RLMG - ECOLI - GREMLIN Contacts

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RLMG - Ribosomal RNA large subunit methyltransferase G

UniProt:	P42596	Sequences: MSHLDNGFRSLTLQRFPATDDVNPLQAWEAADEYLLQQLDDTEIRGPVLILNDAFGALSCALAEHKPYSIGDSYISELATRENLRLNGIDESSVKFLDSTADYPQQPGVVLIKVPKTLALLEQQLRALRKVVTSDTRIIAGAKARDIHTSTLELFEKVLGPTTTTLAWKKARLINCTFNEPQLADAPQTVSWKLEGTDWTIHNHANVFSRTGLDIGARFFMQHLPENLEGEIVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNMPEALDRCEFMINNALSGVEPFRFNAVLCNPPFHQQHALTDNVAWEMFHHARRCLKINGELYIVANRHLDYFHKLKKIFGNCTTIATNNKFVVLKAVKLGRRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12726
Length:	378 (334)
Sequences:	1082 (719)
Seq/√Len:	39.4

ECOLI - RLMG RSMC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
246_L	303_L	5.516	1.00
233_V	299_F	4.296	1.00
320_W	349_K	3.605	1.00
358_T	370_K	3.421	1.00
232_I	246_L	3.385	1.00
219_F	363_N	3.252	1.00
243_G	257_F	3.059	1.00
300_N	331_K	2.934	1.00
335_E	370_K	2.928	1.00
231_E	254_K	2.826	1.00
254_K	284_E	2.818	1.00
337_Y	360_I	2.666	1.00
47_P	108_G	2.560	1.00
231_E	256_V	2.271	1.00
142_A	174_I	2.252	1.00
143_K	171_A	2.239	1.00
55_F	58_L	2.191	0.99
58_L	64_E	2.180	0.99
98_D	101_A	2.172	0.99
144_A	167_A	2.143	0.99
359_T	362_T	2.127	0.99
193_K	200_T	2.119	0.99
129_R	133_T	2.086	0.99
257_F	285_F	2.081	0.99
57_A	64_E	2.078	0.99
217_A	242_I	2.072	0.99
222_Q	363_N	2.063	0.99
146_D	172_R	2.042	0.99
272_V	285_F	2.008	0.99
347_F	367_V	1.988	0.99
188_Q	204_H	1.982	0.99
257_F	268_S	1.981	0.99
326_A	336_L	1.975	0.99
207_V	239_N	1.972	0.99
57_A	62_L	1.958	0.99
142_A	172_R	1.936	0.99
58_L	63_A	1.935	0.99
261_S	309_H	1.931	0.99
160_G	185_D	1.919	0.98
144_A	147_I	1.895	0.98
319_A	323_F	1.885	0.98
266_A	269_R	1.880	0.98
57_A	60_C	1.864	0.98
256_V	286_M	1.837	0.98
58_L	62_L	1.822	0.98
245_T	249_K	1.810	0.98
142_A	146_D	1.802	0.98
223_H	361_A	1.802	0.98
221_M	242_I	1.795	0.98
165_T	175_N	1.775	0.97
232_I	253_A	1.762	0.97
143_K	147_I	1.758	0.97
117_T	206_N	1.758	0.97
237_C	243_G	1.751	0.97
51_L	124_Q	1.713	0.97
57_A	61_A	1.708	0.97
362_T	367_V	1.708	0.97
277_P	281_D	1.705	0.97
61_A	64_E	1.690	0.96
47_P	66_K	1.687	0.96
201_I	271_N	1.660	0.96
244_L	271_N	1.602	0.95
230_G	300_N	1.565	0.95
74_Y	78_L	1.555	0.94
337_Y	370_K	1.554	0.94
53_D	58_L	1.552	0.94
270_L	274_T	1.521	0.94
229_E	250_N	1.512	0.93
219_F	361_A	1.494	0.93
269_R	273_E	1.489	0.93
155_F	176_C	1.484	0.93
308_F	341_N	1.477	0.93
145_R	170_K	1.474	0.93
125_L	129_R	1.462	0.92
109_V	139_I	1.456	0.92
57_A	63_A	1.445	0.92
272_V	283_C	1.440	0.92
215_I	365_K	1.428	0.91
342_R	345_D	1.422	0.91
246_L	253_A	1.415	0.91
72_D	261_S	1.414	0.91
206_N	263_M	1.409	0.91
191_S	200_T	1.389	0.90
63_A	67_P	1.389	0.90
132_V	136_T	1.385	0.90
349_K	353_I	1.383	0.90
209_S	268_S	1.379	0.90
37_Q	168_W	1.372	0.90
342_R	367_V	1.370	0.90
125_L	136_T	1.364	0.89
69_S	80_T	1.362	0.89
304_C	322_M	1.342	0.89
309_H	339_V	1.342	0.89
199_W	244_L	1.341	0.89
128_L	138_I	1.341	0.89
162_T	174_I	1.323	0.88
290_A	321_E	1.320	0.88
55_F	63_A	1.312	0.87
167_A	171_A	1.309	0.87
357_C	369_L	1.303	0.87
55_F	64_E	1.298	0.87
203_N	210_R	1.288	0.86
298_R	329_C	1.269	0.86
58_L	61_A	1.265	0.85
231_E	331_K	1.263	0.85
125_L	128_L	1.263	0.85
128_L	132_V	1.262	0.85
164_T	236_G	1.261	0.85
159_L	176_C	1.259	0.85
216_G	245_T	1.249	0.85
53_D	56_G	1.241	0.84
60_C	64_E	1.239	0.84
148_H	151_T	1.236	0.84
216_G	242_I	1.236	0.84
140_A	155_F	1.234	0.84
143_K	146_D	1.233	0.84
186_A	189_T	1.231	0.84
36_L	61_A	1.229	0.84
271_N	275_N	1.226	0.84
345_D	348_H	1.225	0.83
54_A	113_K	1.220	0.83
216_G	309_H	1.219	0.83
288_N	293_G	1.217	0.83
82_E	86_L	1.216	0.83
115_P	124_Q	1.200	0.82
74_Y	293_G	1.195	0.82
201_I	239_N	1.192	0.82
55_F	61_A	1.174	0.81
129_R	136_T	1.173	0.81
81_R	96_F	1.164	0.80
60_C	84_L	1.160	0.80
231_E	253_A	1.149	0.79
150_S	164_T	1.145	0.79
55_F	62_L	1.143	0.79
132_V	135_D	1.143	0.79
53_D	57_A	1.139	0.79
140_A	148_H	1.139	0.79
207_V	267_S	1.132	0.78
294_V	329_C	1.132	0.78
233_V	294_V	1.131	0.78
304_C	338_I	1.127	0.78
254_K	348_H	1.127	0.78
55_F	60_C	1.120	0.78
289_N	292_S	1.117	0.77
317_N	321_E	1.110	0.77
149_T	153_E	1.104	0.77
123_Q	127_A	1.104	0.77
271_N	274_T	1.101	0.76
54_A	57_A	1.096	0.76
56_G	62_L	1.095	0.76
342_R	362_T	1.079	0.75
242_I	248_D	1.074	0.74
142_A	145_R	1.074	0.74
119_A	122_E	1.063	0.74
320_W	353_I	1.063	0.74
232_I	301_A	1.059	0.73
360_I	370_K	1.048	0.73
128_L	136_T	1.048	0.73
122_E	158_V	1.048	0.73
313_A	322_M	1.047	0.73
345_D	351_K	1.042	0.72
340_A	345_D	1.039	0.72
153_E	207_V	1.033	0.72
145_R	172_R	1.033	0.72
59_S	69_S	1.032	0.71
49_L	107_P	1.029	0.71
325_H	328_R	1.029	0.71
194_L	289_N	1.022	0.71
114_V	140_A	1.021	0.71
256_V	294_V	1.020	0.71
147_I	152_L	1.018	0.70
229_E	232_I	1.011	0.70
256_V	299_F	1.011	0.70
144_A	174_I	1.005	0.69
118_L	121_L	1.004	0.69
245_T	248_D	1.001	0.69
189_T	204_H	0.999	0.69
204_H	266_A	0.998	0.69
247_L	272_V	0.996	0.69
268_S	285_F	0.992	0.68
335_E	372_V	0.990	0.68
346_Y	354_F	0.989	0.68
299_F	329_C	0.987	0.68
125_L	137_R	0.985	0.68
141_G	148_H	0.983	0.68
221_M	245_T	0.983	0.68
269_R	285_F	0.981	0.68
217_A	221_M	0.978	0.67
328_R	339_V	0.974	0.67
37_Q	43_E	0.972	0.67
54_A	61_A	0.970	0.67
170_K	216_G	0.965	0.66
361_A	368_V	0.963	0.66
209_S	212_G	0.954	0.65
247_L	255_V	0.950	0.65
227_N	250_N	0.944	0.65
185_D	188_Q	0.930	0.63
56_G	172_R	0.929	0.63
316_D	320_W	0.923	0.63
291_L	329_C	0.920	0.63
54_A	58_L	0.919	0.62
74_Y	287_I	0.909	0.62
77_E	81_R	0.907	0.61
118_L	122_E	0.904	0.61
139_I	165_T	0.904	0.61
284_E	295_E	0.903	0.61
144_A	166_L	0.899	0.61
169_K	261_S	0.895	0.60
122_E	126_R	0.892	0.60
80_T	84_L	0.891	0.60
209_S	213_L	0.890	0.60
229_E	300_N	0.888	0.60
272_V	277_P	0.881	0.59
147_I	174_I	0.869	0.58
55_F	59_S	0.865	0.58
247_L	277_P	0.863	0.58
56_G	60_C	0.859	0.57
125_L	134_S	0.859	0.57
233_V	329_C	0.858	0.57
256_V	284_E	0.856	0.57
340_A	347_F	0.853	0.57
249_K	338_I	0.846	0.56
113_K	171_A	0.845	0.56
195_E	198_D	0.844	0.56
344_L	350_L	0.842	0.56
260_E	309_H	0.842	0.56
52_N	55_F	0.838	0.55
109_V	137_R	0.836	0.55
316_D	340_A	0.835	0.55
323_F	338_I	0.828	0.54
198_D	248_D	0.828	0.54
289_N	321_E	0.827	0.54
191_S	202_H	0.826	0.54
223_H	368_V	0.826	0.54
209_S	267_S	0.825	0.54
115_P	121_L	0.819	0.54
35_L	139_I	0.818	0.53
199_W	247_L	0.816	0.53
235_L	310_Q	0.811	0.53
351_K	354_F	0.809	0.53
48_V	109_V	0.808	0.53
194_L	213_L	0.807	0.52
222_Q	225_P	0.806	0.52
296_P	328_R	0.803	0.52
223_H	360_I	0.803	0.52
191_S	249_K	0.801	0.52
147_I	155_F	0.799	0.52
120_L	206_N	0.798	0.52
75_I	78_L	0.796	0.51
149_T	164_T	0.793	0.51
164_T	167_A	0.791	0.51
365_K	368_V	0.790	0.51
242_I	304_C	0.787	0.51
236_G	265_V	0.784	0.50
192_W	275_N	0.783	0.50
123_Q	136_T	0.783	0.50
129_R	137_R	0.783	0.50
121_L	170_K	0.781	0.50
347_F	359_T	0.781	0.50
38_Q	175_N	0.781	0.50
224_L	335_E	0.779	0.50
141_G	144_A	0.778	0.50
113_K	141_G	0.776	0.50
116_K	309_H	0.774	0.49
349_K	354_F	0.773	0.49
291_L	318_V	0.772	0.49
237_C	259_D	0.771	0.49
202_H	274_T	0.770	0.49
236_G	300_N	0.765	0.49
161_P	212_G	0.765	0.49
247_L	283_C	0.764	0.49
182_Q	186_A	0.762	0.48
168_W	172_R	0.760	0.48
330_L	334_G	0.759	0.48
115_P	170_K	0.756	0.48
224_L	301_A	0.755	0.48
246_L	250_N	0.755	0.48
184_A	232_I	0.754	0.48
144_A	148_H	0.754	0.48
126_R	158_V	0.748	0.47
189_T	205_A	0.744	0.47
278_E	282_R	0.740	0.46
126_R	130_K	0.739	0.46
277_P	283_C	0.736	0.46
147_I	315_T	0.735	0.46
257_F	265_V	0.732	0.46
132_V	159_L	0.732	0.46
37_Q	40_D	0.731	0.46
170_K	309_H	0.730	0.46
59_S	64_E	0.725	0.45
278_E	281_D	0.725	0.45
56_G	61_A	0.724	0.45
142_A	147_I	0.720	0.45
342_R	359_T	0.720	0.45
75_I	173_L	0.716	0.44
202_H	270_L	0.715	0.44
145_R	148_H	0.711	0.44
52_N	58_L	0.711	0.44
125_L	133_T	0.711	0.44
226_E	250_N	0.709	0.44
295_E	300_N	0.709	0.44
141_G	146_D	0.708	0.44
260_E	311_Q	0.707	0.43
172_R	235_L	0.706	0.43
288_N	292_S	0.704	0.43
110_V	309_H	0.702	0.43
104_P	131_V	0.701	0.43
125_L	132_V	0.700	0.43
343_H	354_F	0.699	0.43
167_A	174_I	0.698	0.43
323_F	350_L	0.697	0.43
184_A	187_P	0.696	0.42
80_T	96_F	0.696	0.42
286_M	294_V	0.696	0.42
124_Q	128_L	0.695	0.42
59_S	62_L	0.695	0.42
104_P	107_P	0.695	0.42
310_Q	315_T	0.694	0.42
52_N	99_S	0.693	0.42
340_A	369_L	0.693	0.42
66_K	296_P	0.693	0.42
117_T	309_H	0.692	0.42
231_E	300_N	0.691	0.42
53_D	170_K	0.691	0.42
35_L	328_R	0.691	0.42
71_G	77_E	0.689	0.42
56_G	64_E	0.687	0.42
123_Q	137_R	0.686	0.42
171_A	174_I	0.680	0.41
254_K	281_D	0.679	0.41
170_K	235_L	0.677	0.41
170_K	174_I	0.668	0.40
148_H	172_R	0.666	0.40
220_F	242_I	0.663	0.40
346_Y	350_L	0.663	0.40
225_P	228_L	0.663	0.40
49_L	197_T	0.657	0.39
126_R	129_R	0.657	0.39
52_N	60_C	0.654	0.39
58_L	336_L	0.654	0.39
148_H	152_L	0.652	0.39
114_V	172_R	0.650	0.38
266_A	270_L	0.649	0.38
139_I	175_N	0.647	0.38
282_R	339_V	0.647	0.38
232_I	252_Q	0.644	0.38
39_L	62_L	0.642	0.38
320_W	352_K	0.641	0.38
115_P	118_L	0.640	0.38
232_I	250_N	0.640	0.38
151_T	162_T	0.640	0.38
270_L	273_E	0.639	0.37
336_L	346_Y	0.638	0.37
235_L	291_L	0.638	0.37
120_L	123_Q	0.637	0.37
39_L	43_E	0.635	0.37
168_W	171_A	0.634	0.37
310_Q	314_L	0.634	0.37
54_A	62_L	0.632	0.37
341_N	346_Y	0.632	0.37
204_H	270_L	0.632	0.37
143_K	170_K	0.631	0.37
52_N	120_L	0.631	0.37
146_D	151_T	0.630	0.37
56_G	59_S	0.629	0.37
187_P	303_L	0.629	0.37
153_E	258_V	0.628	0.37
77_E	80_T	0.627	0.36
78_L	81_R	0.623	0.36
113_K	143_K	0.622	0.36
273_E	278_E	0.622	0.36
122_E	157_K	0.620	0.36
147_I	170_K	0.618	0.36
60_C	63_A	0.618	0.36
123_Q	133_T	0.618	0.36
262_P	266_A	0.617	0.36
246_L	257_F	0.617	0.36
115_P	123_Q	0.616	0.36
236_G	258_V	0.616	0.36
143_K	315_T	0.614	0.35
67_P	173_L	0.613	0.35
219_F	222_Q	0.610	0.35
338_I	371_A	0.606	0.35
255_V	281_D	0.606	0.35
160_G	178_F	0.605	0.35
77_E	287_I	0.604	0.35
139_I	144_A	0.603	0.34
216_G	237_C	0.602	0.34
204_H	311_Q	0.601	0.34
165_T	322_M	0.601	0.34
234_D	309_H	0.600	0.34
52_N	57_A	0.599	0.34
162_T	314_L	0.598	0.34
229_E	339_V	0.598	0.34
126_R	188_Q	0.597	0.34
156_E	160_G	0.596	0.34
47_P	105_Q	0.595	0.34
318_V	325_H	0.595	0.34
341_N	344_L	0.594	0.34
125_L	368_V	0.590	0.33
291_L	325_H	0.589	0.33
114_V	121_L	0.588	0.33
230_G	309_H	0.587	0.33
201_I	242_I	0.585	0.33
205_A	312_H	0.585	0.33
115_P	309_H	0.584	0.33
347_F	351_K	0.584	0.33
37_Q	41_D	0.583	0.33
76_S	79_A	0.583	0.33
47_P	107_P	0.583	0.33
244_L	277_P	0.581	0.33
255_V	283_C	0.580	0.33
155_F	167_A	0.580	0.33
91_E	95_K	0.579	0.33
70_I	73_S	0.578	0.32
127_A	131_V	0.577	0.32
333_N	355_G	0.575	0.32
263_M	322_M	0.574	0.32
206_N	310_Q	0.574	0.32
35_L	135_D	0.574	0.32
46_G	65_H	0.573	0.32
116_K	120_L	0.573	0.32
302_V	328_R	0.571	0.32
38_Q	43_E	0.570	0.32
290_A	318_V	0.569	0.32
262_P	287_I	0.568	0.32
234_D	307_P	0.566	0.31
292_S	331_K	0.565	0.31
56_G	170_K	0.565	0.31
59_S	80_T	0.565	0.31
99_S	263_M	0.565	0.31
201_I	241_V	0.565	0.31
52_N	291_L	0.564	0.31
159_L	309_H	0.564	0.31
130_K	284_E	0.561	0.31
146_D	170_K	0.560	0.31
207_V	344_L	0.558	0.31
309_H	341_N	0.557	0.31
73_S	124_Q	0.556	0.31
281_D	296_P	0.556	0.31
333_N	337_Y	0.556	0.31
357_C	371_A	0.556	0.31
206_N	212_G	0.556	0.31
348_H	351_K	0.555	0.31
199_W	248_D	0.555	0.31
260_E	310_Q	0.555	0.31
224_L	246_L	0.555	0.31
209_S	239_N	0.545	0.30
63_A	94_V	0.544	0.30
165_T	172_R	0.542	0.30
49_L	246_L	0.541	0.30
240_G	305_N	0.541	0.30
163_T	236_G	0.540	0.29
261_S	317_N	0.539	0.29
47_P	65_H	0.539	0.29
85_R	89_I	0.539	0.29
118_L	154_L	0.538	0.29
50_I	266_A	0.537	0.29
67_P	149_T	0.536	0.29
167_A	172_R	0.534	0.29
119_A	194_L	0.534	0.29
72_D	76_S	0.532	0.29
299_F	302_V	0.532	0.29
207_V	268_S	0.531	0.29
254_K	298_R	0.531	0.29
58_L	346_Y	0.530	0.29
302_V	326_A	0.530	0.29
91_E	135_D	0.527	0.29
285_F	288_N	0.526	0.28
358_T	372_V	0.526	0.28
141_G	172_R	0.526	0.28
292_S	372_V	0.526	0.28
167_A	170_K	0.525	0.28
188_Q	205_A	0.523	0.28
112_I	138_I	0.522	0.28
64_E	301_A	0.521	0.28
242_I	245_T	0.520	0.28
245_T	303_L	0.519	0.28
327_R	369_L	0.517	0.28
192_W	213_L	0.517	0.28
209_S	294_V	0.516	0.28
151_T	164_T	0.514	0.28
316_D	319_A	0.512	0.27
187_P	249_K	0.511	0.27
195_E	241_V	0.511	0.27
111_L	346_Y	0.511	0.27
202_H	370_K	0.511	0.27
258_V	291_L	0.510	0.27
107_P	136_T	0.510	0.27
242_I	290_A	0.510	0.27
234_D	306_P	0.509	0.27
324_H	327_R	0.508	0.27
217_A	290_A	0.508	0.27
44_I	256_V	0.508	0.27
219_F	368_V	0.508	0.27
228_L	301_A	0.508	0.27
37_Q	44_I	0.507	0.27
133_T	137_R	0.506	0.27
143_K	217_A	0.503	0.27
116_K	140_A	0.503	0.27
110_V	287_I	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4dcmA	1	0.9524	100	0.39	Contact Map
2pjdA	1	0.881	100	0.474	Contact Map
3dmgA	1	0.9286	100	0.503	Contact Map
1dusA	1	0.5026	100	0.764	Contact Map
2ozvA	2	0.4074	99.9	0.803	Contact Map
3lpmA	2	0.4815	99.9	0.805	Contact Map
2b3tA	1	0.6455	99.9	0.809	Contact Map
4mtlA	4	0.5265	99.9	0.811	Contact Map
3evzA	1	0.4841	99.9	0.813	Contact Map
3m70A	1	0.6429	99.8	0.815	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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