GREMLIN Database
ALX - Inner membrane protein alx
UniProt: P42601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12731
Length: 321 (299)
Sequences: 2167 (1171)
Seq/√Len: 67.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_D194_V4.4141.00
56_N80_L4.3931.00
195_R200_L4.2891.00
34_H40_Q3.7961.00
74_P78_A3.6911.00
155_G274_V3.6471.00
53_L80_L3.5991.00
268_G304_T3.2641.00
125_L217_V3.1651.00
45_S87_K3.1431.00
193_F202_A3.0301.00
106_V187_I2.9531.00
193_F206_M2.9311.00
58_A62_Y2.9211.00
82_G227_I2.8451.00
43_A47_V2.8001.00
136_L143_I2.5201.00
127_T131_F2.4861.00
53_L57_A2.4181.00
271_V300_I2.3981.00
181_L202_A2.3821.00
167_G170_D2.3381.00
39_K43_A2.3101.00
177_L181_L2.3101.00
176_W180_H2.2571.00
85_I230_V2.2001.00
8_L12_G2.1661.00
57_A61_W2.1261.00
311_V315_H2.1201.00
114_V212_V2.0891.00
121_G125_L2.0801.00
23_I27_L2.0621.00
271_V303_M2.0451.00
38_M257_G2.0101.00
182_R199_L2.0091.00
75_Q233_D1.9901.00
35_A109_A1.9801.00
188_D196_K1.9311.00
292_V296_V1.9271.00
54_L58_A1.9241.00
289_P292_V1.9131.00
184_T188_D1.9031.00
291_A295_G1.8891.00
42_A46_L1.8381.00
81_T230_V1.8321.00
11_G15_V1.7781.00
202_A206_M1.7661.00
50_T54_L1.7611.00
56_N79_F1.7581.00
231_T236_I1.7151.00
306_I310_W1.7061.00
121_G213_E1.7051.00
264_M311_V1.6780.99
172_P175_R1.6780.99
143_I146_I1.6730.99
106_V208_V1.6580.99
63_L233_D1.6570.99
35_A108_A1.6480.99
123_I242_L1.6390.99
12_G16_V1.6300.99
157_K160_L1.6200.99
8_L11_G1.6090.99
263_S311_V1.6090.99
278_I282_I1.6080.99
272_I302_V1.5980.99
56_N76_A1.5850.99
19_I23_I1.5830.99
33_A190_E1.5710.99
113_R190_E1.5680.99
272_I301_L1.5570.99
228_F231_T1.5460.99
52_S79_F1.5230.99
196_K201_Y1.5220.99
272_I300_I1.4960.99
282_I285_F1.4920.99
156_V160_L1.4640.99
141_D145_Y1.4580.98
184_T194_V1.4560.98
264_M307_I1.4530.98
275_F296_V1.4370.98
296_V300_I1.4320.98
134_S228_F1.3790.98
112_R116_V1.3410.97
82_G231_T1.3340.97
14_A238_L1.3130.97
261_R312_N1.3090.97
302_V306_I1.3080.97
46_L50_T1.2980.97
57_A60_W1.2790.96
14_A18_A1.2760.96
129_M268_G1.2660.96
77_L81_T1.2640.96
60_W76_A1.2450.96
132_T136_L1.2420.96
152_L156_V1.2350.96
87_K246_L1.2310.96
94_V97_W1.2270.96
178_R185_D1.2150.95
85_I229_A1.2110.95
127_T238_L1.2080.95
91_V94_V1.2060.95
161_A164_D1.2050.95
22_A26_L1.2040.95
78_A236_I1.1890.95
36_M41_A1.1880.95
108_A111_Q1.1870.95
25_L116_V1.1600.94
148_G268_G1.1570.94
148_G281_L1.1550.94
117_Y121_G1.1480.94
90_A251_M1.1460.94
236_I239_T1.1440.94
49_V87_K1.1390.93
60_W65_Q1.1290.93
117_Y209_L1.1280.93
82_G237_V1.1110.93
64_V76_A1.1060.92
54_L57_A1.0940.92
111_Q252_Y1.0940.92
53_L56_N1.0930.92
36_M108_A1.0930.92
106_V209_L1.0900.92
183_M202_A1.0790.91
282_I286_Y1.0730.91
49_V53_L1.0640.91
25_L120_L1.0630.91
172_P176_W1.0630.91
23_I48_W1.0490.90
38_M42_A1.0440.90
152_L277_G1.0430.90
171_K174_V1.0410.90
305_F309_A1.0370.90
109_A113_R1.0360.90
263_S312_N1.0330.89
50_T57_A1.0310.89
76_A80_L1.0270.89
274_V278_I1.0250.89
128_I132_T1.0100.88
13_F239_T1.0060.88
177_L180_H1.0030.88
296_V299_G0.9990.88
137_I143_I0.9960.88
218_I221_V0.9850.87
301_L304_T0.9800.87
187_I208_V0.9730.86
59_F236_I0.9720.86
171_K214_L0.9710.86
98_L259_A0.9690.86
33_A40_Q0.9690.86
88_S264_M0.9530.85
252_Y255_L0.9520.85
14_A19_I0.9510.85
177_L207_L0.9350.84
184_T201_Y0.9290.84
137_I144_L0.9250.84
83_Y87_K0.9250.84
114_V120_L0.9240.83
87_K250_A0.9190.83
9_L58_A0.9110.83
23_I29_G0.9090.82
25_L112_R0.9080.82
11_G14_A0.9040.82
57_A80_L0.9040.82
53_L79_F0.8930.81
75_Q236_I0.8880.81
16_V58_A0.8850.81
168_I173_L0.8800.80
11_G22_A0.8800.80
310_W314_R0.8750.80
42_A254_L0.8720.80
206_M210_I0.8710.80
153_F156_V0.8700.80
12_G15_V0.8690.80
26_L29_G0.8650.79
176_W179_G0.8540.78
41_A44_W0.8540.78
174_V207_L0.8540.78
49_V60_W0.8480.78
18_A22_A0.8470.78
196_K199_L0.8460.78
23_I28_Q0.8450.78
111_Q256_A0.8450.78
303_M307_I0.8370.77
103_Y171_K0.8320.77
234_P242_L0.8320.77
169_G185_D0.8290.76
150_F153_F0.8280.76
145_Y284_D0.8270.76
44_W48_W0.8260.76
299_G303_M0.8170.75
311_V314_R0.8150.75
292_V295_G0.8130.75
45_S49_V0.8120.75
183_M201_Y0.8110.75
122_A216_D0.8090.74
90_A284_D0.8060.74
97_W212_V0.8060.74
87_K251_M0.8040.74
58_A63_L0.8040.74
99_M221_V0.8030.74
213_E245_I0.8020.74
149_A281_L0.8020.74
306_I309_A0.7990.74
196_K200_L0.7980.73
299_G302_V0.7980.73
210_I214_L0.7960.73
38_M45_S0.7960.73
150_F154_T0.7940.73
192_F213_E0.7930.73
52_S83_Y0.7920.73
112_R213_E0.7890.73
300_I303_M0.7870.72
143_I150_F0.7870.72
224_I227_I0.7850.72
102_S105_S0.7820.72
144_L283_V0.7820.72
208_V215_S0.7810.72
227_I230_V0.7780.72
267_Y270_A0.7780.72
26_L32_G0.7780.72
254_L261_R0.7710.71
144_L280_M0.7700.71
182_R201_Y0.7690.71
98_L209_L0.7660.70
32_G35_A0.7630.70
36_M98_L0.7620.70
94_V280_M0.7590.70
28_Q36_M0.7580.70
91_V301_L0.7550.69
41_A45_S0.7500.69
75_Q78_A0.7500.69
178_R183_M0.7470.68
154_T158_M0.7470.68
104_F208_V0.7440.68
84_L298_F0.7430.68
51_L97_W0.7420.68
59_F76_A0.7410.68
125_L213_E0.7400.68
165_E288_I0.7380.68
170_D175_R0.7360.67
45_S48_W0.7300.67
78_A290_I0.7300.67
304_T307_I0.7280.66
116_V213_E0.7210.66
197_N200_L0.7150.65
159_A274_V0.7100.65
46_L57_A0.7090.64
9_L63_L0.7090.64
241_N244_A0.7060.64
59_F75_Q0.7040.64
17_V63_L0.7000.63
36_M112_R0.6990.63
149_A153_F0.6950.63
300_I304_T0.6950.63
233_D236_I0.6940.63
133_G247_G0.6940.63
142_W145_Y0.6900.62
179_G183_M0.6860.62
230_V267_Y0.6850.62
173_L214_L0.6820.61
309_A312_N0.6810.61
114_V209_L0.6800.61
56_N239_T0.6790.61
42_A45_S0.6780.61
44_W47_V0.6770.61
16_V19_I0.6770.61
133_G279_K0.6740.61
122_A125_L0.6730.60
17_V272_I0.6730.60
141_D284_D0.6690.60
23_I26_L0.6670.60
195_R201_Y0.6670.60
129_M304_T0.6660.60
197_N201_Y0.6660.60
244_A256_A0.6630.59
152_L274_V0.6630.59
209_L213_E0.6590.59
96_V298_F0.6590.59
227_I237_V0.6550.58
307_I311_V0.6540.58
177_L210_I0.6510.58
51_L58_A0.6500.58
15_V19_I0.6490.58
141_D287_H0.6470.57
152_L281_L0.6470.57
79_F243_F0.6470.57
170_D179_G0.6440.57
191_H199_L0.6430.57
144_L155_G0.6420.57
293_S297_V0.6400.57
16_V20_M0.6360.56
182_R185_D0.6350.56
117_Y213_E0.6350.56
232_T283_V0.6310.56
153_F157_K0.6310.56
20_M28_Q0.6310.56
98_L255_L0.6300.55
267_Y271_V0.6300.55
29_G32_G0.6290.55
109_A189_N0.6240.55
20_M32_G0.6220.54
235_F239_T0.6220.54
36_M40_Q0.6220.54
119_V208_V0.6210.54
104_F174_V0.6210.54
16_V51_L0.6190.54
83_Y243_F0.6160.54
74_P156_V0.6150.54
158_M270_A0.6150.54
278_I288_I0.6140.54
113_R117_Y0.6110.53
194_V197_N0.6100.53
80_L84_L0.6090.53
21_L116_V0.6080.53
215_S269_L0.6070.53
90_A217_V0.6060.53
9_L16_V0.6060.53
181_L201_Y0.6060.53
13_F235_F0.6050.52
9_L13_F0.6040.52
36_M250_A0.6010.52
34_H112_R0.6000.52
271_V296_V0.5970.51
160_L199_L0.5970.51
59_F64_V0.5940.51
171_K177_L0.5940.51
94_V269_L0.5920.51
15_V26_L0.5910.51
81_T85_I0.5910.51
85_I137_I0.5890.51
136_L140_F0.5880.50
57_A76_A0.5860.50
179_G313_Y0.5850.50
12_G19_I0.5840.50
65_Q175_R0.5840.50
194_V201_Y0.5840.50
39_K51_L0.5840.50
61_W292_V0.5830.50
27_L233_D0.5820.50
176_W194_V0.5820.50
177_L202_A0.5800.49
85_I227_I0.5800.49
310_W316_D0.5800.49
41_A208_V0.5790.49
107_P114_V0.5770.49
298_F302_V0.5770.49
217_V266_K0.5760.49
147_F297_V0.5750.49
82_G258_V0.5750.49
65_Q76_A0.5740.49
94_V252_Y0.5720.48
124_V128_I0.5710.48
114_V213_E0.5690.48
29_G112_R0.5690.48
282_I288_I0.5680.48
43_A46_L0.5680.48
16_V22_A0.5670.48
94_V211_L0.5660.48
116_V269_L0.5650.48
20_M48_W0.5650.48
145_Y149_A0.5630.47
98_L102_S0.5630.47
28_Q44_W0.5620.47
145_Y227_I0.5620.47
130_I151_L0.5620.47
157_K161_A0.5620.47
106_V206_M0.5590.47
29_G36_M0.5570.47
235_F272_I0.5560.47
144_L276_I0.5540.46
185_D195_R0.5530.46
310_W313_Y0.5530.46
91_V98_L0.5530.46
20_M47_V0.5510.46
49_V52_S0.5510.46
272_I296_V0.5510.46
131_F235_F0.5480.46
85_I206_M0.5470.46
47_V50_T0.5460.45
19_I32_G0.5460.45
95_F220_A0.5460.45
125_L128_I0.5450.45
9_L19_I0.5450.45
215_S252_Y0.5440.45
18_A35_A0.5440.45
193_F200_L0.5440.45
117_Y254_L0.5410.45
63_L75_Q0.5410.45
295_G299_G0.5400.45
142_W146_I0.5400.45
81_T136_L0.5380.44
39_K183_M0.5370.44
119_V264_M0.5360.44
270_A274_V0.5360.44
99_M266_K0.5350.44
209_L212_V0.5350.44
29_G190_E0.5340.44
129_M297_V0.5330.44
84_L159_A0.5310.44
176_W181_L0.5290.43
111_Q174_V0.5260.43
52_S246_L0.5240.43
41_A280_M0.5230.43
21_L26_L0.5230.43
9_L23_I0.5220.43
159_A162_H0.5220.43
82_G217_V0.5220.43
141_D283_V0.5220.43
91_V243_F0.5210.42
228_F234_P0.5210.42
39_K146_I0.5200.42
158_M267_Y0.5200.42
307_I310_W0.5200.42
250_A297_V0.5180.42
272_I297_V0.5170.42
192_F217_V0.5170.42
107_P187_I0.5160.42
206_M303_M0.5160.42
214_L218_I0.5160.42
129_M242_L0.5150.42
145_Y250_A0.5140.42
25_L28_Q0.5140.42
85_I297_V0.5130.42
26_L33_A0.5130.42
127_T244_A0.5110.41
99_M152_L0.5100.41
170_D178_R0.5100.41
40_Q44_W0.5090.41
90_A211_L0.5090.41
77_L291_A0.5090.41
295_G298_F0.5080.41
186_T194_V0.5080.41
65_Q74_P0.5080.41
17_V246_L0.5080.41
229_A283_V0.5070.41
169_G172_P0.5070.41
32_G83_Y0.5050.41
17_V139_Q0.5040.40
34_H37_T0.5040.40
143_I191_H0.5040.40
283_V287_H0.5030.40
244_A255_L0.5030.40
45_S96_V0.5020.40
38_M88_S0.5020.40
145_Y154_T0.5010.40
10_W14_A0.5010.40
45_S246_L0.5000.40
115_L120_L0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8941 10.8 0.975 Contact Map
4pypA 1 0.9408 8.7 0.976 Contact Map
3o7qA 1 0.8785 8.6 0.976 Contact Map
4xnjA 1 0.4829 8.6 0.976 Contact Map
4w6vA 1 0.4766 8.2 0.976 Contact Map
3giaA 1 0.8692 8.1 0.976 Contact Map
4tphA 2 0.4206 8 0.976 Contact Map
2cfqA 1 0.486 7.4 0.976 Contact Map
4he8J 1 0.4798 6.8 0.977 Contact Map
2gfpA 2 0.866 6.3 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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