GREMLIN Database
YGJR - Uncharacterized oxidoreductase YgjR
UniProt: P42599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12729
Length: 328 (303)
Sequences: 25753 (19052)
Seq/√Len: 1094.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_E82_L3.0971.00
77_F105_A2.8701.00
124_A186_A2.7861.00
81_Q109_C2.7691.00
197_S218_D2.7271.00
85_S109_C2.6921.00
144_K243_E2.6571.00
36_L40_Q2.6411.00
3_R27_K2.6361.00
131_L134_Q2.5851.00
104_D304_R2.5791.00
71_S79_Q2.4191.00
77_F102_E2.4181.00
81_Q85_S2.3961.00
133_R137_P2.3891.00
196_K220_G2.3821.00
81_Q105_A2.3531.00
5_A58_M2.3351.00
89_N116_V2.3041.00
215_V313_I2.2071.00
30_A52_F2.1531.00
84_L115_V2.1371.00
75_L79_Q2.0971.00
54_S57_A2.0691.00
288_T292_E2.0541.00
108_A112_E2.0141.00
77_F81_Q1.9941.00
131_L135_A1.9691.00
111_R301_A1.9531.00
14_R45_D1.9231.00
80_T92_C1.9211.00
66_A286_F1.9021.00
50_H61_S1.8371.00
40_Q44_N1.8331.00
84_L110_A1.8291.00
142_L242_G1.8051.00
78_S82_L1.8041.00
71_S75_L1.8031.00
109_C113_N1.7991.00
104_D108_A1.7791.00
85_S113_N1.7621.00
89_N115_V1.7601.00
104_D308_K1.7531.00
67_V83_F1.7271.00
5_A64_I1.7091.00
35_S38_Q1.7061.00
100_L311_T1.6981.00
219_Y224_V1.6731.00
4_F66_A1.6651.00
80_T106_A1.6501.00
202_A317_T1.6341.00
99_N102_E1.6331.00
25_K291_D1.6311.00
23_S284_E1.6291.00
20_A68_Y1.6201.00
194_E305_I1.6171.00
26_Y287_A1.6131.00
60_E86_H1.5771.00
133_R190_A1.5771.00
64_I88_I1.5671.00
120_A282_E1.5601.00
59_A83_F1.5581.00
117_L300_L1.5531.00
196_K218_D1.5531.00
53_T57_A1.5501.00
135_A141_K1.5171.00
305_I308_K1.5021.00
55_L82_L1.4981.00
52_F61_S1.4881.00
132_L247_L1.4831.00
107_I304_R1.4811.00
194_E220_G1.4751.00
107_I300_L1.4721.00
85_S112_E1.4641.00
109_C112_E1.4591.00
41_H45_D1.4471.00
98_S102_E1.4291.00
189_V194_E1.4251.00
57_A60_E1.4181.00
36_L53_T1.4141.00
77_F106_A1.4111.00
116_V293_H1.4071.00
149_Y239_E1.3941.00
146_F243_E1.3911.00
56_E60_E1.3701.00
189_V305_I1.3591.00
97_A106_A1.3451.00
84_L113_N1.3421.00
82_L85_S1.3411.00
97_A103_V1.3351.00
52_F58_M1.3171.00
288_T294_L1.3161.00
103_V304_R1.3101.00
100_L308_K1.3091.00
239_E248_V1.2951.00
100_L104_D1.2931.00
9_T31_V1.2801.00
39_A51_L1.2781.00
142_L245_G1.2751.00
201_T218_D1.2681.00
82_L86_H1.2661.00
285_L289_L1.2631.00
285_L297_H1.2611.00
3_R29_T1.2551.00
32_Y55_L1.2341.00
57_A61_S1.2141.00
195_P219_Y1.2091.00
3_R65_D1.2081.00
69_I80_T1.2051.00
87_K113_N1.1961.00
74_S172_F1.1951.00
287_A291_D1.1881.00
83_F90_V1.1881.00
69_I79_Q1.1841.00
237_A248_V1.1841.00
32_Y58_M1.1841.00
41_H44_N1.1761.00
43_A51_L1.1711.00
107_I301_A1.1631.00
105_A108_A1.1621.00
84_L109_C1.1591.00
189_V219_Y1.1561.00
149_Y227_Q1.1561.00
55_L79_Q1.1561.00
22_E280_L1.1431.00
199_Q216_V1.1411.00
185_L309_L1.1391.00
311_T315_R1.1331.00
284_E288_T1.1221.00
299_G302_V1.1221.00
145_V240_I1.1151.00
169_N172_F1.1131.00
96_L103_V1.1131.00
192_F223_S1.1091.00
91_I120_A1.1081.00
37_E40_Q1.1071.00
55_L59_A1.1041.00
91_I282_E1.1031.00
312_E315_R1.0931.00
4_F26_Y1.0911.00
72_P75_L1.0891.00
148_N192_F1.0871.00
58_M64_I1.0841.00
129_F190_A1.0821.00
189_V302_V1.0771.00
105_A109_C1.0751.00
30_A64_I1.0751.00
107_I111_R1.0731.00
62_D88_I1.0711.00
188_A224_V1.0661.00
30_A58_M1.0651.00
108_A111_R1.0641.00
59_A82_L1.0571.00
103_V307_A1.0551.00
312_E316_Q1.0521.00
63_A88_I1.0331.00
281_Y284_E1.0091.00
142_L247_L1.0061.00
248_V259_C1.0061.00
7_I79_Q1.0041.00
102_E105_A1.0021.00
97_A102_E0.9871.00
101_A104_D0.9821.00
39_A53_T0.9801.00
61_S64_I0.9791.00
92_C117_L0.9751.00
81_Q106_A0.9751.00
89_N293_H0.9741.00
148_N224_V0.9721.00
59_A86_H0.9711.00
18_E22_E0.9651.00
16_F68_Y0.9551.00
124_A302_V0.9521.00
125_C285_L0.9471.00
285_L294_L0.9381.00
132_L249_I0.9371.00
38_Q41_H0.9371.00
89_N290_V0.9351.00
285_L288_T0.9281.00
52_F57_A0.9211.00
80_T90_V0.9211.00
100_L304_R0.9191.00
145_V242_G0.9161.00
39_A43_A0.9151.00
101_A105_A0.9091.00
79_Q82_L0.9091.00
301_A305_I0.9091.00
96_L300_L0.9081.00
314_R318_G0.9071.00
106_A117_L0.9051.00
142_L145_V0.9051.00
280_L284_E0.8931.00
96_L117_L0.8891.00
37_E41_H0.8881.00
308_K312_E0.8871.00
315_R318_G0.8871.00
9_T33_S0.8841.00
195_P217_M0.8771.00
77_F97_A0.8741.00
134_Q137_P0.8731.00
145_V192_F0.8731.00
18_E45_D0.8731.00
40_Q43_A0.8701.00
118_F286_F0.8661.00
239_E246_S0.8661.00
110_A113_N0.8631.00
141_K262_P0.8601.00
75_L78_S0.8571.00
137_P193_G0.8561.00
288_T293_H0.8541.00
40_Q51_L0.8541.00
185_L310_L0.8501.00
122_K278_T0.8481.00
36_L39_A0.8461.00
199_Q316_Q0.8451.00
84_L90_V0.8451.00
31_V42_F0.8441.00
149_Y225_T0.8411.00
214_V225_T0.8401.00
5_A30_A0.8391.00
69_I83_F0.8391.00
33_S39_A0.8311.00
2_I290_V0.8281.00
104_D107_I0.8271.00
170_P208_G0.8271.00
4_F20_A0.8261.00
110_A117_L0.8221.00
92_C96_L0.8201.00
29_T63_A0.8191.00
23_S26_Y0.8181.00
151_Q237_A0.8151.00
68_Y283_A0.8141.00
25_K284_E0.8121.00
80_T84_L0.8111.00
14_R41_H0.8031.00
36_L51_L0.8031.00
169_N208_G0.8001.00
116_V289_L0.7961.00
143_R245_G0.7951.00
130_H134_Q0.7951.00
195_P309_L0.7941.00
148_N240_I0.7901.00
289_L292_E0.7891.00
20_A26_Y0.7881.00
110_A115_V0.7881.00
116_V290_V0.7881.00
150_C238_S0.7851.00
33_S38_Q0.7801.00
20_A283_A0.7771.00
148_N188_A0.7731.00
200_A313_I0.7711.00
262_P265_S0.7701.00
25_K288_T0.7681.00
98_S173_S0.7671.00
289_L296_D0.7651.00
92_C106_A0.7651.00
189_V306_T0.7641.00
16_F283_A0.7621.00
295_V299_G0.7621.00
73_N179_D0.7571.00
244_A263_R0.7561.00
289_L294_L0.7551.00
237_A250_E0.7551.00
27_K49_E0.7541.00
110_A300_L0.7541.00
5_A32_Y0.7531.00
6_V17_V0.7511.00
201_T216_V0.7511.00
3_R64_I0.7471.00
279_M282_E0.7461.00
103_V107_I0.7461.00
7_I55_L0.7451.00
217_M224_V0.7441.00
121_F182_F0.7411.00
2_I66_A0.7401.00
12_I70_A0.7401.00
143_R242_G0.7401.00
13_T70_A0.7391.00
43_A48_V0.7371.00
181_G228_H0.7371.00
118_F289_L0.7361.00
136_L242_G0.7351.00
12_I16_F0.7311.00
119_E303_S0.7301.00
84_L117_L0.7281.00
13_T18_E0.7271.00
7_I71_S0.7261.00
50_H63_A0.7261.00
304_R308_K0.7251.00
150_C184_C0.7241.00
176_S228_H0.7231.00
29_T64_I0.7161.00
42_F45_D0.7121.00
96_L119_E0.7121.00
170_P318_G0.7111.00
130_H281_Y0.7091.00
66_A89_N0.7091.00
144_K244_A0.7061.00
175_G210_D0.7051.00
151_Q227_Q0.6991.00
210_D314_R0.6981.00
153_S227_Q0.6951.00
61_S88_I0.6941.00
195_P220_G0.6921.00
182_F306_T0.6921.00
177_I310_L0.6901.00
203_S218_D0.6901.00
76_H92_C0.6891.00
192_F219_Y0.6881.00
177_I213_G0.6871.00
7_I32_Y0.6851.00
123_T126_L0.6851.00
211_A231_V0.6831.00
5_A67_V0.6811.00
194_E308_K0.6811.00
17_V28_L0.6791.00
286_F290_V0.6781.00
12_I279_M0.6771.00
29_T50_H0.6771.00
200_A215_V0.6771.00
81_Q84_L0.6731.00
29_T61_S0.6701.00
302_V305_I0.6681.00
197_S201_T0.6671.00
133_R191_L0.6661.00
2_I291_D0.6661.00
129_F187_S0.6651.00
215_V226_L0.6651.00
4_F287_A0.6641.00
241_Q246_S0.6631.00
77_F109_C0.6621.00
87_K115_V0.6601.00
78_S105_A0.6551.00
80_T117_L0.6541.00
188_A219_Y0.6531.00
186_A306_T0.6511.00
91_I118_F0.6481.00
84_L106_A0.6481.00
300_L303_S0.6451.00
88_I115_V0.6431.00
150_C188_A0.6411.00
130_H297_H0.6401.00
35_S40_Q0.6401.00
174_N178_M0.6391.00
92_C119_E0.6381.00
94_K183_Y0.6361.00
144_K221_D0.6361.00
3_R63_A0.6361.00
179_D230_K0.6341.00
181_G184_C0.6331.00
200_A317_T0.6321.00
307_A311_T0.6301.00
189_V309_L0.6261.00
147_F241_Q0.6251.00
58_M61_S0.6251.00
124_A190_A0.6251.00
9_T39_A0.6251.00
14_R18_E0.6241.00
258_V261_V0.6201.00
191_L240_I0.6181.00
121_F306_T0.6171.00
121_F186_A0.6171.00
116_V295_V0.6151.00
229_S232_S0.6151.00
116_V296_D0.6131.00
11_W15_Q0.6131.00
23_S287_A0.6081.00
200_A213_G0.6071.00
136_L240_I0.6061.00
130_H190_A0.6041.00
67_V88_I0.6031.00
66_A290_V0.6021.00
205_L211_A0.5971.00
185_L313_I0.5971.00
42_F46_F0.5971.00
186_A190_A0.5951.00
270_L273_P0.5921.00
14_R38_Q0.5901.00
25_K287_A0.5861.00
4_F68_Y0.5841.00
56_E78_S0.5831.00
285_L296_D0.5821.00
122_K279_M0.5821.00
9_T42_F0.5811.00
199_Q218_D0.5811.00
14_R46_F0.5791.00
12_I93_E0.5761.00
141_K144_K0.5741.00
55_L83_F0.5731.00
152_Y180_I0.5711.00
216_V225_T0.5691.00
132_L191_L0.5681.00
202_A213_G0.5681.00
68_Y91_I0.5671.00
118_F285_L0.5651.00
26_Y66_A0.5601.00
17_V42_F0.5591.00
262_P266_Q0.5591.00
14_R42_F0.5581.00
135_A260_F0.5551.00
167_T179_D0.5551.00
52_F62_D0.5501.00
23_S280_L0.5481.00
178_M311_T0.5471.00
123_T186_A0.5461.00
277_N280_L0.5461.00
78_S81_Q0.5451.00
10_N70_A0.5441.00
212_Q229_S0.5421.00
93_E120_A0.5411.00
140_G144_K0.5411.00
32_Y52_F0.5401.00
74_S98_S0.5401.00
44_N51_L0.5381.00
80_T110_A0.5371.00
94_K179_D0.5361.00
171_A208_G0.5341.00
34_R71_S0.5331.00
183_Y186_A0.5331.00
154_S180_I0.5331.00
69_I76_H0.5331.00
188_A226_L0.5321.00
107_I110_A0.5321.00
253_S257_K0.5311.00
288_T291_D0.5291.00
118_F282_E0.5291.00
147_F225_T0.5291.00
306_T310_L0.5271.00
65_D291_D0.5261.00
276_I280_L0.5261.00
177_I215_V0.5241.00
70_A93_E0.5231.00
214_V227_Q0.5211.00
147_F212_Q0.5201.00
136_L191_L0.5191.00
13_T42_F0.5191.00
56_E86_H0.5171.00
71_S76_H0.5161.00
166_N169_N0.5151.00
2_I26_Y0.5141.00
173_S209_V0.5121.00
217_M226_L0.5111.00
212_Q227_Q0.5111.00
18_E21_H0.5091.00
85_S105_A0.5071.00
99_N311_T0.5071.00
6_V28_L0.5051.00
127_P281_Y0.5041.00
310_L314_R0.5031.00
6_V68_Y0.5031.00
219_Y223_S0.5021.00
16_F20_A0.5011.00
242_G247_L0.5001.00
147_F227_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zh8A 2 0.9604 100 0.163 Contact Map
1h6dA 8 0.9939 100 0.164 Contact Map
2nvwA 3 0.9604 100 0.172 Contact Map
3dtyA 4 0.9512 100 0.177 Contact Map
3db2A 2 0.9848 100 0.185 Contact Map
3v5nA 4 0.9268 100 0.187 Contact Map
4gqaA 4 0.9939 100 0.189 Contact Map
4hadA 4 0.936 100 0.197 Contact Map
3btvA 2 0.9604 100 0.198 Contact Map
3euwA 4 0.9695 100 0.201 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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