GREMLIN Database
YQJG - Glutathionyl-hydroquinone reductase YqjG
UniProt: P42620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12746
Length: 328 (298)
Sequences: 2161 (1279)
Seq/√Len: 74.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_K81_F3.5761.00
263_R266_D3.4491.00
190_V220_L3.2691.00
189_T216_S3.2131.00
117_Y121_L3.1241.00
185_W219_R3.0901.00
74_K79_E3.0301.00
211_A311_I2.8721.00
114_E118_Q2.7751.00
228_R276_D2.7171.00
22_K208_E2.6941.00
123_A143_T2.6071.00
171_Y176_Q2.5971.00
111_Y142_H2.5091.00
184_G188_D2.4851.00
171_Y180_D2.4761.00
116_L135_V2.4101.00
182_L186_I2.3821.00
301_K307_G2.3801.00
51_E140_K2.3801.00
70_L84_V2.3331.00
174_A234_Q2.3041.00
35_T38_G2.2921.00
207_D311_I2.2631.00
72_M153_I2.2301.00
185_W216_S2.1991.00
61_L288_N2.1921.00
188_D196_K2.1591.00
220_L270_L2.0461.00
72_M240_I2.0171.00
276_D280_M2.0061.00
59_V70_L1.9881.00
35_T47_G1.9871.00
262_H267_Y1.9631.00
240_I277_I1.9371.00
74_K285_E1.9251.00
271_Y274_L1.9041.00
298_R307_G1.8901.00
190_V216_S1.8731.00
190_V213_V1.8651.00
72_M170_Y1.8641.00
122_H142_H1.8331.00
38_G47_G1.8101.00
243_W287_V1.7961.00
225_G269_N1.7841.00
264_I274_L1.7801.00
173_P176_Q1.7681.00
62_A295_H1.7671.00
154_R237_E1.7181.00
157_N169_D1.7151.00
182_L223_I1.6711.00
189_T212_K1.6601.00
197_A210_V1.6331.00
265_S271_Y1.6281.00
182_L231_T1.6160.99
202_S205_A1.6110.99
59_V86_V1.5990.99
255_T297_F1.5900.99
36_A162_A1.5880.99
56_H85_S1.5810.99
210_V261_K1.5770.99
290_D294_N1.5600.99
246_L273_F1.5550.99
113_N122_H1.5470.99
196_K212_K1.5380.99
33_W155_M1.5080.99
294_N298_R1.4980.99
113_N119_L1.4680.99
256_H300_H1.4680.99
295_H300_H1.4400.99
85_S109_T1.4280.99
111_Y122_H1.4200.99
221_E268_L1.4140.99
90_L294_N1.4130.99
185_W189_T1.4110.99
276_D279_Q1.4000.99
88_N99_D1.3940.98
205_A209_A1.3870.98
271_Y275_R1.3780.98
61_L70_L1.3480.98
48_F141_N1.3440.98
89_P294_N1.3420.98
235_L277_I1.3300.98
52_K163_L1.3120.98
178_K181_E1.3080.98
235_L280_M1.2830.97
67_H286_T1.2710.97
251_P317_L1.2640.97
178_K223_I1.2510.97
247_V274_L1.2460.97
183_N241_R1.2430.97
76_K161_D1.2420.97
216_S219_R1.2420.97
252_V256_H1.2420.97
218_A262_H1.2290.97
38_G46_G1.2220.96
25_R192_N1.2190.96
146_S155_M1.2160.96
261_K311_I1.2100.96
283_I287_V1.2060.96
56_H139_K1.2010.96
164_G168_G1.1910.96
274_L317_L1.1820.96
81_F163_L1.1810.96
170_Y240_I1.1810.96
61_L86_V1.1790.96
221_E269_N1.1770.96
94_N97_T1.1540.95
164_G167_A1.1420.95
83_S109_T1.1420.95
223_I231_T1.1400.95
94_N115_F1.1300.95
81_F164_G1.1270.94
182_L220_L1.1170.94
235_L240_I1.1140.94
94_N117_Y1.1110.94
256_H295_H1.1100.94
67_H244_T1.1080.94
67_H287_V1.1070.94
284_A318_D1.1060.94
261_K267_Y1.1050.94
247_V317_L1.1040.94
165_A168_G1.0960.94
135_V144_I1.0950.94
37_D47_G1.0920.94
189_T219_R1.0810.93
228_R272_G1.0770.93
16_T19_T1.0760.93
293_R312_G1.0690.93
111_Y119_L1.0660.93
38_G45_T1.0640.93
45_T141_N1.0610.93
71_I240_I1.0550.92
222_Q225_G1.0520.92
260_D312_G1.0480.92
58_Y108_D1.0480.92
69_T152_I1.0450.92
222_Q226_Q1.0440.92
90_L298_R1.0410.92
272_G276_D1.0360.92
62_A300_H1.0330.91
30_F123_A1.0310.91
218_A267_Y1.0300.91
255_T306_T1.0220.91
37_D45_T1.0200.91
35_T50_A1.0180.91
197_A213_V1.0170.91
82_I156_F1.0160.91
161_D168_G1.0150.91
47_G50_A1.0110.91
247_V289_F0.9960.90
264_I267_Y0.9930.90
210_V262_H0.9930.90
277_I280_M0.9890.90
252_V300_H0.9870.90
254_V263_R0.9860.89
18_S22_K0.9850.89
65_W192_N0.9820.89
16_T20_G0.9800.89
277_I283_I0.9800.89
271_Y317_L0.9790.89
62_A252_V0.9750.89
221_E272_G0.9740.89
35_T49_I0.9650.88
228_R279_Q0.9650.88
179_I183_N0.9600.88
256_H303_I0.9550.88
188_D212_K0.9530.88
58_Y111_Y0.9520.88
110_L113_N0.9370.87
196_K209_A0.9360.87
297_F309_I0.9290.86
243_W283_I0.9280.86
265_S319_E0.9240.86
77_G165_A0.9230.86
298_R301_K0.9210.86
36_A159_A0.9180.86
240_I280_M0.9180.86
47_G141_N0.9130.85
109_T113_N0.9100.85
252_V295_H0.9080.85
177_T181_E0.9080.85
247_V287_V0.9060.85
210_V311_I0.9040.85
119_L137_W0.9030.85
100_D107_G0.9010.85
28_S150_A0.8990.85
32_N48_F0.8910.84
83_S139_K0.8850.84
60_S295_H0.8850.84
35_T46_G0.8850.84
261_K314_W0.8850.84
229_Y276_D0.8820.83
231_T238_A0.8810.83
176_Q180_D0.8810.83
37_D50_A0.8800.83
300_H303_I0.8780.83
62_A256_H0.8740.83
52_K80_P0.8720.83
182_L219_R0.8720.83
288_N291_H0.8610.82
215_E219_R0.8610.82
71_I244_T0.8560.82
16_T26_S0.8550.82
298_R309_I0.8540.81
76_K157_N0.8500.81
18_S24_Q0.8460.81
171_Y179_I0.8430.81
25_R65_W0.8430.81
15_D18_S0.8430.81
220_L223_I0.8410.80
71_I277_I0.8410.80
110_L122_H0.8340.80
56_H83_S0.8300.80
49_I141_N0.8270.79
260_D293_R0.8240.79
282_G287_V0.8230.79
282_G285_E0.8220.79
49_I140_K0.8210.79
89_P102_F0.8190.79
316_D319_E0.8180.79
229_Y277_I0.8180.79
272_G279_Q0.8150.78
161_D164_G0.8110.78
177_T180_D0.8110.78
216_S220_L0.8100.78
26_S128_S0.8090.78
189_T215_E0.8050.77
83_S119_L0.8040.77
123_A137_W0.8040.77
98_F116_L0.8040.77
15_D19_T0.8020.77
269_N272_G0.8000.77
271_Y315_Q0.8000.77
32_N47_G0.7980.77
30_F143_T0.7980.77
207_D210_V0.7970.77
295_H299_S0.7950.77
86_V291_H0.7950.77
223_I227_H0.7940.76
219_R223_I0.7930.76
211_A261_K0.7900.76
58_Y85_S0.7830.75
187_Y192_N0.7820.75
53_D83_S0.7780.75
186_I238_A0.7750.75
65_W187_Y0.7700.74
243_W247_V0.7670.74
189_T220_L0.7630.74
69_T156_F0.7630.74
116_L119_L0.7630.74
32_N46_G0.7580.73
182_L230_L0.7570.73
258_K304_N0.7560.73
92_L298_R0.7550.73
281_P285_E0.7530.73
191_N245_T0.7510.72
113_N118_Q0.7490.72
92_L295_H0.7360.71
66_A133_V0.7360.71
178_K227_H0.7360.71
107_G113_N0.7340.71
169_D176_Q0.7320.70
81_F165_A0.7310.70
97_T115_F0.7230.70
72_M277_I0.7190.69
16_T302_T0.7170.69
20_G24_Q0.7160.69
31_R151_E0.7150.69
17_K20_G0.7140.69
26_S29_A0.7100.68
157_N161_D0.7090.68
29_A127_Y0.7070.68
149_S187_Y0.7050.68
175_L236_T0.7030.67
297_F306_T0.7020.67
181_E185_W0.7010.67
279_Q317_L0.6990.67
228_R233_N0.6930.66
57_L69_T0.6920.66
121_L131_V0.6890.66
150_A241_R0.6870.66
69_T73_R0.6850.65
35_T159_A0.6840.65
62_A299_S0.6830.65
279_Q320_P0.6800.65
252_V292_I0.6780.65
217_L264_I0.6780.65
289_F317_L0.6770.64
195_Y253_Y0.6770.64
275_R319_E0.6740.64
67_H71_I0.6740.64
51_E54_R0.6710.64
247_V251_P0.6690.64
45_T50_A0.6690.64
195_Y199_F0.6680.63
71_I283_I0.6670.63
161_D167_A0.6660.63
92_L97_T0.6620.63
227_H276_D0.6600.63
98_F108_D0.6590.62
88_N102_F0.6590.62
289_F292_I0.6580.62
148_E151_E0.6580.62
24_Q27_A0.6580.62
91_M299_S0.6580.62
293_R297_F0.6560.62
88_N97_T0.6540.62
33_W159_A0.6520.62
150_A183_N0.6500.61
272_G275_R0.6500.61
17_K24_Q0.6490.61
175_L178_K0.6470.61
19_T24_Q0.6470.61
207_D293_R0.6460.61
303_I306_T0.6450.61
213_V259_C0.6440.61
255_T258_K0.6440.61
178_K231_T0.6420.60
21_G205_A0.6400.60
251_P315_Q0.6390.60
89_P298_R0.6380.60
264_I271_Y0.6360.60
60_S87_V0.6360.60
53_D80_P0.6320.59
33_W146_S0.6310.59
111_Y137_W0.6300.59
121_L128_S0.6270.59
110_L142_H0.6270.59
208_E212_K0.6260.58
29_A124_D0.6210.58
15_D20_G0.6210.58
23_F26_S0.6200.58
262_H266_D0.6180.57
151_E154_R0.6160.57
179_I231_T0.6150.57
104_G108_D0.6110.57
183_N237_E0.6110.57
28_S146_S0.6110.57
59_V84_V0.6090.56
26_S124_D0.6090.56
193_G209_A0.6090.56
293_R310_S0.6080.56
203_Q207_D0.6080.56
238_A242_L0.6070.56
237_E241_R0.6050.56
116_L131_V0.6050.56
153_I241_R0.6040.56
211_A215_E0.6010.55
161_D169_D0.5980.55
255_T312_G0.5970.55
204_E208_E0.5970.55
161_D166_K0.5970.55
82_I136_L0.5970.55
26_S127_Y0.5960.55
214_F249_F0.5920.54
34_L152_I0.5880.54
67_H243_W0.5870.54
183_N238_A0.5870.54
254_V260_D0.5850.53
119_L122_H0.5820.53
117_Y131_V0.5820.53
255_T260_D0.5820.53
58_Y87_V0.5810.53
32_N146_S0.5800.53
22_K196_K0.5790.53
194_V198_G0.5790.53
34_L50_A0.5760.52
273_F277_I0.5760.52
257_F296_Y0.5760.52
89_P92_L0.5760.52
251_P289_F0.5730.52
255_T293_R0.5720.52
53_D139_K0.5720.52
60_S86_V0.5660.51
317_L320_P0.5660.51
148_E153_I0.5660.51
48_F155_M0.5650.51
100_D103_P0.5650.51
255_T309_I0.5650.51
193_G199_F0.5650.51
153_I238_A0.5640.51
181_E184_G0.5640.51
315_Q318_D0.5580.50
85_S88_N0.5580.50
153_I157_N0.5550.50
135_V152_I0.5540.50
297_F310_S0.5520.49
94_N118_Q0.5520.49
77_G164_G0.5520.49
214_F260_D0.5510.49
246_L270_L0.5490.49
48_F55_Y0.5480.49
47_G155_M0.5440.48
15_D302_T0.5440.48
240_I283_I0.5430.48
260_D310_S0.5430.48
97_T107_G0.5410.48
53_D81_F0.5400.48
137_W143_T0.5400.48
36_A46_G0.5390.48
79_E83_S0.5390.48
155_M159_A0.5380.48
201_T306_T0.5380.48
203_Q206_Y0.5370.47
121_L124_D0.5350.47
278_Y287_V0.5340.47
219_R222_Q0.5340.47
48_F51_E0.5340.47
34_L136_L0.5330.47
195_Y257_F0.5330.47
48_F123_A0.5330.47
274_L315_Q0.5320.47
108_D111_Y0.5310.47
71_I91_M0.5310.47
186_I223_I0.5290.46
247_V292_I0.5280.46
157_N183_N0.5240.46
185_W190_V0.5220.46
227_H231_T0.5210.45
240_I244_T0.5200.45
182_L227_H0.5190.45
56_H111_Y0.5170.45
38_G49_I0.5170.45
228_R320_P0.5170.45
122_H143_T0.5160.45
182_L185_W0.5130.44
194_V257_F0.5110.44
77_G168_G0.5100.44
35_T45_T0.5100.44
195_Y296_Y0.5100.44
199_F257_F0.5090.44
136_L156_F0.5080.44
159_A164_G0.5080.44
193_G196_K0.5060.44
103_P290_D0.5050.43
199_F253_Y0.5040.43
186_I231_T0.5030.43
198_G257_F0.5030.43
113_N142_H0.5030.43
77_G167_A0.5030.43
228_R231_T0.5020.43
73_R79_E0.5020.43
198_G296_Y0.5020.43
224_L230_L0.5020.43
244_T292_I0.5000.43
90_L97_T0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g0iA 2 0.997 100 0.316 Contact Map
3m1gA 2 0.8018 100 0.384 Contact Map
4ptsA 2 0.9299 100 0.408 Contact Map
3ppuA 2 0.9329 100 0.42 Contact Map
4ussA 2 0.8994 100 0.603 Contact Map
4fquA 2 0.9512 100 0.616 Contact Map
2yv9A 2 0.7622 100 0.685 Contact Map
1b8xA 2 0.7012 100 0.735 Contact Map
4bl7A 1 0.6067 100 0.799 Contact Map
4puaA 2 0.747 99.9 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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