GREMLIN Database
YHAK - Pirin-like protein YhaK
UniProt: P42624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12750
Length: 233 (194)
Sequences: 5781 (3907)
Seq/√Len: 280.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_S219_V3.0271.00
76_R82_H2.9631.00
146_P150_M2.9321.00
173_N217_T2.7991.00
171_S217_T2.7741.00
72_E86_S2.6441.00
202_L208_A2.5701.00
191_H219_V2.5551.00
173_N215_N2.4861.00
45_Q113_T2.4601.00
74_E82_H2.4431.00
89_E134_A2.3861.00
66_N114_R2.3501.00
70_D111_P2.1931.00
189_K222_S2.1841.00
190_F224_L2.1791.00
189_K201_A2.1061.00
74_E84_Q2.0861.00
70_D113_T2.0311.00
189_K203_T2.0001.00
97_P127_N1.9381.00
46_E49_A1.9051.00
187_H225_R1.9021.00
164_I226_A1.9011.00
56_P100_S1.8801.00
168_K222_S1.8531.00
126_E156_R1.8531.00
167_D223_P1.7841.00
191_H201_A1.7541.00
140_Q164_I1.7441.00
163_H225_R1.7331.00
176_L181_A1.7071.00
123_P126_E1.7041.00
61_K125_R1.6731.00
189_K221_D1.6661.00
165_V225_R1.6651.00
96_Q126_E1.6521.00
191_H221_D1.6491.00
175_Q215_N1.5891.00
78_S100_S1.5841.00
48_L114_R1.5771.00
203_T206_D1.5671.00
74_E106_L1.5451.00
115_M186_I1.5321.00
94_S126_E1.5231.00
72_E84_Q1.5181.00
37_Y182_Y1.5071.00
191_H199_K1.5041.00
43_L117_L1.4981.00
63_D94_S1.4771.00
56_P102_S1.4771.00
115_M227_L1.4581.00
164_I172_A1.4531.00
185_S190_F1.4401.00
69_L186_I1.4331.00
131_Q154_Q1.4131.00
76_R102_S1.3941.00
58_T100_S1.3771.00
60_P125_R1.3551.00
145_S152_S1.3451.00
168_K223_P1.3431.00
142_L145_S1.3351.00
79_E99_V1.3211.00
52_A55_Q1.3141.00
210_I216_I1.3131.00
72_E106_L1.2841.00
220_A223_P1.2761.00
91_L130_I1.2751.00
123_P156_R1.2691.00
37_Y209_F1.2631.00
92_L131_Q1.2601.00
38_A180_R1.2561.00
129_L154_Q1.2551.00
187_H204_C1.2361.00
166_L220_A1.2311.00
185_S202_L1.2241.00
35_L41_R1.2221.00
68_I114_R1.2211.00
137_M170_E1.1801.00
158_Q179_P1.1771.00
167_D170_E1.1711.00
218_L226_A1.1691.00
47_V113_T1.1451.00
45_Q184_Q1.1441.00
190_F226_A1.1361.00
138_G170_E1.1341.00
137_M167_D1.1291.00
183_L228_L1.1141.00
142_L149_A1.0931.00
46_E114_R1.0811.00
70_D110_K1.0701.00
119_L159_V1.0611.00
92_L129_L1.0601.00
36_G120_D1.0561.00
68_I73_A1.0511.00
174_F228_L1.0451.00
142_L162_H1.0391.00
84_Q106_L1.0241.00
113_T187_H1.0201.00
86_S89_E1.0191.00
89_E135_L1.0141.00
192_A208_A1.0121.00
140_Q145_S1.0111.00
49_A111_P1.0031.00
140_Q162_H0.9991.00
67_V163_H0.9981.00
65_L119_L0.9901.00
43_L115_M0.9841.00
57_R101_Y0.9841.00
187_H223_P0.9831.00
143_I163_H0.9791.00
138_G167_D0.9731.00
117_L229_I0.9681.00
166_L170_E0.9641.00
120_D124_Q0.9571.00
73_A112_L0.9481.00
182_Y209_F0.9471.00
129_L156_R0.9451.00
183_L210_I0.9431.00
136_N167_D0.9251.00
192_A218_L0.9251.00
45_Q205_G0.9061.00
64_I93_L0.9031.00
56_P76_R0.8981.00
183_L190_F0.8811.00
89_E132_K0.8801.00
160_W179_P0.8651.00
43_L229_I0.8501.00
115_M184_Q0.8501.00
182_Y207_G0.8471.00
61_K124_Q0.8331.00
92_L119_L0.8231.00
139_K145_S0.8180.99
72_E107_S0.8170.99
70_D187_H0.8170.99
97_P128_P0.8160.99
202_L206_D0.8140.99
165_V223_P0.8130.99
92_L144_A0.8120.99
181_A228_L0.8050.99
164_I228_L0.8010.99
62_V120_D0.7980.99
59_Y101_Y0.7980.99
186_I225_R0.7950.99
39_S120_D0.7780.99
75_Y103_E0.7760.99
75_Y93_L0.7750.99
34_L209_F0.7750.99
75_Y130_I0.7670.99
183_L218_L0.7660.99
162_H174_F0.7650.99
44_N114_R0.7650.99
139_K165_V0.7640.99
73_A114_R0.7640.99
192_A202_L0.7620.99
149_A160_W0.7580.99
60_P124_Q0.7550.99
122_C158_Q0.7390.99
85_A132_K0.7380.99
190_F218_L0.7370.99
122_C126_E0.7360.99
70_D87_A0.7340.99
38_A182_Y0.7320.99
168_K220_A0.7300.99
90_A143_I0.7290.99
67_V161_L0.7270.99
146_P160_W0.7240.99
182_Y229_I0.7240.99
85_A89_E0.7230.99
72_E110_K0.7120.99
119_L155_L0.7060.98
141_Q163_H0.7050.98
166_L172_A0.7040.98
137_M145_S0.7000.98
192_A210_I0.6960.98
86_S134_A0.6950.98
65_L92_L0.6940.98
155_L159_V0.6900.98
68_I112_L0.6900.98
36_G41_R0.6860.98
65_L144_A0.6830.98
47_V111_P0.6830.98
75_Y101_Y0.6820.98
53_A104_H0.6780.98
97_P125_R0.6710.98
169_G221_D0.6700.98
166_L169_G0.6690.98
178_G212_D0.6690.98
93_L99_V0.6680.98
60_P100_S0.6570.98
185_S208_A0.6570.98
57_R116_Q0.6550.98
221_D224_L0.6530.98
65_L161_L0.6520.97
160_W177_H0.6510.97
140_Q172_A0.6500.97
220_A224_L0.6440.97
184_Q229_I0.6430.97
50_P53_A0.6400.97
185_S188_G0.6390.97
44_N64_I0.6390.97
161_L229_I0.6340.97
161_L227_L0.6330.97
180_R212_D0.6330.97
48_L112_L0.6320.97
142_L160_W0.6290.97
103_E130_I0.6220.97
170_E220_A0.6140.96
83_V132_K0.6140.96
60_P120_D0.6120.96
75_Y91_L0.6110.96
144_A155_L0.6100.96
37_Y181_A0.6080.96
69_L115_M0.6080.96
172_A175_Q0.6080.96
184_Q205_G0.6080.96
107_S110_K0.6070.96
122_C146_P0.6070.96
141_Q165_V0.6030.96
92_L153_L0.6020.96
86_S135_L0.6020.96
184_Q207_G0.6010.96
122_C156_R0.6010.96
69_L113_T0.5990.96
97_P126_E0.5980.96
39_S180_R0.5950.96
117_L161_L0.5940.96
146_P177_H0.5930.96
55_Q104_H0.5910.96
38_A120_D0.5900.96
62_V157_Q0.5840.95
141_Q145_S0.5810.95
57_R75_Y0.5800.95
133_L151_G0.5770.95
48_L52_A0.5770.95
40_L182_Y0.5690.95
69_L163_H0.5680.94
169_G219_V0.5650.94
34_L37_Y0.5650.94
46_E50_P0.5600.94
183_L192_A0.5590.94
94_S129_L0.5580.94
168_K221_D0.5570.94
191_H217_T0.5560.94
183_L226_A0.5550.94
138_G166_L0.5540.94
187_H222_S0.5520.94
185_S204_C0.5510.94
181_A216_I0.5510.94
81_N132_K0.5480.93
89_E133_L0.5430.93
192_A224_L0.5420.93
156_R159_V0.5410.93
65_L89_E0.5400.93
82_H104_H0.5390.93
183_L208_A0.5370.93
83_V93_L0.5370.93
133_L153_L0.5360.93
45_Q186_I0.5350.93
198_E217_T0.5340.93
139_K167_D0.5310.92
74_E107_S0.5310.92
186_I204_C0.5310.92
147_E152_S0.5300.92
43_L184_Q0.5290.92
133_L152_S0.5270.92
37_Y96_Q0.5250.92
201_A215_N0.5250.92
56_P78_S0.5240.92
65_L143_I0.5210.92
198_E213_E0.5210.92
113_T204_C0.5200.92
62_V93_L0.5190.91
138_G172_A0.5190.91
55_Q114_R0.5180.91
139_K144_A0.5160.91
169_G220_A0.5150.91
141_Q146_P0.5140.91
76_R104_H0.5130.91
46_E66_N0.5130.91
69_L225_R0.5120.91
147_E216_I0.5110.91
45_Q204_C0.5100.91
118_W130_I0.5090.91
91_L132_K0.5090.91
42_V46_E0.5080.91
192_A198_E0.5030.90
53_A130_I0.5020.90
139_K142_L0.5010.90
42_V64_I0.5010.90
142_L152_S0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tq5A 1 0.9742 100 0.056 Contact Map
2vecA 1 0.9528 100 0.061 Contact Map
2p17A 1 0.9442 100 0.239 Contact Map
4eweA 1 0.9442 100 0.257 Contact Map
3o14A 2 0.897 99.8 0.706 Contact Map
1sq4A 5 0.9442 99.5 0.775 Contact Map
3h7jA 1 0.9099 99.3 0.793 Contact Map
1sefA 5 0.9485 99.2 0.802 Contact Map
1rc6A 4 0.9099 99.2 0.808 Contact Map
2d40A 3 0.9571 99.1 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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