GREMLIN Database
YHAM - UPF0597 protein YhaM
UniProt: P42626 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12752
Length: 436 (415)
Sequences: 797 (619)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_K158_H9.6831.00
343_R346_T5.9261.00
278_I282_M3.8461.00
39_V152_I3.7691.00
202_R295_D3.5721.00
186_L308_S3.5411.00
294_D297_R3.5211.00
14_I192_F3.4781.00
293_A297_R3.4441.00
214_L267_A3.3501.00
206_D209_K3.3441.00
51_V84_A3.2771.00
42_A89_A3.1351.00
215_S251_R3.0091.00
50_R135_W2.9351.00
49_E137_G2.8881.00
142_C156_E2.8231.00
337_A342_G2.7651.00
43_E155_I2.6901.00
58_N424_D2.6821.00
51_V134_V2.6291.00
288_A298_L2.6011.00
88_N98_D2.5931.00
103_A106_D2.5681.00
194_N338_W2.5270.99
39_V42_A2.4120.99
20_E318_R2.3970.99
42_A90_N2.3930.99
216_Q220_S2.3890.99
131_R142_C2.3710.99
311_Y406_E2.3520.99
261_G368_N2.3500.99
185_T188_E2.3260.99
46_G136_N2.2850.99
46_G139_K2.2160.99
205_L299_A2.1980.98
251_R286_V2.1960.98
187_A344_Y2.1940.98
10_W200_A2.1840.98
270_N306_H2.1820.98
142_C154_H2.1610.98
49_E136_N2.1330.98
91_A97_K2.1260.98
212_C282_M2.1120.98
280_A305_S2.1110.98
191_K195_E2.0890.98
52_E133_K2.0240.97
270_N309_A2.0090.97
126_E147_G1.9960.97
100_T103_A1.9950.97
212_C289_E1.9860.97
156_E159_D1.9830.97
17_V303_M1.9780.97
198_F299_A1.9060.96
402_A411_N1.8930.96
134_V141_A1.8930.96
197_P200_A1.8790.96
233_K390_D1.8730.96
143_V155_I1.8460.95
355_I412_L1.8330.95
151_N165_Q1.8240.95
52_E119_K1.8030.95
199_A202_R1.7970.95
129_F144_T1.7880.95
73_M108_K1.7510.94
154_H164_T1.7370.94
109_A113_A1.7360.94
205_L302_L1.7340.94
337_A385_V1.7290.94
40_A134_V1.7220.93
280_A309_A1.7190.93
82_L107_A1.7110.93
48_V136_N1.7100.93
143_V152_I1.6680.92
121_Q131_R1.6560.92
344_Y348_S1.6450.92
54_W119_K1.6280.91
190_L347_I1.6010.91
337_A346_T1.5940.90
342_G346_T1.5940.90
280_A306_H1.5890.90
144_T154_H1.5810.90
362_I400_I1.5600.89
39_V43_E1.5470.89
422_Q425_R1.5470.89
190_L194_N1.5130.88
68_V82_L1.5060.88
19_E181_L1.5050.88
33_L63_G1.5010.87
29_E149_H1.4950.87
55_V63_G1.4860.87
247_S290_H1.4820.87
110_L115_K1.4650.86
281_T285_V1.4630.86
148_G318_R1.4580.86
420_M423_T1.4540.86
133_K142_C1.4450.85
106_D109_A1.4370.85
39_V155_I1.4260.85
32_S130_S1.4130.84
45_E157_T1.4000.83
247_S286_V1.3830.83
33_L80_A1.3700.82
313_H324_A1.3670.82
157_T162_V1.3640.82
54_W131_R1.3580.81
302_L306_H1.3550.81
190_L304_L1.3480.81
362_I415_L1.3470.81
120_I428_I1.3410.81
146_V153_V1.3300.80
257_D401_V1.3300.80
71_T82_L1.3290.80
136_N139_K1.3270.80
154_H161_V1.3240.80
87_G95_V1.3190.80
414_A426_Q1.3160.79
23_P210_L1.3150.79
131_R144_T1.3050.79
91_A98_D1.2930.78
207_S281_T1.2770.77
109_A112_A1.2690.77
42_A88_N1.2630.76
43_E141_A1.2580.76
324_A367_S1.2570.76
214_L265_L1.2560.76
33_L53_A1.2520.76
81_A116_V1.2460.75
315_Q410_A1.2440.75
308_S331_G1.2380.75
139_K157_T1.2310.75
52_E135_W1.2310.75
301_A339_L1.2260.74
249_V379_S1.2260.74
21_V268_M1.2190.74
337_A381_A1.2170.74
395_T398_E1.2120.73
208_A298_L1.2060.73
242_K247_S1.2030.73
411_N430_I1.2020.73
385_V389_L1.2010.73
102_Q106_D1.1960.72
33_L76_L1.1950.72
361_M377_S1.1910.72
355_I408_S1.1860.72
104_I108_K1.1750.71
193_V303_M1.1740.71
50_R117_S1.1700.71
135_W140_W1.1700.71
88_N91_A1.1680.71
36_A143_V1.1670.71
16_A184_T1.1650.70
25_L96_L1.1650.70
280_A331_G1.1630.70
54_W133_K1.1620.70
53_A132_A1.1590.70
349_M393_A1.1510.69
35_L143_V1.1320.68
217_E220_S1.1280.68
309_A331_G1.1240.68
308_S335_G1.1190.67
313_H367_S1.1160.67
205_L295_D1.1160.67
284_V336_M1.0900.65
84_A116_V1.0890.65
205_L303_M1.0890.65
315_Q413_C1.0880.65
337_A389_L1.0860.65
413_C419_S1.0840.65
208_A302_L1.0840.65
53_A80_A1.0810.64
226_H392_T1.0810.64
222_K229_A1.0790.64
161_V164_T1.0770.64
187_A348_S1.0670.63
137_G158_H1.0650.63
270_N281_T1.0640.63
333_A382_W1.0630.63
196_V303_M1.0620.63
284_V332_A1.0590.63
244_L248_I1.0590.63
121_Q129_F1.0570.63
101_A105_A1.0490.62
191_K194_N1.0490.62
286_V290_H1.0480.62
21_V306_H1.0450.62
271_S326_T1.0420.62
426_Q429_E1.0320.61
23_P268_M1.0270.60
206_D299_A1.0270.60
423_T427_I1.0220.60
219_L282_M1.0220.60
341_D346_T1.0190.60
330_M354_M1.0160.60
400_I412_L1.0120.59
219_L251_R1.0070.59
56_S366_A1.0040.59
291_F340_V1.0040.59
293_A301_A1.0010.58
38_A89_A0.9990.58
160_G332_A0.9980.58
42_A45_E0.9980.58
202_R206_D0.9950.58
302_L401_V0.9860.57
337_A347_I0.9780.57
215_S286_V0.9750.56
27_C66_V0.9730.56
59_L130_S0.9710.56
47_P106_D0.9640.56
267_A317_P0.9610.55
43_E157_T0.9610.55
186_L311_Y0.9610.55
186_L347_I0.9590.55
194_N297_R0.9500.54
207_S270_N0.9500.54
368_N398_E0.9490.54
248_I286_V0.9480.54
34_A96_L0.9400.54
67_T261_G0.9320.53
36_A132_A0.9290.53
63_G76_L0.9280.53
282_M285_V0.9270.53
342_G389_L0.9240.52
32_S152_I0.9220.52
337_A350_A0.9200.52
296_E300_R0.9130.51
251_R282_M0.9110.51
304_L331_G0.9100.51
253_S298_L0.9080.51
260_M275_N0.9060.51
25_L94_E0.9040.51
227_I387_M0.9030.51
316_L416_A0.9020.51
94_E97_K0.9010.51
45_E48_V0.8970.50
313_H317_P0.8950.50
407_Q410_A0.8940.50
96_L99_A0.8910.50
35_L145_I0.8850.49
105_A112_A0.8840.49
21_V269_S0.8840.49
282_M286_V0.8830.49
402_A407_Q0.8790.49
36_A145_I0.8770.49
204_I303_M0.8730.48
27_C260_M0.8680.48
357_D376_T0.8670.48
25_L406_E0.8660.48
309_A318_R0.8640.48
41_A87_G0.8540.47
141_A157_T0.8530.47
63_G130_S0.8520.47
267_A324_A0.8460.46
14_I201_I0.8450.46
329_A381_A0.8440.46
215_S219_L0.8360.45
37_A84_A0.8340.45
414_A418_H0.8330.45
228_G257_D0.8290.45
235_C241_A0.8280.45
110_L114_G0.8270.45
362_I423_T0.8270.45
287_V336_M0.8260.45
356_G394_V0.8240.44
66_V366_A0.8230.44
215_S282_M0.8220.44
293_A339_L0.8180.44
226_H229_A0.8160.44
190_L344_Y0.8150.44
86_G103_A0.8110.43
269_S307_L0.8100.43
66_V260_M0.8070.43
248_I251_R0.8000.43
352_S393_A0.7970.42
227_I230_T0.7960.42
41_A84_A0.7960.42
263_A394_V0.7920.42
254_A279_T0.7910.42
362_I427_I0.7890.42
41_A48_V0.7880.42
346_T349_M0.7870.42
17_V419_S0.7870.42
35_L92_G0.7870.42
321_A423_T0.7850.41
20_E279_T0.7830.41
419_S426_Q0.7820.41
352_S404_D0.7820.41
123_P126_E0.7790.41
46_G137_G0.7780.41
196_V201_I0.7770.41
227_I428_I0.7750.41
209_K213_A0.7740.41
285_V298_L0.7720.40
46_G138_E0.7700.40
41_A134_V0.7690.40
340_V385_V0.7690.40
359_S415_L0.7650.40
231_L250_I0.7650.40
241_A278_I0.7640.40
212_C216_Q0.7620.40
44_L141_A0.7620.40
297_R341_D0.7610.40
404_D407_Q0.7580.39
37_A132_A0.7570.39
374_V382_W0.7550.39
354_M412_L0.7520.39
305_S335_G0.7520.39
332_A336_M0.7490.39
223_W270_N0.7460.38
44_L136_N0.7460.38
86_G99_A0.7430.38
217_E221_G0.7420.38
206_D295_D0.7410.38
97_K377_S0.7380.38
369_S394_V0.7370.38
225_L387_M0.7360.38
41_A47_P0.7360.38
35_L38_A0.7350.38
66_V275_N0.7340.37
284_V305_S0.7340.37
343_R391_D0.7340.37
55_V60_M0.7310.37
198_F201_I0.7260.37
185_T406_E0.7240.37
333_A356_G0.7240.37
80_A116_V0.7210.36
65_G398_E0.7190.36
284_V335_G0.7190.36
324_A368_N0.7170.36
223_W276_Q0.7170.36
231_L249_V0.7170.36
10_W197_P0.7160.36
156_E335_G0.7140.36
271_S276_Q0.7120.36
46_G158_H0.7120.36
70_G81_A0.7100.36
37_A51_V0.7080.36
145_I405_V0.7080.36
186_L335_G0.7080.36
196_V300_R0.7070.35
140_W156_E0.7060.35
56_S223_W0.7060.35
321_A431_M0.7020.35
220_S242_K0.6980.35
400_I415_L0.6960.35
192_F270_N0.6950.35
343_R388_A0.6940.35
416_A426_Q0.6940.35
109_A157_T0.6930.34
212_C286_V0.6930.34
58_N366_A0.6920.34
329_A376_T0.6920.34
73_M78_I0.6910.34
141_A155_I0.6900.34
16_A310_I0.6900.34
55_V116_V0.6890.34
198_F300_R0.6880.34
181_L314_N0.6880.34
155_I163_F0.6870.34
295_D299_A0.6850.34
201_I303_M0.6820.34
125_D331_G0.6810.34
298_L302_L0.6790.33
156_E161_V0.6770.33
35_L322_L0.6730.33
334_A351_I0.6710.33
252_T255_A0.6700.33
248_I382_W0.6690.33
196_V200_A0.6680.33
154_H162_V0.6650.32
260_M366_A0.6650.32
227_I253_S0.6650.32
403_H407_Q0.6640.32
82_L103_A0.6640.32
198_F205_L0.6640.32
27_C367_S0.6620.32
296_E338_W0.6600.32
198_F303_M0.6600.32
81_A115_K0.6590.32
308_S334_A0.6580.32
29_E320_S0.6580.32
271_S316_L0.6560.32
135_W160_G0.6550.32
367_S385_V0.6520.32
232_E250_I0.6510.31
47_P110_L0.6460.31
302_L329_A0.6450.31
240_L386_L0.6450.31
107_A110_L0.6450.31
276_Q325_A0.6440.31
137_G162_V0.6420.31
271_S321_A0.6420.31
202_R205_L0.6420.31
210_L268_M0.6410.31
33_L130_S0.6410.31
210_L372_M0.6410.31
354_M381_A0.6380.31
202_R299_A0.6370.31
68_V78_I0.6360.30
50_R403_H0.6360.30
85_L110_L0.6360.30
296_E429_E0.6350.30
60_M316_L0.6350.30
223_W261_G0.6340.30
128_L271_S0.6330.30
129_F146_V0.6290.30
133_K140_W0.6290.30
160_G220_S0.6290.30
24_A29_E0.6280.30
81_A107_A0.6270.30
333_A361_M0.6240.30
140_W159_D0.6240.30
276_Q366_A0.6240.30
25_L214_L0.6230.30
396_G403_H0.6220.30
44_L137_G0.6210.29
207_S306_H0.6210.29
331_G335_G0.6210.29
268_M306_H0.6190.29
269_S327_T0.6180.29
140_W157_T0.6170.29
107_A381_A0.6160.29
29_E62_N0.6140.29
34_A53_A0.6130.29
191_K391_D0.6120.29
140_W289_E0.6120.29
276_Q316_L0.6120.29
322_L412_L0.6120.29
357_D380_A0.6100.29
117_S410_A0.6100.29
279_T329_A0.6090.29
271_S309_A0.6090.29
320_S353_S0.6090.29
37_A332_A0.6080.29
31_I35_L0.6070.29
168_C335_G0.6070.29
317_P324_A0.6060.28
302_L420_M0.6060.28
80_A140_W0.6050.28
201_I405_V0.6050.28
299_A303_M0.6050.28
71_T116_V0.6040.28
253_S371_A0.6040.28
333_A385_V0.6030.28
190_L348_S0.6020.28
19_E178_L0.6010.28
65_G257_D0.6010.28
287_V340_V0.6010.28
381_A393_A0.6010.28
98_D185_T0.6010.28
270_N276_Q0.5990.28
270_N310_I0.5990.28
275_N366_A0.5980.28
27_C275_N0.5980.28
317_P367_S0.5980.28
41_A89_A0.5970.28
81_A185_T0.5970.28
287_V290_H0.5970.28
269_S280_A0.5970.28
50_R125_D0.5950.28
95_V228_G0.5950.28
44_L134_V0.5930.28
256_S431_M0.5920.28
15_L19_E0.5900.27
244_L290_H0.5890.27
27_C366_A0.5890.27
108_K430_I0.5890.27
240_L374_V0.5890.27
233_K345_E0.5880.27
326_T357_D0.5880.27
184_T357_D0.5870.27
11_Q15_L0.5850.27
52_E117_S0.5840.27
249_V334_A0.5840.27
414_A430_I0.5830.27
208_A285_V0.5820.27
15_L168_C0.5810.27
313_H368_N0.5810.27
85_L100_T0.5810.27
201_I412_L0.5800.27
144_T164_T0.5780.27
105_A109_A0.5770.27
21_V33_L0.5770.27
213_A265_L0.5770.27
137_G159_D0.5770.27
100_T140_W0.5760.27
102_Q138_E0.5760.27
334_A347_I0.5750.26
55_V76_L0.5750.26
21_V207_S0.5750.26
192_F196_V0.5750.26
278_I285_V0.5750.26
410_A413_C0.5750.26
54_W121_Q0.5740.26
178_L318_R0.5730.26
11_Q165_Q0.5720.26
14_I197_P0.5700.26
256_S325_A0.5650.26
148_G310_I0.5640.26
15_L92_G0.5640.26
146_V167_A0.5630.26
121_Q428_I0.5610.26
25_L264_T0.5610.26
63_G263_A0.5590.26
352_S401_V0.5590.26
89_A108_K0.5590.26
128_L270_N0.5590.26
201_I300_R0.5580.25
86_G329_A0.5570.25
18_Q203_F0.5570.25
55_V81_A0.5570.25
358_V361_M0.5570.25
73_M111_L0.5550.25
121_Q144_T0.5550.25
145_I423_T0.5550.25
378_A381_A0.5540.25
295_D407_Q0.5540.25
269_S276_Q0.5520.25
214_L324_A0.5520.25
12_R99_A0.5520.25
35_L39_V0.5510.25
197_P303_M0.5510.25
279_T377_S0.5500.25
13_Y188_E0.5500.25
29_E34_A0.5480.25
68_V72_G0.5480.25
355_I358_V0.5460.25
101_A104_I0.5450.25
423_T431_M0.5450.25
279_T355_I0.5430.25
189_I406_E0.5430.25
359_S400_I0.5430.25
207_S310_I0.5420.24
111_L163_F0.5420.24
197_P330_M0.5420.24
346_T391_D0.5410.24
270_N374_V0.5410.24
387_M411_N0.5400.24
281_T306_H0.5400.24
15_L200_A0.5400.24
291_F336_M0.5380.24
324_A330_M0.5380.24
235_C240_L0.5360.24
92_G130_S0.5360.24
270_N278_I0.5350.24
186_L406_E0.5350.24
136_N158_H0.5350.24
96_L258_A0.5340.24
381_A388_A0.5320.24
106_D195_E0.5290.24
330_M334_A0.5280.24
152_I163_F0.5280.24
272_G324_A0.5280.24
60_M334_A0.5280.24
19_E179_T0.5280.24
83_G321_A0.5280.24
71_T104_I0.5270.24
204_I433_S0.5270.24
43_E143_V0.5260.24
328_A331_G0.5260.24
74_V397_N0.5260.24
325_A361_M0.5250.23
234_Q390_D0.5240.23
33_L227_I0.5230.23
205_L312_I0.5230.23
334_A430_I0.5230.23
342_G350_A0.5220.23
222_K226_H0.5220.23
39_V87_G0.5220.23
58_N66_V0.5220.23
315_Q392_T0.5210.23
109_A187_A0.5210.23
351_I354_M0.5210.23
108_K111_L0.5210.23
193_V304_L0.5190.23
11_Q135_W0.5190.23
143_V196_V0.5180.23
203_F255_A0.5180.23
112_A176_S0.5180.23
409_I424_D0.5180.23
58_N428_I0.5180.23
184_T430_I0.5180.23
241_A244_L0.5170.23
400_I427_I0.5160.23
90_N132_A0.5160.23
218_G257_D0.5160.23
105_A187_A0.5150.23
80_A132_A0.5150.23
203_F354_M0.5150.23
342_G351_I0.5140.23
43_E162_V0.5140.23
119_K190_L0.5140.23
15_L18_Q0.5140.23
157_T160_G0.5140.23
258_A263_A0.5130.23
108_K112_A0.5130.23
61_K272_G0.5130.23
246_S249_V0.5130.23
267_A367_S0.5120.23
269_S384_A0.5120.23
82_L128_L0.5120.23
35_L150_T0.5110.23
139_K155_I0.5110.23
303_M419_S0.5110.23
186_L405_V0.5100.23
351_I409_I0.5100.23
71_T78_I0.5090.23
264_T412_L0.5090.23
349_M391_D0.5080.23
320_S431_M0.5080.23
340_V386_L0.5080.23
90_N164_T0.5070.22
96_L231_L0.5060.22
305_S309_A0.5060.22
31_I276_Q0.5060.22
257_D368_N0.5040.22
29_E272_G0.5030.22
82_L381_A0.5030.22
146_V191_K0.5030.22
63_G328_A0.5010.22
136_N157_T0.5010.22
365_G370_C0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rqoA 2 0.9083 100 0.719 Contact Map
2hp0A 2 0.5252 93.3 0.965 Contact Map
1szqA 2 0.5092 92.7 0.966 Contact Map
3oj0A 1 0.3142 12.9 0.983 Contact Map
2ca5A 1 0.1399 11.7 0.984 Contact Map
4xeaA 2 0.2775 10.6 0.984 Contact Map
3ojcA 4 0.1376 10 0.984 Contact Map
3zf7J 1 0.4427 9.6 0.984 Contact Map
3j61z 1 0.445 9.4 0.984 Contact Map
3eauA 3 0.1972 8.3 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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