GREMLIN Database
YHAO - Inner membrane transport protein YhaO
UniProt: P42628 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12754
Length: 443 (405)
Sequences: 494 (246)
Seq/√Len: 12.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_I273_T5.1311.00
142_L147_V5.1041.00
33_F38_T4.9911.00
124_V376_L4.8171.00
139_A149_E3.6370.99
270_L330_T3.4210.98
189_L269_I3.3640.98
289_E292_K3.3450.98
372_F376_L3.2370.97
188_K270_L3.0980.97
188_K330_T3.0640.96
131_S166_L3.0140.96
417_H420_K2.9140.95
124_V372_F2.7650.94
122_M394_C2.7500.93
70_L433_L2.7440.93
87_I242_V2.7300.93
96_C246_R2.6200.91
289_E307_F2.5050.89
188_K273_T2.4980.89
70_L217_L2.4770.89
292_K296_Q2.4090.87
167_V332_F2.3780.87
344_Q369_I2.3190.85
181_S330_T2.2790.84
273_T330_T2.2460.83
37_D258_K2.2460.83
233_L236_Q2.2010.82
174_E340_R2.1620.81
164_C374_I2.1470.80
240_P337_L2.1260.80
75_G228_T2.1110.79
407_A423_S2.0800.78
379_S439_F2.0700.78
246_R258_K2.0460.77
225_L434_L1.9950.75
94_P179_K1.9920.75
365_V421_G1.9880.75
425_Y429_V1.9810.75
212_P217_L1.9650.74
183_G208_V1.9610.74
188_K196_G1.9580.74
416_L420_K1.9400.73
159_G310_G1.9370.73
29_E117_A1.8750.70
348_M369_I1.8660.70
388_L419_Y1.8620.70
411_Y428_I1.8570.70
386_P389_S1.8570.70
404_L408_W1.8410.69
270_L273_T1.8410.69
140_S305_A1.8180.68
197_V383_L1.8050.67
139_A158_Y1.7940.67
231_S323_L1.7780.66
43_M191_V1.7740.66
124_V284_A1.7510.65
82_F221_A1.7420.64
33_F37_D1.7290.64
178_F188_K1.7280.64
369_I379_S1.7210.63
46_G328_V1.7130.63
296_Q316_V1.7100.63
160_L374_I1.6880.62
141_Y325_I1.6880.62
129_V273_T1.6870.62
104_S349_N1.6510.60
62_L80_Y1.6400.60
328_V426_L1.6330.59
266_A273_T1.6330.59
34_D244_S1.6240.59
139_A153_S1.6170.58
74_I436_V1.6130.58
53_I330_T1.6090.58
96_C163_I1.6050.58
181_S270_L1.5910.57
121_V394_C1.5810.57
344_Q366_Q1.5790.57
267_F273_T1.5690.56
146_G161_V1.5450.55
404_L428_I1.5360.54
144_T192_V1.5310.54
368_G372_F1.5150.53
245_Y259_A1.4980.52
160_L164_C1.4910.52
200_V433_L1.4900.52
160_L261_R1.4820.52
113_I346_I1.4810.52
258_K261_R1.4750.51
184_M318_V1.4720.51
142_L148_T1.4650.51
330_T333_F1.4590.50
157_F206_Y1.4480.50
99_Y236_Q1.4330.49
196_G276_F1.4250.49
32_K70_L1.4160.48
148_T153_S1.4130.48
127_M332_F1.3960.47
53_I270_L1.3750.46
75_G224_T1.3710.46
390_F397_I1.3620.46
43_M196_G1.3560.45
121_V172_R1.3520.45
242_V259_A1.3500.45
181_S236_Q1.3480.45
315_W390_F1.3310.44
237_T330_T1.3150.43
49_I188_K1.3150.43
99_Y336_Y1.3020.43
122_M326_F1.2920.42
113_I117_A1.2910.42
212_P323_L1.2810.42
178_F330_T1.2710.41
404_L432_L1.2700.41
181_S188_K1.2620.41
132_T172_R1.2600.41
141_Y321_V1.2600.41
231_S346_I1.2570.40
60_V275_F1.2550.40
174_E247_S1.2540.40
194_A295_E1.2500.40
107_L402_G1.2480.40
85_L172_R1.2460.40
138_S162_L1.2390.40
242_V427_I1.2320.39
398_F438_P1.2310.39
171_S320_S1.2280.39
143_H306_Q1.2270.39
199_M331_A1.2250.39
45_I330_T1.2190.39
127_M240_P1.2190.39
70_L221_A1.2150.38
38_T373_A1.2140.38
332_F336_Y1.2090.38
80_Y419_Y1.2020.38
343_T347_V1.2010.38
218_V408_W1.2000.38
270_L333_F1.2000.38
252_I416_L1.1950.37
110_N213_P1.1950.37
117_A418_K1.1910.37
267_F270_L1.1760.36
174_E377_A1.1710.36
228_T267_F1.1620.36
197_V248_R1.1590.36
155_S187_T1.1580.36
45_I266_A1.1500.35
408_W421_G1.1490.35
323_L331_A1.1440.35
346_I427_I1.1420.35
195_L274_V1.1360.35
99_Y233_L1.1330.34
93_S102_V1.1280.34
247_S319_V1.1260.34
98_D102_V1.1240.34
55_F387_V1.1230.34
188_K331_A1.1180.34
76_Y231_S1.1100.33
408_W428_I1.1100.33
197_V295_E1.1070.33
188_K320_S1.0960.33
291_V295_E1.0890.33
102_V395_S1.0860.32
131_S177_L1.0820.32
140_S316_V1.0800.32
55_F135_T1.0770.32
60_V342_A1.0770.32
161_V165_I1.0770.32
126_W233_L1.0710.32
380_A418_K1.0700.32
78_A137_D1.0570.31
85_L134_I1.0460.31
73_V376_L1.0450.31
170_S188_K1.0410.30
45_I267_F1.0390.30
190_L197_V1.0350.30
128_F405_I1.0320.30
363_N367_R1.0310.30
410_V428_I1.0300.30
235_I275_F1.0290.30
49_I273_T1.0280.30
69_L429_V1.0260.30
275_F380_A1.0250.30
231_S364_L1.0240.30
177_L300_A1.0200.30
394_C420_K1.0150.29
184_M336_Y1.0140.29
391_T395_S1.0140.29
390_F395_S1.0140.29
51_A56_L1.0130.29
45_I177_L1.0120.29
208_V310_G1.0120.29
425_Y428_I1.0060.29
156_P439_F1.0050.29
190_L194_A1.0020.29
188_K267_F1.0010.29
131_S266_A0.9990.29
144_T187_T0.9980.29
319_V393_I0.9960.29
194_A276_F0.9950.28
70_L363_N0.9950.28
411_Y425_Y0.9910.28
163_I179_K0.9890.28
72_S224_T0.9870.28
292_K295_E0.9870.28
62_L194_A0.9860.28
79_M396_P0.9840.28
99_Y391_T0.9800.28
380_A394_C0.9780.28
411_Y420_K0.9750.28
144_T285_M0.9730.28
242_V329_M0.9720.28
289_E336_Y0.9710.27
28_R322_I0.9680.27
35_S134_I0.9610.27
49_I270_L0.9580.27
126_W398_F0.9570.27
142_L145_F0.9570.27
142_L149_E0.9530.27
66_W69_L0.9500.27
117_A205_L0.9490.27
169_I432_L0.9480.27
101_S365_V0.9420.26
190_L425_Y0.9330.26
157_F372_F0.9270.26
323_L368_G0.9270.26
114_L428_I0.9270.26
176_L435_C0.9260.26
159_G378_W0.9260.26
33_F246_R0.9240.26
300_A336_Y0.9240.26
73_V202_M0.9220.26
298_I326_F0.9150.25
188_K237_T0.9150.25
227_F395_S0.9130.25
196_G273_T0.9120.25
142_L266_A0.9100.25
245_Y248_R0.9070.25
407_A424_L0.9050.25
256_R260_L0.9040.25
249_E435_C0.9040.25
71_S103_I0.8980.25
89_T246_R0.8960.25
141_Y303_I0.8920.24
173_G390_F0.8890.24
427_I432_L0.8880.24
208_V387_V0.8850.24
129_V377_A0.8850.24
407_A428_I0.8840.24
69_L121_V0.8810.24
36_T245_Y0.8770.24
99_Y342_A0.8760.24
192_V426_L0.8750.24
75_G237_T0.8740.24
60_V233_L0.8740.24
162_L378_W0.8730.24
154_D423_S0.8720.24
168_A197_V0.8710.24
191_V323_L0.8710.24
182_T237_T0.8620.23
156_P382_V0.8610.23
77_P203_W0.8610.23
191_V279_V0.8570.23
99_Y122_M0.8530.23
132_T387_V0.8520.23
45_I188_K0.8510.23
350_I375_L0.8440.23
73_V179_K0.8430.23
159_G225_L0.8430.23
45_I87_I0.8420.23
335_V381_I0.8420.23
184_M414_P0.8400.23
122_M236_Q0.8360.22
80_Y269_I0.8360.22
243_I271_F0.8340.22
266_A330_T0.8340.22
399_G402_G0.8340.22
421_G425_Y0.8340.22
223_I320_S0.8340.22
165_I368_G0.8330.22
409_L424_L0.8330.22
121_V318_V0.8320.22
55_F136_N0.8300.22
46_G130_Y0.8300.22
193_A197_V0.8290.22
236_Q391_T0.8280.22
175_K195_L0.8280.22
299_S333_F0.8280.22
237_T273_T0.8260.22
76_Y178_F0.8250.22
285_M305_A0.8180.22
146_G367_R0.8180.22
142_L184_M0.8170.22
168_A217_L0.8150.22
97_K133_A0.8130.22
183_G253_E0.8110.22
182_T188_K0.8100.21
290_A300_A0.8090.21
194_A322_I0.8070.21
265_I390_F0.8060.21
196_G266_A0.8050.21
371_I410_V0.8050.21
136_N155_S0.8040.21
75_G90_L0.8030.21
188_K323_L0.8020.21
60_V228_T0.8020.21
29_E95_E0.7980.21
287_H291_V0.7980.21
49_I65_L0.7960.21
114_L117_A0.7920.21
383_L428_I0.7920.21
131_S273_T0.7900.21
411_Y433_L0.7870.21
99_Y235_I0.7860.21
102_V112_G0.7850.21
352_R420_K0.7820.21
406_P431_G0.7810.21
168_A208_V0.7790.20
29_E190_L0.7790.20
190_L413_V0.7780.20
366_Q412_K0.7730.20
200_V325_I0.7700.20
143_H192_V0.7690.20
91_A298_I0.7670.20
86_F238_L0.7640.20
166_L231_S0.7630.20
172_R298_I0.7620.20
112_G118_L0.7600.20
156_P197_V0.7570.20
218_V433_L0.7540.20
189_L208_V0.7530.20
44_S47_M0.7490.19
347_V362_E0.7490.19
41_V291_V0.7490.19
92_E259_A0.7480.19
181_S326_F0.7480.19
75_G299_S0.7420.19
67_V88_N0.7420.19
179_K274_V0.7400.19
163_I377_A0.7380.19
44_S402_G0.7380.19
178_F333_F0.7350.19
127_M286_G0.7350.19
235_I398_F0.7340.19
197_V242_V0.7310.19
117_A346_I0.7310.19
143_H404_L0.7290.19
292_K432_L0.7280.19
393_I408_W0.7260.19
178_F270_L0.7260.19
411_Y424_L0.7260.19
159_G434_L0.7260.19
319_V337_L0.7250.19
69_L346_I0.7240.19
218_V221_A0.7240.19
196_G320_S0.7230.19
190_L256_R0.7230.19
413_V420_K0.7210.19
66_W380_A0.7200.19
142_L197_V0.7200.19
130_Y203_W0.7190.19
159_G370_M0.7190.19
114_L212_P0.7190.19
100_P120_F0.7170.18
66_W261_R0.7170.18
393_I401_V0.7150.18
29_E215_G0.7150.18
182_T224_T0.7140.18
110_N432_L0.7120.18
171_S188_K0.7110.18
70_L368_G0.7100.18
62_L231_S0.7090.18
83_Q385_A0.7080.18
136_N384_N0.7080.18
400_M404_L0.7070.18
161_V433_L0.7030.18
379_S383_L0.7030.18
27_W30_A0.7000.18
233_L335_V0.6980.18
141_Y332_F0.6980.18
214_L379_S0.6970.18
49_I330_T0.6960.18
239_S327_A0.6950.18
166_L333_F0.6950.18
188_K266_A0.6940.18
60_V271_F0.6930.18
43_M178_F0.6930.18
106_Y416_L0.6930.18
53_I273_T0.6920.18
267_F330_T0.6920.18
120_F396_P0.6910.18
45_I270_L0.6910.18
35_S410_V0.6910.18
266_A270_L0.6900.18
227_F387_V0.6900.18
264_N363_N0.6890.18
430_T439_F0.6870.18
211_L333_F0.6870.18
130_Y327_A0.6830.17
125_I230_T0.6810.17
62_L259_A0.6810.17
39_G76_Y0.6810.17
146_G368_G0.6770.17
229_L233_L0.6760.17
198_S278_A0.6740.17
114_L357_A0.6740.17
194_A375_L0.6730.17
217_L344_Q0.6720.17
284_A420_K0.6710.17
131_S429_V0.6710.17
363_N387_V0.6690.17
43_M330_T0.6690.17
253_E298_I0.6690.17
213_P216_L0.6680.17
324_N331_A0.6660.17
212_P345_G0.6660.17
234_F278_A0.6660.17
275_F333_F0.6630.17
411_Y430_T0.6630.17
155_S232_I0.6600.17
87_I405_I0.6580.17
36_T262_A0.6580.17
325_I377_A0.6580.17
56_L239_S0.6560.17
126_W230_T0.6540.17
102_V423_S0.6530.17
379_S427_I0.6530.17
270_L328_V0.6520.17
183_G326_F0.6520.17
194_A315_W0.6510.17
181_S333_F0.6510.17
118_L274_V0.6490.16
241_M398_F0.6490.16
26_E439_F0.6490.16
145_F166_L0.6480.16
214_L417_H0.6480.16
269_I295_E0.6480.16
87_I267_F0.6460.16
298_I302_A0.6410.16
131_S231_S0.6410.16
124_V361_N0.6410.16
276_F397_I0.6390.16
77_P130_Y0.6370.16
102_V378_W0.6370.16
233_L342_A0.6360.16
73_V436_V0.6360.16
299_S437_S0.6360.16
361_N368_G0.6350.16
65_L139_A0.6340.16
45_I53_I0.6320.16
275_F342_A0.6320.16
133_A267_F0.6320.16
70_L387_V0.6310.16
167_V336_Y0.6300.16
75_G268_G0.6290.16
266_A271_F0.6280.16
177_L330_T0.6270.16
186_L192_V0.6270.16
257_H433_L0.6270.16
32_K379_S0.6250.16
217_L377_A0.6230.16
360_I383_L0.6210.16
43_M188_K0.6210.16
237_T266_A0.6200.16
36_T217_L0.6180.16
234_F338_G0.6170.16
211_L243_I0.6170.16
174_E325_I0.6160.16
436_V440_L0.6140.16
411_Y416_L0.6140.16
408_W424_L0.6130.16
39_G45_I0.6130.16
284_A308_I0.6130.16
31_I350_I0.6120.15
192_V387_V0.6080.15
236_Q402_G0.6060.15
284_A351_L0.6050.15
97_K105_G0.6050.15
123_L405_I0.6040.15
303_I335_V0.6040.15
385_A395_S0.6030.15
163_I223_I0.6020.15
48_A119_Y0.6010.15
161_V371_I0.5990.15
110_N113_I0.5990.15
38_T265_I0.5980.15
213_P369_I0.5980.15
74_I97_K0.5970.15
66_W186_L0.5970.15
259_A410_V0.5960.15
71_S240_P0.5960.15
92_E220_N0.5950.15
174_E344_Q0.5940.15
267_F333_F0.5930.15
31_I253_E0.5930.15
263_M434_L0.5920.15
197_V317_K0.5910.15
221_A433_L0.5910.15
53_I181_S0.5910.15
76_Y181_S0.5900.15
223_I230_T0.5900.15
346_I350_I0.5890.15
145_F169_I0.5870.15
91_A286_G0.5850.15
398_F402_G0.5840.15
168_A427_I0.5830.15
186_L339_F0.5830.15
247_S258_K0.5820.15
122_M222_I0.5820.15
26_E29_E0.5820.15
67_V287_H0.5820.15
170_S270_L0.5810.15
42_I76_Y0.5800.15
93_S432_L0.5780.15
274_V299_S0.5780.15
146_G292_K0.5770.15
56_L135_T0.5760.15
161_V164_C0.5760.15
186_L306_Q0.5760.15
110_N420_K0.5760.15
60_V99_Y0.5700.14
168_A367_R0.5690.14
73_V288_D0.5690.14
163_I428_I0.5680.14
288_D359_K0.5650.14
403_C434_L0.5650.14
362_E371_I0.5640.14
76_Y228_T0.5620.14
41_V323_L0.5600.14
89_T240_P0.5580.14
180_I416_L0.5560.14
47_M83_Q0.5550.14
199_M306_Q0.5550.14
107_L324_N0.5550.14
33_F190_L0.5550.14
155_S321_V0.5540.14
343_T373_A0.5530.14
177_L337_L0.5530.14
213_P272_V0.5520.14
316_V401_V0.5510.14
99_Y181_S0.5510.14
264_N419_Y0.5500.14
144_T314_A0.5500.14
310_G438_P0.5490.14
83_Q334_G0.5470.14
81_L179_K0.5460.14
115_L166_L0.5430.14
166_L329_M0.5420.14
126_W238_L0.5410.14
68_F306_Q0.5390.14
84_R192_V0.5390.14
160_L378_W0.5380.14
58_V192_V0.5370.14
216_L430_T0.5360.14
186_L237_T0.5360.14
122_M376_L0.5350.14
170_S196_G0.5350.14
34_D249_E0.5350.14
142_L153_S0.5340.14
45_I196_G0.5330.14
325_I379_S0.5320.13
134_I216_L0.5300.13
292_K367_R0.5290.13
263_M316_V0.5290.13
405_I436_V0.5270.13
178_F273_T0.5270.13
36_T377_A0.5250.13
91_A337_L0.5250.13
304_A331_A0.5230.13
44_S199_M0.5220.13
117_A350_I0.5200.13
351_L361_N0.5200.13
339_F388_L0.5190.13
44_S48_A0.5190.13
247_S261_R0.5180.13
274_V340_R0.5180.13
51_A83_Q0.5170.13
197_V389_S0.5150.13
347_V370_M0.5150.13
261_R325_I0.5140.13
75_G430_T0.5120.13
72_S189_L0.5110.13
93_S176_L0.5110.13
237_T270_L0.5100.13
36_T173_G0.5100.13
216_L359_K0.5100.13
49_I326_F0.5100.13
32_K110_N0.5090.13
404_L436_V0.5090.13
118_L263_M0.5090.13
131_S377_A0.5070.13
236_Q342_A0.5070.13
309_S419_Y0.5070.13
146_G429_V0.5070.13
38_T41_V0.5060.13
163_I200_V0.5060.13
343_T369_I0.5050.13
82_F85_L0.5050.13
271_F275_F0.5050.13
394_C435_C0.5040.13
104_S432_L0.5040.13
277_Y331_A0.5040.13
208_V332_F0.5020.13
200_V272_V0.5010.13
385_A391_T0.5000.13
191_V320_S0.5000.13
192_V304_A0.5000.13
198_S328_V0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8555 99.8 0.868 Contact Map
3giaA 1 0.8736 99.7 0.885 Contact Map
4djkA 2 0.8555 99.3 0.912 Contact Map
4wgvA 2 0.7946 98 0.945 Contact Map
4us3A 1 0.8307 93.2 0.964 Contact Map
4xp4A 1 0.86 93 0.965 Contact Map
3dh4A 3 0.842 91.9 0.966 Contact Map
2a65A 2 0.8578 91.3 0.966 Contact Map
2xq2A 2 0.8465 73.3 0.973 Contact Map
2jlnA 1 0.8623 69.5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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