GREMLIN Database
YGJV - Inner membrane protein YgjV
UniProt: P42603 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12733
Length: 183 (160)
Sequences: 312 (239)
Seq/√Len: 18.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_A121_V3.1390.99
22_F145_E2.7340.98
133_N145_E2.5120.97
66_I79_F2.4960.97
44_H138_S2.3320.95
130_V142_T2.2460.94
22_F152_N2.2130.94
87_G100_V2.1600.93
114_K117_T2.0500.91
81_V150_L2.0400.90
27_E30_F2.0270.90
46_F54_G1.9840.89
129_W152_N1.9750.89
123_W126_T1.9520.88
155_N159_F1.9210.87
62_I78_I1.8710.86
102_G130_V1.7400.82
47_L130_V1.7270.81
27_E155_N1.7050.80
62_I128_C1.6490.78
30_F140_G1.6340.77
129_W133_N1.5890.75
9_G85_G1.5880.75
8_Q145_E1.5720.74
30_F115_G1.5680.74
96_E132_H1.5590.74
11_G18_G1.5510.73
52_P128_C1.5510.73
94_P131_I1.5460.73
153_G157_I1.5260.72
8_Q111_F1.5250.72
27_E115_G1.5020.71
31_K67_T1.4990.71
27_E140_G1.4930.70
94_P98_L1.4840.70
70_T75_V1.4810.70
23_F151_M1.4800.70
14_A40_V1.4610.69
74_W81_V1.4570.68
91_F102_G1.4210.66
16_L146_G1.4070.66
94_P104_I1.3980.65
22_F111_F1.3860.64
9_G134_F1.3840.64
50_T83_T1.3820.64
82_L101_I1.3820.64
14_A53_A1.3600.63
111_F152_N1.3520.62
17_I94_P1.3300.61
43_V92_H1.3100.60
7_A11_G1.3090.60
154_L158_R1.3080.60
64_T106_S1.2980.59
81_V85_G1.2770.58
52_P96_E1.2720.58
93_H96_E1.2720.58
30_F48_L1.2680.57
115_G155_N1.2490.56
36_V127_C1.2480.56
62_I100_V1.2450.56
77_A134_F1.2290.55
74_W77_A1.2220.55
32_K65_L1.2070.54
13_I134_F1.2040.53
44_H119_R1.1880.52
51_Y153_G1.1850.52
13_I88_L1.1800.52
50_T64_T1.1640.51
59_L64_T1.1630.51
84_G104_I1.1590.51
36_V88_L1.1500.50
58_I97_L1.1430.50
13_I62_I1.1420.49
11_G44_H1.1360.49
45_F138_S1.1340.49
13_I36_V1.1310.49
119_R138_S1.1280.49
73_L131_I1.1120.48
150_L163_Q1.1120.48
22_F133_N1.1010.47
111_F129_W1.1000.47
14_A41_I1.0940.46
10_V48_L1.0870.46
145_E152_N1.0740.45
27_E116_L1.0630.45
24_N27_E1.0580.44
34_L148_F1.0570.44
39_A84_G1.0560.44
53_A148_F1.0360.43
56_S99_P1.0360.43
7_A18_G1.0310.43
22_F63_R1.0210.42
102_G129_W1.0130.41
21_T63_R1.0000.41
145_E148_F0.9890.40
151_M155_N0.9850.40
20_T47_L0.9800.39
29_R55_A0.9690.39
74_W84_G0.9690.39
86_I89_A0.9650.39
91_F96_E0.9610.38
132_H155_N0.9590.38
26_D134_F0.9420.37
106_S125_S0.9420.37
115_G118_M0.9380.37
146_G150_L0.9210.36
126_T148_F0.9200.36
118_M132_H0.9160.36
59_L106_S0.9080.35
18_G44_H0.9070.35
11_G140_G0.9050.35
58_I62_I0.9030.35
30_F113_C0.9030.35
34_L76_M0.9010.35
29_R85_G0.8960.35
36_V65_L0.8890.34
46_F149_L0.8850.34
140_G155_N0.8810.34
18_G133_N0.8790.34
59_L103_T0.8710.33
62_I164_K0.8660.33
68_L125_S0.8600.32
126_T149_L0.8580.32
8_Q133_N0.8520.32
111_F144_I0.8480.32
17_I61_A0.8480.32
76_M132_H0.8380.31
95_V98_L0.8350.31
53_A160_W0.8350.31
8_Q119_R0.8300.31
19_I151_M0.8270.31
40_V57_A0.8230.30
8_Q140_G0.8230.30
62_I134_F0.8210.30
111_F145_E0.8200.30
108_W154_L0.8180.30
115_G140_G0.8180.30
6_L81_V0.8160.30
22_F129_W0.8150.30
39_A85_G0.7980.29
82_L163_Q0.7970.29
21_T33_Q0.7880.29
75_V130_V0.7790.28
106_S126_T0.7660.28
109_A119_R0.7620.27
44_H137_G0.7550.27
95_V108_W0.7540.27
38_S57_A0.7510.27
68_L109_A0.7450.26
105_V124_F0.7440.26
66_I80_I0.7380.26
22_F34_L0.7380.26
104_I125_S0.7370.26
84_G114_K0.7310.26
6_L9_G0.7300.26
159_F162_M0.7300.26
61_A122_M0.7270.26
37_Y144_I0.7270.26
80_I108_W0.7200.25
82_L164_K0.7100.25
9_G43_V0.7080.25
41_I144_I0.7040.25
5_W12_V0.7040.25
24_N44_H0.7030.24
97_L105_V0.6970.24
44_H122_M0.6970.24
43_V134_F0.6880.24
83_T103_T0.6870.24
26_D121_V0.6740.23
143_M154_L0.6730.23
63_R69_R0.6680.23
47_L138_S0.6660.23
36_V153_G0.6540.22
65_L134_F0.6440.22
36_V71_R0.6420.22
51_Y55_A0.6410.22
30_F110_L0.6400.22
5_W20_T0.6390.22
43_V74_W0.6310.21
99_P124_F0.6310.21
97_L143_M0.6290.21
73_L100_V0.6230.21
96_E110_L0.6200.21
45_F76_M0.6200.21
43_V77_A0.6140.21
51_Y154_L0.6140.21
127_C149_L0.6080.20
45_F148_F0.6070.20
82_L157_I0.6070.20
152_N155_N0.6020.20
43_V121_V0.6010.20
50_T53_A0.6010.20
69_R122_M0.6000.20
15_F42_G0.5990.20
85_G160_W0.5970.20
111_F119_R0.5970.20
32_K81_V0.5950.20
81_V121_V0.5900.20
22_F45_F0.5880.20
6_L101_I0.5870.19
35_S38_S0.5780.19
8_Q22_F0.5740.19
125_S136_A0.5740.19
13_I43_V0.5720.19
35_S59_L0.5720.19
42_G149_L0.5700.19
14_A37_Y0.5660.19
47_L123_W0.5640.19
130_V149_L0.5590.18
78_I120_C0.5570.18
34_L111_F0.5550.18
46_F60_N0.5510.18
22_F148_F0.5510.18
131_I150_L0.5480.18
75_V107_T0.5480.18
14_A146_G0.5440.18
90_K96_E0.5430.18
20_T62_I0.5420.18
61_A77_A0.5420.18
32_K88_L0.5420.18
7_A139_I0.5390.18
122_M126_T0.5380.18
23_F30_F0.5350.17
71_R149_L0.5350.17
26_D67_T0.5340.17
116_L156_I0.5330.17
78_I101_I0.5260.17
58_I124_F0.5230.17
26_D29_R0.5220.17
85_G153_G0.5160.17
63_R110_L0.5160.17
150_L164_K0.5160.17
129_W145_E0.5120.17
131_I157_I0.5090.17
84_G124_F0.5070.17
11_G115_G0.5070.17
18_G24_N0.5060.16
6_L62_I0.5050.16
85_G136_A0.5040.16
21_T27_E0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qncA 2 0.3716 89 0.909 Contact Map
4x5mA 2 0.4372 86.3 0.912 Contact Map
4qtnA 3 0.6776 82.4 0.917 Contact Map
4rngA 2 0.388 54.7 0.932 Contact Map
4qndA 2 0.4536 36.4 0.939 Contact Map
4qinA 2 0.8962 27.7 0.943 Contact Map
4xk8K 1 0.1257 21.2 0.946 Contact Map
4j05A 3 0.847 20.1 0.946 Contact Map
4mndA 2 0.847 12.6 0.951 Contact Map
3wdoA 1 0.8361 9.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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