GREMLIN Database
RLMG - Ribosomal RNA large subunit methyltransferase G
UniProt: P42596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12726
Length: 378 (334)
Sequences: 1082 (719)
Seq/√Len: 39.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
246_L303_L5.5161.00
233_V299_F4.2961.00
320_W349_K3.6051.00
358_T370_K3.4211.00
232_I246_L3.3851.00
219_F363_N3.2521.00
243_G257_F3.0591.00
300_N331_K2.9341.00
335_E370_K2.9281.00
231_E254_K2.8261.00
254_K284_E2.8181.00
337_Y360_I2.6661.00
47_P108_G2.5601.00
231_E256_V2.2711.00
142_A174_I2.2521.00
143_K171_A2.2391.00
55_F58_L2.1910.99
58_L64_E2.1800.99
98_D101_A2.1720.99
144_A167_A2.1430.99
359_T362_T2.1270.99
193_K200_T2.1190.99
129_R133_T2.0860.99
257_F285_F2.0810.99
57_A64_E2.0780.99
217_A242_I2.0720.99
222_Q363_N2.0630.99
146_D172_R2.0420.99
272_V285_F2.0080.99
347_F367_V1.9880.99
188_Q204_H1.9820.99
257_F268_S1.9810.99
326_A336_L1.9750.99
207_V239_N1.9720.99
57_A62_L1.9580.99
142_A172_R1.9360.99
58_L63_A1.9350.99
261_S309_H1.9310.99
160_G185_D1.9190.98
144_A147_I1.8950.98
319_A323_F1.8850.98
266_A269_R1.8800.98
57_A60_C1.8640.98
256_V286_M1.8370.98
58_L62_L1.8220.98
245_T249_K1.8100.98
142_A146_D1.8020.98
223_H361_A1.8020.98
221_M242_I1.7950.98
165_T175_N1.7750.97
232_I253_A1.7620.97
143_K147_I1.7580.97
117_T206_N1.7580.97
237_C243_G1.7510.97
51_L124_Q1.7130.97
57_A61_A1.7080.97
362_T367_V1.7080.97
277_P281_D1.7050.97
61_A64_E1.6900.96
47_P66_K1.6870.96
201_I271_N1.6600.96
244_L271_N1.6020.95
230_G300_N1.5650.95
74_Y78_L1.5550.94
337_Y370_K1.5540.94
53_D58_L1.5520.94
270_L274_T1.5210.94
229_E250_N1.5120.93
219_F361_A1.4940.93
269_R273_E1.4890.93
155_F176_C1.4840.93
308_F341_N1.4770.93
145_R170_K1.4740.93
125_L129_R1.4620.92
109_V139_I1.4560.92
57_A63_A1.4450.92
272_V283_C1.4400.92
215_I365_K1.4280.91
342_R345_D1.4220.91
246_L253_A1.4150.91
72_D261_S1.4140.91
206_N263_M1.4090.91
191_S200_T1.3890.90
63_A67_P1.3890.90
132_V136_T1.3850.90
349_K353_I1.3830.90
209_S268_S1.3790.90
37_Q168_W1.3720.90
342_R367_V1.3700.90
125_L136_T1.3640.89
69_S80_T1.3620.89
304_C322_M1.3420.89
309_H339_V1.3420.89
199_W244_L1.3410.89
128_L138_I1.3410.89
162_T174_I1.3230.88
290_A321_E1.3200.88
55_F63_A1.3120.87
167_A171_A1.3090.87
357_C369_L1.3030.87
55_F64_E1.2980.87
203_N210_R1.2880.86
298_R329_C1.2690.86
58_L61_A1.2650.85
231_E331_K1.2630.85
125_L128_L1.2630.85
128_L132_V1.2620.85
164_T236_G1.2610.85
159_L176_C1.2590.85
216_G245_T1.2490.85
53_D56_G1.2410.84
60_C64_E1.2390.84
148_H151_T1.2360.84
216_G242_I1.2360.84
140_A155_F1.2340.84
143_K146_D1.2330.84
186_A189_T1.2310.84
36_L61_A1.2290.84
271_N275_N1.2260.84
345_D348_H1.2250.83
54_A113_K1.2200.83
216_G309_H1.2190.83
288_N293_G1.2170.83
82_E86_L1.2160.83
115_P124_Q1.2000.82
74_Y293_G1.1950.82
201_I239_N1.1920.82
55_F61_A1.1740.81
129_R136_T1.1730.81
81_R96_F1.1640.80
60_C84_L1.1600.80
231_E253_A1.1490.79
150_S164_T1.1450.79
55_F62_L1.1430.79
132_V135_D1.1430.79
53_D57_A1.1390.79
140_A148_H1.1390.79
207_V267_S1.1320.78
294_V329_C1.1320.78
233_V294_V1.1310.78
304_C338_I1.1270.78
254_K348_H1.1270.78
55_F60_C1.1200.78
289_N292_S1.1170.77
317_N321_E1.1100.77
149_T153_E1.1040.77
123_Q127_A1.1040.77
271_N274_T1.1010.76
54_A57_A1.0960.76
56_G62_L1.0950.76
342_R362_T1.0790.75
242_I248_D1.0740.74
142_A145_R1.0740.74
119_A122_E1.0630.74
320_W353_I1.0630.74
232_I301_A1.0590.73
360_I370_K1.0480.73
128_L136_T1.0480.73
122_E158_V1.0480.73
313_A322_M1.0470.73
345_D351_K1.0420.72
340_A345_D1.0390.72
153_E207_V1.0330.72
145_R172_R1.0330.72
59_S69_S1.0320.71
49_L107_P1.0290.71
325_H328_R1.0290.71
194_L289_N1.0220.71
114_V140_A1.0210.71
256_V294_V1.0200.71
147_I152_L1.0180.70
229_E232_I1.0110.70
256_V299_F1.0110.70
144_A174_I1.0050.69
118_L121_L1.0040.69
245_T248_D1.0010.69
189_T204_H0.9990.69
204_H266_A0.9980.69
247_L272_V0.9960.69
268_S285_F0.9920.68
335_E372_V0.9900.68
346_Y354_F0.9890.68
299_F329_C0.9870.68
125_L137_R0.9850.68
141_G148_H0.9830.68
221_M245_T0.9830.68
269_R285_F0.9810.68
217_A221_M0.9780.67
328_R339_V0.9740.67
37_Q43_E0.9720.67
54_A61_A0.9700.67
170_K216_G0.9650.66
361_A368_V0.9630.66
209_S212_G0.9540.65
247_L255_V0.9500.65
227_N250_N0.9440.65
185_D188_Q0.9300.63
56_G172_R0.9290.63
316_D320_W0.9230.63
291_L329_C0.9200.63
54_A58_L0.9190.62
74_Y287_I0.9090.62
77_E81_R0.9070.61
118_L122_E0.9040.61
139_I165_T0.9040.61
284_E295_E0.9030.61
144_A166_L0.8990.61
169_K261_S0.8950.60
122_E126_R0.8920.60
80_T84_L0.8910.60
209_S213_L0.8900.60
229_E300_N0.8880.60
272_V277_P0.8810.59
147_I174_I0.8690.58
55_F59_S0.8650.58
247_L277_P0.8630.58
56_G60_C0.8590.57
125_L134_S0.8590.57
233_V329_C0.8580.57
256_V284_E0.8560.57
340_A347_F0.8530.57
249_K338_I0.8460.56
113_K171_A0.8450.56
195_E198_D0.8440.56
344_L350_L0.8420.56
260_E309_H0.8420.56
52_N55_F0.8380.55
109_V137_R0.8360.55
316_D340_A0.8350.55
323_F338_I0.8280.54
198_D248_D0.8280.54
289_N321_E0.8270.54
191_S202_H0.8260.54
223_H368_V0.8260.54
209_S267_S0.8250.54
115_P121_L0.8190.54
35_L139_I0.8180.53
199_W247_L0.8160.53
235_L310_Q0.8110.53
351_K354_F0.8090.53
48_V109_V0.8080.53
194_L213_L0.8070.52
222_Q225_P0.8060.52
296_P328_R0.8030.52
223_H360_I0.8030.52
191_S249_K0.8010.52
147_I155_F0.7990.52
120_L206_N0.7980.52
75_I78_L0.7960.51
149_T164_T0.7930.51
164_T167_A0.7910.51
365_K368_V0.7900.51
242_I304_C0.7870.51
236_G265_V0.7840.50
192_W275_N0.7830.50
123_Q136_T0.7830.50
129_R137_R0.7830.50
121_L170_K0.7810.50
347_F359_T0.7810.50
38_Q175_N0.7810.50
224_L335_E0.7790.50
141_G144_A0.7780.50
113_K141_G0.7760.50
116_K309_H0.7740.49
349_K354_F0.7730.49
291_L318_V0.7720.49
237_C259_D0.7710.49
202_H274_T0.7700.49
236_G300_N0.7650.49
161_P212_G0.7650.49
247_L283_C0.7640.49
182_Q186_A0.7620.48
168_W172_R0.7600.48
330_L334_G0.7590.48
115_P170_K0.7560.48
224_L301_A0.7550.48
246_L250_N0.7550.48
184_A232_I0.7540.48
144_A148_H0.7540.48
126_R158_V0.7480.47
189_T205_A0.7440.47
278_E282_R0.7400.46
126_R130_K0.7390.46
277_P283_C0.7360.46
147_I315_T0.7350.46
257_F265_V0.7320.46
132_V159_L0.7320.46
37_Q40_D0.7310.46
170_K309_H0.7300.46
59_S64_E0.7250.45
278_E281_D0.7250.45
56_G61_A0.7240.45
142_A147_I0.7200.45
342_R359_T0.7200.45
75_I173_L0.7160.44
202_H270_L0.7150.44
145_R148_H0.7110.44
52_N58_L0.7110.44
125_L133_T0.7110.44
226_E250_N0.7090.44
295_E300_N0.7090.44
141_G146_D0.7080.44
260_E311_Q0.7070.43
172_R235_L0.7060.43
288_N292_S0.7040.43
110_V309_H0.7020.43
104_P131_V0.7010.43
125_L132_V0.7000.43
343_H354_F0.6990.43
167_A174_I0.6980.43
323_F350_L0.6970.43
184_A187_P0.6960.42
80_T96_F0.6960.42
286_M294_V0.6960.42
124_Q128_L0.6950.42
59_S62_L0.6950.42
104_P107_P0.6950.42
310_Q315_T0.6940.42
52_N99_S0.6930.42
340_A369_L0.6930.42
66_K296_P0.6930.42
117_T309_H0.6920.42
231_E300_N0.6910.42
53_D170_K0.6910.42
35_L328_R0.6910.42
71_G77_E0.6890.42
56_G64_E0.6870.42
123_Q137_R0.6860.42
171_A174_I0.6800.41
254_K281_D0.6790.41
170_K235_L0.6770.41
170_K174_I0.6680.40
148_H172_R0.6660.40
220_F242_I0.6630.40
346_Y350_L0.6630.40
225_P228_L0.6630.40
49_L197_T0.6570.39
126_R129_R0.6570.39
52_N60_C0.6540.39
58_L336_L0.6540.39
148_H152_L0.6520.39
114_V172_R0.6500.38
266_A270_L0.6490.38
139_I175_N0.6470.38
282_R339_V0.6470.38
232_I252_Q0.6440.38
39_L62_L0.6420.38
320_W352_K0.6410.38
115_P118_L0.6400.38
232_I250_N0.6400.38
151_T162_T0.6400.38
270_L273_E0.6390.37
336_L346_Y0.6380.37
235_L291_L0.6380.37
120_L123_Q0.6370.37
39_L43_E0.6350.37
168_W171_A0.6340.37
310_Q314_L0.6340.37
54_A62_L0.6320.37
341_N346_Y0.6320.37
204_H270_L0.6320.37
143_K170_K0.6310.37
52_N120_L0.6310.37
146_D151_T0.6300.37
56_G59_S0.6290.37
187_P303_L0.6290.37
153_E258_V0.6280.37
77_E80_T0.6270.36
78_L81_R0.6230.36
113_K143_K0.6220.36
273_E278_E0.6220.36
122_E157_K0.6200.36
147_I170_K0.6180.36
60_C63_A0.6180.36
123_Q133_T0.6180.36
262_P266_A0.6170.36
246_L257_F0.6170.36
115_P123_Q0.6160.36
236_G258_V0.6160.36
143_K315_T0.6140.35
67_P173_L0.6130.35
219_F222_Q0.6100.35
338_I371_A0.6060.35
255_V281_D0.6060.35
160_G178_F0.6050.35
77_E287_I0.6040.35
139_I144_A0.6030.34
216_G237_C0.6020.34
204_H311_Q0.6010.34
165_T322_M0.6010.34
234_D309_H0.6000.34
52_N57_A0.5990.34
162_T314_L0.5980.34
229_E339_V0.5980.34
126_R188_Q0.5970.34
156_E160_G0.5960.34
47_P105_Q0.5950.34
318_V325_H0.5950.34
341_N344_L0.5940.34
125_L368_V0.5900.33
291_L325_H0.5890.33
114_V121_L0.5880.33
230_G309_H0.5870.33
201_I242_I0.5850.33
205_A312_H0.5850.33
115_P309_H0.5840.33
347_F351_K0.5840.33
37_Q41_D0.5830.33
76_S79_A0.5830.33
47_P107_P0.5830.33
244_L277_P0.5810.33
255_V283_C0.5800.33
155_F167_A0.5800.33
91_E95_K0.5790.33
70_I73_S0.5780.32
127_A131_V0.5770.32
333_N355_G0.5750.32
263_M322_M0.5740.32
206_N310_Q0.5740.32
35_L135_D0.5740.32
46_G65_H0.5730.32
116_K120_L0.5730.32
302_V328_R0.5710.32
38_Q43_E0.5700.32
290_A318_V0.5690.32
262_P287_I0.5680.32
234_D307_P0.5660.31
292_S331_K0.5650.31
56_G170_K0.5650.31
59_S80_T0.5650.31
99_S263_M0.5650.31
201_I241_V0.5650.31
52_N291_L0.5640.31
159_L309_H0.5640.31
130_K284_E0.5610.31
146_D170_K0.5600.31
207_V344_L0.5580.31
309_H341_N0.5570.31
73_S124_Q0.5560.31
281_D296_P0.5560.31
333_N337_Y0.5560.31
357_C371_A0.5560.31
206_N212_G0.5560.31
348_H351_K0.5550.31
199_W248_D0.5550.31
260_E310_Q0.5550.31
224_L246_L0.5550.31
209_S239_N0.5450.30
63_A94_V0.5440.30
165_T172_R0.5420.30
49_L246_L0.5410.30
240_G305_N0.5410.30
163_T236_G0.5400.29
261_S317_N0.5390.29
47_P65_H0.5390.29
85_R89_I0.5390.29
118_L154_L0.5380.29
50_I266_A0.5370.29
67_P149_T0.5360.29
167_A172_R0.5340.29
119_A194_L0.5340.29
72_D76_S0.5320.29
299_F302_V0.5320.29
207_V268_S0.5310.29
254_K298_R0.5310.29
58_L346_Y0.5300.29
302_V326_A0.5300.29
91_E135_D0.5270.29
285_F288_N0.5260.28
358_T372_V0.5260.28
141_G172_R0.5260.28
292_S372_V0.5260.28
167_A170_K0.5250.28
188_Q205_A0.5230.28
112_I138_I0.5220.28
64_E301_A0.5210.28
242_I245_T0.5200.28
245_T303_L0.5190.28
327_R369_L0.5170.28
192_W213_L0.5170.28
209_S294_V0.5160.28
151_T164_T0.5140.28
316_D319_A0.5120.27
187_P249_K0.5110.27
195_E241_V0.5110.27
111_L346_Y0.5110.27
202_H370_K0.5110.27
258_V291_L0.5100.27
107_P136_T0.5100.27
242_I290_A0.5100.27
234_D306_P0.5090.27
324_H327_R0.5080.27
217_A290_A0.5080.27
44_I256_V0.5080.27
219_F368_V0.5080.27
228_L301_A0.5080.27
37_Q44_I0.5070.27
133_T137_R0.5060.27
143_K217_A0.5030.27
116_K140_A0.5030.27
110_V287_I0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dcmA 1 0.9524 100 0.39 Contact Map
2pjdA 1 0.881 100 0.474 Contact Map
3dmgA 1 0.9286 100 0.503 Contact Map
1dusA 1 0.5026 100 0.764 Contact Map
2ozvA 2 0.4074 99.9 0.803 Contact Map
3lpmA 2 0.4815 99.9 0.805 Contact Map
2b3tA 1 0.6455 99.9 0.809 Contact Map
4mtlA 4 0.5265 99.9 0.811 Contact Map
3evzA 1 0.4841 99.9 0.813 Contact Map
3m70A 1 0.6429 99.8 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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