_F1.0370.78
298_A302_K1.0250.78
292_I400_A1.0240.78
187_S356_E1.0230.77
94_G109_V1.0220.77
54_S62_T1.0200.77
126_G129_I1.0150.77
5_F212_I1.0130.77
301_D312_I1.0040.76
226_T241_V0.9980.76
133_K138_L0.9960.76
331_S432_G0.9940.75
190_G314_R0.9940.75
42_T131_A0.9940.75
427_T434_D0.9930.75
360_G364_Q0.9910.75
175_G179_K0.9900.75
427_T447_L0.9840.75
341_G405_N0.9820.75
76_Q211_R0.9790.74
326_Y353_G0.9780.74
170_D195_N0.9770.74
55_L345_V0.9750.74
68_M83_I0.9720.74
250_S412_R0.9720.74
24_N76_Q0.9600.73
269_L397_A0.9600.73
318_A322_I0.9600.73
171_F321_A0.9580.73
46_V132_W0.9580.73
423_K452_V0.9560.72
133_K139_L0.9550.72
214_Q309_E0.9510.72
66_I113_I0.9490.72
262_D412_R0.9480.72
10_I212_I0.9440.72
264_I401_V0.9430.71
324_A372_A0.9370.71
430_E450_K0.9320.71
247_L263_W0.9320.71
347_C399_N0.9300.70
160_S163_V0.9250.70
263_W303_F0.9230.70
41_A133_K0.9230.70
345_V372_A0.9220.70
324_A328_M0.9220.70
213_W217_H0.9210.70
299_Y303_F0.9200.70
198_A205_I0.9160.69
38_L42_T0.9150.69
30_I99_A0.9140.69
54_S117_P0.9130.69
79_V82_E0.9130.69
128_R140_S0.9120.69
31_D99_A0.9110.69
86_F89_L0.9090.69
39_L98_V0.9080.69
337_V432_G0.8990.68
170_D173_S0.8970.68
40_T102_A0.8960.68
134_G137_E0.8940.67
193_M197_L0.8940.67
62_T168_P0.8890.67
168_P195_N0.8890.67
311_S314_R0.8850.67
265_N397_A0.8800.66
2_I6_D0.8780.66
55_L444_R0.8740.66
210_A310_R0.8690.65
42_T98_V0.8690.65
153_E157_F0.8660.65
13_G17_S0.8650.65
31_D34_E0.8600.64
334_G337_V0.8590.64
116_H119_M0.8560.64
141_K155_E0.8550.64
97_P102_A0.8540.64
154_E158_G0.8530.64
229_V233_P0.8500.63
20_V24_N0.8500.63
39_L42_T0.8490.63
168_P198_A0.8430.63
62_T115_F0.8430.63
153_E156_H0.8430.63
345_V373_M0.8420.63
188_I318_A0.8330.62
222_R226_T0.8260.61
379_L398_I0.8250.61
176_E183_Y0.8250.61
82_E89_L0.8220.61
224_M244_R0.8140.60
300_Y304_R0.8130.60
109_V113_I0.8070.59
366_C415_S0.8030.59
87_I91_T0.8030.59
199_L205_I0.8020.59
89_L92_R0.7940.58
208_G211_R0.7940.58
292_I343_I0.7920.58
48_D114_I0.7910.58
177_L321_A0.7900.58
209_F320_G0.7890.58
120_L142_T0.7870.57
47_V129_I0.7860.57
211_R214_Q0.7850.57
348_S424_V0.7800.57
207_A211_R0.7770.56
331_S334_G0.7720.56
301_D307_V0.7690.56
150_F327_K0.7670.55
251_D259_N0.7670.55
187_S314_R0.7650.55
256_D264_I0.7650.55
12_I68_M0.7620.55
37_G40_T0.7600.55
13_G18_H0.7590.55
227_E241_V0.7580.55
9_K20_V0.7530.54
39_L99_A0.7530.54
82_E85_A0.7530.54
221_E298_A0.7520.54
81_D84_P0.7520.54
384_V419_V0.7520.54
28_S32_R0.7490.54
31_D35_S0.7450.53
169_Y180_M0.7440.53
84_P87_I0.7430.53
366_C413_R0.7410.53
64_V443_S0.7400.53
56_T59_G0.7390.53
167_V199_L0.7370.53
257_P262_D0.7360.52
120_L144_Y0.7350.52
189_S318_A0.7350.52
96_L105_V0.7330.52
180_M185_G0.7310.52
169_Y195_N0.7310.52
48_D64_V0.7310.52
49_L113_I0.7290.52
300_Y357_L0.7280.52
426_E433_K0.7270.52
94_G106_D0.7160.50
160_S165_T0.7140.50
152_V157_F0.7080.50
256_D259_N0.7080.50
71_A89_L0.7080.50
341_G432_G0.7060.49
78_V83_I0.7060.49
226_T277_A0.7040.49
372_A409_M0.7040.49
258_M408_R0.7030.49
364_Q371_I0.7020.49
251_D254_S0.7010.49
264_I405_N0.7000.49
141_K151_I0.7000.49
93_S104_I0.6960.48
193_M313_A0.6900.48
220_I301_D0.6880.48
301_D311_S0.6880.48
204_E208_G0.6880.48
13_G16_S0.6860.47
64_V334_G0.6840.47
84_P88_E0.6830.47
111_K175_G0.6800.47
168_P199_L0.6790.47
193_M310_R0.6780.47
2_I328_M0.6780.47
88_E91_T0.6760.46
243_L267_Y0.6740.46
318_A352_A0.6740.46
39_L102_A0.6740.46
14_P17_S0.6730.46
221_E302_K0.6720.46
50_Y116_H0.6700.46
420_S424_V0.6700.46
251_D255_N0.6700.46
258_M329_N0.6700.46
304_R358_L0.6690.46
267_Y329_N0.6680.46
87_I109_V0.6650.45
63_D113_I0.6630.45
221_E244_R0.6620.45
14_P18_H0.6610.45
124_E144_Y0.6600.45
293_I319_A0.6590.45
45_I122_R0.6590.45
98_V105_V0.6580.45
409_M418_R0.6560.45
356_E362_P0.6560.45
242_A246_Q0.6550.44
292_I397_A0.6550.44
345_V429_Y0.6550.44
435_M440_R0.6540.44
265_N401_V0.6520.44
329_N334_G0.6520.44
355_T409_M0.6500.44
192_M321_A0.6490.44
13_G19_T0.6480.44
66_I124_E0.6460.44
320_G324_A0.6460.44
71_A97_P0.6440.43
58_K423_K0.6410.43
262_D376_N0.6400.43
10_I281_V0.6380.43
348_S376_N0.6370.43
337_V405_N0.6370.43
63_D405_N0.6370.43
28_S143_Y0.6370.43
173_S329_N0.6350.42
43_S137_E0.6350.42
315_Y357_L0.6340.42
301_D308_N0.6340.42
26_G66_I0.6340.42
93_S106_D0.6340.42
325_L329_N0.6320.42
68_M402_K0.6310.42
124_E440_R0.6310.42
23_M336_E0.6300.42
266_M269_L0.6290.42
357_L362_P0.6280.42
184_N194_H0.6260.42
326_Y425_I0.6260.42
345_V424_V0.6250.41
304_R311_S0.6240.41
427_T439_Y0.6230.41
317_L397_A0.6220.41
153_E376_N0.6220.41
243_L401_V0.6220.41
278_G336_E0.6220.41
385_A390_I0.6220.41
193_M314_R0.6210.41
85_A89_L0.6200.41
221_E224_M0.6190.41
80_I222_R0.6180.41
413_R440_R0.6170.41
58_K61_A0.6170.41
45_I103_H0.6170.41
61_A443_S0.6150.41
336_E346_A0.6130.40
55_L117_P0.6120.40
201_S207_A0.6110.40
67_I86_F0.6110.40
367_N427_T0.6090.40
237_P414_T0.6090.40
191_L361_S0.6070.40
334_G432_G0.6060.40
129_I142_T0.6060.40
237_P242_A0.6050.40
337_V397_A0.6050.40
427_T450_K0.6050.40
256_D304_R0.6040.39
43_S106_D0.6040.39
353_G365_V0.6040.39
32_R36_S0.6030.39
326_Y424_V0.6030.39
76_Q451_V0.6030.39
364_Q411_M0.6020.39
14_P19_T0.6020.39
68_M84_P0.6020.39
44_H111_K0.6020.39
142_T174_A0.6010.39
326_Y352_A0.6000.39
257_P408_R0.6000.39
43_S139_L0.5990.39
77_D80_I0.5980.39
418_R423_K0.5970.39
261_I398_I0.5960.39
207_A210_A0.5960.39
154_E157_F0.5950.39
181_C405_N0.5950.39
186_L242_A0.5950.39
201_S208_G0.5940.39
215_V219_G0.5920.38
46_V50_Y0.5910.38
376_N398_I0.5900.38
110_A114_I0.5900.38
45_I96_L0.5890.38
94_G110_A0.5890.38
105_V112_N0.5880.38
217_H302_K0.5870.38
312_I316_F0.5860.38
306_P311_S0.5860.38
24_N28_S0.5850.38
12_I83_I0.5840.38
30_I38_L0.5840.38
265_N341_G0.5840.38
47_V67_I0.5830.38
31_D211_R0.5830.38
43_S186_L0.5830.38
33_L42_T0.5830.38
409_M425_I0.5820.37
35_S229_V0.5800.37
126_G142_T0.5800.37
167_V198_A0.5800.37
116_H355_T0.5800.37
46_V140_S0.5780.37
252_N259_N0.5780.37
419_V427_T0.5780.37
343_I346_A0.5770.37
304_R357_L0.5760.37
372_A376_N0.5760.37
91_T113_I0.5760.37
405_N437_D0.5750.37
41_A92_R0.5740.37
92_R182_D0.5740.37
109_V112_N0.5740.37
300_Y354_L0.5740.37
106_D242_A0.5730.37
186_L363_A0.5710.36
83_I87_I0.5710.36
2_I205_I0.5700.36
15_S18_H0.5700.36
134_G139_L0.5690.36
42_T139_L0.5690.36
11_G22_P0.5680.36
267_Y357_L0.5660.36
300_Y347_C0.5660.36
261_I345_V0.5650.36
213_W301_D0.5640.36
88_E93_S0.5640.36
219_G272_S0.5630.36
10_I218_D0.5630.36
438_K445_G0.5610.35
345_V405_N0.5610.35
137_E305_R0.5610.35
26_G47_V0.5610.35
126_G144_Y0.5600.35
346_A432_G0.5600.35
29_F131_A0.5600.35
215_V313_A0.5600.35
423_K430_E0.5570.35
54_S66_I0.5560.35
434_D438_K0.5540.35
124_E348_S0.5540.35
35_S40_T0.5530.35
224_M443_S0.5530.35
214_Q237_P0.5530.35
77_D215_V0.5520.35
287_N327_K0.5510.35
104_I111_K0.5510.35
374_E394_E0.5510.35
266_M387_Q0.5510.35
186_L235_N0.5500.35
175_G180_M0.5500.35
208_G290_C0.5500.35
222_R279_G0.5490.34
117_P399_N0.5480.34
54_S63_D0.5480.34
322_I355_T0.5480.34
420_S423_K0.5480.34
15_S21_G0.5480.34
102_A129_I0.5480.34
76_Q222_R0.5480.34
46_V112_N0.5470.34
387_Q440_R0.5460.34
186_L190_G0.5460.34
252_N255_N0.5460.34
414_T417_P0.5460.34
399_N409_M0.5460.34
143_Y401_V0.5450.34
50_Y120_L0.5450.34
113_I279_G0.5450.34
373_M420_S0.5450.34
85_A92_R0.5440.34
361_S414_T0.5430.34
9_K241_V0.5420.34
297_L315_Y0.5410.34
347_C379_L0.5400.34
325_L409_M0.5390.34
103_H106_D0.5380.33
146_V242_A0.5370.33
138_L310_R0.5360.33
239_R287_N0.5360.33
124_E409_M0.5350.33
90_V113_I0.5350.33
45_I102_A0.5350.33
162_D214_Q0.5340.33
217_H309_E0.5340.33
11_G18_H0.5340.33
162_D166_S0.5330.33
122_R409_M0.5330.33
201_S222_R0.5320.33
320_G328_M0.5310.33
336_E432_G0.5310.33
187_S191_L0.5310.33
35_S84_P0.5300.33
132_W137_E0.5300.33
23_M341_G0.5300.33
61_A115_F0.5300.33
191_L197_L0.5290.33
165_T198_A0.5290.33
194_H320_G0.5290.33
134_G138_L0.5290.33
375_H394_E0.5280.33
46_V92_R0.5280.33
30_I98_V0.5280.33
188_I356_E0.5270.32
88_E203_A0.5270.32
23_M278_G0.5260.32
41_A183_Y0.5260.32
440_R450_K0.5260.32
304_R307_V0.5250.32
26_G269_L0.5250.32
258_M262_D0.5250.32
50_Y373_M0.5240.32
331_S336_E0.5240.32
2_I324_A0.5220.32
47_V307_V0.5220.32
179_K203_A0.5210.32
143_Y402_K0.5200.32
215_V226_T0.5200.32
185_G226_T0.5200.32
95_R144_Y0.5200.32
24_N158_G0.5190.32
82_E104_I0.5190.32
87_I90_V0.5190.32
233_P390_I0.5180.32
362_P384_V0.5180.32
56_T335_A0.5180.32
73_N113_I0.5180.32
265_N269_L0.5180.32
201_S255_N0.5180.32
277_A293_I0.5170.32
20_V75_P0.5170.32
264_I299_Y0.5170.32
292_I423_K0.5160.32
280_R295_A0.5160.32
348_S408_R0.5160.32
449_I452_V0.5150.31
318_A333_S0.5150.31
139_L183_Y0.5140.31
23_M321_A0.5140.31
146_V379_L0.5140.31
41_A185_G0.5140.31
220_I426_E0.5140.31
321_A336_E0.5140.31
76_Q409_M0.5140.31
430_E445_G0.5130.31
130_T137_E0.5130.31
372_A444_R0.5120.31
171_F336_E0.5120.31
337_V429_Y0.5120.31
155_E159_L0.5110.31
47_V113_I0.5110.31
40_T137_E0.5100.31
30_I34_E0.5100.31
236_V279_G0.5100.31
251_D409_M0.5090.31
59_G62_T0.5090.31
384_V447_L0.5090.31
16_S21_G0.5090.31
334_G398_I0.5090.31
171_F324_A0.5090.31
348_S420_S0.5080.31
319_A353_G0.5070.31
23_M432_G0.5070.31
146_V152_V0.5070.31
36_S104_I0.5060.31
410_A424_V0.5060.31
231_P272_S0.5060.31
191_L419_V0.5040.31
50_Y269_L0.5040.31
24_N74_S0.5040.31
78_V154_E0.5030.30
170_D198_A0.5020.30
353_G364_Q0.5010.30
106_D111_K0.5010.30
24_N259_N0.5000.30
365_V443_S0.5000.30
384_V398_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rqoA 2 0.9868 100 0.174 Contact Map
2iafA 1 0.304 100 0.736 Contact Map
1ygyA 4 0.4405 99.4 0.92 Contact Map
1szqA 2 0.5154 69.1 0.978 Contact Map
2hp0A 2 0.533 62.8 0.978 Contact Map
4d0gC 1 0.0991 19.3 0.984 Contact Map
3tsoC 2 0.1167 16.7 0.984 Contact Map
4zacA 2 0.3634 14.3 0.985 Contact Map
4zadA 2 0.37 13.3 0.985 Contact Map
2nptA 1 0.2137 12.8 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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